Evaluation of postoperative comfort after 3rd molar

12
319 QUINTESSENCE INTERNATIONAL VOLUME 45 • NUMBER 4 • APRIL 2014 Evaluation of postoperative discomfort after impacted mandibular third molar surgery using three different types of flap Andrea Enrico Borgonovo, MD, DMD 1 /Adriano Giussani, DDS 2 /Giovanni Battista Grossi, MD, DMD 3 / Carlo Maiorana, MD, DDS 4 Objective: The surgical extraction of an impacted third molar involves a wide range of consequences such as trismus, swell- ing, and pain, as well as more significant complications, tem- porary or permanent, that can manifest altered sensitivity of the tongue or lips. The purpose of this prospective study was to evaluate the effects of three different flaps on postoperative discomfort considering trismus, edema, and pain, after the extraction of impacted third molars. The data derived from the analysis of the surgical trials performed at the Oral Surgery Unit, Department of Surgical, Reconstructive and Diagnostic Sciences, IRCCS Policlinico, University of Milan, directed by Professor F. Santoro, MD. Method and Materials: This study, developed over 2 years, involved 238 patients for a total of 238 extractions of impacted mandibular third molars. The 238 sur- geries were performed on 114 men and 124 women: 54 avul- sions were performed with the elevation of an envelope flap (Group 1), 48 avulsions through the elevation of a triangular flap (Group 2), and the remaining 136 avulsions were per- formed using a trapezoidal flap (Group 3). Results: Trismus was significantly reduced (P < .05) in patients treated with envelope flap, as was the swelling perceived by the patient (P < .05). Pain was closely related to the elevation of a muco- periosteal flap and osteotomy. Our study does not reveal statis- tically significant differences between the three types of flap used; however, the number of analgesic tablets taken was lower in cases of elevation of a less traumatic flap (envelope and triangular flaps). Conclusion: The data collected in this study indicate the envelope flap as the most suitable for the reduction of the expression of postoperative complications such as swelling and trismus. (Quintessence Int 2014;45:319–330; doi: 10.3290/j.qi.a31333) Key words: discomfort, flap, impacted third molar, surgery ORAL SURGERY Andrea Enrico Borgonovo cedure in the oral cavity. They are present in 90% of the population, of whom 33% have at least one impacted third molar. 2,3 These impactions are probably the result of both genetic and environmental factors. 1,4 The surgical extraction of an impacted third molar involves a wide range of consequences such as trismus, swelling, and pain, as well as more significant complica- tions, temporary or permanent, that can manifest altered sensitivity of the tongue or lips. It is therefore important to assess the risks related to surgery and compare them with the possible patho- Third molars are the most commonly impacted teeth, 1 and their removal is the most frequent surgical pro- 1 Clinical Assistant Professor, Postgraduate School of Oral Surgery, University of Milan, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy. 2 Resident, Postgraduate School of Oral Surgery University of Milan, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy. 3 Head of the Department of Implantology, Fondazione IRCCS Cà Granda, Osped- ale Maggiore Policlinico, Milan, Italy. 4 Professor and Director of Postgraduate School of Oral Surgery, University of Milan, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy. Correspondence: Dr Adriano Giussani, Dental Clinic, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, University of Milan, Via della Commenda 10, 20122 Milan, Italy. Email: [email protected]

description

third molar extraction is expected to cause many complications and affect the quality life of the patient. here is a study about patient comfort

Transcript of Evaluation of postoperative comfort after 3rd molar

  • 319

    Q U I N T E S S E N C E I N T E R N AT I O N A L

    VOLUME 45 NUMBER 4 APRIL 2014

    Evaluation of postoperative discomfort after impacted mandibular third molar surgery using three different types of flapAndrea Enrico Borgonovo, MD, DMD1/Adriano Giussani, DDS2/Giovanni Battista Grossi, MD, DMD3/ Carlo Maiorana, MD, DDS4

    Objective: The surgical extraction of an impacted third molar involves a wide range of consequences such as trismus, swell-ing, and pain, as well as more significant complications, tem-porary or permanent, that can manifest altered sensitivity of the tongue or lips. The purpose of this prospective study was to evaluate the effects of three different flaps on postoperative discomfort considering trismus, edema, and pain, after the extraction of impacted third molars. The data derived from the analysis of the surgical trials performed at the Oral Surgery Unit, Department of Surgical, Reconstructive and Diagnostic Sciences, IRCCS Policlinico, University of Milan, directed by Professor F. Santoro, MD. Method and Materials: This study, developed over 2 years, involved 238 patients for a total of 238 extractions of impacted mandibular third molars. The 238 sur-geries were performed on 114 men and 124 women: 54 avul-sions were performed with the elevation of an envelope flap

    (Group 1), 48 avulsions through the elevation of a triangular flap (Group 2), and the remaining 136 avulsions were per-formed using a trapezoidal flap (Group 3). Results: Trismus was significantly reduced (P < .05) in patients treated with envelope flap, as was the swelling perceived by the patient (P < .05). Pain was closely related to the elevation of a muco-periosteal flap and osteotomy. Our study does not reveal statis-tically significant differences between the three types of flap used; however, the number of analgesic tablets taken was lower in cases of elevation of a less traumatic flap (envelope and triangular flaps). Conclusion: The data collected in this study indicate the envelope flap as the most suitable for the reduction of the expression of postoperative complications such as swelling and trismus. (Quintessence Int 2014;45:319330; doi: 10.3290/j.qi.a31333)

    Key words: discomfort, flap, impacted third molar, surgery

    ORAL SURGERY

    Andrea Enrico Borgonovo

    cedure in the oral cavity. They are present in 90% of the

    population, of whom 33% have at least one impacted

    third molar.2,3 These impactions are probably the result

    of both genetic and environmental factors.1,4

    The surgical extraction of an impacted third molar

    involves a wide range of consequences such as trismus,

    swelling, and pain, as well as more significant complica-

    tions, temporary or permanent, that can manifest

    altered sensitivity of the tongue or lips.

    It is therefore important to assess the risks related to

    surgery and compare them with the possible patho-

    Third molars are the most commonly impacted teeth,1

    and their removal is the most frequent surgical pro-

    1 Clinical Assistant Professor, Postgraduate School of Oral Surgery, University of Milan, Fondazione IRCCS C Granda, Ospedale Maggiore Policlinico, Milan, Italy.

    2 Resident, Postgraduate School of Oral Surgery University of Milan, Fondazione IRCCS C Granda, Ospedale Maggiore Policlinico, Milan, Italy.

    3 Head of the Department of Implantology, Fondazione IRCCS C Granda, Osped-ale Maggiore Policlinico, Milan, Italy.

    4 Professor and Director of Postgraduate School of Oral Surgery, University of Milan, Fondazione IRCCS C Granda, Ospedale Maggiore Policlinico, Milan, Italy.

    Correspondence: Dr Adriano Giussani, Dental Clinic, Fondazione IRCCS C Granda, Ospedale Maggiore Policlinico, University of Milan, Via della Commenda 10, 20122 Milan, Italy. Email: [email protected]

  • 320

    Q U I N T E S S E N C E I N T E R N AT I O N A L

    Borgonovo et al

    VOLUME 45 NUMBER 4 APRIL 2014

    logic changes when third molars remain in place: in

    about 33% of cases the risk consists in the possibility of

    causing pathologic changes.5

    The purpose of this prospective study was to evalu-

    ate the effects of three different flaps on postoperative

    discomfort considering trismus, edema, and pain, after

    the extraction of impacted third molars. The data

    derived from the analysis of the surgical trials per-

    formed at the Oral Surgery Unit, Department of Surgi-

    cal, Reconstructive and Diagnostic Sciences, IRCCS

    Policlinico, University of Milan, directed by Professor F.

    Santoro, MD.

    All authors agreed that third molars should be

    extracted for therapeutic reasons when they are associ-

    ated with pathologic conditions such as untreatable

    caries lesions, infections, cysts, and root and bone

    resorption.

    However, in 35% of cases third molars are extracted

    even in the absence of disease due to strategic reasons,

    either to facilitate or allow second molar treatment

    (conservative treatment, prosthetics, periodontics, and

    orthodontics), or for prophylactic purposes, in order to

    avoid the occurrence of possible future complications.6

    Prophylactic extraction is recommended only in par-

    ticular conditions, when the risk-benefit ratio appears

    particularly favorable, thus justifying the avulsion of

    nonsuffering elements.

    The extraction of impacted teeth is associated with

    a large number of operative complications.7-10 It is

    therefore essential to provide complete information to

    the patient about the risks and benefits of this type of

    surgery.

    The flap design depends on some factors closely

    related to the characteristics of the impacted tooth,

    such as the depth of inclusion and the morphology and

    anatomy of the tooths root. It has to be planned pre-

    operatively. The flap must ensure sufficient surgical

    access in order to facilitate the extraction without caus-

    ing excessive tissue tension, it has to prevent injuries to

    adjacent anatomic structures (buccinator nerve, lingual

    nerve, and facial artery),11-14 and it allows proper reposi-

    tioning to avoid dehiscence.

    The envelope flap can be used in cases of partial

    inclusion of teeth in the mucosa. This kind of flap is

    indicated in situations that do not require a consider-

    able dislocation and ostectomy to allow the extraction

    of the teeth. It represents the most conservative flap

    (Fig 1).

    The triangular flap is indicated in cases of partial or

    total bone inclusions. These flaps allow good access to

    the operative site and permit a major osteotomy to

    complete avulsion (Fig 2).

    The trapezoidal flap is larger than the other flap

    designs and is indicated in cases of particularly com-

    plex inclusions, such as a third molar that is near impor-

    tant anatomic structures, or for particular root confor-

    mations (eg, diverging curved apices) (Fig 3).15

    METHOD AND MATERIALS

    The aim of this prospective study was to evaluate the

    magnitude of the postoperative discomfort in a sample

    of healthy subjects who need surgical extraction of an

    impacted mandibular third molar, in relation to the flap

    Fig 1 Envelope flap. Fig 2 Triangular flap. Fig 3 Trapezoidal flap.

  • 321

    Q U I N T E S S E N C E I N T E R N AT I O N A L

    Borgonovo et al

    VOLUME 45 NUMBER 4 APRIL 2014

    design. The study related to the Oral Surgery Unit,

    Department of Surgical, Reconstructive and Diagnostic

    Sciences, IRCCS Policlinico, University of Milan.

    Impacted third molars considered in this study

    belonged to Pell and Gregory classification 2B, in verti-

    cal position.

    It was attempted to create a homogenous distribu-

    tion of the cases. The trapezoidal flap, which allows

    greater intraoperative vision, was employed in patients

    who were uncooperative, who had a reduced interinci-

    sal distance (less than 3 cm), or in patients with small

    mouths.

    Exclusion criteria were patients with systemic or

    psychiatric diseases or allergies to medications, unco-

    operative subjects, pregnant or lactating women,

    patients who did not follow the antibiotic therapy, and

    those with episodes of pericoronitis less than 1 month

    previously, severe periodontal disease, or tooth-associ-

    ated cysts. Patients were also excluded if, after extrac-

    tion of the mandibular third molar, they failed to

    appear at the control visit 7 days later or did not com-

    plete the forms after surgery. Cases where a flap was

    not necessary for the extraction were also excluded.

    All patients underwent antibiotic prophylaxis with

    2 g of oral amoxicillin + clavulanic acid (Augmentin,

    Clavulin), 1 hour before surgery.16

    The sample was divided into three groups accord-

    ing to the type of flap. All data were transferred to a

    spreadsheet in Excel 2011 (Microsoft), and statistical

    analysis was performed using SPSS 17 (SPSS). P values

    greater than .05 were not considered significant.

    The study was carried out and presented in accor-

    dance with the ethical standards laid down in the Dec-

    laration of Helsinki, and informed consent was

    obtained from all participants prior to their enrollment

    in the study.

    Surgical procedurePreoperatively, panoramic radiographs and informed

    consent were obtained. Interincisal distance was mea-

    sured to evaluate the objective assessment of trismus.

    All patients were treated by the same surgeon and

    dental assistant under standard clinical conditions.

    Before beginning any surgical procedure, the

    patient used chlorhexidine 0.2% mouthwash for 1 min-

    ute.16 Mepivacaine without adrenaline was used for

    troncular anesthesia, and mepivacaine with adrenaline

    1:100,000 was used for local anesthesia in all study

    patients.

    Once the flap was reflected, the surgical site was

    inspected. Any bone overlying the crown of the

    impacted third molar was removed with a surgical bur;

    a fissure bur was used if the tooth required sectioning,

    under irrigation with saline solution (Figs 4 to 6). Dental

    follicular soft tissue was removed and the socket thor-

    oughly irrigated. Finally, the flap was repositioned and

    sutured (Ethicon, 3-0 silk).

    The duration of surgery was recorded in minutes,

    from the incision to the end of the suture. At the end of

    the surgery the patient took one tablet of analgesic

    (paracetamol 500 mg) and an ice-pack was instantly

    applied to combat postoperative edema.

    Fig 4 Envelope flap: intrasulcular incision. Fig 5 Flap reflection. Fig 6 Site exploration.

  • 322

    Q U I N T E S S E N C E I N T E R N AT I O N A L

    Borgonovo et al

    VOLUME 45 NUMBER 4 APRIL 2014

    Postsurgical evaluationSeven days after surgery the interincisal distance was

    measured again during the control visit. The progress

    of the healing process was also assessed. All assess-

    ments were made by the same author who had previ-

    ously performed the preoperative evaluations.

    In the final phase, the patient completed a form that

    recorded the number of analgesic tablets taken, in

    order to quantify objectively the pain, and the Postop-

    erative Symptom Severity (PoSSe scale),17 where

    patients expressed how the side effects during the

    postoperative period influenced their quality of life.

    This questionnaire was divided into subscales corre-

    sponding to seven main adverse effects, and for each

    possible answer there was a score ranging from 0 to a

    variable number. It is a valid and reliable measure of the

    severity of symptoms after extraction of third molars,

    and of the impact of those symptoms on patients per-

    ceived health.

    RESULTS

    The study, developed over 2 years, involved 238

    patients for a total of 238 extractions of impacted man-

    dibular third molars. The 238 surgeries were performed

    on 114 men and 124 women: 54 avulsions were per-

    formed with the elevation of an envelope flap (Group

    1), 48 avulsions through the elevation of a triangular

    flap (Group 2), and the remaining 136 avulsions were

    performed using a trapezoidal flap (Group 3). The mean

    time of surgery was 25.6 minutes (range 14 to 45 min-

    utes) for Group 1, 27.7 minutes (range 12 to 45 min-

    utes) for Group 2, and 19.9 minutes (range 7 to 50

    minutes) for Group 3 (Table 1). No patients had wound

    infections, or abnormalities of the healing process. The

    summary of data collected is shown in Table 2.

    Evaluation of trismusTrismus seems to be influenced by the type of flap

    (Table 3). The analysis of variance (ANOVA) found statis-

    tically significant differences between the values for the

    variation of the interincisal distance in the three study

    groups (P = .031) (Table 4). Since three variables were

    compared, Bonferroni post hoc test was used to study

    the significance of the comparisons. A statistically sig-

    nificant difference was found between Group 1 (enve-

    lope flap) and Group 2 (triangular flap) (P = .040). There

    was no statistically significant difference between

    Group 1 (envelope flap) and Group 3 (trapezoidal flap)

    (P = .089), or between Group 2 (triangular flap) and

    Group 3 (trapezoidal flap) (P = 1.00) (Table 3).

    Evaluation of painTable 5 shows the number of analgesic tablets taken by

    patients within 7 days postoperatively, in order to

    evaluate objectively the perceived pain.

    The ANOVA test denotes the absence of a statisti-

    cally significant difference among the three groups of

    patients (P = .162) (Table 6).

    Evaluation of PoSSe scaleThe values of the questionnaire and the individual sub-

    scales are shown in Table 7. The level of significance of

    each subscale was rated (Table 8), and the appear-

    ance subscale was the only one that showed statisti-

    cally significant values for ANOVA (P = .000). By per-

    forming the Bonferroni post hoc test we noticed that

    differences were statistically significant between

    Group 1 (envelope flap) and Group 2 (triangular flap)

    (P = .005), and between Group 1 (envelope flap) and

    Group 3 (trapezoidal flap) (P = .000).

    In the literature there are few data concerning post-

    operative discomfort related to the type of flap per-

    formed, and those consider only two variances, the

    envelope flap and the triangular flap. For this reason

    the statistical analysis was revised excluding Group 3

    (trapezoidal flap), in order to compare the data of this

    study with previous studies (Table 9). P values greater

    than .05 were not considered significant.

    Evaluation of trismusTrismus is influenced by the type of flap performed

    (Table 10).

    ANOVA found statistically significant differences

    between the values for the variation of the interincisal

    distance in the two study groups (P = .014) (Table 11).

  • 323

    Q U I N T E S S E N C E I N T E R N AT I O N A L

    Borgonovo et al

    VOLUME 45 NUMBER 4 APRIL 2014

    Table 2 Summary of collected data in the three groups

    Parameter

    Envelope flap Triangular flap Trapezoidal flap

    Mean Mean SD Mean Mean SD Mean Mean SD

    Total PoSSe 32.13 31.32 12.31 36.81 35.77 14.39 37.07 35.33 13.60

    PoSS

    e su

    bsc

    ales

    Eating 11.23 10.50 4.71 12.19 10.50 5.19 13.13 13.13 5.07

    Speech 2.80 2.50 2.17 3.39 3.75 2.23 3.10 2.50 2.37

    Sensation 2.19 2 2.86 2.29 1 3.52 2.22 0.00 3.45

    Appearance 2.86 3 2.37 4.59 4.5 2.63 4.97 4.50 2.89

    Pain 7.75 7.13 3.69 8.69 7.13 4.01 8.37 9.50 4.38

    Sickness 0.90 0.00 1.62 0.83 0.00 1.66 0.67 0.00 1.37

    Interference 4.40 4.41 1.94 4.83 5.23 2.51 4.61 4.96 2.26

    Used painkillers 4.87 3.00 4.21 4.25 3.00 3.59 5.59 4.00 4.63

    Difference in interincisal distance (mm)

    6.56 4.50 7.00 10.63 6.50 9.32 9.46 7.00 8.29

    Age 26.70 26.00 7.08 26.69 26.00 6.13 27.34 26.00 7.97

    SD, standard deviation.

    Table 1 Summary of the three groups

    Parameter Envelope flap (n = 54) Triangular flap (n = 48) Trapezoidal flap (n = 136) Total (n = 238)

    Age (years) 26.7 26.68 27.33 27.06

    SexMale 18 24 72 114

    Female 36 24 64 124

    SmokerYes 12 15 45 72

    No 42 33 91 166

    Time of surgery (min) 25.6 27.7 19.9 24.33

    Table 4 Comparison of interincisal differences ( trismus): analysis of variance

    Sum of squares df Mean square P

    Between groups 477.412 2 238.706 .031

    Within groups 15960.319 235 67.916

    Total 16437.731 237

    df, degrees of freedom.

    Table 3 Comparison of interincisal differences ( trismus) detected in the three groups

    Flap type N Mean SD SE Min Max

    Envelope flap 54 6.56 6.995 0.952 0 26

    Triangular flap 48 10.63 9.321 1.345 0 35

    Trapezoidal flap 136 9.46 8.293 0.711 0 36

    Total 238 9.03 8.328 0.540 0 36

    SD, standard deviation; SE, standard error.

    Table 6 Pain: analysis of variance

    Sum of squares df Mean square P

    Between groups 69.214 2 34.607 .162

    Within groups 4436.034 235 18.877

    Total 4505.248 237

    df, degrees of freedom.

    Table 5 Comparison of number of painkillers taken (as an indicator of pain) in the three groups

    Flap type N Mean SD SE Min Max

    Envelope flap 54 4.87 4.212 0.573 0 14

    Triangular flap 48 4.25 3.594 0.519 0 14

    Trapezoidal flap 136 5.59 4.626 0.397 0 21

    Total 238 5.16 4.360 0.283 0 21

    SD, standard deviation; SE, standard error.

  • 324

    Q U I N T E S S E N C E I N T E R N AT I O N A L

    Borgonovo et al

    VOLUME 45 NUMBER 4 APRIL 2014

    Evaluation of painTable 12 shows the number of analgesic tablets taken

    within 7 days postoperatively by patients from the two

    groups, in order to evaluate objectively the perceived

    pain. In this case the ANOVA test denotes the absence

    of a statistically significant difference between the two

    groups of patients (P = .428) (Table 13).

    Evaluation of PoSSe scaleThe values of the questionnaire and the individual sub-

    scales are shown in Table 14.

    The appearance subscale of the questionnaire is

    the only one to be statistically significant using ANOVA

    (P = .001) (Table 15). Compared with results of this

    study, the literature is in agreement.

    Table 7 Evaluation of PoSSe scale in the three groups

    Flap type N Mean SD Min Max

    Total PoSSe

    Envelope flap 54 32.1280 12.30772 5.11 56.46

    Triangular flap 48 36.8098 14.38729 9.01 67.93

    Trapezoidal flap 136 37.0719 13.60133 5.38 81.65

    Total 238 35.8973 13.58307 5.11 81.65

    PoSSe eating

    Envelope flap 54 11.232 4.7122 0.0 21.0

    Triangular flap 48 12.192 5.1895 0.0 21.0

    Trapezoidal flap 136 13.127 5.0716 0.0 21.0

    Total 238 12.508 5.0566 0.0 21.0

    PoSSe speech

    Envelope flap 54 2.801 2.1710 0.0 7.5

    Triangular flap 48 3.385 2.2325 0.0 8.8

    Trapezoidal flap 136 3.097 2.3715 0.0 8.8

    Total 238 3.088 2.2984 0.0 8.8

    PoSSe sensation

    Envelope flap 54 2.19 2.862 0 12

    Triangular flap 48 2.29 3.525 0 16

    Trapezoidal flap 136 2.22 3.448 0 16

    Total 238 2.23 3.327 0 16

    PoSSe appearance

    Envelope flap 54 2.861 2.3720 0.0 12.0

    Triangular flap 48 4.594 2.6330 0.0 12.0

    Trapezoidal flap 136 4.974 2.8850 0.0 12.0

    Total 238 4.418 2.8479 0.0 12.0

    PoSSe pain

    Envelope flap 54 7.7454 3.69495 0.00 14.26

    Triangular flap 48 8.6852 4.00922 0.00 17.63

    Trapezoidal flap 136 8.3703 4.38276 0.00 19.00

    Total 238 8.2920 4.15756 0.00 19.00

    PoSSe sickness

    Envelope flap 54 0.90 1.618 0 6

    Triangular flap 48 0.83 1.658 0 8

    Trapezoidal flap 136 0.67 1.369 0 6

    Total 238 0.76 1.486 0 8

    PoSSe interference with activities

    Envelope flap 54 4.4009 1.94366 0.00 7.16

    Triangular flap 48 4.8288 2.51395 0.00 9.90

    Trapezoidal flap 136 4.6112 2.25614 0.00 9.90

    Total 238 4.6074 2.23993 0.00 9.90

    SD, standard deviation.

  • 325

    Q U I N T E S S E N C E I N T E R N AT I O N A L

    Borgonovo et al

    VOLUME 45 NUMBER 4 APRIL 2014

    Table 9 Summary of collected data in the envelope and triangular flap groups

    Envelope flap Triangular flap

    Mean Mean SD Mean Mean SD

    Total PoSSe 32.13 31.32 12.31 36.81 35.77 14.39

    PoSS

    e su

    bsc

    ales

    Eating 11.23 10.50 4.71 12.19 10.50 5.19

    Speech 2.80 2.50 2.17 3.39 3.75 2.23

    Sensation 2.19 2.00 2.86 2.29 1.00 3.52

    Appearance 2.86 3.00 2.37 4.59 4.50 2.63

    Pain 7.75 7.13 3.69 8.69 7.13 4.01

    Sickness 0.90 0.00 1.62 0.83 0.00 1.66

    Interference 4.40 4.41 1.94 4.83 5.23 2.51

    Used painkillers 4.87 3.00 4.21 4.25 3.00 3.59

    Difference in interincisal distance (mm)

    6.56 4.50 7.00 10.63 6.50 9.32

    Age 26.70 26.00 7.08 26.69 26.00 6.13

    SD, standard deviation.

    Table 8 PoSSe scale: analysis of variance

    Sum of squares df Mean square P

    Total PoSSe

    Between groups 994.834 2 497.417 .067

    Within groups 42731.630 235 181.837

    Total 43726.464 237

    PoSSe Eating

    Between groups 144.915 2 72.458 .058

    Within groups 5914.902 235 25.170

    Total 6059.817 237

    PoSSe Speech

    Between groups 8.708 2 4.354 .440

    Within groups 1243.314 235 5.291

    Total 1252.022 237

    PoSSe Sensation

    Between groups 0.301 2 0.150 .987

    Within groups 2623.447 235 11.164

    Total 2623.748 237

    PoSSe Appearance

    Between groups 174.456 2 87.228 .000

    Within groups 1747.696 235 7.437

    Total 1922.152 237

    PoSSe Pain

    Between groups 24.391 2 12.195 .496

    Within groups 4072.223 235 17.329

    Total 4096.614 237

    PoSSe Sickness

    Between groups 2.434 2 1.217 .578

    Within groups 520.807 235 2.216

    Total 523.241 237

    PoSSe Interference with activities

    Between groups 4.656 2 2.328 .631

    Within groups 1184.437 235 5.040

    Total 1189.092 237

    df, degrees of freedom.

  • 326

    Q U I N T E S S E N C E I N T E R N AT I O N A L

    Borgonovo et al

    VOLUME 45 NUMBER 4 APRIL 2014

    Table 14 Evaluation of PoSSe Scale in the two groups

    Flap type N Mean SD Min Max

    Total PoSSe

    Envelope flap 54 32.1280 12.30772 5.11 56.46

    Triangular flap 48 36.8098 14.38729 9.01 67.93

    Total 102 34.3312 13.46583 5.11 67.93

    PoSSe Eating

    Envelope flap 54 11.232 4.7122 0.0 21.0

    Triangular flap 48 12.192 5.1895 0.0 21.0

    Total 102 11.683 4.9413 0.0 21.0

    PoSSe Speech

    Envelope flap 54 2.801 2.1710 0.0 7.5

    Triangular flap 48 3.385 2.2325 0.0 8.8

    Total 102 3.076 2.2087 0.0 8.8

    PoSSe Sensation

    Envelope flap 54 2.19 2.862 0 12

    Triangular flap 48 2.29 3.525 0 16

    Total 102 2.24 3.175 0 16

    PoSSe Appearance

    Envelope flap 54 2.861 2.3720 0.0 12.0

    Triangular flap 48 4.594 2.6330 0.0 12.0

    Total 102 3.676 2.6332 0.0 12.0

    PoSSe Pain

    Envelope flap 54 7.7454 3.69495 0.00 14.26

    Triangular flap 48 8.6852 4.00922 0.00 17.63

    Total 102 8.1876 3.85570 0.00 17.63

    PoSSe Sickness

    Envelope flap 54 0.90 1.618 0 6

    Triangular flap 48 0.83 1.658 0 8

    Total 102 0.87 1.629 0 8

    PoSSe Interference with activities

    Envelope flap 54 4.4009 1.94366 0.00 7.16

    Triangular flap 48 4.8288 2.51395 0.00 9.90

    Total 102 4.6023 2.22922 0.00 9.90

    SD, standard deviation.

    Table 13 Pain: analysis of variance

    Sum of squares df Mean square P

    Between groups 9.780 1 9.780 .428

    Within groups 1547.093 100 15.471

    Total 1556.873 101

    df, degrees of freedom.

    Table 12 Comparison of number of painkillers taken (as an indicator of pain) in the two groups

    Flap type N Mean SD Min Max

    Envelope flap 54 4.87 4.212 0 14

    Triangular flap 48 4.25 3.594 0 14

    Total 102 4.58 3.926 0 14

    SD, standard deviation.

    Table 11 Comparison of interincisal differences ( trismus): analysis of variance

    Sum of squares df Mean square P

    Between groups 420.828 1 420.828 .014

    Within groups 6676.583 100 66.766

    Total 7097.412 101

    df, degrees of freedom.

    Table 10 Comparison of interincisal differences ( trismus) detected in the two groups

    Flap type N Mean SD Min Max

    Envelope flap 54 6.56 6.995 0 26

    Triangular flap 48 10.63 9.321 0 35

    Total 102 8.47 8.383 0 35

    SD, standard deviation.

  • 327

    Q U I N T E S S E N C E I N T E R N AT I O N A L

    Borgonovo et al

    VOLUME 45 NUMBER 4 APRIL 2014

    DISCUSSION

    Surgery of impacted third molars is associated with

    significant postoperative discomfort.7-10 For this reason

    several authors have followed different surgical proto-

    cols in order to identify the most effective treatment.

    Data from the present study demonstrate that con-

    cerning the extraction of an impacted mandibular third

    molar the use of a mucoperiosteal envelope flap can be

    effective in reducing postoperative discomfort, most

    specifically in the reduction of the expression of trismus

    and swelling.

    All patients underwent antibiotic prophylaxis (2 g

    amoxicillin 1 hour before surgery), in order to reduce

    the incidence of infection of the surgical wound.16,17

    Pain is closely related to the elevation of a muco-

    periosteal flap and osteotomy. Our study does not

    reveal statistically significant differences between the

    three types of flap used; however, the number of anal-

    gesic tablets taken was lower in cases of elevation of a

    less traumatic flap (envelope and triangular flaps).

    In patients treated with envelope flap, trismus was

    significantly reduced (P < .05) as well as the swelling

    perceived by the patient (P

  • 328

    Q U I N T E S S E N C E I N T E R N AT I O N A L

    Borgonovo et al

    VOLUME 45 NUMBER 4 APRIL 2014

    value 67.93) and trapezoidal flap (mean 37.08, maxi-

    mum value 81.65).

    In a study by Garca et al,19 218 patients needing the

    avulsion of mandibular third molars were divided into

    three groups: the first group did not need any flap ele-

    vation, the second group needed a full-thickness muco-

    periosteal flap for the extraction, and the third group

    needed a flap and osteotomy. The assessment of tris-

    mus was obtained by comparing the interincisal dis-

    tance before and after surgery: differences were not

    significant in the first group, while significant in the

    second and third groups. Similar considerations have

    also been assessed by analyzing the pain experienced

    by patients, which was higher in the second and third

    groups compared to patients who were not subject to

    a flap and osteotomy.

    Sandhu et al20 compared the effects of flap design

    on postoperative sequelae such as pain, swelling, tris-

    mus, and wound dehiscence after bilateral surgical

    avulsion of the mandibular impacted third molars. They

    selected 20 patients aged 20 to 30 years, and the

    interincisal distance and some facial measurements

    were recorded before surgery. An envelope flap was

    used on one side and a triangular flap was used on the

    contralateral side. Pain, swelling, trismus, and wound

    dehiscence were evaluated after surgery. The pain and

    the rate of wound dehiscence were significantly greater

    in the case of elevation of an envelope flap, compared

    to the other group (P .05).

    Erdogan et al21 compared the effects of an envelope

    flap and a triangular flap on trismus, pain, and swelling:

    20 patients with bilateral impacted mandibular third

    molars were placed in a double-blind, prospective, and

    randomized trial. One third molar was extracted by the

    elevation of an envelope flap, and the other using a

    triangular flap. Trismus was determined by measuring

    maximum interincisal distance, swelling using facial

    measurements, and pain using a visual analog scale

    (VAS) and the number of analgesic tablets taken. The

    swelling and VAS scores were lower in cases of enve-

    lope flap, while no significant difference was deter-

    mined by analyzing the data for trismus and pain.

    Kirk et al22 considered 32 patients with bilateral

    impacted third molars which were extracted using an

    envelope flap for one tooth, and a triangular flap for

    the other. Postoperative pain was recorded using a

    VAS, and postoperative swelling was assessed by com-

    paring models of laser scans of each patients cheek

    before and 2 days after surgery. There were no statisti-

    cally significant differences between the designs of the

    flap in terms of severity of postoperative pain and tris-

    mus. A statistically significant difference was observed

    in postoperative swelling after 2 days: the triangular

    flap was associated with increased swelling, and the

    envelope flap with a higher incidence of alveolar oste-

    itis (AO). The flap designs used did not seem to affect

    patients in terms of postoperative pain and trismus.

    Koyuncu and Cetingl23 tried to estimate the influ-

    ence of flap design on AO and postoperative side

    effects following third molar surgery. Eighty patients

    with impacted mandibular third molars participated in

    the study. The envelope flap design was associated

    with a higher incidence of AO, but this was not statisti-

    cally significant. On the second day, postoperative pain

    and swelling were observed as significantly different

    with the envelope flap technique.

    Dolanmaz et al24 evaluated envelope and modified

    triangular flaps for postoperative pain and swelling

    after mandibular impacted third molar surgery. Postop-

    erative pain and swelling were evaluated until day 7

    using two verbal rating scales. Authors found no sig-

    nificant difference between the envelope and modified

    triangular flaps regarding postoperative pain and swell-

    ing after impacted third molar surgery.

    CONCLUSION

    Surgery of the mandibular impacted third molars may

    cause severe discomfort to the patient postoperatively.

    The related factors and the methods that can be imple-

    mented to reduce the disease should be known to

    every oral surgeon. It is reasonable to think that the

    incision of soft tissues and ostectomy necessary to

  • 329

    Q U I N T E S S E N C E I N T E R N AT I O N A L

    Borgonovo et al

    VOLUME 45 NUMBER 4 APRIL 2014

    enhance the extraction increase the discomfort in

    terms of postoperative trismus, swelling, and pain.

    Although the choice of flap is conveyed by the

    degree of complexity of extraction, the inclusion depth,

    and the spatial arrangement of the impacted tooth, a

    triangular or trapezoidal flap can simplify the operators

    intervention in case of uncooperative patients with

    poor mouth opening. Difficulty opening the mouth

    (interincisal distance less than 30 mm)25 can inhibit the

    use of drills and require osteotomy and odontotomy,

    complicating the surgical procedure and lengthening

    the operating time. In these cases, the use of a triangu-

    lar or trapezoidal flap may be advisable.

    The envelope flap is easier to perform and to suture,

    compared to a triangular or trapezoidal flap, but does

    not facilitate access to the surrounding structures, mak-

    ing it more difficult to perform osteotomy. The triangu-

    lar and trapezoidal flaps allow for easier access to sur-

    rounding structures, facilitating the osteotomy

    required to extract the tooth. However, in the latter two

    types of flap suturing is more complex, and more

    extensive exposure of the bone surface tends to trigger

    increased bone resorption by osteoclasts.26-28 It is nota-

    ble, however, that after performing an envelope flap

    there is a higher chance of finding a distal dehiscence

    of the wound. Regardless of the design of the flap, the

    periodontal condition of the second molar is compro-

    mised.29-31

    The data from the present study indicate the enve-

    lope flap as the most suitable for the reduction of the

    expression of postoperative complications such as

    swelling and trismus.

    The search for an optimal surgical approach for the

    removal of third molars is extremely important. The

    decision to use a certain type of flap is closely linked to

    the preference of the surgeon and the degree of com-

    plexity of extraction of the impacted tooth.32,33 How-

    ever, when a choice between different types of flap is

    possible, the conclusions drawn from this study may

    help the surgeon to choose the approach that gives the

    least discomfort to the patient in the healing phase.

    REFERENCES 1. Suarez-Cunqueiro MM, Gutwald R, Reichman J, Otero-Cepeda XL, Schmel-

    zeisen R. Marginal flap versus paramarginal flap in impacted third molar sur-gery: a retrospective study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003;95:403408.

    2. Rosa AL, Carneiro MG, Lavrador MA, Novaes AB Jr. Influence of flap design on periodontal healing of second molars after extraction of impacted mandibu-lar third molars. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;93:404407.

    3. Seward GR, Harris M, McGowan DA (eds). An Outline of Oral Surgery I. Oxford: Wright, 1999:5292.

    4. Richardson M. Impacted third molars. Br Dent J 1995;178:92.

    5. Punwutikorn J, Waikakul A, Ochareon P. Symptoms of unerupted mandibular third molars. Oral Surg Oral Med Oral Pathol 1999;87:305310.

    6. Worral SF, Riden K, Haskell R, Corrigan AM. UK National Third Molar Project: the initial report. Br J Oral Maxillofac Surg 1998;36:1418.

    7. Iizuka T, Tanner S, Berthold H. Mandibular fractures following third molar extraction. A retrospective clinical and radiological study. Int J Oral Maxillofac Surg 1997;26:338343.

    8. Walters H. Reducing lingual nerve damage in third molar surgery: a clinical audit of 1350 cases. Br Dent J 1995;25;178:140104.

    9. Chiapasco M, De Cicco L, Marrone G. Side effects and complications associat-ed with third molar surgery. Oral Surg Oral Med Oral Pathol 1993;76:412420.

    10. Sands T, Pynn BR, Nenniger S. Third molar surgery: current concepts and controversies. Part 2. Oral Health 1993;19:2730.

    11. Pogrel MA, Renaut A, Schmidt B, Ammar A. The relationship of the lingual nerve to the mandibular third molar region: an anatomic study. J Oral Maxil-lofac Surg 1995;53:11781181.

    12. De Boer MPJ, Raghoebar GM, Stegenga B, Schoen PJ, Boering G. Complication after mandibular third molar extraction. Quintessence Int 1995;26:779784.

    13. Robinson PP, Smith KG. Lingual nerve damage during lower third molar removal: a comparison of two surgical methods. Br Dent J 1996;180:456461.

    14. Kiesselbach JE, Chamberlain JG. Clinical and anatomic observations on the relationship of the lingual nerve to the mandibular third molar region. J Oral Maxillofac Surg 1984;42:565567.

    15. Andreasen JO, Kolsen Petersen J, Laskin DM. Textbook and Color Atlas of Tooth Impactions. Copenhagen: Munksgaard, 1997.

    16. Delibasi C, Saracoglu U, Keskin A. Effects of 0.2% chlorhexidine gluconate and amoxicillin plus clavulanic acid on the prevention of alveolar osteitis following mandibular third molar extractions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;94:301304.

    17. Monaco G, Staffolani C, Gatto MR, Checchi L. Antibiotic therapy in impacted third molar surgery. Eur J Oral Sci 1999;107:437431.

    18. Ruta DA, Bissias E, Ogston S, Ogden GR. Assessing health outcomes after extraction of third molars: the postoperative symptom severity (PoSSe) scale. Br J Oral Maxillofac Surg 2000;38:480487.

    19. Garca A, Gude Sampedro F, Gallas Torrella M, Gndara Vila P, Madrin-Graa P, Gndara-Rey JM. Trismus and pain after removal of a lower third molar. Effects of raising a mucoperiosteal flap. Med Oral 2001;6:391396.

    20. Sandhu A, Sandhu S, Kaur T. Comparison of two different flap designs in the surgical removal of bilateral impacted mandibular third molars. Int J Oral Maxillofac Surg 2010;39:10911096.

    21. Erdogan O, Tatl U, Ustn Y, Damlar I. Influence of two different flap designs on the sequelae of mandibular third molar surgery. Oral Maxillofac Surg 2011;15:147152.

    22. Kirk DG, Liston PN, Tong DC, Love RM. Influence of two different flap designs on incidence of pain, swelling, trismus, and alveolar osteitis in the week fol-lowing third molar surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;104:e16.

    23. Koyuncu BO, Cetingl E. Short-term clinical outcomes of two different flap techniques in impacted mandibular third molar surgery. Oral Surg Oral Med Oral Pathol Oral Radiol 2013;116:e179184.

  • 330

    Q U I N T E S S E N C E I N T E R N AT I O N A L

    Borgonovo et al

    VOLUME 45 NUMBER 4 APRIL 2014

    24. Dolanmaz D, Esen A, Isik K, Candirli C. Effect of 2 flap designs on postoperative pain and swelling after impacted third molar surgery. Oral Surg Oral Med Oral Pathol Oral Radiol 2013;116:e244246.

    25. Checchi L, Monaco G (eds). Terzi molari inclusi. Soluzioni terapeutiche. Edizioni Martina, 2009.

    26. Wood DL, Hoag PM, Donnenfeld W, Rosenfeld LD. Alveolar crest reduction following full and partial thickness flaps. J Periodontol 1972;43:141144.

    27. Yaffe A, Fine N, Binderman I. Regional accelerated phenomenon in the man-dible following mucoperiosteal flap surgery. J Periodontol 1994;65:7983.

    28. Yaffe A, Iztkovich M, Earon Y, Alt I, Lilov R, Binderman I. Local delivery of an amino bisphosphonate prevents the resorptive phase of alveolar bone fol-lowing mucoperiosteal flap surgery in rats. J Periodontol 1997;68:884889.

    29. Rosa AL, Carneiro MG, Lavrador MA, Novaes AB Jr. Influence of flap design on periodontal healing of second molars after extraction of impacted mandibu-lar third molars. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;93:404407.

    30. Dodson TB. Management of mandibular third molar extraction sites to pre-vent periodontal defects. J Oral Maxillofac Surg 2004;62:12131224.

    31. Quee TA, Gosselin D, Millar EP, Stamm JW. Surgical removal of the fully impacted mandibular third molar. The influence of flap design and alveolar bone height on the periodontal status of the second molar. J Periodontol 1985;56:625630.

    32. Grossi GB, Maiorana C, Garramone RA, Borgonovo A, Creminelli L, Santoro F. Assessing postoperative discomfort after third molar surgery: a prospective study. J Oral Maxillofac Surg 2007;65:901917.

    33. Sisk AL, Hammer WB, Shelton DW, Joy ED Jr. Complications following removal of impacted third molars: the role of the experience of the surgeon. J Oral Maxillofac Surg 1986;44:855859.