EPIDEMIOLOGY OF TUBERCULOSIS · Objectives • Identify trends in global, national, and Michigan TB...
Transcript of EPIDEMIOLOGY OF TUBERCULOSIS · Objectives • Identify trends in global, national, and Michigan TB...
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EPIDEMIOLOGY OF TUBERCULOSIS...the Who, the Where, and (perhaps) the WhyShona Smith, MPHEpidemiologistMDHHS TB Control Unit
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Disclosures• None of the speakers or planners involved in this activity has
any relevant conflict of interest.
• Approval status does not imply endorsement by the provider, ONA, MSMS, or any products displayed in conjunction with an activity.
• The use of trade names and commercial sources during this presentation is for identification only, and does not imply endorsement.
• No commercial support has been received for this program.
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Objectives
• Identify trends in global, national, and Michigan TB epidemiology that have contributed to the number of TB cases in 2015
• Identify important risk-factors that have contributed to the number of TB cases in 2015
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Main Topics
• Epidemiologic trends in TB Disease across the world, the United States, and Michigan
• Characteristics of high-risk “moving” TB populations in the US and Michigan including:
– Foreign Born
– Homeless
– Those who moved during therapy
• Immigrant and Refugee TB screening
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A GLIMPSE OF THE GLOBAL BURDEN
“It’s a small world after all!”
http://www.thenation.com/wp-content/uploads/2015/09/foster-shutterstock-hands_img.jpg
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How many new cases of TB were
reported globally to
WHO in 2014?
A. 4.1 MillionB. 6.3 MillionC. 9.8 MillionD.12.4 Million
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Status of the Global TB Epidemic and Response –Global Tuberculosis Report 2015
http://www.who.int/tb/publications/global_report/GTBreport2015.jpeg?ua=1
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Global TB Incidence 2014
http://www.who.int/gho/map_gallery/en/
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Global TB Notifications,1990 -2014
http://www.who.int/tb/publications/global_report/en/
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A DOMESTIC DISTRIBUTION OF
BURDEN
“Think Global. Act Local.”
http://www.cdc.gov/tb/publications/infographic/takeontbinfographic.htm
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Reported TB Cases United States, 1982–2014*
*Updated as of June 5, 2015.
0
5,000
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15,000
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No.
of C
ases
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TB Case Rates,* United States, 2014
*Cases per 100,000.
< 3.0 (2014 national average)>3.0
D.C.
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Reported Tuberculosis Cases and RatesMichigan, 2005-2015
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Case
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Clinical Characteristics of TB Cases, Michigan, 2015• Verification Criteria:– 71% Culture Positive
– <1% NAAT Positive (no culture)
– 24% Clinical
– 5% Provider Diagnosed
• Site of TB Disease:– 55% Pulmonary
– 33% Extrapulmonary• 25% Ocular
– 12% Concurrent
• 100% of culture positive cases were genotyped
• 15% in a genotype cluster
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Number of TB Cases inU.S.-born vs. Foreign-born Persons,
United States, 1993–2014*
*Updated as of June 5, 2015
No.
of C
ases
0
5,000
10,000
15,000
20,000
U.S.-born Foreign-born
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Number and Proportion of U.S. vs. Foreign-born TB Cases
Michigan, 1997–2015
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ases
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Foreign-born U.S.-born % Foreign-born
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Proportion of TB Cases by Race/ EthnicityMichigan, 2010–2015
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Hispanic/Latino
Arab
Black or African American*
Asian*
Caucasian*
American Indian or Alaskan Native*Native Hawaiian or Other Pacific Islander*Other*
U.S-born: 62% Black or African AmericanForeign-born: 58% Asian
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Proportion of TB Cases by Age Michigan, 2010–2015
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Year
0-4 yrs
5-14 yrs
15-24 yrs
25-44 yrs
45-64 yrs
65+ yrs
U.S-born: 37% 45-64 year oldsForeign-born: 38% 25-44 year olds
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Proportion of TB Cases by Gender Michigan, 2010–2015
U.S-born: 67% MaleForeign-born: 57% Male
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TB Case Rates by Age Group and Sex, United States, 2014
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es p
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Under 5 5 - 14 15 - 24 25 - 44 45 - 64 ≥65Male Female
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TB Case Rates by Age Group and Sex Michigan, 2014
0.0
1.0
2.0
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Under 5 5-14 15-24 25-44 45-64 ≥65
Repo
rted
TB
Cas
es p
er 1
00,0
00
Male Female
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TB Cases Reported as Homeless in the 12 Months Prior to Diagnosis,
Age ≥15, United States, 1993-2014*
*Updated as of June 5, 2015.Note: Homeless within past 12 months of TB diagnosis.
0.01.02.03.04.05.06.07.08.0
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No. of Cases Percent of Total Cases
No. of Cases Percentage
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TB Cases Reported as Homeless in the 12 Months Prior to Diagnosis
Michigan, 2007 - 2015
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2007 2008 2009 2010 2011 2012 2013 2014 20150.0
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No. of Homeless Cases % Reported as Homeless % with Unknown Homeless Status
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0.0
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Moved In State
Moved Out of State
Moved Out of U.S.
Moved Both In Stateand Out of State
Moved Both Out ofState and Out of U.S.
Proportion of TB Cases Reported as Moved During Treatment
Michigan, 2010-2014
U.S-born: 6.9%Foreign-born: 14.0%
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Estimated HIV Coinfection in Persons Reported with TB, United States, 1993 – 2014*
*Updated as of June 5, 2015.Note: Minimum estimates based on reported HIV-positive status among all TB cases in the age group.
% C
oinf
ectio
n
0
10
20
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All Ages Aged 25-44
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0
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HIV-TB Co-infection
Undocumented HIVTest Results
TB-HIV Coinfection and Undocumented HIV Test Result in TB Cases
Michigan, 2005 - 2015
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Additional Characteristics and TB Risk Factors among U.S-born Vs. Foreign-born Cases, Michigan, 2005-2015Characteristic U.S.-born Foreign-born TotalPrevious Diagnosis of TB 4.3% 6.0% 5.2%
Student 4.1% 8.1% 6.3%
Resident of Correctional Facility at Diagnosis
2.3% 0.6% 1.4%
Resident of a Long-term Care Facility at Diagnosis
7.6% 1.4% 4.2%
Injecting Drug Use 4.8% 0.6% 2.5%
Non-Injecting Drug Use 18.3% 0.6% 8.5%
Excess Alcohol Use 20.4% 3.9% 11.3%
Diabetes 11.7% 15.8% 14.2%
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SCREENING OF IMMIGRANT AND
REFUGEES
“Don’t Tell Me What I Can’t Do – Tell Me How To Do It!”
http://science-all.com/image.php?pic=/images/iceberg/iceberg-02.jpg
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Immigrant and Refugee Arrivals to Michigan
• Immigrant and Refugee Classifications Requiring TB Screening:– Class A – active TB disease
– Class B1 – suspect TB disease
– Class B2 – suspect LTBI
– Class B3 – TB Contact
• 2015: 353 arrivals requiring screening
• 2014: 348 arrivals requiring screening
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TB Evaluation and Treatment of Immigrants and Refugees
Michigan, 2014
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Total Arrivals InitiatedEvaluation
CompletedEvaluation
LTBI or TBDiagnosed
TreatmentRecommended
US TreatmentStarted
US TreatmentCompleted
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Drug – ResistantTuberculosis
http://gamapserver.who.int/mapLibrary/Files/Maps/Global_TB_MDRcases.pnghttp://gamapserver.who.int/mapLibrary/Files/Maps/Global_TB_cases_xdr_2014.png
Multi-Drug and Isoniazid Resistance, U.S., 2010-2015
U.S. MichiganMDR INH MDR INH
2010 1.1% 8.0% 1.1% 4.9%
2011 1.3% 9.1% 0.6% 5.9%
2012 1.0% 8.9% 1.3% 1.3%
2013 1.3% 9.2% 0.0% 2.1%
2014 1.3% 9.8% 0.0% 6.7%
2015 -- -- 0.0% 3.8%
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Thank you!Acknowledgements:
• Local Health Department TB Nurses and Staff
• MDHHS TB Control Unit
Contact Information:
References:1. World Health Organization. Global tuberculosis report 2015. Geneva, Switzerland: World Health
Organization; 2015. http://apps.who.int/iris/bitstream/10665/191102/1/9789241565059_eng.pdf?ua=1
2. CDC. Reported tuberculosis in the United State, 2014. Atlanta, GA: US Department of Health and Human Services, CDC; 2015. http://www.cdc.gov/tb/statistics/reports/2014/default.htm
3. Salinas JL, Mindra G, Haddad MB, Pratt R, Price SF, Langer AJ. Leveling of Tuberculosis Incidence – United States, 2013-2015. MMWR Morb Mortal Wkly Rep 2016;65:273–278. DOI: http://dx.doi.org/10.15585/mmwr.mm6511a2
4. US Census Bureau. Current estimates data. Washington, DC: US Census Bureau; 2014. http://www.census.gov/popest/data/state/asrh/2014/index.html