Evidence Based Practice Regarding Chlorhexidine Use to Prevent Surgical Site Infection
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Transcript of Evidence Based Practice Regarding Chlorhexidine Use to Prevent Surgical Site Infection
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Evidence Based Practice Regarding Chlorhexidine Use to Prevent Surgical Site InfectionPresented by:
Cindy MagirlEric NelsonTennille SassanoJennifer Vicarie
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What does the literature say about the use of Chlorhexidine in the
prevention of surgical site infections (SSI’s)?
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• It is estimated that between 750,000 and 1 million SSIs occur in the United States each year (Edmiston et al., 2010).
• SSIs remains a substantial cause of post-operative morbidity and increased health care costs (Riley et al., 2012).
• SSIs result in 3.7 million additional hospital days and $845 million spent nationally. (Zinn et al., 2010)
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The aim is to evaluate the effectiveness of evidence-based prevention and control strategies to reduce rates of SSIs.
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TABLE 1. Selected Patient and Procedural Characteristics Associated With Increased Risk of Surgical Site Infections
Patient (intrinsic)• Age• Diabetes (metabolic disease)• Perioperative hyperglycemia• Tobacco use• Concurrent infection (distant)• Obesity• Malnutrition• Immunocompromise• Low preoperative serum albumin
level• Corticosteroid use• Prolonged hospitalization before
surgery• Prior radiation to surgical field tissue• Staphylococcus aureus colonization
Procedural (extrinsic)• Lack of preoperative shower• Site shaving the night before
surgery• Extended operative time• Flawed skin antisepsis• Flawed surgical prophylaxis• Effects of the OR environment
(eg, hypothermia)• Break in aseptic technique• Hypothermia or hypoxia• Perioperative blood transfusion• Surgical technique
• Hemostasis• Tissue trauma
Edmiston et al., 2010
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Surgical Studies• 1978 – study showed that application of
CHG to the skin surface resulted in a greater microbial log reduction and it persisted several hours after application compared with povidone iodine
• 1988 – documentation shows that repeat application of CHG 4% was superior to a single shower in reducing staphylococcal skin contamination
Edmiston et al., 2010
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Total Joint Replacement Surgical StudyPRE-INTERVENTION
GROUP• 727 patients• Self bathing of
povidone iodine night prior to surgery
• After 3 months, 3.19% infection rate
POST-INTERVENTION
GROUP• 737 patients• Self bathing of CHG
2% impregnated polyester cloths night prior to surgery and staff assisted bath on admission to hospital
• After 3 months, 1.59% infection rate
Edmiston et al., 2010
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Appraisal
Overall the evidence is strong in supporting the use of CHG. In the journal article, the authors identify some weakness within the studies they included. For example, in one of the studies the author lists several problematic issues involving study design, implementation, and analysis. Another weakness of this literature review is several studies were included and because of this, there was a lot of pertinent information left out in order to summarize the amount of information.
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Riley et. al, 2012
LOW TRANSVERSE CESAREAN SECTIONSURGICAL STUDY
• Observational study conducted to determine LTCS SSI rates and impact of infection control interventions from Oct. 2005-Dec. 2008
• Included use of 2% Chlorhexidine gluconate (CHG) for surgical skin prep and no rinse CHG cloths
• Four study periods
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Low Transverse Cesarean Section (LTCS) Surgical Study
Time LineBaseline Period
(October, 2005 - March, 2006)
SSI rate retrospective identification for comparison
Riley et al., 2012
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Low Transverse Cesarean Section (LTCS) Surgical Study Time Line
Outbreak Period(April, 2006 – October, 2006)
• Obstetrics and gynecology (OBGYN) clinicians noticed an increase in post-LTCS patients returning with SSI in 2006
• Focused on identifying critical control points and analyzing hazards by directly observing LTCS procedures• Labor and delivery (L&D) operating room (OR) walks• Self administered employee survey
• Limited personnel traffic during surgery• Improved surgical hand scrub• Modified surgical skin preparation• Changed the timing of antimicrobial prophylaxis• Revised L&D OR policies• Performed SSI prevention in-services• Completed employee competency training
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Low Transverse Cesarean Section (LTCS) Surgical Study Time Line
Intervention One Period(November, 2006 – September, 2007)
• Focused on changing practice and fully implementing all recommendations from outbreak period
• Fully implemented recommendations based on the CDC’s SSI prevention guidelines
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Low Transverse Cesarean Section (LTCS) Surgical Study Time Line
Intervention Two Period(October, 2007 - December, 2008)
• Chloroprep, a combination of 2% CHG and 70% isopropyl alcohol (IPA) replaced povidone-iodine for surgical skin prep
• Implementation of preoperative CHG skin cleansing program• Scheduled – patient performed night before surgery• Unscheduled – nurse performed as part of pre-surgery prep
• Moved into new hospital building• Changed administration time of antibiotic• Nurses in OBGYN clinics educated patients about SSI
prevention
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AppraisalEvidence in itself was strong based on the reduction of SSIs during the study. However, there were also several limitations to the study:• Implementation of multiple interventions at
the same time. Which intervention was successful?
• Cost analysis was not studied in depth.• Although patients were instructed to contact
their physician for signs and symptoms of infection, no official follow-up was coordinated.
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Zinn et al., 2010
Intra-operative Patient Skin Prep Agents: Is There a Difference?
• The authors conducted an article review to evaluate if there is a superior intra-operative prep available for open abdominal and general surgery procedures.
• The authors concluded that there is no one prep that is superior in all situations.
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Comparison of Prep Solutions Povidone-iodine
Advantages• Excellent gram-
positive activity• Good gram-negative
activity• Broad spectrum• Moderate rapidly of
action• Long established as
an effective agent
ChlorhexidineAdvantages
• Excellent gram-positive activity
• Good gram-negative activity
• Broad spectrum• Moderate rapidly of
action• Excellent persistent
and residual activityZinn et al., 2010
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Comparison of Prep Solutions Povidone- iodine
Disadvantages• Minimal persistence
and residual activity• Decreased
effectiveness in the presence of blood and organic material
• Lack of recent empirical evidence
ChlorhexidineDisadvantages
• Contraindicated for use on eyes, ears, brain and spinal tissue, genitalia, mucus membranes
• Inactivity in the presence of saline solution
• Drying effect on the skin
Zinn et al., 2010
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Appraisal• Only 29 studies were involved in this literature
review• Each prep agent has specific advantages and
disadvantages.• The study reviewed several prep agents
because of the considerations for patient allergies, natural flora, surgical site, and surgeon preference.
• The study did not include any research of ChloraPrep
• The researchers stated that they did not find adequate information to prove one prep agent used exclusively.
• The article was easy to read however lacked specific information or statistical evidence; leaving a lot of unanswered questions.
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Thompson & Houston, 2012
Decreasing methicillin-resistant staphylococcus aureus surgical site infections with chlorhexidine and mupirocin. • This was a case controlled study of 29,862
patients over a 3 year period• Only orthopedic, cardiac, neurological, and
vascular cases were in the study
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Thompson & Houston, 2012
Purpose of the study• To determine if a regimen of 2% chlorhexidine for
5 days pre-op along with intra-nasal mupiricin decreases MRSA surgical site infections
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Thompson & Houston, 2012
Results• Cardiac 92% decrease• Orthopedic 43% decrease• Neurology 100% decrease• Vascular 52% decrease
• Total MRSA SSI reductions from 2006-2008
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Appraisal • Pre-operative bathing with 2% chlorhexidine and
use of mupiricin ointment may be beneficial in reducing MRSA SSI’s
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Our experience with CHG• We currently use a variety of products• ChloraPrep w/ tint• 4% chlorhexidine solution• ChloraPrep SEPP• 2% chlorhexidine cloths
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Recommendations • Use of chlorhexidine intra-op skin prep when not
contraindicated• Appropriate education to patients and staff about
use and application• Pre-operative chlorhexidine bathing • Ongoing follow up on post operative infection rate
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References• Edminster, C.E. Jr, Okoli, O., Graham, M.B., Sinski, S., & Seabrook,
G.(2010). Evidence for using chlorhexidine gluconate preoperative cleansing to reduce risk of surgical site infection. Association of Perioperative Registered Nurses Journal, 92(5), 509-518.
• Riley, M., Suda, D., Tabsh, K., Flood, A., & Pegues, D.(2011). Reduction of surgical site infections in low transverse cesarean section at a university hospital. American Journal of Infection Control, doi:10.1016/j.ajic.2011.12.011
• Thompson, P., Houston, S. (2012). Decreasing methicillin-resistant staphylococcus aureus surgical site infections with chlorhexidine
and mupirocin. American journal of infection control, 9(3).• Zinn, J., Jenkins, J., Swofford, V., Harrelson, B., & McCarter, S.(2010).
Intraoperative patient skin prep agents: Is there a difference? Association of Perioperative Registered Nurses Journal, 92(6),
662-671. doi:10.1016/j.aorn.2010.07.016
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References (Photographs)• CMPA Good Practices Guide. 2012. [Surgical
Preparation]. Retrieved from http://www.cmpa-acpm.ca
• Mayo Healthcare Pty. Ltd. n.d. Interventional Hygiene. Retrieved from http://www.mayohealthcare.com.au/products/Resp_intvH
ygiene_skinPrep.htm