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DOPA Dopamine

?

1) Mention the name of the enzyme?

2) Name one drug that inhibit this

enzyme?

Answer: nzyme:DOPA de!arbo"y#ase

Drugs: $arbidopa%

benserazide

&2'($O2 &2$O ? *!arboni!a!id)

1) Mention the name of the enzyme?

2) Name one drug that inhibit this

enzyme?

Answer: nzyme : $arboni! anhydrase

Drugs: A!etazo#amide%

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Dorzo#amide%Methiazo#amide

Angiotensin I Angiotensin II

?

1) Mention the name of the enzyme?

2) Name one drug that inhibit this

enzyme?Answer: nzyme :

Angiotensin !on+erting enzyme

Drugs: ena#apri# , #isinopri#,

!aptopri#, benazepri#, -uinapri#,

perindopri#, ramipri#, fosinopri#.

Acetylcholine Choline +Aceticacid

?

1) Mention the name of the enzyme?

2) Name one drug that inhibit this

enzyme?

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Answer: nzyme : !ho#inesterase

Drugs: physostigmine,neostigmine, pyridostigmine,D/P,

!hothiophate, Any Organophosphorus

$ompound ,drophonium,

0i+astigmine

cAMP 5- AMP (inactive)

?

1) Mention the name of the enzyme?

2) Name one drug that inhibit thisenzyme?

Answer: nzyme : phosphodiesterase

Drugs: inamrinone,

mi#rinone, si#denafi#

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Angiotensinogen Angiotensin - I

?1) Name the substan!e that is

in+o#+ed in this pro!ess?

2) Name one inhibitor?

Answer: nzyme : reninDrug: a#isiren,remiiren,

ena#iran

GTP cGMP

?

1) Mention the name of the enzyme?

2) Name one drug that a!ti+ates this

enzyme?

Answer: nzyme : guany#y# !y!#ase

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Drugs: g#y!ery# trinitrate,

isosorbide dinitrate

ATP CAMP

?1) Mention the name of the enzyme?

2) Name one drug that a!ti+ates this

enzyme?Answer: nzyme : adeny#y# !y!#ase

Drugs:ephedrine,

adrena#ine,sa#butamo#, ritodrine,

terbuta#ine

Acetylcholine Choline +Aceticacid

?

1) Mention the name of the enzyme?

2) Name one drug that a!ti+ates this

enzyme?Answer: nzyme : $ho#inesterase

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Drugs: Pra#ido"ime,

Obido"ime, Dia!ty# mono"ime

Norepinephrine Inactive

eta!olite

?1) Mention the name of the enzyme?

2) Name one drug that inhibit thisenzyme?

Answer: nzyme : monoamine

o"idase% !ate!ho# ortho methy#

transferase

Drugs: MAO inhibitor:4e#egi#ine

$OM5 inhibitor: 5o#!apone,

nta!apone

Angiotensin II AT" receptors

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1) Mention two drugs a!ting at the

A51 re!eptors

Answer:Drugs: #osartan, !andesartan,+a#sartan,irbesartan,eprosartan.

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1)What is meant by indirect acting?2)Name one drug which acts indirectly?

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Answer: 1) A!t by re#easing

norepinephrine from sympatheti! ner+eendings

2) Amphetamine,5yramine,phedrine

Answer: 1) drugs a!ting both dire!t9

indire!t means

1)What is meant bymixed acting?

2)Mention one drugwhich acts so

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2) ephedrine, metho"amine

1'

1)What is meant by direct acting?

2)Name one drug which acts indirectly?

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Answer: 1) ;y intera!ting withadrenergi! re!eptors

2) Noradrena#ine,Adrena#ine, Dopamine,

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Answer: 1) any >agonist adrena#ine,

isoprena#ine, sa#butamo#, terbuta#ine,

sa#metro#

12

1) Name the two agonists

acting on this site?

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1

1)Name two antagonists

acting at this site?

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Answer: 1) any >b#o!er : praprano#o#,

nado#o#, timo#o#, sota#o#, metopro#o#,

ateno#o#, a!ebuta#o#, #abeta#o#, !ar+edi#o#

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Answer: 1) Phosphodiesterase inhibitor:

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Answer: 1) !a#!ium !hanne# b#o!ers :

nifedipine, am#odipine, fe#odipine,

nimodipine, ni!ardipine, isradipine.

16

1)Name two drugs acting at this

site?

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PA#A $I%&$'*IC

? ACI$

1) Name the enzyme?

2) Name one inhibitor of that

enzyme?

Answer: nzyme : /o#i! a!idsynthetase Drugs: 4u#phonamides,

4u#fone

$% TT'A%&$'

? *IC ACI$

1) Name the enzyme ?2) Mention one inhibitor of the

enzyme?

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Answer: nzyme : dihydrofo#ate

redu!tase

Drugs: 5rimethoprim,Pyrimethamine, Methotre"ate

,ANT%IN 'IC ACI$

1) Name the enzyme ?

2) Mention one inhibitor of the

enzyme?Answer: nzyme : @anthine o"idase

Drugs: A##opurino#

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