Enzymes at McBride Prebes...Enzymes at McBride - Prebes 19 March 2019 Half face masks are for short...

19th March 2019

Enzymes at McBride

Prebes

3 in UK

2 in Belgium

3 in France

1 in Spain

1 in Italy

1 in Poland

2 in Denmark

1 in Luxembourg

McBride owns several production

centres in Europe:

Hong Kong

Vietnam

Malaysia

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Our Locations

Enzymes at McBride - Prebes 19 March 2019

Enzymes at McBride - Prebes 19 March 2019 3

Introduction of enzymes usage in detergents

• Enzymes incorporated into detergents since the mid 1960’s.

• First detergent enzyme was an alkaline protease.

• Recognized in the late 1960’s that enzymes could cause some safety concerns i.e. allergy.

• Enzyme and detergent manufacturers made changes in production and handling of enzyme- and detergent products.

• development of low-dust encapsulated enzymes

• improvements of manufacturing sites

• improvement of industrial hygiene practices and procedures

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Why Enzymes ?


Filmpje Novozymes

Animation of Lipase enzyme in action.mp4

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Why Enzymes ?



Health Hazards Associated to Enzymes

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Health Hazards Associated to Enzymes

Irritation

• Occurs upon direct contact with protease containing products

• Is local

• Appears as redness and itching of eyes and/or skin

• Will disappear

Allergy • Occurs upon inhalation

• Can lead to occupational Asthma when no action is taken

Enzymes are not ”toxic”

Enzymes are biodegradable


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Allergens

Commonly known allergies e.g. towards birch pollen

or cats are caused by proteins.

i.e. proteins in the birch pollen or in the fur of the cat

Enzymes are proteins

When handled incorrectly, enzymes may cause

allergy just like the proteins, which are behind other

commonly known allergies.

Enzymes are only able to cause allergy by inhalation (Type I).

Enzymes can not cause allergy by skin contact (Type IV).

Enzymes have not been associated with food allergy.

Enzymes are neither worse nor better than common allergens.


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Allergy symptoms

Running eyes

Running nose

Asthma

Hay fever

Sneezing

Coughing

Tightness

of chest

Breathing difficulties

Hoarseness



What we do to control Enzymes



Exposure control to enzymes is like other industrial hygiene programs:

1. Prevent exposure as much as possible

2. Respect the exposure limits

• Workplace atmosphere monitoring

• Personal exposure monitoring

Strategies include:

• Guarding.

• Local exhaust ventilation.

• Housekeeping.

• Emergency spillage procedures.

• RPE & PPE.

• Signage & Instructions

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Control the hazard.

Keep the hazard at bay with enclosures &

guarding.

- Enzyme automated dosing room

- Enclosed filling lines

Remove the hazard with

Local Exhaust Ventilation

(LEV)


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Process design

Handling processes of enzyme products must be designed in a way,

that does not create dust or aerosols.

Closed Automatic dosing

room with exhaust

ventilation


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Control measures: LEV (Local Exhaust Ventilation)

The principles of LEV is that an extraction of air is applied to a source of contamination

which takes it away to be exhausted to a safe area.

The contaminated air is filtered before releasing it to atmosphere, usually outside

the building.

LEV can be applied in several scenarios from machine extraction on production lines to

personal extraction at point of task.


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Control measures: LEV (Local Exhaust Ventilation)

Other types of LEV can be portable and mobile. These are specific for task extraction.

They operate with an internal high efficiency HEPA filter for recycling air.


LEV FILM 1

24 capture and working zones Best.mpg

24 capture and working zones Best.mpg



PPE & RPE

And

Signage

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Control measures: next step = RPE & PPE


http://www.google.co.uk/url?sa=i&rct=j&q=&esrc=s&frm=1&source=images&cd=&cad=rja&uact=8&docid=TbQo7H-JhmiduM&tbnid=OTwgY-n8l3Nm0M:&ved=0CAcQjRw&url=http://www.aliexpress.com/item/cotton-book-white-yarn-hunting-double-gloves-Shipbuilding-Metallurgy-Forestry-Port-Architecture-Carry-Farm-work-gloves/658463206.html&ei=7aUyVN-UEKaf7gbJiYC4CQ&bvm=bv.76802529,d.ZGU&psig=AFQjCNGIBrTj8JNF1mRBxsOnzwa8DaIWag&ust=1412691764580222

http://www.google.co.uk/url?sa=i&rct=j&q=&esrc=s&frm=1&source=images&cd=&cad=rja&uact=8&docid=H0pLkbpSg3Ns-M&tbnid=4GOgaFKt7zb8kM:&ved=0CAcQjRw&url=http://www.esidirect.com.au/3m-half-face-respirator-6200dd-p/6120062724.htm&ei=gaYyVOz-FouV7AbIo4GYDg&bvm=bv.76802529,d.ZGU&psig=AFQjCNHyhbVJQ9CmU5YXT3N3xzGnW8OK_Q&ust=1412691908226287

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Control measures: RPE P3 masks


Half face masks are for

short term use and need to

be face fit tested (with

Bitrix) to 100% fit

Power assisted hoods are

more comfortable and

used for extended use

Paper P3 masks are for

infrequent / short term

use (e.g. visitors)

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Control measures: Signage


Signage is used to remind persons to

wear their PPE and RPE when needed



safe ways of working

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Control measures: training and awareness

Last resort but last but certainly not least:

Training and awareness are essential to prevent exposure!

It is all down to creating the correct mind-set to

employees that the given controls are respected.


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• Avoid creation of liquid enzyme aerosols

• Avoid vigorously splashing or stirring of enzyme containing liquids

Safe handling processes – Liquid products


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Clean up spills immediately !

Do not let liquid

spills dry out !

Any enzyme spill

must be removed

immediately!


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Control measures: Housekeeping – correct methods..

When cleaning liquid spillages the following procedures should be followed:

• Contain it to prevent it spreading spill kit

• Vacuum it up if you have that type of equipment

• Bag it for waste disposal

• Mob the floor using water and Bleach (neutralizer)


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Good work practices

• Avoid direct contact with enzymes and avoid enzyme

contamination of clothes (powders)

• Change and wash work clothes frequently

• Wash hands often


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Control measures: training and awareness

Training and awareness are essential to prevent exposure!

It is all down to creating the correct mind-set to employees that the given

controls are respected.

‘It’s about telling you what we do to control it.

It’s about informing you what you can do to prevent it.’

“take care of your mask, it will take care of you”

Next slides will give some examples of human behaviour that can

jeopardize the provided controls.


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Steps to exposure

Not storing RPE correctly.


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Routes to exposure

Not wearing RPE correctly.

Not fitting straps correctly.

Wearing a Half face

mask

With stubble.

In these cases the mask is not sealed to the face!


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Routes to exposure

Not Reporting Faults and Issues.


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Public Enemy No 1

Broken or left open doors increase air movement and

migrates the Hazard across site.



What we do to check our control measures

Enzymes exposure monitoring

2nd part: Exposure limits and controls


Not all Enzymes exposure limits in regulations, in Codex only 1 enzyme:

Threshold Codex / EU : 60 ng/m3

Threshold UK : 40 ng/m3

Best practise = 10% : 4 ng/m3

Same exposure limits also in AISE ( industry association) guidance.

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Monitoring of enzyme exposure

• Monitoring informs about the workplace exposure to airborne enzyme dust

or aerosols.

• Two main ways of monitoring:

• Air monitoring for workplace exposure

• Personal monitoring medical surveillance


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Monitoring of enzyme exposure

• Air Monitoring informs about the

workplace exposure to airborne

enzyme dust or aerosols.

Galley sampler dust

monitoring is undertaken

using a high volume air

pump which pulls

air into the unit and captures

any particles that may be

airborne onto a filter paper.

Personal Dust monitoring is undertaken using a low

volume air pump which pulls air into

the unit and captures any particles that may be airborne

onto a filter paper


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Analysis of enzyme protein

ELISA

(immuno-assay)

Kone Lab

(activity assay)

• The filter from the air sampler is eluted in a buffer.

• The concentration of enzyme protein is analyzed by use of a sensitive assay.


Personal follow –up : Medical surveillance

Purpose of medical surveillance:

Establish pre-employment allergy status of each employee.

Follow up on the allergy status or upon indication of sensitization by: Skin testing,

RAST/CAP analysis or development of symptoms.

36 Enzymes at McBride - Prebes 19 March 2019

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Outcome/actions of skin-prick tests

Negative result (no reaction).

Continue to work using safe working procedures.

Continue medical surveillance.


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Sensitised but symptom free (positive reaction).

Continue to work using safe working practices.

RAST Sampling is undertaken and sent to the Royal Brompton

Hospital for Antibody analysis.

Vulnerable Person Risk Assessments undertaken.

(Lung function test possible)

Outcome/actions of skin prick tests RAST Testing



Management of sensitized employees

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Management of sensitised employees

SENSITISATION IS NOT A DISEASE

SENSITISATION DOES NOT PREVENT EMPLOYEES FROM WORKING

IN A CONTROLLED ENVIRONMENT

Sensitised employees are at a greater risk of developing allergy

symptoms.

Sensitised employees are monitored closely on high risk monitoring

programme.

Where appropriate, a sensitised employee may be moved to an area

of “lower risk” exposure.

Possible action : Upgrade PPE (air vented hood rather than mask).


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Questions ?

and…

Lets go and have a look!

Please think about:

Safety shoes, lab coat & Hi-vi vests, safety glasses, no watches or

jewelry

Enzymes at McBride Prebes...Enzymes at McBride - Prebes 19 March 2019 Half face masks are for short...

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