Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established...

48
Etsuo Tsuchikane, MD, PhD Toyohashi Heart Center, Japan Toyohashi Heart Center, Japan

Transcript of Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established...

Page 1: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

Etsuo Tsuchikane, MD, PhD

Toyohashi Heart Center, JapanToyohashi Heart Center, Japan

Page 2: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

DisclosureDisclosure

Within the past 12 months, the presenter or their spouse/partnerhave had a financial interest/arrangement or affiliation with theorganizations listed below.organizations listed below.

Physician Name

Etsuo Tsuchikane, MD, PhD

Company/Relationship

Boston Scientific, Japan Consultant

Asahi Intecc, Japan Consultant

NIPRO, Japan Consultant

Page 3: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

●●CCT HistoryCCT History

CCT was started in early 1990’, as “Osaka intervention meeting”.

1992 Osaka Intervention Meeting1992 Osaka Intervention Meeting

1993-1994 Naka-Nihon Live Demonstrations

1995-2000 CCIC

2001-present CCT (Complex Cardiovascular Therapeutics)

CCICCCICNakaNaka--NihonNihon CCICCCICNakaNaka--NihonNihon

1993 1995 2001 2015

CComplexomplex CCardiovascularardiovascular TTherapeuticsherapeutics

Page 4: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

6,000 Industrial Professional

Co-medical Industrial

4,000

5,000

Co-medical

Medical

IndustrialProfessional,

Others

1,758

3,000

4,000

Co-medical1,063

2,000

1,063

Medical2,451

0

1,000

2,451

02001 2002 2003 2004 2005 2006 2008 2009 2010 2012 2013 2014 2015 2016

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●● International ParticipantsInternational Participants

Comparison between 2014, 2015 and 2015

Asia America Europe Middle East Oceania

1229

48

80

24

2016

Asia America Europe Middle East Oceania

Total:1,4191229

39

80

38

19

2016Total:1,419

Total:1334

1197

39

59

20

19

2015

Total:1334

Best ever

799

31

75

20

15

2014Total:922

Best everattendance

from overseas

12

Page 6: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

●●CCT HistoryCCT History

CCT was started in early 1990’, as “Osaka intervention meeting”.

1992 Osaka Intervention Meeting1992 Osaka Intervention Meeting

1993-1994 Naka-Nihon Live Demonstrations

1995-2000 CCIC

2001-present CCT (Complex Cardiovascular Therapeutics)

CCICCCICNakaNaka--NihonNihon CCICCCICNakaNaka--NihonNihon

1992 1995 2001 2015

CComplexomplex CCardiovascularardiovascular TTherapeuticsherapeutics

Page 7: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

Japanese CTOJapanese CTO--PCI RegistryPCI Registry

Currently,Currently,

‘Retrograde Summit General Registry’‘Retrograde Summit General Registry’

andand

‘Japanese CTO PCI Expert Registry’‘Japanese CTO PCI Expert Registry’

are being conducted in Japan.are being conducted in Japan.

Page 8: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

Registry OverviewRegistry Overview

Retrograde SummitJapanese CTO PCI

Expert RegistryRegistryGeneralRegistryRegistry

Pts.Enrollment

Jan. 2009~Dec. 2013

Jan. 2014~ Jan. 2014~

Participants 56 of 40 of42 of Japanese Expert physicians

ParticipantsAs of Jun. 2015

42 of Japanese Expert physiciansJapanese Centers

Criteria for

Participants

• Centers approved byRetrograde Summit

• More than 300 cases of experience of CTO-PCIParticipants

• Cases treated by Expert areexcluded

• More than 50 cases of CTO-PCI per year• Recommendation from two or more steering

committee member

Adjudication of Indication and ProcedureCore lab None

Adjudication of Indication and ProcedureSuccess

Organization Retrograde Summit Japanese Board of CTO interventional specialist

Habara (initiated byChairman

Habara (initiated byTsuchikane)

Tsuchikane (initiated by Katoh, late Mitsudo)

Page 9: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

Etsuo Tsuchikane, MD, PhD

on behalf ofon behalf ofJapanese Board of CTO Interventional Specialist

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JapaneseJapanese CTO PCI ExpertCTO PCI Expert RegistryRegistry

The Japanese Board of CTO Interventional Specialists was

established in 2013 to accumulate quantitative data to identify

issues such as stagnation in the development of CTO-PCI

techniques.

Starting from 2014, Japanese CTO PCI Expert Registry began Starting from 2014, Japanese CTO PCI Expert Registry began

establishing a database of CTO-PCI performed by certified

expert physicians who have a certain level of CTO-PCI skills.expert physicians who have a certain level of CTO-PCI skills.

Patients are enrolled by certified expert operators.

Procedure success is adjudicated by an independent Corelab. Procedure success is adjudicated by an independent Corelab.

Page 11: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

The database for Retrograde Summit general registry has

already been modified to collect same dataset as Japanese CTO

PCI Expert Registry.

The outcome from both Retrograde Summit General Registry

and Japanese CTO PCI Expert Registry will be compared and

reported in the near future.

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Officially it started from January 2014, will end in December Officially it started from January 2014, will end in December

2022.

All clinical data including patient background data and details All clinical data including patient background data and details

of the procedures are input via an electronic capture system.

Pre-procedural CAG and CTA (optional), and procedural Pre-procedural CAG and CTA (optional), and procedural

angiograms and IVUS images are sent as DICOM data to an

independent core laboratory.independent core laboratory.

Annual clinical follow-up data are collected for 5 years (only in

domestic pts).domestic pts).

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t=2208000

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20142014 20152015 20162016

Number of ExpertNumber of Expert3030 3232 4141 4545

20142014 20152015 20162016

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The enrolled CTO-PCI procedure; n=4205 proceduresthe number of target CTO lesion in each procedure

(1 lesion:n=4148, 2 lesions:n=57)

CTO-PCI outside Japann=1359

CTO-PCI in Japann=2846

N= 2816

2 CTO lesions in one procedure: n=30

Inadequate anatomical indication: n=62sub-total lesion: n=104 ,non-CTO lesion: n=1, unanalyzable n=4

N=2645

Inappropriate data of pt. /lesionbackground: n=49

N=2596

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The procedure was defined here as bidirectional approach (BA) The procedure was defined here as bidirectional approach (BA)

where an attempt was made to cross the collateral channel for

retrograde revascularization techniques.retrograde revascularization techniques.

Cases were divided into 3 groups based on ITT principle;

primary antegrade approach (PAA), primary BA (PBA), andprimary antegrade approach (PAA), primary BA (PBA), and

rescue BA (RBA).

PAA included rescue BA and re-switched antegrade approach. PAA included rescue BA and re-switched antegrade approach.

No antegrade dissection and reentry device was used.

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Overall PAA PBA PAA vs. PBAN=2596 N=1872 N=724 P-value

72.1% 27.9%72.1% 27.9%Age 66.9±10.9 66.8±10.9 66.9±10.7 0.863BMI 24.7±3.8 24.7±3.8 24.6±3.8 0.413

LVEF 54.8±12.9 54.9±12.9 54.6±12.8 0.458LVEF 54.8±12.9 54.9±12.9 54.6±12.8 0.458eGFR 64.9±29.0 65.1±30.2 64.3±25.7 0.458

Male gender, % 86.1 85.1 88.4 0.018Hypertension, % 78.5 78.0 80.8 0.12Dyslipidemia, % 77.5 76.1 82.1 0.001Dyslipidemia, % 77.5 76.1 82.1 0.001

Diabetes, % 44.9 44.9 45.8 0.35Current smoking, % 54.4 58.0 62.3 0.057

OMI, % 51.0 51.7 51.3 0.895Prior CABG, % 7.9 7.4 9.4 0.105

Prior PCI, % 63.2 61.8 67.5 0.007Reattempt, % 20.6 15.1 34.8 <0.0001Syntax score 15.9±8.6 16.0±8.4 15.6±8.9 0.062Syntax score 15.9±8.6 16.0±8.4 15.6±8.9 0.062J-CTO score 2.0±1.1 1.9±1.1 2.4±1.1 <0.0001

Target vessel, % <0.0001LAD 30.9 32.9 25.7LCX 17.1 20.4 8.6LCX 17.1 20.4 8.6LMT 0.6 0.6 0.6RCA 51.5 46.2 65.2

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Overall PAA PBA PAA vs. PBAN=2596 N=1872 N=724 P-valueN=2596 N=1872 N=724 P-value

In-stent occlusion, % 13.6 16.9 5.1 <0.0001Distal run off (<3.0mm), % 65.0 64.9 67.2 0.274CTO length (≥20mm), % 60.5 57.0 69.6 <0.0001CTO length (≥20mm), % 60.5 57.0 69.6 <0.0001

Side branch at proximal cap,% 34.1 34.8 32.0 0.181

Collateral filling, % <0.0001Contralateral 50.7 47.6 58.8Contralateral 50.7 47.6 58.8

Ipsilateral 13.3 15.9 6.6Both 35.2 35.5 34.4None 0.7 1.0 0.1None 0.7 1.0 0.1

Lesion calcification, % 52.3 50.5 56.9 0.003Proximal tortuosity, % 50.7 49.1 49.3 0.108

Tortuosity of CTO lesion, % 24.6 21.6 32.5 <0.0001Morphology of proximal cap,Morphology of proximal cap,

% 0.002Blunt 23.7 23.6 23.9

No stump 19.1 17.7 22.7No stump 19.1 17.7 22.7Tapered/tunnel 56.7 58.3 52.3

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Overall PAA PBA PAA vs. PBAOverall PAA PBA PAA vs. PBAN=2596 N=1872 N=724 P-value

GW success, % 92.0 92.9 90.1 0.016Technical success, % 89.9 91.0 87.3 0.006

Procedural success, % 88.8 90.3 85.0 <0.0001Procedural success, % 88.8 90.3 85.0 <0.0001Procedure time 160.4±89.6 143.8±81.9 201.5±94.4 <0.0001

Contrast volume 230.8±105.9 224.7±104.5 245.8±108.0 <0.0001In hospital death, % 0.2 0.2 0.4 0.362In hospital death, % 0.2 0.2 0.4 0.362

MI, % 1.2 0.8 2.0 0.018Acute stent thrombosis, % 0.2 0.2 0.1 1.000

Stroke, % 0.2 0.2 0.3 0.628Emergent CABG, % 0 0 0Emergent CABG, % 0 0 0

Emergent PCI 0.2 0.2 0.1 1.000Coronary embolism, % 0.2 0.1 0.6 0.06Coronary perforationCoronary perforation

(tamponade), % 0.4 0.2 0.9 <0.0001Complications of puncture

site, % 1.3 1.2 1.4 0.844CIN, % 1.7 1.2 3.1 0.031CIN, % 1.7 1.2 3.1 0.031

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AntegradeAntegradeAntegradeapproach

N=1872

Antegradeapproach

N=1872(74.3%) (25.7%)

Antegrade AloneN=1390

Antegrade AloneN=1390

Rescue Bidirectional

N=482

Rescue Bidirectional

N=482

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Antegrade alone RBA Ant vs. RBAN=1390 N=482 P-valueN=1390 N=482 P-value

Age 67.1±11.0 66.2±10.8 0.171BMI 24.6±3.7 24.8±3.9 0.370

LVEF 55.0±13.0 54.6±12.8 0.434

eGFR 64.5±30.8 66.6±28.4 0.277Male gender, % 84.1 88.2 0.031Hypertension, % 77.6 78.0 0.784Dyslipidemia, % 75.2 77.8 0.166Dyslipidemia, % 75.2 77.8 0.166

Diabetes, % 44.7 44.5 0.434Current smoking, % 51.9 57.1 0.137

OMI, % 49.7 55.0 0.120Prior CABG, % 6.6 9.6 0.096

Prior PCI, % 59.9 65.5 0.025Syntax score 16.1±8.5 15.8±8.1 0.797J-CTO score 1.7±1.1 2.2±1.1 <0.0001J-CTO score 1.7±1.1 2.2±1.1 <0.0001

Target vessel, % <0.0001LAD 33.9 29.9LCX 22.9 13.3LMT 0.6 0.4LMT 0.6 0.4RCA 42.6 56.4

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Antegrade alone RBA Ant vs. RBAAntegrade alone RBA Ant vs. RBAN=1390 N=482 P-value

Reattempt, % 12.7 22.2 <0.0001In-stent occlusion, % 20.2 7.3 <0.0001In-stent occlusion, % 20.2 7.3 <0.0001

Distal run off (<3.0mm), % 64.2 65.1 0.762CTO length (≥20mm), % 53.5 67.2 <0.0001

Side branch at proximal cap, % 35.5 33.0 0.325Collateral filling, % <0.0001Collateral filling, % <0.0001

Contralateral 46.6 50.4Ipsilateral 18.4 8.9

Both 33.8 40.5Both 33.8 40.5None 1.2 0.2

Lesion calcification, % 48.8 55.4 0.013Proximal tortuosity, % 49.2 49.0 0.836

Tortuosity of CTO lesion, % 18.7 29.9 <0.0001Tortuosity of CTO lesion, % 18.7 29.9 <0.0001Morphology of proximal cap, % 0.008

Blunt 24.6 20.7No stump 16.0 22.6

Tapered/tunnel 59.1 56.2Tapered/tunnel 59.1 56.2

Page 23: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

AntegradeAntegradeAntegradeapproach

N=1872

Antegradeapproach

N=1872(74.3%) (25.7%)

Antegrade AloneN=1390

Antegrade AloneN=1390

Rescue Bidirectional

N=482

Rescue Bidirectional

N=482

Success

N=1327

Success

N=1327

Failure

N=63

Failure

N=63

Rescue Bidirectionalalone N=400

Rescue Bidirectionalalone N=400

Re-switched toantegrade N=82Re-switched to

antegrade N=82

95.5%

Failure

N=70

Failure

N=70

Success

N=330

Success

N=330

Success

N=46

Success

N=46

Failure

N=36

Failure

N=36

95.5%

78.0%78.0%

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Frequency Success

100 82.575.0 78.8 88.9

Frequency Success

%

40

60

8078.8 88.9

0

20

40 14.4

3.2

28.4

15.50

PAA

Parallel wire

Parallel wire

IVUS guide

IVUS guidePAA

Antegrade after PBA failure

IVUS guide

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Primary bidirectionalapproach N=724

Primary bidirectionalapproach N=724

(84.0%) (16.0%)

Bidirectional aloneN=608

Bidirectional aloneN=608

Switched toantegrade N=116

Switched toantegrade N=116

FailureFailure SuccessSuccess SuccessSuccess FailureFailure87.3%

N=69N=69 N=539N=539 N=93N=93 N=23N=2387.3%

80.1% (93/116)

Page 26: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

Frequency Success

100 82.575.0 78.8 88.9

Frequency Success

%

40

60

8078.8 88.9

0

20

40 14.4

3.2

28.4

15.50

PAA

Parallel wire

Parallel wire

IVUS guide

IVUS guidePAA

Antegrade after PBA failure

IVUS guide

Page 27: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

RBA PBA RBA vs. PBAN=482 N=724 P-valueN=482 N=724 P-value

Age 66.2±10.8 66.9±10.7 0.289BMI 24.8±3.9 24.6±3.8 0.227

LVEF 54.6±12.8 54.6±12.9 0.982eGFR 66.6±28.4 64.3±25.7 0.286eGFR 66.6±28.4 64.3±25.7 0.286

Male gender, % 88.2 88.4 0.927Hypertension, % 78.0 80.5 0.449Dyslipidemia, % 77.8 81.9 0.175Dyslipidemia, % 77.8 81.9 0.175

Diabetes, % 44.5 45.5 0.906Current smoking, % 57.1 57.4 0.915

OMI, % 55.0 50.8 0.320Prior CABG, % 9.6 9.4 0.972Prior CABG, % 9.6 9.4 0.972

Prior PCI, % 66.5 67.2 0.948Syntax score 15.8±8.1 15.6±8.9 0.182J-CTO score 2.2±1.1 2.4±1.1 0.001J-CTO score 2.2±1.1 2.4±1.1 0.001

Target vessel, % 0.007LAD 29.9 25.7LCX 13.3 8.6LMT 0.4 0.5LMT 0.4 0.5RCA 56.4 65.2

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RBA PBA RBA vs. PBARBA PBA RBA vs. PBAN=482 N=724 P-value

Reattempt, % 22.2 34.8 <0.0001In-stent occlusion, % 7.3 5.1 0.137

Distal run off (<3.0mm), % 65.1 66.4 0.793Distal run off (<3.0mm), % 65.1 66.4 0.793CTO length (≥20mm), % 67.2 69.6 0.729

Side branch at proximal cap, % 33.0 32.0 0.754Lesion calcification, % 55.4 56.9 0.635Lesion calcification, % 55.4 56.9 0.635Proximal tortuosity, % 49.0 49.3 0.401

Tortuosity of CTO lesion, % 29.9 32.5 0.644Morphology of proximal cap, % 0.303

Blunt 20.7 23.9Blunt 20.7 23.9No stump 22.6 22.7

Tapered/tunnel 56.2 52.3Collateral used, % 0.801Collateral used, % 0.801

Sepal 66.3 69.0Epicardial 24.7 23.4

Arterial 6.4 5.2Graft 2.7 2.4Graft 2.7 2.4

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RBA PBA RBA vs. PBAN=482 N=724 P-value

Failed collateral crossing, % 20.2 16.0 0.062GW success, % 80.3 90.1 <0.0001GW success, % 80.3 90.1 <0.0001

Technical success, % 78.0 87.3 <0.0001Procedural success, % 76.5 85.0 <0.0001

Procedure time 218.0±79.8 201.5±94.4 <0.0001Contrast volume 279.5±123.9 245.8±108.0 <0.0001Contrast volume 279.5±123.9 245.8±108.0 <0.0001

In hospital death, % 0 0.4 0.296MI, % 1.4 2.0 0.688

Acute stent thrombosis, % 0 0.1 1.000Acute stent thrombosis, % 0 0.1 1.000Stroke, % 0.7 0.3 0.370

Emergent CABG, % 0 0Emergent PCI 0.2 0.1 1.000

Coronary embolism, % 0 0.6 0.171Coronary embolism, % 0 0.6 0.171Coronary perforation (tamponade), % 0.4 0.9 0.295

Complications of puncture site, % 1.2 1.4 0.796CIN, % 2.4 3.1 0.72CIN, % 2.4 3.1 0.72

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PBAUnivariate analysisUnivariate analysis

OR CI P-valuePrior CABG 1.87 1.024-3.416 0.042Dyslipidemia 0.565 0.349-0.915 0.02

Side branch at proximal cap 2.086 1.373-3.167 0.001Side branch at proximal cap 2.086 1.373-3.167 0.001Tortuosity of CTO 1.813 1.191-2.760 0.006

Severe lesion calcification 2.876 1.622-5.101 <0.0001

multivariate analysisOR CI p-valueOR CI p-value

Severe lesion calcification 3.264 1.739-6.125 <0.0001Tortuosity of CTO 1.699 1.075-2.686 0.023

Side branch at proximal cap 2.399 1.524-3.776 <0.0001Dyslipidemia 0.535 0.322-0.889 0.016

Page 31: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

RBAUnivariate analysisUnivariate analysis

OR CI P-valueSex 0.328 0.180-0.598 <0.001BMI 1.604 1.024-2.511 0.039

Diabetes 1.720 1.097-2.698 0.018Diabetes 1.720 1.097-2.698 0.018eGFR<60 0.630 0.401-0.988 0.044

In-stent occlusion 2.780 1.329-5.814 0.007Lesion>20mm 1.722 1.039-2.855 0.035Lesion>20mm 1.722 1.039-2.855 0.035

Tortuosity of CTO 1.734 1.087-2.765 0.021Severe lesion calcification 4.242 2.074-8.677 <0.0001

multivariate analysisOR CI p-valueOR CI p-value

Severe lesion calcification 2.711 1.188-6.185 0.018Sex 0.302 0.155-0.590 <0.0001BMI 1.807 1.084-3.012 0.023

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Japanese experts frequently chose the bidirectional approach as

the primary strategy (27.9%), especially for more complex CTOthe primary strategy (27.9%), especially for more complex CTO

lesions, with a technical success rate of about 90%.

For intermediate CTO lesions (J-CTO score < 2), experts For intermediate CTO lesions (J-CTO score < 2), experts

mainly performed the antegrade approach alone, with a very

high success rate (more than 95%).high success rate (more than 95%).

However, for RBA, the success rate decreased to less than 80%.

The experts frequently used the parallel wiring and IVUS- The experts frequently used the parallel wiring and IVUS-

guided penetration in antegrade approach, with high technical

success (75.0%–88.9%).success (75.0%–88.9%).

Severe lesion calcification was a strong predictor of failure.

Page 33: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

CTO-PCI performed by highly experienced expertsCTO-PCI performed by highly experienced experts

achieved a high technical success rate and a low rate

of major complications.of major complications.

Page 34: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

Development of CTO-PCI procedure

Miracle

Conquest

Fielder XTFielder XT

Fielder XTR

BridgePoint

Corsair

wire, deviceSION

IVUS guidance

Fielder XTR

GAIA

MDCTimaging modality

Parallel wiring

IVUS guidance

Bidirectional approachwiring technique

1995 2000 2005 2010

wiring technique

2015

Euro CTO ClubEuro CTO ClubCTO Fundamentals

Hybrid approach

Page 35: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

SeoulBeijing

NagoyaShanghai

TaipeiGuangzhou

Singapore

Brisbane

Sydney Auckland

Wellington

Page 36: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

Kick-off Meeting@CIT2015, BeijingMarch 19th, 2015March 19th, 2015

Page 37: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

ObjectiveObjective

To promote CTO-PCI based on the well developedtechnology (devices, techniques) for more than 20

years in Asian-Pacific region.years in Asian-Pacific region.

To educate the next generation of Asian-Pacific CTOTo educate the next generation of Asian-Pacific CTOoperators for the patients living in this region.

Page 38: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

DirectorsDirectors

Ji Yan Chen Guangdong General Hospital ChinaLei Ge Zhongshan Hospital Fudan University ChinaScott Harding Wellington Hospital New ZealandScott Harding Wellington Hospital New ZealandPaul Hsien-Li Kao National Taiwan University Hospital TaiwanSeung-Whan Lee Asan Medical Center KoreaSoo Teik Lim National Heart Centre Singapore SingaporeSidney Tsz Ho Lo Liverpool Hospital AustraliaSidney Tsz Ho Lo Liverpool Hospital AustraliaJie Qian Fu Wai Hospital ChinaEtsuo Tsuchikane Toyohashi Heart Center JapanEugene B. Wu Prince of Wales Hospital Hong Kong

Page 39: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

LeeQian

TsuchikaneGe

KaoChen

Wu

Lim

LoLo

Harding

Page 40: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

SupervisorsSupervisors

Jumbo Ge Zhongshan Hospital Fudan University ChinaYang-Soo Jang Severance Hospital, Yonsei University Hospital KoreaYang-Soo Jang Severance Hospital, Yonsei University Hospital KoreaOsamu Katoh JapanTian Hai Koh National Heart Centre Singapore SingaporeSum Kin Leung Keen Heart Medical Practice HongKongJim Stewart Auckland City Hospital New ZealandJim Stewart Auckland City Hospital New ZealandYeujin Yang Beijing Fuwai Hospital ChinaChiung-Jen Wu Kaohsiung Chang Gung Memorial Hospital Taiwan

Page 41: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

What’s AP CTO Club role and activityin AP region?in AP region?

1. Development of AP CTO-PCI Algorithm1. Development of AP CTO-PCI Algorithm

Page 42: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

Careful analysis of angiogram / MSCT

Yes

In-stent restenosis

Consider use of CrossBoss asProximal cap ambiguity IVUS guided entry

No

Yes

NoYes

Consider use of CrossBoss asprimary crossing strategy

for straight ISO

No

Poor quality distal vessel orbifurcation at distal cap

YesInterventional collaterals present

Yes

Retrograde approach

No

Antegrade wirebased approach

Primary use of KWT and/or dissection re-entry

• Ambiguous course in CTODissection Reentry Parallel wiring

If suitablere-entryzone

• Ambiguous course in CTO• Tortuous CTO segment• Heavy calcification

Rescue use of KWT and/or dissection re-entry• Length >20 mm

(Stingray)Parallel wiring

IVUS guided wiring • Length >20 mm• Previous failed attempt

Consider stopping if >3 hours, 3.7 x eGFR ml contrast, Air Kerma > 5 Gy unless procedure well advanced

IVUS guided wiring

Page 43: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

What’s AP CTO Club activities• “Umbrella” covering CTO workshops and major meetings in AP region

– Jun. 19-20 CTO Club in Nagoya– Aug. 21-22 Guangzhou CTO Workshop in China– Sep. 11-12 CTO Interventions Live course in Singapore– Sep. 11-12 CTO Interventions Live course in Singapore– Oct. 23-24 CTOCC in Shanghai– Oct. 29-31 CCT in Kobe– Nov. 18-20 ANZCCT in Brisbane

2015– Nov. 18-20 ANZCCT in Brisbane– Jan. 8-9 TTT in Taipei– Jan. 21-23 Asia PCR in Singapore– Mar. 17-20 CIT in Beijing

2016– Mar. 17-20 CIT in Beijing– Apr. 26 CTO Live@TCT AP in Seoul– Jun. 9-10 ANZCTO Club in Perth– Jun. 17-18 CTO Club in Nagoya– Aug. 18-19 Guangzhou CTO Workshop in China– Aug. 18-19 Guangzhou CTO Workshop in China– Sep. 9-10 CTO Interventions Live course in Singapore– Oct. 20-22 CCT in Kobe– Jan. 7-8 TTT in Taipei 2017– Jan. 7-8 TTT in Taipei 2017

Page 44: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

What’s AP CTO Club activities• “Umbrella” covering CTO workshops and major meetings in AP region

– Jun. 19-20 CTO Club in Nagoya– Aug. 21-22 Guangzhou CTO Workshop in China– Sep. 11-12 CTO Interventions Live course in Singapore– Sep. 11-12 CTO Interventions Live course in Singapore– Oct. 23-24 CTOCC in Shanghai– Oct. 29-31 CCT in Kobe– Nov. 18-20 ANZCCT in Brisbane

2015– Nov. 18-20 ANZCCT in Brisbane– Jan. 8-9 TTT in Taipei– Jan. 21-23 Asia PCR in Singapore– Mar. 17-20 CIT in Beijing

2016– Mar. 17-20 CIT in Beijing– Apr. 26 CTO Live@TCT AP in Seoul– Jun. 9-10 ANZCTO Club in Perth– Jun. 17-18 CTO Club in Nagoya– Aug. 18-19 Guangzhou CTO Workshop in China– Aug. 18-19 Guangzhou CTO Workshop in China– Sep. 9-10 CTO Interventions Live course in Singapore– Oct. 20-22 CCT in Kobe– Jan. 7-8 TTT in Taipei 2017– Jan. 7-8 TTT in Taipei 2017

Page 45: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

What’s AP CTO Club role and activityin AP region?in AP region?

1. Development of AP CTO-PCI Algorithm1. Development of AP CTO-PCI Algorithm

2. Web Site Open www.apcto.club

Page 46: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

What’s AP CTO Club role and activityin AP region?in AP region?

1. Development of AP CTO-PCI Algorithm1. Development of AP CTO-PCI Algorithm

2. Web Site Open

3. APCTO Registry by course directors from 2016 by usingsame database as Japanese Expert Registry

www.apcto.club

3. APCTO Registry by course directors from 2016 by usingsame database as Japanese Expert Registry

4. Educational Training Program

– Workshop with live cases for young physician’s CTO training– Workshop with live cases for young physician’s CTO trainingw/wo proctorship

Page 47: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

What’s AP CTO Club activities• “Umbrella” covering CTO workshops and major meetings in AP region

– Jun. 19-20 CTO Club in Nagoya

– Aug. 21-22 Guangzhou CTO Workshop in China

– Sep. 11-12 CTO Interventions Live course in SingaporeDr. Eugene B Wu– Sep. 11-12 CTO Interventions Live course in Singapore

– Oct. 23-24 CTOCC in Shanghai

– Oct. 29-31 CCT in Kobe

– Nov. 18-20 ANZCCT in Brisbane

2015

Dr. Eugene B Wu

– Nov. 18-20 ANZCCT in Brisbane

– Jan. 8-9 TTT in Taipei

– Jan. 21-23 Asia PCR in Singapore

– Mar. 17-20 CIT in Beijing

2016

– Apr. 26 CTO Live@TCT AP in Seoul

– Jun. 9-10 ANZCTO Club in Perth

– Jun. 17-18 CTO Club in Nagoya

– Aug. 18-19 Guangzhou CTO Workshop in China– Aug. 18-19 Guangzhou CTO Workshop in China

– Sep. 9-10 CTO Interventions Live course in Singapore

– Oct. 20-22 CCT in Kobe

– Jan. 7-8 TTT in Taipei2017

– Jan. 7-8 TTT in Taipei

– Feb. 18-19 The 1st APCTO Club Proctorship Live in HKCTO Live 2017

Page 48: Etsuo Tsuchikane, MD, PhD · The Japanese Board of CTO Interventional Specialists was established in 2013 to accumulate quantitative data to identify issues such as stagnation in

What’s AP CTO Club role and activityin AP region?in AP region?

1. Development of AP CTO-PCI Algorithm1. Development of AP CTO-PCI Algorithm

2. Web Site Open

3. APCTO Registry from course directors from 2016 byusing same database as Japanese Expert Registry

www.apcto.club

3. APCTO Registry from course directors from 2016 byusing same database as Japanese Expert Registry

4. Educational Training Program

– Workshop in each regional meeting for young physician’s– Workshop in each regional meeting for young physician’sCTO training w/wo proctorship