Evidence-based Diagnosis in Medicine
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Transcript of Evidence-based Diagnosis in Medicine
Diagnostics
Using an online dating analogy
Likey or no likey: process. Show one ‘hottie’, one ‘nottie’
Ultimately, they may be ‘hot’ or they may be ‘not hot’ when you actually meet them – more pics
2x2 table for Tinder
What are you interested in? PPV and NPV
But is that all you want to know?
Coin toss analogy in low/high prevalence cohorts (bunnyburners.com and richmusclyheroes.com)
Sensitivity and specificity: What God knows
Pooling both perspectives: likelihood ratios
Bayesian theory in practice
ROC curves: let’s say that (instead of swiping yes or no) you rate the profiles out of 100
Where do you put the cut-off? Examples
ROC curve: show and explain
Talk about AUC. Advantages (global measure)
Disadvantages of AUC: show odd shaped ROC curve
Where do you set the cut-off? Show
• Also, what do you do next? Validate in another cohort as performance calibrated to yours
Summary