Engineering Innovations for Future Healthcare - who.int · Engineering Innovations for Future...

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Engineering Innovations for Future Healthcare James Goh, PhD Head and Professor, Department of Biomedical Engineering, NUS President, International Federation of Medical and Biological Engineering NO DISCLOSURE TO MAKE

Transcript of Engineering Innovations for Future Healthcare - who.int · Engineering Innovations for Future...

Page 1: Engineering Innovations for Future Healthcare - who.int · Engineering Innovations for Future Healthcare James Goh, PhD Head and Professor, Department of Biomedical Engineering, NUS

Engineering Innovations for Future Healthcare

James Goh, PhD Head and Professor, Department of Biomedical Engineering, NUS

President, International Federation of Medical and Biological Engineering

NO DISCLOSURE TO MAKE

Page 2: Engineering Innovations for Future Healthcare - who.int · Engineering Innovations for Future Healthcare James Goh, PhD Head and Professor, Department of Biomedical Engineering, NUS

Gaps identification

+3.9% CAGR (2011-2018)

Page 3: Engineering Innovations for Future Healthcare - who.int · Engineering Innovations for Future Healthcare James Goh, PhD Head and Professor, Department of Biomedical Engineering, NUS

How would Future Medicine looks like?

Wearables

Genomics

Proteomics

Internet of things

Drones

Robotics

3D printing

Nanotechnology

Telehealth

Data Analytics

Machine Learning

Artificial Intelligence

Future Medicine

Patient-centered, physician-directed teams

Value-driven: high quality at lowest cost

Connected and integrated – culturally and

digitally

Delivers measurable quality health care

Data management – health tracking, records,

data mining

Innovation: • Needs oriented

• Un-predictability

• Complexity – cross

disciplinary

• Time limited

• Disruptive

• Fanatical commitment

Drivers:

• Ageing population

• Rise in chronic diseases

• Shortage of health workers

• Shift from Independence to Interdependence

Page 4: Engineering Innovations for Future Healthcare - who.int · Engineering Innovations for Future Healthcare James Goh, PhD Head and Professor, Department of Biomedical Engineering, NUS

Big Data will get even Bigger

• Healthcare data (records, profile, images, fitness data…)

will grow exponentially with increased digitization

• Need for game-changing products and services portfolios

for big data management

• Increasingly customized and in real-time

Page 5: Engineering Innovations for Future Healthcare - who.int · Engineering Innovations for Future Healthcare James Goh, PhD Head and Professor, Department of Biomedical Engineering, NUS

Health Centric Devices and Digital Health • Rise of connected health with increased

fitness awareness

• Web portals will enable healthcare

agencies to remotely manage thousands

of wireless health devices

Page 6: Engineering Innovations for Future Healthcare - who.int · Engineering Innovations for Future Healthcare James Goh, PhD Head and Professor, Department of Biomedical Engineering, NUS

Microfluidic Technologies for Personalized Oncology

Exosomes Micro-

vesicles

Cancer

Cells CTCs

Detection &

Isolation

Single Cell

Analysis

Isolation &

Extraction

Patient blood Blood Salvage System

(CTC Dialysis)

CTC

Culture

Isolation

from urine

Page 7: Engineering Innovations for Future Healthcare - who.int · Engineering Innovations for Future Healthcare James Goh, PhD Head and Professor, Department of Biomedical Engineering, NUS

CTChip Technology Genetic & molecular Analysis

Medical Report

Name : XXXXXXX

XXXXX XXXX XXXX

XXXXX

XXXXX

XXX

XXX

XXXXX

CTC Analysis:

Cell Count XXX

Druggable Mutation – XXXX

XXXXXX

XXXXX

CTCs, plasma,

ctDNAs, buffy coat

Personalized treatment

CTCs for Targeted Therapy & Personalized Medicine

Prof Chwee-Teck LIM

Page 8: Engineering Innovations for Future Healthcare - who.int · Engineering Innovations for Future Healthcare James Goh, PhD Head and Professor, Department of Biomedical Engineering, NUS

Development of Integrated Photo Therapy Device (IPTD)

1

Yeo ELL, Cheah JUJ, Lim BY, Thong PSP, Soo KC,

Kah JCY*. Protein Corona around Gold Nanorods as a

Drug Carrier for Multimodal Cancer Therapy, ACS

Biomaterials Science & Engineering, submitted.

0 10 20 30 40 50

0

20

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120

0 1 2 3 4

0 10 20 30 40

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0

20

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1200 10 20 30 40

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Ce

ll via

bili

ty (

%)

[NR] (pM)

[Ce6] (nM)

[Dox] (nM)

B

Ce

ll via

bili

ty (

%)

[NR] (pM)

NR-HS-Ce6-Dox

NR-HS-Ce6

NR-HS-Dox

Ce6 + Dox

NR-HS alone

Ce6 alone

Dox alone

A

[Dox] (nM)

[Ce6] (nM)

Dr. James CY Kah

Page 9: Engineering Innovations for Future Healthcare - who.int · Engineering Innovations for Future Healthcare James Goh, PhD Head and Professor, Department of Biomedical Engineering, NUS

Development of Integrated Photo Therapy Device (IPTD)

Yeo ELL, Thong PSP, Soo KC, Kah JCY*. Exploiting the Protein Corona around Gold Nanorods for Simultaneous Dual Modal Therapy in vivo,

ACS Nano, submitted.

0 min 10 min 20 min1 min

Saline

NR-MS-Ce6(PDT+PTT)

NR-MS(PTT)

MS-Ce6(PDT)

Page 10: Engineering Innovations for Future Healthcare - who.int · Engineering Innovations for Future Healthcare James Goh, PhD Head and Professor, Department of Biomedical Engineering, NUS

Rapid fiber-optic Raman endoscopy for real-time in vivo

cancer diagnosis in gastrointestinal tracts

Bergholt et al, Gastroenterology, 146(1), 27-32 (2014).

www.endofotonics.com

OD=1.8 mm

Page 11: Engineering Innovations for Future Healthcare - who.int · Engineering Innovations for Future Healthcare James Goh, PhD Head and Professor, Department of Biomedical Engineering, NUS

In vivo Raman endoscopy in determining lesion margins for endoscopic submucosal dissection

Page 12: Engineering Innovations for Future Healthcare - who.int · Engineering Innovations for Future Healthcare James Goh, PhD Head and Professor, Department of Biomedical Engineering, NUS

Summary

• Growth of MedTech R&D funding

• Drivers of MedTech growth

• Convergence of Technologies

– Advances in Omics

– Exciting Engineering Innovations

– Data Analytics and Machine Learning

• Immense opportunities and possibilities

Page 13: Engineering Innovations for Future Healthcare - who.int · Engineering Innovations for Future Healthcare James Goh, PhD Head and Professor, Department of Biomedical Engineering, NUS

Up Coming IFMBE-Sponsored Conferences

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ASIA-PACIFIC CONFERENCE ON MEDICAL AND

BIOLOGICAL ENGINEERING 2017

November 2017, Sydney, Australia

Page 14: Engineering Innovations for Future Healthcare - who.int · Engineering Innovations for Future Healthcare James Goh, PhD Head and Professor, Department of Biomedical Engineering, NUS