EU Preparednessand Response programsin Emerging and Re ... fileOctaviQUINTANA TRIAS (director) Unit...
Transcript of EU Preparednessand Response programsin Emerging and Re ... fileOctaviQUINTANA TRIAS (director) Unit...
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Anna Lönnroth (Deputy Head of Unit), Infectious Diseases, Health
Directorate, Research Directorate General, European Commission
Rome, 23 May 2007
EU Preparedness and Response
programs in Emerging and
Re-emerging Infectious Diseases
Who are we?
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Directorate General
RESEARCH (DG RTD)Jose Maria SILVA RODRIGUEZ (DG)
Directorate
HEALTHOctavi QUINTANA TRIAS (director)
Unit
INFECTIOUS DISEASESBernard MULLIGAN (acting HoU)
Anna Lönnroth (deputy HoU)
EUROPEAN
COMMISSION
HIV / AIDS Malaria TB Neglected
Infectious
diseases
Antimicrobial drug
resistanceEmerging Epidemics
Cornelius Schmaltz
+ ~ 40 other
DGs (ex. SANCO)
+ 14 other
Directorates
(8 thematic + 7 horizontal)
+ 5 other Units: Coordination, Medical &
Public Health Research, Genomics & System
Biology, Health Biotechnology,
Administration & Finance
EDCTP
FP 7 (2007-2013)
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3,27 5,36 6,613,12 14,96 17,5
68,3
0
10
20
30
40
50
60
70
80
1984-1987 1987-1991 1990-1994 1994-1998 1998-2002 2002-2006 2007-2013
€ Billion
Budgets of the EU Framework Programmes
Indicative breakdown (million €)
Total = 50.4 billion € over 7 years
Average 40% increase of yearly budget comparedto FP6, but heavily “tail-loaded“
ERC
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Annual updates of Workprogrammes
1. Address major medical needs
2. Attract cutting-edge technologies
3. Foster translational research (“from genomics to public health”)
4. Involve industry, in particular SMEs
5. Involve International Cooperation PartnerCountries (ICPC), where relevant
Topics should:
First two calls for the Health theme
Specificities:
� not all areas will be open in each call
� ceilings for EU contribution (eligibility criteria!)
�S/M CP > 3 m€
�L IP 6-12 m€
�unless otherwise specified in the Workprogramme
� new provisions for ethics: no additional information to be asked
� page number limitation for proposals
�3 evaluation criteria:
�Scientific excellence
�Implementation
�Impact
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Conditions for collaborative research
Collaborative projects must involve at least :
2 participants from 2 different Member States or Associated countries
2 partners from 2 different ICPCs
Specific international
cooperation actions (SICA )
ACP (African/ Caribbean/ Pacific)
ASIA
EASTERN EUROPE AND CENTRAL
ASIA (EECA)
LATIN AMERICA
MEDITERRANEAN PARTNER
COUNTRIES (MPC)
WESTERN BALKAN COUNTRIES
(WBC)
International
Co-operation
Partner
Countries
(ICPC)
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Activities in 4 fields:
1. Antimicrobial drug resistance
2. HIV/AIDS, malaria and tuberculosis
3. Emerging epidemics
4. Neglected (tropical) infectious diseases
Translational research in infectious diseases
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EU Research on Emerging
Epidemics
5th and 6th Framework Programmes
�No dedicated area for Emerging Epidemics
�Funding mobilized in response to crises
�Dedicated call on SARS in 2003 (15 million €)
�Dedicated call on influenza in 2006 (28 million €)
�EU support since 2001 approx.15 million € / year
overall
7th Framework Programme
�Dedicated area on Emerging epidemics
�2007 call on flu / 2008 call on preparedness
�Future?
�Budget not earmarked – will be driven by need
Spring 2003 – outbreak in
South-East Asia and Canada
Immediate mobilization of 15 million € of
available resources – 7 projects funded
SARS 2003
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Pandemic Influenza
2000 - 2007
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011
EPIZONE 14 M€
HEALTHY POULTRY 1.2 M€
ESNIP 0.27 M€
AVIFLU 1.8 M€
FLUPAN 2.1 M€
ESNIP 2 0.3 M€
LAB-ON-SITE 1.5 M€
FLUAID 1.2 M€
FLUVACC 9.2 M€
VIZIER 13 M€
SARS/FLU VACCINE 1.6 M€
NOVAFLU 1.7 M€
VIRGIL 9 M€
Universal Vaccine 1.2 M€
MUCADJ 1M€
199919981997
2006, Key year for
EU Influenza Research:
• Early start, some
promising results
already available
• Critical mass of
ongoing collaborative
research projects
• New call for proposals
2006, Key year for
EU Influenza Research:
• Early start, some
promising results
already available
• Critical mass of
ongoing collaborative
research projects
• New call for proposals
Human Flu
Animal Flu
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2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018200620052004
Human Flu
Animal Flu
FLUPOL 2 M€
FLUINNATE 1.4 M
PANFLUVAC 3.3 M€
Intranasal H5 2.7 M
FLUVAC 3.5 M€
EUROFLU 1.4 M€
NOVADUCK 1.4 M€
FLUTEST 1.5 M€
FLUPATH 1.9 M€
New Flubird 1.9 M€
FLUTEST 1.5 M€
FLURESIST 0.9 M€
FLU-LAB-NET 0.9M€
FLUTRAIN 1.8 M€
AIV VAC DIAGNOS 1.4 M€
INN-FLU 1.8 M€
RIVERS 1.4 M€
ConFluTech 0.5M€
“Preventing infection and spread
among humans”
• Making flu vaccines more efficient
• Understanding the biology of the
influenza virus
“Preventing infection and spread
among humans”
• Making flu vaccines more efficient
• Understanding the biology of the
influenza virus
“Early warning and strike at the
source”
• Diagnostics
• Surveillance
• Vaccination of birds
“Early warning and strike at the
source”
• Diagnostics
• Surveillance
• Vaccination of birds
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Workprogramme 2007 / 2008
Emerging Epidemics
� Development of broadly protective influenzavaccine candidates – S/M CP (up to 6 million!)
� Molecular mechanisms of protection for influenza vaccines - S/M CP
� Standardisation of immunological assays for evaluation of flu vaccines in clinical trials – CSA
� Innovative point-of-care diagnostic tests for influenza – S/M CP
Workprogramme
Emerging Epidemics =
Influenza (19 April)
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� Development of additional treatment strategiesfor Highly Pathogenic influenza – S/M CP
� Development of pandemic influenza containmentand mitigation strategies - S/M CP
� Highly innovative inter-disciplinary research on influenza – S/M CP (up to 1.5 million!)
SICA
� Influenza research with Asian partners – S/M CP
Workprogramme
Emerging Epidemics =
Influenza (19 April)
� Strengthening prediction, identification, modellingand surveillance of newly emerging infectiousdiseases in humans – L IP
� Definition of research needs and priorities in Europe in Emerging Infectious Diseases - CSA
Workprogramme
Emerging Epidemics
(18 September )
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Option under
discussion for future
Workprogrammes
1 or 2 stage evaluation?
� Longer evaluation procedure
� Less workload for applicants – or not?
� Bottom-up topic definition…
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