Euro Chemistry 2016...Notes Page 17 Euro Chemistry 2016 June 16-18, 2016 Chem Sci J 2016 Volume 7,...

June 16-18, 2016 Rome, ItalyEuropean Chemistry Congress

conferenceseries.com 513th Conference

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Euro Chemistry 2016

Scientific Tracks & Abstracts(Day 1)

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Euro Chemistry 2016June 16-18, 2016

Volume 7, Issue 2(Suppl)Chem Sci J 2016

ISSN: 2150-3494, CSJ an open access journal



Jarintzi Rico et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

An innovative method for the extraction and quantification of curcuminoids from a complex matrixJarintzi Rico, Mishra Prashant K and Casarín AlbertoEuro-Nutec Premix SA de CV, Mexico

In recent years because of the increasing resistance and regulations on the use of antibiotics in animal feed, plant extracts have gained a lot of attention as an effective substitute to antibiotic growth promoters in animal nutrition. Due to the low inclusion levels of essential oils in products, extraction and quantification of the active compounds become a major challenge. The different steps involved in the process can be destructive and affect the properties of natural extracts and it is important to have a precise way to quantify the active compounds. In this study, a quick and easy method was developed to extract curcuminoids (bisdemetoxycurcumin-BDMC, demetoxicurcumin-DMC and curcumin-CUR) from complex matrix, which were quantified by Reverse phase Ultra Performance Liquid Cromatography coupled to Mass Spectrometry. For curcuminoids extraction 20 g of sample with 60 ml of solvent was deposited in Teflon flask, closed and placed in an autoclave for 2 minutes at sterilization temperature and this was kept to cool down and evaporated with nitrogen until 2 ml remain then filtered and analyzed. For the 3 curcminoids in premix and feed, the extraction recovery for this method ranged from 94.5 to 99.3% with relative standard deviation

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Radovan Buffa, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Conjugates of hyaluronic acid with tyramine - synthesis and applicationRadovan BuffaContipro Pharma, Czech Republic

Hyaluronic acid (HA) is a natural linear polyglycosaminoglycan composed of repetitive disaccharide units, each consisting of N-acetyl-D-glucosamine and D-glucuronic acid. This polysaccharide is an important part of the extra-cellular matrix, vitreous humour and skin. HA modified with a tyramine moiety (HA-tyr) is a biocompatible polymer soluble in water, widely used for many biomedicinal applications. The main advantage of the HA-tyr is its ability to react with various phenolic groups under physiological conditions. This capability has been extensively used mainly for the preparation of biodegradable hydrogels using cross-linking reactions between tyramine molecules. This work presents a simple and effective method for synthesis of HA-Tyr conjugates connected via C6 linker: Tyramine is condensed with 6-aminohexanoic acid and the final substrate is attached on HA-aldehyde by reductive amination. Optimised method is suitable for production in industrial scale.

BiographyRadovan Buffa has completed his PhD in 2002 from Comenius University in Bratislava, Slovakia and Post-doctoral studies from ETH Zurich, Switzerland. He is the Head of the Department of Chemical Modification in the Contipro Pharma Company, Czech Republic. He has published more than 15 papers in reputed journals and is the author/co-author of more than 20 patents.

[email protected]

http://dx.doi.org/10.4172/2150-3494.C1.002mailto:[email protected]

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Daniel T Gryko, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Diketopyrrolopyrroles - the journey from ferrari pigments to fluorescent functional dyesDaniel T GrykoPolish Academy of Sciences, Poland

Two-photon absorption (2PA) is a non-linear optical phenomenon with broad scope of applications. It has already been applied, or is under intensive investigation, in fields such as: optical limiting, polymerization-microfabrication, 3D-data storage, photodynamic therapy, two-photon excited fluorescence etc.1Structurally unique π-expanded diketopyrrolopyrroles were designed and synthesized. Strategic placement of a fluorene scaffold at the periphery of a diketopyrrolopyrrole via tandem Friedel-Crafts-dehydratation reactions,2 resulted in dyes with supreme solubility. Despite the extended ring system, the dye still preserved good solubility and was further functionalized using Pd-catalyzed coupling reactions, such as Buchwald-Hartwig amination. By placing two amine groups at peripheral positions of the resulting dyes, we have achieved values of two-photon absorption cross-section on the level of 2000 GM around 1000 nm, which generated a two-photon brightness of ~1600 GM. These characteristics in combination with red emission (665 nm) make these new π-expanded diketopyrrolopyrroles of major promise as two-photon dyes for bioimaging applications.

BiographyDaniel T Gryko obtained his PhD from the Institute of Organic Chemistry of the Polish Academy of Sciences in 1997, under the supervision of Prof. J. Jurczak. After a Postdoctoral stay with Prof. J. Lindsey at North Carolina State University (1998–2000), he started his independent career in Poland. He became Full Professor in 2008. The same year he received the Society of Porphyrins and Phthalocyanines Young Investigator Award. His current research interests are focused on the synthesis of various functional dyes as well as on two-photon absorption, artificial photosynthesis, excited-state intramolecular proton transfer and fluorescence probes.

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Takumi Konno, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Non-coulombic ionic crystals with non-alternate arrangement of complex cations and inorganic anionsTakumi KonnoOsaka University, Japan

In natural ionic solids, cations and anions are alternately arranged to avoid Coulombic repulsion between them. Thus, it is very hard to imagine that a number of cations and anions are separately aggreated to form a non-alternate arrangement. As part of our continuing research on the development of chiral multinuclear and supramolecular coordination systems with thiol-containing amino acids, we designed and synthesized a cationic AuI4Co

III2 hexanuclear complex having both D-penicillamine and 1,2-bis(diphenylphosphino)ethane. Remarkably, this complex was found to crystallize with appropriate inorganic anions to form ionic crystals, in which six AuI4Co

III2 complex-cations are aggregated into an octahedron-shaped supramolecular structure, with the concomitant aggregation of inorganic counter-anions into an unprecedented cluster structure.

BiographyTakumi Konno received his PhD degree in 1985 from University of Tsukuba. After working at University of Cincinnati as a Postdoctoral fellow, he became an Assistant Professor at University of Tsukuba in 1987. In 1997, he moved to Gunma University as an Associate Professor and was promoted to a Full Professor in 1998. He was appointed as a Full Professor of Osaka University in 2000. He has published more than 200 papers in reputed journals and is now serving as a section editor of Chemistry Letters and a research director of CREST (Japan Science and Technology).

[email protected]


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Sungjin Park, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Toward molecular designing on graphene-based materials for catalytic applicationsSungjin ParkInha University, South Korea

During the last half decade, carbon-based nano-materials have been studied in the wide range of applications, due to its excellent electrical, mechanical, and thermal properties as well as good tolerance for chemical modification. Revealing chemical structures of the carbon-based nano-materials is highly important to understand materials properties and to develop optimized processing. This understanding enables us to make new molecular/nano hybrids, which showed interesting performances for catalytic applications. Chemical designing on nano-materials in molecular level would be a promising route to create new hybrid materials and to control various properties of nano- and molecular materials. Organometallic compounds have been a center of molecular catalysts with pre-eminent catalytic activity and selectivity in a wide range of chemical transformations. Hybridization of organometallic complexes with graphene-based materials can give rise to enhance catalytic performances. In this presentation, I will discuss my recent research activities on the fundamental chemistry of carbon-based nano-materials as well as catalytic applications.

BiographySungjin Park has completed his PhD from KAIST, Korea and Postdoctoral studies from Northwestern University and University of Texas at Austin. Now, he is an Assoicate Professor at Inha University. He has published more than 65 papers in reputed journals.

[email protected]


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Ok-Sang Jung, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Tailor-made synthesis of multilayered trimetallocyclophanes via transannula π-π InteractionsOk-Sang JungPusan National University, Korea

Synthesis and operation of a nano-demension 24 × 24 × 15 Å3 “left and right ball-joint-type host-guest system” via one π∙∙∙π interaction and three NH∙∙∙O=C hydrogen-bonds along with the combined helicity are described. The system consists of unprecedented conglomerate aggregates of two distinct helical metallacyclophanes, chiral isomer (P)-[Pd3X6(L1)2]@(M)-[Pd3X6(L1)(L2)] and its enantiomer (M)-[Pd3X6(L1)2]@(P)-[Pd3X6(L1)(L2)] are described. Successive reactions afford desirable four-layered metallacyclophanes via tailor-made procedure. Synthesis and operation of a nano-demension size multilayered metallacyclophane system via one π∙∙∙π interaction along with the combined helicity are described.

BiographyOk-Sang Jung has completed his PhD in 1990 from Korea Advanced Institute of Science and Technology and did his Postdoctoral studies from University of Colorado in 1992-1993. He is the Director of BK21+ program of Pusan national University. He has published more than 230 papers in reputed journals and has been serving as an Associate Editor of Bull. Korean Chem. Soc.

[email protected]


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Chunying Duan, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Supramolecular catalysis within confined environment of metal-organic architecturesChunying DuanDalian University of Technology, P R China

Metal-organic architectures constructed through the coordination of metal ions and organic linkers, represent a unique class of functional molecular containers that display interesting recognition properties and fascinating reactivity reminiscent of the natural enzymes. These architectures generating well-defined cavities provided specific confined inner environments for selective bonding of guest molecules and catalyzing their transfermations with intrinsic activities and selectivities. The great flexibility in terms of the molecular design and the potential benefits of integrating inorganic and organic components within a single composite make them interesting candidates for supramolecular catalytic chemical transformation. Yet only few “artificial enzymes” achieved the magnificent catalysis of natural enzymes. Through incorporating amide-containing multidentate chelators or the chiral organocatalyst within the ligand backbone or the cavities of the architectures, we described herein the syntheses and catalytic properties of several metal-organic architecture to investigate the possibility in the application of molecular flasks and heterogeneous catalysts.

BiographyChunying Duan has completed his PhD in Inorganic Chemistry from Nanjing University, China, and was promoted to be a Full Professor in 2000. Now, he is the Deputy Director of State Key Laboratory of Fine Chemicals, Dalian University of Technology, China. He is dedicated towards chemistry of Werner type architectures, focusing on the biomimetic sensing and molecular imaging, asymmetric catalysis and enzyme-inspired catalysis, and has published more than 200 papers in reputed journals such as Nat. Commun., J. Am. Chem. Soc., Angew. Chem. Int. Ed., and etc.

[email protected]


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Yahdiana Harahap et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Quantification of valproic acid in human plasma using high performance liquid chromatography-photodiode arrayYahdiana Harahap, Muhammad Ikhsan and HarmitaUniversitas Indonesia, Indonesia

Valproic acid is one of the mostly used antiepileptic drug that has a lot of side effects, therefore it is highly recommended to determine its plasma concentration. This research objective is to develop an analytical method of valproic acid without derivation in human plasma starting from optimum chromatography condition, optimum plasma preparation method, analysis method validation, until application of validated analysis method. The optimum chromatographic condition was obtained using: C-8 Symmetry® (5µm; 150 x 3.9mm), 45°C temperature column, the mobile phase contains buffer sodium dihydrogen phosphate 40 mM pH 3.5 – acetonitrile (56:44 %v/v); flow rate was 1.00 mL/min; which was detected by photodiode array detector at wavelength of 210 nm; and nonanoic acid as internal standard. Optimum preparation method is liquid-liquid extraction method using phosphate acid and n-hexana extracted with 150 µL trietylamine 0.5%; shaken with vortex for 2 minutes; and centrifuged for 10 minutes. Validation result of valproat acid analysis method fulfilled the validation requirement using EMEA Bioanalytical Guideline in the year 2011. The acquired method is linear at concentration range of 2.0 – 200.0 µg/mL with r>0.9992. This validated method analysis was successfully applied on one healthy subject to determine valproic acid concentration after oral administration of 500mg valproic acid extended release caplet.

BiographyYahdiana Harahap has completed her PhD from Department of Pharmacy, Institute Technology Bandung, Indonesia. At present she is the Head of Biavailability and Bioequivalence laboratory Faculty of Pharmacy, Universitas Indonesia. Prior to this position, she was the Dean of Faculty of Pharmacy, Universitas Indonesia. She has published 40 papers published in both international and national journals. She has been invited to be the speakers in many international conference, especially in the field of BA/BE and Bioanalysis technique. She currently serves as an expert at Indonesia National Agency of Drug and Food Control, specifically in BA/BE evaluation.

[email protected]


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Laila A Al-Shatti, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Validation guidelines of hydralazine hydrochloride spectrophotometric methodLaila A Al-ShattiThe Public Authority for Applied Education and Training, Kuwait

Spectrophotometric method was applied for the determination of hydralazine hydrochloride in pure and pharmaceutical tablet formulations. The method was validated for the elements postulated by the International Conference on Harmonization (ICH) guidelines Q2(R1) with respect to linearity and range, precision, accuracy, detection limit and quantitation limit. The method was based on a simple one-step method for the generation a yellow color ion-pair of hydralazinium ion and Bromophenol blue in acidic medium. The ion pair exhibits λmax at 416 nm and obeys Beer's Law in a linear range extended between 10-50 µg/mL. The detection limit and quantitation limit were found to be 0.82 and 0.27 µg/mL, respectively. The calculated molar absorptivity and Sandell's sensitivity are 1.01×104 L/mol.cm-1 and 0.0514 µg/mL, respectively. The method showed high recoveries equal to 98.94 and 99.5% for both pure and pharmaceutical formulations. In general, the method was found to be valid for the determination hydralazine hydrochloride and is expected to be useful in a variety of quality control pharmaceutical applications.

BiographyLaila A Al-Shatti has completed her PhD at 2009 from Kuwait University. She has published more than 13 papers in reputed journals and has been serving as an Assistant Professor in The Public Authority for Applied Education and Training.

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http://dx.doi.org/10.4172/2150-3494.C1.002http://mol.cm/mailto:[email protected]

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S L Chen et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Synthesis of ultramarine pigment from the mudstone of kutingkeng formation and the improvement of its refractory propertiesS L Chen and D T RayNational Cheng-Kung University, Taiwan

Ultramarine (Na8-x[SiAlO4]6[S2,S3,SO4Cl.]2-x) is an inorganic nontoxic blue pigment, consists of an aluminosilicate framework, constructed from sodalite cages (ß type). In this study, the mudstone from Kutingkeng Formation exposed in Southern Taiwan was used as the raw material to synthesize ultramarine pigment via a traditional solid state reaction route. The mudstone was first hydraulically classified to collect the

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Ionel I Mangalagiu et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

New podants with azaheterocycles skeleton as smart versatile building blocks for multiple tasksIonel I Mangalagiu and Violeta Vasilache “Al.I.Cuza” University of Iasi, Romania

Five and six member ring azaheterocycles are “privileged structures” in drug design, material science, agriculture, etc., the azaheterocycle scaffold being a core skeleton for multiple purposes. Within this work we present some core results obtained by our group in the field of new polifunctional azaheterocycles derivatives (nitrogen podants and compounds containing π–reach and/or π–deficient heterocycles) as smart versatile building blocks for multiple tasks: biologically active molecule (anticancer, antimycobacterial), chemosensors, logic gates and so on.

BiographyIonel I Mangalagiu is a Professor in department of Organic Chemistry at “Al.I.Cuza” University of Iasi, Romania.

[email protected]

Logic gates

Fluorescentcompounds

N

NN

N

Z

n

n

Anti- microbialAnticancer

Z

IN1IN2

H+

OUTMm+


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Yiu-chung Wong, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Analysis of Botulinum Neurotoxin A (BoNT/A) in pharmaceutical products using MALDI-TOF and LC-MS/MSYiu-chung WongHong Kong Government Laboratory, Hong Kong

Botulinum neurotoxins (BoNT) are produced by the anaerobic bacterium Clostridium botulinum and are one of the most lethal known poisons (LD50 = 0.8 µg for a 70 kg human by inhalation). Despite its high lethal toxicity, BoNT have been used to treat spasms and other muscle problems. Most recently, BoNT serotype A (BoNT/A) gains its worldwide popularity in cosmetic surgery to prevent development of facial wrinkles. Clinical testing of BoNT/A is conventionally relied on in vivo mouse lethality assay in accordance with pharmacopieal and AOAC methods. In response to increased public pressure to the inhumane testing, sensitive non-anaimal assays are of urgent need. Identification of BoNT/A in pharmaceutical products by chemical means is always a challenge due to its complex structure, ultra-trace level and the interference from excipients. This work reported a mass spectrometry study on BoNT/A in pharmaceutical injection samples. BoNT/A was isolated using magnetic beads immunoprecipitation, followed by on-beads digestion and was characterized by peptide mass finger printing using high-resolution tandem mass spectrometry coupled with ion mobility and Q-ToF in MSE mode. The activity of the toxin was confirmed by its proteolytic activity towards specially designed synthetic SNAP-25 substrate. The specific cleaved peptide fragments obtained from SNAP-25 substrate correlated well with its proteolytic activity in linear range from 10 – 100 MLD50/uL (r0 > 0.99). Proteolytic activities of BoNT/A in different excipient matrices were also investigated. The method has been validated across few brands of BoNT/A pharmaceutical injections commonly available in the Asia Pacific and was found to produce reliable results.

BiographyAfter working in the industry and academia, Dr. Wong joined the Hong Kong Government Laboratory in 1999 and is presently the Head of the Pharmaceutical Chemistry Section in the Laboratory. He is interested in the measurement of trace organic and inorganic toxicants in environment, food, dietary supplement and pharmaceutical matrices. Dr. Wong has organized a number of international proficiency testing programmes and developed several certified reference materials for food and herbal medicine. He has published more than 60 scientific papers and chapters. One of his papers has been awarded the Best Paper in analytical chemistry by CITAC in 2015. He is also the co-author of the book “Toxins and Toxicants in Food”, which will be published by Wiley in late 2016.

[email protected]


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Maia Merlani et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Synthesis of natural biologically active poly[3-(3,4-dihydroxyphenyl)-glyceric acid] analoguesMaia Merlani1, Vakhtang Barbakadze1, Lela Amiranashvili1, Lali Gogilashvili1 and Tamaki Nakano21Tbilisi State Medical University, Georgia2CRC Hokkaido University, Japan

The caffeic acid-derived polyether poly[3-(3,4-dihydroxyphenyl)glyceric acid] (PDPGA) isolated from comfrey species is a biologically active, water soluble polymer with antioxidant, antilipoperoxidant, antiinflammatory and anticancer properties. This compound is a representative of a new class of natural polyethers The first step for obtaining of PDPGA analogue was performed by cationic polymerization of 2-methoxycarbonyl-3-(3,4-dimethoxyphenyl)-oxirane (MCDMPO). An unsymmetrically 2,3-disubstituted oxirane monomer was synthesized from veratraldehyde (3,4-dimethoxybenzaldehyde, methyl vanillin) and methyl chloroacetate. MCDMPO was polymerized using BF3·OEt2 in CH2Cl2 under various conditions. Under all conditions examined, the monomer was almost completely consumed to afford a polymer. Mn of the polymer ranged from 2900 to 12 800 as determined by size-exclusion chromatography (SEC) with right-angle laser light scattering detection. MCDMPO leads to a polymer having a rather stiff conformation having a novel π-stacked structure between aromatic and carbonyl groups of neighbouring monomeric units, leading to ICT interactions. Although regulated π-stacked structures of a polymer have been prepared for accumulated aromatic groups in the side- and main-chain, such a “hetero π-stacked conformation” of the polymer chain consisting of different types of π-electron systems is unprecedented to the best of our knowledge.

BiographyMaia Merlani has completed her PhD from Tbilisi State University. She is Senior Research Scientist at Tbilisi State Medical University and at the same time holds a position of an Assistant Professor at Caucasian International University. Her field of interest is a chemistry and synthesis of natural compounds. She is the author of more than 45 papers in reputed journals and presentations at 55 international scientific conferences. She was granted Georgian Presidential scholarship for young scientists (1997), NATO scholarship (2002) and Matstumae International foundation scholarship (2013).

[email protected]


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Hyun-Joon Ha, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Preparation and synthetic application of 1-Azoniabicyclo[n.1.0]alkanesHyun-Joon HaHankuk University of Foreign Studies, Korea

Efficient and selective syntheses of nitrogen-containing heterocycles have attracted considerable attention from many chemists due to their particular interest within the realm of organic and medicinal chemistry. Recent advances in the field of ring-expansion chemistry, involving 1-azoniabicyclo[n.1.0]alkane scaffolds (bicyclic aziridinium ions) as a key transient intermediates, made it possible to efficiently construct a broad variety of medium- and large-sized functionalized nitrogen-containing heterocycles. The deployment of 2-(3-hydroxypropyl)aziridine for the synthesis of a variety of 3-substituted piperidines and their regioisomeric pyrrolidines has extensively been investigated. The structure of the decisive 1-azoniabicyclo [3.1.0] hexane tosylate was identified by means of NMR analysis, which was treated with various nucleophiles in CH3CN. The ring-opening reactions proceed through two different pathways to yield either pyrrolidines or piperidines, depending on the nature of the selected nucleophile. These regioselective nucleophile-dependent ring transformations were also supported by DFT-calculations to rationalize the observed reactivities. In the same manner 1-azoniabicyclo [4.1.0] hepane tosylate was prepared and its ring opening was also achieved by various nucleophiles. The regiochemical pathways of its ring opening are quite similar to the previous case in 1-azoniabicyclo [3.1.0] hexane tosylate depending on the nature of nucleophile to afford either piperidine and (or) azepane as the kinetic and the thermodynamic products respectively.

BiographyHyun-Joon Ha obatined his BA from Seoul National University (1982), PhD from Brown (1987) University and Postdoctoral studies from Stanford University (1987-1988). Then he came back to Korea for his first position as a Senior Research Scientist at KIST. In 1991, he joined the faculty of the Chemistry Department at Hankuk University of Foreign Studies, and is now a Full Professor of this department. His research includes aziridine chemistry, synthetic methodology, lipase-mediated reactions, asymmetric synthesis with publications of more than 140 papers and 25 patents. He serves as an Associate Editor of Asian J.Org. Chem.

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http://dx.doi.org/10.4172/2150-3494.C1.002http://j.org/mailto:[email protected]

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Makwena Justice Moloto, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Sulfur based metal complexes for synthesis of semiconductor nanoparticlesMakwena Justice MolotoVaal University of Technology, South Africa

The thiol based ligands have been used extensively for thei use as sources of semiconductor nanopartcles using different methods. Some of those ligands include thiourea and derivatives, dithiocarbamates, thiurams, thiarams and others. These are generally reacted with various metals and most commonly cadmium, cobalt, copper, zinc to use the advantage of their bonding to the sulfide. The single source precursor route is normally the approach fllowed to explore the nanoparticles synthesis from these complexes. Higher temperatures are required to carryout such reactions and using high boiling point organic solvents such as hexadecylamine, trioctylphosphine, oleylamine to produce different mrophologies. The presentation will discuss some examples with more focus on thiourea based ligands as explored by the authors to discuss their properties and potential in various applications. Technqies to be explored include optical properties using absorption and fluorescence spectrometry, thermal studies using TGA, chemical structural interactions using FTIR spectrometry, determine phases of materials prepared using XRD, TEM for sizes and shapes of nanomaterials. An overview of some of those selected complexes on their synthesis and nanoparticles approach used will be discussed.

BiographyMakwena Justice Moloto has completed his PhD at the age of 30 years from the University of Zululand and spend time at the University of Manchester to complete his PhD hosted by school of chemistry. He is the researcher at one of the technically orientated university in the department of chemistry. He has published more than 40 papers in reputed journals and has been serving as a reviewer for a number of materials chemistry journals of repute.

[email protected]


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Anjali Patel, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Functionalization of Keggin type nickel substituted phosphotungstate by immidazole: Synthesis, characterization and catalytic activityAnjali PatelThe M S University of Baroda, India

Transition metal substituted polyoxometalates (TMSPOMs) are of excellent candidate in Polyoxometalates chemistry due to their unique electrochemical, magnetic, medicinal and catalytic properties. In the TMSPOMs, the transition metal is coordinated with available five oxygen atoms of the POMs, while the sixth coordination site on the metal is occupied by an aqua ligand. Thus aqua ligand is labile and can be replaced by any organic group or even by organometallic groups. The obtained materials are called as functionalized materials and have potential applications in various fields from material science to biology. In present talk synthesis of a new polyoxometalate based functionalized material comprising Keggin type mono nickel substituted phosphotungstate and immidazole in an aqueous media by simple ligand substitution method was discussed. The synthesized material was systematically characterized in solid as well as in solution by various physicochemical techniques such as elemental analysis, TGA, UV–Vis, FT-IR, ESR, multinuclear solution NMR (31P, 1H, 13C) and Cyclic Voltammetry. From the above study, it was revealed that the attachment of Keggin type mono nickel substituted phosphotungstate was through N→Ni dative bond. The catalytic activity was also evaluated for non-solvent liquid phase oxidation of alkenes using H2O2 and O2 under mild condition.

BiographyAnjali Patel has completed PhD degree from The Maharaja Sayajirao University of Baroda, Vadodara and Post-doctoral from IRC, CNRS, Lyon, France. She is working as a Professor (Inorganic Chemistry) at The M. S. University of Baroda. She has published more than 95 papers in international journals (55 papers since 2011) including 1 review article in Green Chemistry (RSC). She has 05 book chapters and 2 books (2013 Springer, ISBN: 978-94-007-6709-6; 2015 Springer Briefs in Molecular Science, ISBN 978-3-319-12988-4) to her credit. She has also 1 process patent (US 762047 B2) and 2 catalysts patent (Indian Patent Filed: 2078/MUM/2010; 3280/MUM/2010).

[email protected]


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Dániel Filotás, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Novel double-barrel microelectrodes for simultaneous detection of Zn2+ and pH in SECM investigation of corrosion problemsDániel FilotásUniversity of Pécs, Hungary

Zinc and magnesium are two of the most widely used metals in modern industries and for their important biological role they are of major interest of both chemists and life scientists. Magnesium and its alloys own a series of beneficial properties, such as low toxicity, high tensile strength-weight ratio.However, its applicability is severely limited by their poor corrosion resistance. On the other hand, the relative reactivity of magnesium and zinc makes these metals efficient anti-corrosion agents. The presentation is focused on the development of selective sensors in order to investigate the corrosion mechanism of magnesium and zinc in different samples.

A new double barrel type of ionselective microelectrode and dual potentiometric experiments has been introduced in Scanning Electrochemical Microscopy. Single and double-barrel microelectrodes were fabricated in a critical assessment of probe performance, namely pH sensitive antimony, Zn ion selective single-barrel microelectrodes, and Sb-Zn ISME double-barrel electrodes. The assessment showed that these microelectrodes are well-functioning devices. The calibration curves show Nernstian response in each case.

Local pH and zinc concentration changes were simultaneously detected using double-barrel antimony and Zn ISME electrodes in the real corroding system. Line scans were recorded over cut edge of organic coated, galvanized steel exposed to saline solution. The concentration profiles taken with the new double barrel ISME show great similarity comparing with the ones recorded with the single barrel ISME’s. Results presented show promising perspective of the further application of the novel probes in scanning surface investigations.

BiographyDániel Filotás has graduated with his master’s degree in chemistry at the age of 23 years at the University of Pécs and started PhD studies in 2015. He was awarded the Fellowship granted by the Hungarian Republic twice, and for his Master Thesis written in English received the Award of Excellence by the Hungarian Chemical Society.

[email protected]


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Shahid Sultan et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Microanalysis of pigments in ancient polychromic artworks for identifying original and fakeShahid Sultan, Khalida Kareem and Ling HeXi’an Jiaotong University, China

Fake and forgeries is a serious crime that can only be corroborated through scientific acumen. Compositional characterization of the ancient pigments is significant for identifying the original and fakes. In the present work, 29 ancient painted samples from precious tombs, grotto, caves and paintings of Tang Dynasty (618-907 AD) and Ming Dynasty (1368-1644 AD) are characterized and evaluated for their elemental compositional patterns by inductively coupled plasma optical emission spectrometry (ICP-OES), and further confirmed by X-ray diffraction (XRD), Fourier transform Infrared spectroscopy (FT-IR) and the morphologies by optical microscopy (OM). The complex nature of inorganic components (23 elements in each) with minimal interferences is resolved and characterised for originality. These techniques empower us to conclude that 5 samples (white, blue and three black colors) out of 29 ancient samples are far from the originality, and possibly retouched with modern colors, while other 25 samples are quiet unadulterated. In these collected ancient samples, the most used pigments are miniumite (2PbO.PbO2) or red lead (Pb3O4), hematite (Fe2O3) and cinnabar (HgS) for red color, anglesite (PbSO4) with zinc white and gypsum (CaSO4.2H2O) for white color, malachite (CuCO3.Cu(OH)2) and atacamite (CuCl2.3Cu(OH)2) for green color and cobalt pigment for blue one. It is believed that the used methodology is an innovative to discriminate between original and fake.

BiographyShahid Sultan has completed his Master Degree in Science at the age of 22 years from BZ University, Pakistan and currently in the final year of PhD at Xi’an Jiaotong University Xi’an China. He got the scholarship from Chinese Govt Scholarship to study archaeology and its conservation and protection. He has done valuable works in archaeological conservation sciences by synthesising nano pigment composites. He is very much intrested in seeking the oraginality and fakness of archaeological painted artefacts.

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http://dx.doi.org/10.4172/2150-3494.C1.002http://cuco3.cu/mailto:[email protected]

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Zivko Nikolov, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Protein-specific approach to osteopontin purification from Chlamydomonas reinhardtii Zivko Nikolov Texas A&M University College Station, USA

Microalgae in recent years have gained interest as a potential protein expression platform. Eukaryotic microalgae - Chlamydomonas reinhardtii, having a GRAS status, exemplifies the potential of this expression system to produce a variety of therapeutic proteins including vaccines and monoclonal antibodies. Our study focuses on osteopontin (OPN), a versatile extracellular structural protein, cancer biomarker, promoter of cell-mediated immunity, and potential therapeutic protein. OPN is an acidic intrinsically disordered extracellular glycoprotein found in many human tissues and body fluids including bone, skin, urine, milk and blood. The chloroplast of C. reinhardtii has the ability to phosphorylate proteins – a crucial post-translational modification for in-vivo biomineralization and presumably functional integrity of osteopontin. This study describes the development of a purification process leveraging the unique properties of the target recombinant protein. Osteopontin being a highly acidic protein, much like the majority of host protein in C. reinhardtii, combined with the susceptibility to proteolytic degradation makes the purification development both challenging and intriguing. In an attempt to stabilize and partially purify osteopontin in the algal lysate, we screened several extract pretreatment methods. The impact of pretreatments on osteopontin yield, proteolytic stability and removal of host cell impurities will be presented. We also report and compare capture chromatography of OPN on anion exchange, hydroxyapatite, and Fe- and Ga- immobilized metal affinity resins that were selected to leverage osteopontin’s unique biochemical and structural properties.

BiographyZivko Nikolov received his PhD degree in Chemical Engineering from the Iowa State University and is currently Dow Professor in Bioprocess Engineering at Texas A&M University. He is Associate Director of the National Center for Therapeutic Manufacturing at Texas A&M. Before joining Texas A&M in 2003, he was Vice President of Bioprocess Development with ProdiGene Inc. He has published more than 90 scientific articles and book chapters in the area of bioprocess engineering and protein recovery. He is a recognized expert in bioprocessing of transgenic plants for production of high-value protein products and therapeutic proteins.

[email protected]


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Janis Gravitis, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Green forest and agricultural waste bio-refinery techniques and breakthrough materials Janis GravitisLatvian State Institute of Wood Chemistry, Latvia

The current report describes challenges and opportunities of green chemistry technologies of forest and agriculture integrated bio-refineries for processing the value added from wood-based lignocellulosics and agriculture biomass. Biomass processing employing not only chemical, but also thermochemical and biochemical techniques. The circular forest bio-economy covers forest primary (biomass pre-treatment, pulping technologies, etc.) and secondary (macromolecular components functionalization, biomimetic synthesizing, new micro-, nano-biocomposites processing, etc) and also chemical components separation and downstream processing technologies. The report emphasizes advanced breakthrough approaches, for instance, direct conversion of biomass to electricity, reducing of biomass recalcitntrace in biofuels production, electro-, nano-spinning for new textiles, boards without binders from fossil oil, biomimetic hybrid (organic + inorganic) materials, etc. Biorefinery concept includes e.g. ionic liquid, supercrytical, steam explosion, treatments of renewables using green chemistry principles. The author tries to explain employed treatments through the changes of complex architecture of lignocellulosics. In structural characterisation crucial role play small and super-small (synchrotron) X-ray or neutron scattering. The topic covers bioinspired modelling and simulation and sometimes bordering with synthetic biology. The report demonstrates high economic, social and environmental importance.

BiographyJanis Gravitis gained his PhD and DocSci from the fomer USSR Academy of Science. He is the Author and co-author of more than 300 scientific publications, Visiting Professor at the United Nations University, Institute of Advanced Studies, Tokyo, Japan from 1996–2000. He is the Fellow of the International Academy of Wood Science, Foreign Member of the International Research Centre for Sustainable Materials (Tokyo). He is the Head of the Laboratory of Biomass Eco-Efficient Conversation, Latvian State Institute of Wood Chemistry, currently.

[email protected]


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Peter Brüggeller et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Photocatalytic H2-production by homogeneous and heterogeneous advanced materialsPeter Brüggeller, Christof M Strabler, Johannes Prock, Wolfgang Viertl, Richard Pehn, Johann Pann and Katharina Ehrmann University of Innsbruck, Austria

There are three possibilities: Homogeneous catalysis using dyads or triads and also intermolecular approaches. Nearly homogeneous systems containing quantum dots or nanomaterials as WRC (water reduction catalyst). Truely heterogeneous systems consisting of suspensions of inorganic particles. Interestingly triadic systems containing noble metals are suitable as model systems: single crystal X-ray structure of a typical supramolecular triad A-L-C consisting of a visible light absorber (A), a tetraphosphane as bridging ligand (L), and a water reduction catalyst (C). This is a homogeneous, molecular approach.

Though it has been known for some time that colloidal palladium catalyzes the photochemical water splitting reaction, a new type of nanomaterial consisting of 2.0 nanometer sized particles was developed. Photocatalytic hydrogen production of the semiconductor Ga2B3O7(OH) in methanol/water has been achieved only recently.

BiographyPeter Brüggeller has completed his PhD from the University of Innsbruck/Austria and Post-doctoral studies from EPFL Lausanne. He is now working as a Professor at the University of Innsbruck. He has published more than 50 papers in reputed journals and has been serving as a referee of repute.

[email protected]


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Toshifumi Dohi, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

New conceptual diaryliodonium salts for metal-free arylation of carboxylic acids and other coupling reactionsToshifumi DohiRitsumeikan University, Japan

Diaryliodonium salts are used in organic synthesis as versatile arylating agents and for other many applications. However, the methods utilizing these salts in synthesis still have limitations, such as the requirements of base, and sometimes accompanied problems in the product yields and aryl selectivities for low nucleophilic compounds and the salts having two different aryl groups. Herein, we have developed a more efficient arylation of carboxylic acids meeting green chemistry by utilizing new conceptual diaryliodonium salts. By utilizing the newly designed salts 1, the efficient metal-free arylations of carboxylic acids occur upon heating without base and solvent, giving aryl esters in extremely high yields in short reaction times. In comparison, the reactions are more efficient, especially for low nucleophilic carboxylic acids, such as p-nitrobenzoic acid, that were unsatisfactory as substrates in known intermolecular coupling methods using ordinary diaryliodonium salts. In addition, the arylations usually proceeded with perfect chemoselectivities even in the presence of other nucleophilic groups.

It is known that diaryliodonium salts show unique reactivities’ for other metal-free arylating reactions depending on the nature of the ligands. The summary of developments in our laboratory is presented together with the recent research study.

BiographyToshifumi Dohi received his PhD in 2005 (Y. Kita), subsequently became Assistant Professor at Osaka University and Ritsumeikan University, and was promoted to Associate Professor (PI) in 2014. He received the IUPAC-ICOS 15 Poster Award for most excellent presentation, the PSJ Award for Young Scientists (2009), Banyu Chemist Award (2013), Thieme Chemistry Journal Award (2014), and GSC Encouragement Award (2015). His current research interest in organic synthesis is focused on hypervalent iodine chemistry.

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Zhicai He, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Loss mechanism in the open circuit voltage of polymer solar cellsZhicai HeSouth China University of Technology, P R China

Polymer solar cells(PSCs) have become a promising candidate for next-generation photovoltaics because the advantages of flexible, lightweight, large-area devices and room-temperature solution processible.Dispite the power conversion efficiencies(PCE) of single junction PSCs has been improve to 10% recently,the open circuit voltage(VOC) is still qiute far away from the theoretic limit.Therefore it will open a new opportunities to further improve the PCE if the gap between the open circuit voltage and the bandgaps of the donor materials can be minmized.So the study on the formation and the loss mechanism of VOC is in urgent need.In our recent work , the fundamental losses in VOC of PSCs based on narrow bandgap polymers was found to can be effectively alleviated and be modulated over a wide range through the control over the band tailing below the LUMO of PC71BM. By combining the analysis on the electrical, photocurrent spectral response characteristics of the working devices and the results from structure characterizations, the band tailing and the concomitant increase in the splitting of the electron and hole quasi-Fermi levels were found to be responsible for the VOC. And a correlation between the band tailing and the photovoltage output of the device was established ,thus can provide more insight into the origins and loss mechanism of the VOC and guidelines for further improvement through either materials chemistry or device optimization.

BiographyZhicai He has completed his PhD from South China University of Technology and became an Associate Professor in South China University of Technology in 2013. His resarch interest is recently centered on high performance organic solar cells . He has published more than 30 SCI papers in reputed journals and has 3000 citations.

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http://dx.doi.org/10.4172/2150-3494.C1.002http://minmized.so/http://need.in/mailto:[email protected]

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El-Refaie Kenawy et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Preparation and swelling capacity of superabsorbent polymer composites based on attapulgite clayEl-Refaie Kenawy1, Ahmed Abd El-Fattah2, Mohamed Mansour2 and Sherif Kandil2 1Tanta University, Egypt2Institute of Graduate Studies and Research, Egypt

A highly efficient starch-graft-poly(acrylamide)/attapulgite superabsorbent composite was synthesized by graft copolymerization reaction of starch, acrylamide (AM), and attapulgite clay (APT) using N.N'-methylene-bis-acrylanide (MBA) as crosslinker and ammonium persulphate (APS) as an initiator, then subjected hydrolysis with sodium hydroxide. The prepared composites were characterized by Fourier transform infrared spectroscopy (FTIR). The factors affecting the swelling capacity of the composite, such as the ratios of the crosslinker, initiator, attapulgite clay, as well as the pH and the presence of saline solutions, were investigated. The water absorbencies for the prepared composites reached 2700 g /g and 380 g /g in distilled water and in 0.9 wt% NaCl solution respectively, which opens the door for agricultural applications.

BiographyDr. El-Refaie Kenawy is distinguished Professor of polymer chemistry at University of Tanta, Egypt. He is internationally recognized in the field of polymer chemistry. He is a graduate of Tanta University, Egypt. He did his PhD. work according to channel Scheme at Strathclyde University, UK. He worked as postdoctoral fellow and visiting professor at many international universities as Pisa University, Gent University, Virginia Commonwealth University, Tokyo Institute of Technology, and Tanta University. Professor Kenawy is a member of editorial board of many international journals. He participated actively in many international conferences. In 2004, he was Abdul Hameed Shoman Award for Young Arab Scientists in Chemistry 2004. http://www.shoman.org.jo/prize/Viewer.aspx Recent award for Professor Kenawy in 2012 is the most cited award from Miser El-Kher Foundation, Egypt. He has many publications and reviews in international journals. He is research interest mainly focused on bioactive polymers, biomedical applications of polymers, antimicrobial polymers, electrospinng of polymers nanofibers, etc. Prof. Kenawy and Prof. Wnek and others from VCU, USA explored for the first time the use of nanofibers for drug delivery applications. Prof. Kenawy is a member of Egyptian Universities Promotion Committee For Organic Chemistry (2013-2015).

[email protected]

http://dx.doi.org/10.4172/2150-3494.C1.002http://www.shoman.org.jo/prize/Viewer.aspxmailto:[email protected]

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M Paula Robalo et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Laccases: Biocatalysts towards new heterocyclic cores M Paula Robalo1,2, A C Sousa1,2 and L O Martins3 1Instituto Politécnico de Lisboa, Portugal2Universidade de Lisboa, Portugal 3Universidade Nova de Lisboa, Portugal

The oxidation of molecules is a central transformation in organic chemistry for the introduction of chemical functionality/diversity in simple and available starting materials. Biocatalysis can be faced as a green solution, since enzymes operate under mild reaction conditions, physiological pH and temperature, in a non-polluting solvent (water) and they have a relatively small environmental footprint. Laccases are multicopper oxidases (EC 1.10.3.2) that catalyze the oxidation of a wide range of substituted phenols and anilines, leading to the formation of value-added products for dye and pharmaceutical industries by more sustainable methodologies and higher yields. The process uses molecular oxygen as the oxidizing agent and produces water as the only by-product, showing clearly environmental advantages. We previously showed that aromatic amines can be transformed by laccases leading to dimeric and trimeric dyes, phenazine, phenoxazinone and benzocarbazole derivatives, with moderate to good yields. These diverse structural motifs were obtained from the homo and heteromolecular coupling of radical intermediates formed directly by the laccase oxidation. These results prompted us to extend our studies to other aromatic substrates looking for the production of different heterocyclic cores, increasing the scope of scaffolds obtained by this approach. These results highlighted the potential of these enzymes for the green production of diverse heterocycle cores, which are well-defined building blocks for the development of biologically active molecules.

BiographyM Paula Robalo is currently Coordinator Professor at Chemical Engineering Department, Instituto Superior Engenharia de Lisboa (ISEL). She earned her PhD in Inorganic Chemistry from the Faculty of Sciences, University of Lisbon, in 1993. After, she got a position as Assistant Professor at Chemical Department, University of Évora and coordinated the Organic Chemistry subarea until 2002, where she moved to ISEL. She has published more than 40 papers in reputed journals. Her research interests include the synthesis of transition metal complexes as NLO materials or anti-cancer agents; the electrochemical studies of antitumor metalo-drugs as well as the synthesis of aromatic cores with biological interest by biocatalysis with laccases.

[email protected]


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Marwa E Kenawy et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

Effect of Quercetin and Apigenin on LDL receptor gene (LDLR) and Hydroxy-methyl glutrate reductase gene (Hmgcr) in a cholesterol attenuating trial.Marwa E Kenawy, Abeer A Khamis, Afrah F Salama and Tarek M MohamedTanta University, Egypt

Hypercholesterolemia is a major risk factor upon developing cardiovascular diseases and opens up the way for other risk factors such as hy perlipedimia, hypertension, and diabetes. This study aimed to investigate the effect of quercetin and apigenin for attenuating hypercholesterolemia. In this study using male Wistar rats, We studied the effect of quercetin and apigenin by inducing Hypercholesterolemia in such rats by Tyloxapol (WR 1339) at the dose was 50 mg /100 g body Weight day other day injection (IV) for 12 days. In addition, rats were treated with different doses of quercetin and Apigenin alone and in combination. Serum cholesterol, triacylglycerol, HDL, LDLcholesterol and total lipids levels were evaluated. Moreover, hepatic catalase, malondialdehyde (MDA) and total protein were estimated. Our results showed that in quercetin and apigenin fat groups'serum cholesterol, triacylglycerol, LDL-cholesterol and total lipids levels and hepatic MDA were significantly decreased as compared with control. However, serum HDL, hepatic catalase and total protein significantly increased in quercetin and apigenin groups as compare with control. The decrease of Hydroxy-methyl glutrate reductase gene (Hmgcr) which is responsible for cholesterol synthesis occured and was proved by RT-PCR analysis and LDL receptor gene (LDLR) increased in response to Hmgcr decrease for regulation. In conclusion, quercetin and Apigenin may consider to serve as a new candidate for the future development of hypocholesterolemic agents.

BiographyMarwa completed her masters at the age of 24 years from Tanta university and Bachelor degree with excellent mark 89.9% from Tanta University, Faculty of Science. I was chosen to be the ideal student for 2011. Teaching assistant in facultyof Science, Chemistry Departement since march 2013.

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conferenceseries.com 513th Conference


Euro Chemistry 2016

Scientific Tracks & Abstracts(Day 2)

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressImpacts of conformational geometries in fluorinated hydrocarbonsTim BrandenburgHelmholtz Zentrum Berlin, Germany

Research in blood substitute formulations is gaining more attention in the scientific community in recent years as more pharmaceutical companies start clinical trials on different artificial blood approaches. In general, artificial blood consists of emulsions of different liquid or protein compounds to increase oxygen solubility and transport capabilities as well as to decrease toxicity to biological tissue. Two of the more promising approaches center themselves around hemoglobin-based carriers or fluorinated microemulsions. Despite setbacks regarding clinical tests and medicinal approval of recent formulations, an emulsion named Fluosol was successfully approved by the U.S. Food and Drug Administration in 1989 (New Drug Application N860909). The main oxygen carrier in Fluosol, perfluorodecalin, is part of the family of perfluorocarbons. They have a wide range of applications ranging from tissue oxygenation to post-operative treatment. Their wide range of extraordinary properties, like high density, high viscosity, high biological and chemical inertness and the high gas solubility, create opportunities for the applications in biomedicine and physical chemistry as well as a high interest for scientific development. Few experimental studies based on photoelectron and X-ray absorption spectroscopy have already been performed, but the development of more complex theoretical models and new experimental techniques give opportunities for further investigation of perfluorocarbons.

BiographyTim Brandenburg is a PhD candidate who started to work on his thesis in September 2013. His Master of Science was received at the Freie Universität Berlin working on resonant inelastic X-ray scattering dynamics on fluorinated decalin. Beforehand, he studied nanostructured thin cobalt surfaces and self-deposited thiol on nanostructured gold surfaces.

[email protected]

Tim Brandenburg, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

mailto:[email protected]://dx.doi.org/10.4172/2150-3494.C1.002

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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressDecarboxylative fluorination of carboxylic acids with heterogeneous catalystsGiulia TarantinoCardiff University, UK

Fluorinated compounds find application in most fields of the chemical industry, such as agrochemicals, pharmaceuticals and materials. Furthermore, 18F compounds are widely used as tracers for positron emission tomography (PET). Unfortunately, the synthesis of fluorinated molecules is difficult because of the C-F bond strength and, although several breakthroughs have been observed, fluorination reactions are still challenging, particularly, C(sp3)-F bond synthesis. Recently, several studies have been demonstrating that transition metals such as Fe(II), Ag(I) or Pd(II) can react with fluorinating reagents like F-TEDA (SELECTFLUOR, Figure 1) giving new C(sp3)-F and C(sp2)-F bonds. However, many of these methods require stoichiometric metal loadings, and heterogeneous catalysts –typically preferred for several process intensification reasons – are rarely employed. In this context, supported Ag supported nanopaticles on titania have been prepared and, for the first time, effectively employed for decarboxylative fluorination of aliphatic carboxylic acids (scheme 1).

Figure 1

In this context, supported Ag supported nanopaticles on titania have been prepared and, for the first time, effectively employed for decarboxylative fluorination of aliphatic carboxylic acids (scheme 1).

Scheme 1BiographyGiulia Tarantino is a second year PhD student. She has joined Hammond Research Group at Cardiff University last year in January 2015.

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Giulia Tarantino, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002

NN

NN

CCll

FF

22BBFF44--

NN

Cl

F

2BF4-+ R FAg/TiO2

H2O, RT, 2hR COOH

N2


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressConceptual design of a nano-leaf for artificial photosynthesisJacinto Sá1,21Uppsala University, Sweden2Institute of Physical Chemistry of the Polish Academy of Sciences, Poland

The increase of atmospheric CO2 to levels, which threatens human existence forced mankind to immediately address the production of carbon-neutral, renewable and storable energy. In nature, plants and some bacteria convert CO2 and H2O into sugars and O2 via photosynthesis, and many research groups are exploring the prospect of performing photosynthesis artificially by means of stable, inorganic photocatalysts. To achieve the all desired active under visible light artificial leaf one needs to improve the following three aspects:

• Efficient visible light absorber • Improve reduction catalyst (H2, CH4, CH3OH production)• Effective oxidation catalyst (O2 evolution)

Plasmonic nano-structures of d10 metals are suggested to be the future of photo-voltaics and photo-catalysis under solar irradiation thanks to their large light absorption cross-section, versatility, and stability. We investigated the impact of continuous plasmon excitation at 532 nm on the density of states of gold nanoparticles, and found an increase of the unoccupied density of d states of gold nanoparticles at the Fermi level, consistent with the formation of electron-hole pairs. Some of those electrons have sufficient energy to overcome the Schottky barrier, and be injected into TiO2 conduction band, which we confirmed using a synchrotron based transient broadband mid-infrared spectroscopy. The results confirm that d10 metals plasmonic structures can act as direct light sensitizers, and use to drive photo-catalysis processes and produce electricity.

BiographyJacinto Sá (PhD-Physical-Chemistry) is the group leader of Nanoleaves and Heterogeneous Catalysis at Uppsala University and Modern Heterogeneous Catalysis (MohCa) at Institute of Physical-Chemistry, Polish Acdemy of Sciences. He (H-index 19, i10-index 35) has published more that 80 publications in peer-reviewed journals, edited 3 books, wrote 12 book chapters, has one commercial development, gave 30 oral presentation at international conferences (4 as invited speaker), presented more than 50 posters, 25 departmental seminars. He received several awards, most recently the Joseph Wang award (2015) for outstanding contributions to the field of nanoscience.

[email protected]

Jacinto Sá, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressFabrication and characterization of Pd-Ni porous membrane for hydrogen separationSun Hee Choi1,21Korea Institute of Science and Technology, Republic of Korea2Korea University of Science and Technology, Republic of Korea

We demonstrate for the first time the fabrication of ultrathin palladium membrane on porous nickel rod type support with mechanical treatment for H2 separation. Porous nickel membrane has so small and uniform pore size to be the support of dense Pd membrane. However, small nickel cluster on surface caused defects on Pd membrane supported by porous Ni rod because porous Ni rod is made by uniaxial pressing. The effect of mechanical treatment was found to have a significant effect on surface to get rid of small nickel cluster as well as selectivity to reduce pore size. After 10 cycles electroless plating, as-deposited Pd film is uniform and defect-free except few pinholes. Pinholes were eliminated through 100 nm-thick Pd thin film deposited by the DC magnetron sputtering process. The gas permeation properties of Pd membranes were characterized by permeation experiments with H2, N2, CO, and CO2 single gases at 623K with a pressure of 1~4 bar. Also, gas permeation properties of Pd membranes were characterized by permeation experiments with mixture gas (N2:CO2:H2:CO:H2O = 0.275:0.129:0.235:0.002:0.359 mole fraction) at 623 K with a pressure of 1~4 bar. It was clarified that the surface condition of porous nickel rod is very important to the H2 permeability and selectivity because the permeation of H2 gas was contributed by solution diffusion mechanis. And to conclude, Pd membranes on porous Ni support in this study showed superior performances, and proved to be impermeable to carbon monoxide.

BiographySun Hee Choi has completed his PhD from Seoul National University. She has published more than 30 papers in reputed journals.

[email protected]

Sun Hee Choi, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressTitle: Anti-inflammatory and wound healing activities of Hemisgraphis alternataJoo Kheng GohMonash University Malaysia, Malaysia

Therapeutic properties of plant are attributed to bioactive compounds found within them. These compounds can be promising candidates for drug development. This presentation focused on the wound healing and anti-inflammatory properties of Hemigraphis alternata and that the isolation and identification using chromatography and spectroscopic methods is currently employed. Available treatments for wound healing and inflammation are antibiotics and anti-inflammatory drugs, which some are reported to be high cost, low availability and associated with adverse effects. Therefore there is a need to search for alternatives treatments and plant-based drugs represent a key prospect to it. The leaves of Hemigraphis alternata exhibited promising wound healing and anti-inflammatory activities through scratch assay, tube formation assay, nitric oxide production inhibition assay, cytokine TNF-α production inhibition assay and lipoxygenase enzyme inhibition assay. To the best of our knowledge, this is the first report on the bioactivities of Hemigraphis alternata.

BiographyDr. Joo Kheng Goh is currently a senior lecturer in the School of Science, Monash University Malaysia. Her research group focuses on isolation and identification of bioactive compounds from medicinal plants and she has particular interest in the synthesis of bioactive compounds. She has published more than 20 papers in reputed journals and has been serving as an journal reviewer in a number of repute.

[email protected]

Joo Kheng Goh, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressRNA self-assembly and RNA bio-nanotechnologyLuc JaegerUniversity of California, USA

The nascent use of nucleic acids as a material to coordinate the precise arrangements of specific molecule marked an important milestone in the relatively recent history of bionanotechnology and synthetic biology. While DNA served as the pioneer building material in nucleic acid nanotechnology, RNA emerges as viable alternative material with its own distinct advantages for nanoconstruction. Several complementary assembly strategies have been used to build a diverse set of RNA nanostructures having unique structural attributes and the ability to self-assemble in a highly programmable and controlled manner. Of the different strategies, the architectonics approach uniquely endeavours to understand integrated structural RNA architectures through the arrangement of their characteristic structural building blocks. With the design principles found in natural structures, a number of synthetic RNAs have been constructed. In addition to affording essential insights into RNA design, RNA nanostructures have provided important platforms to characterize and validate the structural self-folding and assembly properties of RNA modules or building blocks, and have also shown great promise for applications in nanomedicine and RNA-based therapeutics. Nevertheless, synthetic RNA architectures achieved thus far are still far from matching the structural and functional complexity of natural responsive structural elements such as the ribosome, large ribozymes, and riboswitches. Implementation of these same types of dynamic and responsive architectures into artificial nanostructures functioning as real nanomachines in and outside the cell will be outlined.

BiographyLuc Jaeger has completed his PhD from the University of Strasbourg in 1993, and Postdoctoral studies from Scripps Research Institute, La Jolla, CA. He joined the faculty of the University of California Santa Barbara in 2002. He has been a visiting Professor at the National Cancer Institute, and he has held a ULP-NIBH (National Institute of Bioscience and Human Technology and Information Services) grant for work in Japan. He served as a member of the John Templeton Foundation board of advisors from 2011 to 2013. He has contributed to more than seventy papers published in scientific journals.

[email protected]

Luc Jaeger, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressExtraction and characterization of collagen from the white jellyfish (Lobonema smithi Mayer.)Ubon Rerk-am, Khanittha Chawananorasest, Bantika Kongsombat, Sinn Tanstirapakdee, Tuanta Sematong and Sirinan ThubthimthedThailand Institute of Scientific and Technological Research, Thailand

Collagen has been used in a wide range of applications in health pharmaceutical and cosmetic industries. White jellyfish (Lobonema smithi Mayer) are edible after brining with salt, blooming every year in the bay of Thailand, has become a new natural source of collagen for using in health products industries. This project aims to study the extraction process of collagen from the white jellyfish in order to get rid of its fishy odour. The processes were used pepsin to extract collagen from fresh (CF) and brining with salt (CB) of White jellyfish. The result showed that the CB gave 39.2% yield of collagen which was higher than CF, 22.2%. The characteristic of collagen base on HPLC and 1H-NMR techniques exhibited that all collagen contained high content of glycine, glutamic acid, alanine and proline. FT-IR spectra pattern of CB presented the strong signal of peak at 1,543.66 cm-1 (Amide II) whereas CF gave that of weak peak. To confirm of collagen type by using sodiumdodecyl sulfate-polyacrylamide gel ellectrophoretic patterns and FT-IR spectra, indicated that both of collagen CB and CF are in the collagen type I. Moreover, CB possessed lower level of fishy smell than CF. From the results could suggest that the white jelly fish should be brined with salts for extraction and pepsin was the suitable process for collagen extraction in this experiment. Further works will focus on toxicity of collagen extracted from fresh and brined white jelly fish.

BiographyUbon Rerk-am has completed her Master’s degree in Analytical Chemistry from King Mongkut’s Institute of Technology Ladkrabang, Thailand. She has excellent experienced in analysis of essential oils using GC-MS for more than 15 years. She has worked in peptides and the products development in cosmetics for more than 5 years. She has published more than 10 proceeding papers in the international conferences.

[email protected]

Ubon Rerk-am et al., Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressInterfacial assembly and theranostic applications of organic-inorganic hybrid nanomaterialsKen Cham-Fai LeungThe Hong Kong Baptist University, Hong Kong

Nanotheranostic materials have been recently involved the use of nanoparticles for simultaneous diagnostic and therapeutic purposes. New materials have been extensively developed towards drug delivery and tumor imaging. In the first part of the presentation, the synthesis, characterization, and properties of theranostic nanoparticles based on organic-inorganic hybrid nano-particles will be described. The hybrid nanoparticle consists of a superparamagnetic iron oxide core and a series of coatings which are stimuli-responsive supramolecules or polymers. By the concept of nanovalve based on supra-molecular gate-keepers, stimuli-responsive drug delivery nanosystem was synthesized by (i) modified solvothermal reaction; (ii) sol-gel reaction; and (iii) coupling reaction of supramolecules. In these systems, the “ON/OFF” switching of the gatekeeper supramolecules can be controlled by pH-sensitive intramolecular hydrogen bonding or electrostatic interaction (such as metal chelating). Biological evaluation of the nanoparticles renders them non-cytotoxic and can be uptaken by several cell types. The anti-tumor drug (doxorubicin) loading and release profiles which were studied by the UV/visible absorption spectroscopy, were demonstrated by using ultrasonic wave. Magnetic resonance imaging analysis of the particles reveals a high relaxivity, rendering them useful nanotheranostic agents. Another part of the presentation will focus on design, synthesis, purification, and property-exploration of mono-functionalized gold nanoparticles.

BiographyKen Cham-Fai Leung has completed his BSc and PhD degress at The Chinese University of Hong Kong and did his Postdoctoral work with Sir J. Fraser Stoddart at UCLA. He has published more than 70 papers in reputed journals and has a H-index of 32.

[email protected]

Ken Cham-Fai Leung, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressAn efficient coformers selection for co-crystals screening of active pharmaceutical ingredientsPiotr CysewskiNicolaus Copernicus University in Toruń, Poland

According to commonly accepted definition a cocrystal is a homogeneous crystalline solid that consists of stoichiometric amounts of discrete neutral molecular species, which are solids under ambient conditions. These kind of dispersions differ from other solutions as for example eutectic or monotectic systems by molecular complex formation and congruent melting. The change of physico-chemical properties of co-crystals with respect of the co-formers is especially useful and important in the case of active pharmaceutical ingredients (API). There are many examples in the literature of significant improving of API behaviors both in vivo and in vitro. The advantages of cocrystallization for pharmaceutical industry are not only related to bioavailability enhancement but also to the increase of stability, hygroscopicity decrease, mechanical properties and intellectual property issues. Unfortunately predicting of the ability of co-crystal formation of an API with other co-formers is non-trivial and not straightforward task. That is whys two alternatives are proposed. Experimental part relies on fastening of co-crystal screening by utilization of orientation samples on glass surfaces as efficient, robust, fast and cost-preserving approach. On the other hand the QSPR approach was used for distinguishing of pairs of co-formers forming co-crystals from ones exhibiting simple eutectic behavior.

Fig.1. Histograms distinguishing properties of pairs forming cocrystals (left) from simple eutectic mixtures (right) based on heat of formation.

BiographyPiotr Cysewski received Profesor of Chemistry honour in 2013. He is the Director of Department of Physical Chemistry, Medical College of Bydgoszcz. He has published more than 60 papers in reputed journals in domain of theoretical and computational chemistry. Nowadays his activity is concerned with experimental and theopreica screeing of co-crystals of active pharmaceutica ingredients.

[email protected]

Piotr Cysewski, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressData mining drug, chemical probe and their biological activity in PubChemYanli WangNational Center for Biotechnology Information, USA

The PubChem Project started in 2004 by the National Center for Biotechnology Information (NCBI) at NIH to provide an open repository for chemical structures and research data supporting open access. The PubChem databases experienced a tremendous growth over the past decade and now contain 150 million substance submissions, one million bioassay submissions and 200 million bioactivity outcomes. The biological test result in the BioAssay database largely consists of high throughput screening (HTS) data generated from the NIH efforts in the discovery of chemical probes, which may be used as tools for studying biological functions of proteins and genes. During the development of chemical tools, a compound library of over 400, 000 compounds, including many drug molecules, were screened towards many biologically important and disease associated molecular targets and cell lines, producing a huge amount of information for pursuing drug repositioning. The chemical probes from the HTS campaigns demonstrated high selectivity and potency as agonists and antagonists for specific molecular targets. For many of these, the utility of the tools remain to be validated and utilized by researchers, and the mechanism of action may be further explored. Literature based bioactivity data, contributed by journal authors and curation projects, such as ChEMBL and PDBBind, represents another important component of the BioAssay database. The integration of literature data and HTS greatly facilitates comparison to prior arts and systematic investigation on drugs and their potential targets. This presentation will provide an overview of the biological activity information in PubChem, and a review how these information are used by the community in drug discovery and development. Data in PubChem can be freely accessed and downloaded using the NCBI information retrieval system Entrez, with additional suite of services. PubChem welcomes further contributions from the community for sharing experimental and annotation data. Chemical structures and assay results can be deposited via the submission tool; new functions have been developed recently facilitating data management and release to synchronize with manuscript review and paper publication process.

BiographyYanli Wang obtained her PhD in Computational Biology in 1995 from Peking University, China and completed Post-doctoral studies from the National Institute of Cancer and National Center for Biotechnology Information (NCBI) during 1995-1998. She is currently the lead Scientist of NCBI, primarily responsible for managing the PubChem BioAssay resource. She has published more than 40 papers in reputed journals.

[email protected]

Yanli Wang, Chem Sci J 2016, 7:2(Suppl)http://dx.doi.org/10.4172/2150-3494.C1.002


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June 16-18, 2016 Rome, ItalyEuropean Chemistry CongressNMR molecular replacement, NMR2

Julien OrtsSwiss Federal Institute of Technology, Switzerland

X-ray crystallography molecular replacement (MR) is a highly versatile tool for the detailed characterization of lead compounds and binding modes in the pharmaceutical industry. The two major limitations of its application to drug research are (i) the availability of a similar protein structure, which, in the area of structure-based drug design, is most often a complex of the protein with a lead compound, and (ii) obtaining well-diffracting crystals of the ligand-protein complexes of interest. While nowadays the first point is often not a limitation anymore, obtaining well-diffracting crystals might be difficult. In such situations structure determination of protein-ligand complexes by liquid-state NMR is a good option. Unfortunately, the established standard structure determination protocol is in general time-consuming, and a shortcut using available structural data as in the case of MR in X-ray crystallography is not available. Here, we present NMR2, a MR-like approach in NMR to determine the str

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