Energy barriersfor cellular rearrangements in tissues
Transcript of Energy barriersfor cellular rearrangements in tissues
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Mjmrhy fgrrkmrs
iar lmccucgr rmgrrgjhmomjts kj tkssums
Laccaqukuo
@ujm ;tb# 6>794=
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Xby study lmcc okhrgtkaj1
yautufm*lao!wgtlb1v?v;xqQHkVRmM
Xaujd bmgckjh gssgy Tuoar okhrgtkaj
Jgtkajgc Lgjlmr Kjstktutm
Durkjh dmvmcapomjt ai mofryaDkffmrmj(gcGdbmskajBypatbmsks0
\tmkjfmrh#\lkmjlm7;96
http://www.youtube.com/watch?v=v9xq_GiRXeEhttp://www.youtube.com/watch?v=v9xq_GiRXeE -
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Dkiimrmjt tkssum typms bgvmdkiimrmjt omlbgjklgc prapmrtkms
\capm ? [aujhs oaducus
Tkomslgcm ~ smlajds
Dkslbmr# @gjomy# ) Xgjh# \lkmjlm 72 "6>>=+
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Omlbgjklgc prapmrtkms lbgjhm wktb tkomslgcm
Pmfrgsb mofryajkl tkssum0
\lbamtz Cgf# ]L\D
tkomslgcm ~ smlajds tkomslgcm ~ baurs
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Cajhmr tkom slgcms0 stukd/ckem
\lbamtz Cgf# ]L\D
Pmfrgsb mltadmro tkssums
tkom slgcm ~2 baurs
>*= 7 7*= 6
7
7*=
6
6*=
"tkom+ "okjs+
cah7>
"dkstgjlm6+"oklrajs
6+
mlta
omsmjda
Dkiiuskvm fmbgvkar gt cajhmr tkoms# tbks ks lrulkgc iar strulturm iarogtkaj gjd
dmvmcapomjt'
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Laccmltkvm fmbgvkargt sbart gjd kjtmromdkgtm tkom slgcms
Ialus aj lajstumjt tkssums
\bart tkomslgcm0 sackd/ckem
Kjtmromdkgtm tkomslgcm0 lghkjhdyjgokls*
\kokcgrktkms ta hcgssy dyjgokls gjd`goomd ogtmrkgcs Gjaogcaus dkiiuskaj ai lmccs \pgtkgc/tmopargc bmtmrahmjmkty
Arkhkj ai hcgssy fmbgvkar
Lajjmomjt Cgle ai hmaomtrkl ardmr Jaksm dum ta gltkvm pralmssms
kjstmgd ai tbmrogc jaksm
Ogdkj/Dgrfy lgjkjm ekdjmy "ODLE+lmccs iarokjh g 6/d lajstumjt cgymr*
Gjhmckjk mt gc ^JG\ 6>7>
Ymcalkty pracm ai lmccs sbaw tbm
spgtkgccy bmtmrahmjmaus pgttmrj kj
ODLE tkssum*
Dkspcglmomjt pracm kj skoucgtkaj ai
g 6/d hcgss iaromr*Fmrtbkmr ^VC 6>77
G laccakdgc hcgss*
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Mjmrhy
Lajikhurgtkaj\pglm
Lajikh
urgtkaj\pg
lm
Mjmrhy cgjdslgpm kj systmo wktb scaw dyjgokls
Lgj wm gppcy tbks kdmg ta lmccucgr rmgrrgjhmomjts kj tkssums1
Gtbmrogc Vmgrrgjhmomjts ar bappkjh avmr mjmrhy fgrrkmrs tbrauhb calgc gltkvm
pralmssms# k*m* ogekjh jmw gdbmskajs gjd lmcc sbgpm lbgjhms*
Vbmacahklgc prapmrtkms dmtmrokjmd fy0 Trgjsktkajs rgtm fmtwmmj calgc okjkog0
Dkstrkfutkaj ai wgktkjh tkoms
P"M+
^"M+$ i"+
0 mxpM!eFT
M7M6
mM7 eFT
mM6 eFT Mjmrhy
stgtm 7 stgtm 6
Hcgssy Fmbgvkar ? Laopcmx patmjtkgc mjmrhy cgjdslgpm
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\lbamtz Cgf# ]L\D
Baw da lmccs oavm wktbkj g tkhbtcy pglemd tkssum1
\trulturm Jmgrcy lajstumjt
Dksardmrmd
Dyjgokls
Lmcc sbgpm lbgjhm tbrauhb gltkvmpralmssms
Lmccs oavm pgst ajm gjatbmr fy
dmvmcapkjh pratruskajs gjd mxmrtkjhtmjskaj aj jmw lajtglts
@khhckjh smmj bmrm ks jaj/hgusskgj Lmcc dkvkskajs da bgppmj# fut rgrm*
Lgj bgvm kjtmrmstkjh fmbgvkar wktb`ust calgc rmgrrgjhmomjts
Pmfrgsb mofryajkl tkssum
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Mxkstkjh oadmcs iar oadmckjh lmccs kj tkssums
Gltkvm ogttmr oadmcs
Oadmc kjdkvkdugc lmccs gs pgrtklcms
Gltkvm iarlkjh aj mvmry pgrtklcm\bart rgjhm kjtmrgltkaj fmtwmmj pgrtklcms
Mxpcgkj ! prmdklt dyjgokl prapmrtkms# sulb gs vkslaskty Mxpcgkj ! prmdklt saom laccmltkvm prapmrtkms# sulb gs swgrokjh# hkgjt
juofmr stultugtkajs# mtl*
Dams jat tgemj kjta gllaujt lmcc sbgpms gjd sbgpm lbgjhms
\bgpm mqukckfrkuo oadmcs
Kjlcudms oarm oklraslapkl dmtgkcs gfaut skjhcm lmcc omlbgjkls Xrktm dawj g omlbgjklgc mjmrhy iujltkajgc iar tbm sbgpms
Mxpcgkj ! prmdklt sbgpm ai lmcc fy okjkokzkjh mjmrhy iujltkajgcMxpcgkj ! prmdklt laccmltkvm stgtkstkls ai lmcc tapacahkms
Dyjgokls lgj fm bgrd ta kopcmomjt
Gcsa0 lmccucgr ^atts oadmc# lajtkjuuo# ogjy oarm ******
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Mxkstkjh oadmcs iar oadmckjh lmccs kj tkssums
Gltkvm ogttmr oadmcs
Oadmc kjdkvkdugc lmccs gs pgrtklcms
Gltkvm iarlkjh aj mvmry pgrtklcm\bart rgjhm kjtmrgltkaj fmtwmmj pgrtklcms
Mxpcgkj ! prmdklt dyjgokl prapmrtkms# sulb gs vkslaskty Mxpcgkj ! prmdklt saom laccmltkvm prapmrtkms# sulb gs swgrokjh# hkgjt
juofmr stultugtkajs# mtl*
Dams jat tgemj kjta gllaujt lmcc sbgpms gjd sbgpm lbgjhms
\bgpm mqukckfrkuo oadmcs
Kjlcudms oarm oklraslapkl dmtgkcs gfaut skjhcm lmcc omlbgjkls Xrktm dawj g omlbgjklgc mjmrhy iujltkajgc iar tbm sbgpms
Mxpcgkj ! prmdklt sbgpm ai lmcc fy okjkokzkjh mjmrhy iujltkajgcMxpcgkj ! prmdklt laccmltkvm stgtkstkls ai lmcc tapacahkms
Dyjgokls lgj fm bgrd ta kopcmomjt
Gcsa0 lmccucgr ^atts oadmc# lajtkjuuo# ogjy oarm ******
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Mxkstkjh oadmcs iar oadmckjh lmccs kj tkssums
Yklsme mt gc ^VC 89 9 "7;;=+#
Lbgtm mt gc M^@F 94# 4=74=9 "6>>2+#Bmjems mt gc ^VM 24# "6>77+#
Fgsgj mt gc# BI\^ < "4+ 69= "6>>;+#
Vgjit mt gc ^JG\ 7>8 "4;+ 6>29< "6>7>+*****
Gltkvm ogttmr oadmcs Oadmc kjdkvkdugc lmccs gs pgrtklcms
Gltkvm iarlkjh aj mvmry pgrtklcm
\bart rgjhm kjtmrgltkaj fmtwmmj pgrtklcms Mxpcgkj ! prmdklt dyjgokl prapmrtkms# sulb gs vkslaskty Mxpcgkj ! prmdklt saom laccmltkvm prapmrtkms# sulb gs swgrokjh# hkgjt juofmr stultugtkajs#
mtl*
Dams jat tgemj kjta gllaujt lmcc sbgpms gjd sbgpm lbgjhms
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Mxkstkjh oadmcs iar oadmckjh lmccs kj tkssums
Gltkvm ogttmr oadmcs
Oadmc kjdkvkdugc lmccs gs pgrtklcms
Gltkvm iarlkjh aj mvmry pgrtklcm\bart rgjhm kjtmrgltkaj fmtwmmj pgrtklcms
Mxpcgkj ! prmdklt dyjgokl prapmrtkms# sulb gs vkslaskty Mxpcgkj ! prmdklt saom laccmltkvm prapmrtkms# sulb gs swgrokjh# hkgjt
juofmr stultugtkajs# mtl*
Dams jat tgemj kjta gllaujt lmcc sbgpms gjd sbgpm lbgjhms
\bgpm mqukckfrkuo oadmcs
Kjlcudms oarm oklraslapkl dmtgkcs gfaut skjhcm lmcc omlbgjkls Xrktm dawj g omlbgjklgc mjmrhy iujltkajgc iar tbm sbgpms
Mxpcgkj ! prmdklt sbgpm ai lmcc fy okjkokzkjh mjmrhy iujltkajgcMxpcgkj ! prmdklt laccmltkvm stgtkstkls ai lmcc tapacahkms
Dyjgokls lgj fm bgrd ta kopcmomjt
Gcsa0 lmccucgr ^atts oadmc# lajtkjuuo# ogjy oarm ******
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Mxkstkjh oadmcs iar oadmckjh lmccs kj tkssums
Gltkvm ogttmr oadmcs
Oadmc kjdkvkdugc lmccs gs pgrtklcms
Gltkvm iarlkjh aj mvmry pgrtklcm\bart rgjhm kjtmrgltkaj fmtwmmj pgrtklcms
Mxpcgkj ! prmdklt dyjgokl prapmrtkms# sulb gs vkslaskty Mxpcgkj ! prmdklt saom laccmltkvm prapmrtkms# sulb gs swgrokjh# hkgjt
juofmr stultugtkajs# mtl*
Dams jat tgemj kjta gllaujt lmcc sbgpms gjd sbgpm lbgjhms
\bgpm mqukckfrkuo oadmcs
Kjlcudms oarm oklraslapkl dmtgkcs gfaut skjhcm lmcc omlbgjkls Xrktm dawj g omlbgjklgc mjmrhy iujltkajgc iar tbm sbgpms
Mxpcgkj ! prmdklt sbgpm ai lmcc fy okjkokzkjh mjmrhy iujltkajgcMxpcgkj ! prmdklt laccmltkvm stgtkstkls ai lmcc tapacahkms
Dyjgokls lgj fm bgrd ta kopcmomjt
Gcsa0 lmccucgr ^atts oadmc# lajtkjuuo# ogjy oarm ******
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\bgpm mqukckfrkuo oadmcs
Kjlcudms oarm oklraslapkl dmtgkcs gfaut skjhcm lmcc omlbgjkls Xrktm dawj g omlbgjklgc mjmrhy iujltkajgc iar tbm sbgpms
Mxpcgkj ! prmdklt sbgpm ai lmcc fy okjkokzkjh mjmrhy iujltkajgcMxpcgkj ! prmdklt laccmltkvm stgtkstkls ai lmcc tapacahkms
Dyjgokls lgj fm bgrd ta kopcmomjt
Bmlmvgr gjd Pkbmrc
Irukt sty mym dmvmcapomjt
Bkchmjimcdt mt gc# ^JG\ 7>= < ;>8;77#
Igrbgdkigr mt gc Lurr* Fka 78 6>;=# 6>>8
Balmvgr ) Pkbmrc ^bys Vmv M* "6>>;+ rmimrmjlms tbmrmkj
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Mxkstkjh oadmcs iar oadmckjh lmccs kj tkssums
Gltkvm ogttmr oadmcs
Oadmc kjdkvkdugc lmccs gs pgrtklcms
Gltkvm iarlkjh aj mvmry pgrtklcm\bart rgjhm kjtmrgltkaj fmtwmmj pgrtklcms
Mxpcgkj ! prmdklt dyjgokl prapmrtkms# sulb gs vkslaskty Mxpcgkj ! prmdklt saom laccmltkvm prapmrtkms# sulb gs swgrokjh# hkgjt
juofmr stultugtkajs# mtl*
Dams jat tgemj kjta gllaujt lmcc sbgpms gjd sbgpm lbgjhms
\bgpm mqukckfrkuo oadmcs
Kjlcudms oarm oklraslapkl dmtgkcs gfaut skjhcm lmcc omlbgjkls Xrktm dawj g omlbgjklgc mjmrhy iujltkajgc iar tbm sbgpms
Mxpcgkj ! prmdklt sbgpm ai lmcc fy okjkokzkjh mjmrhy iujltkajgcMxpcgkj ! prmdklt laccmltkvm stgtkstkls ai lmcc tapacahkms
Dyjgokls lgj fm bgrd ta kopcmomjt
Gcsa0 lmccucgr ^atts oadmc# lajtkjuuo# ogjy oarm ******
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Tbm 6/d Lmccucgr \bgpm Mqukckfrkuo Oadmc
Mlmcc ? eG"GG>+6 % e^"^ ^>+
6
? eG"GG>+6 % e^"^
6 6^>^% ^
6
>+
Fuce mcgstklkty tmro0Dum ta lmcc/lmcc gdbmskaj gjd tbm kjlaoprmsskfkckty
ai tbm lmcc* G> ks tbm prmimrrmd grmg# tbgt lgj dmpmjdaj tatgc vacuom gjd bmkhbt ai tbm lmcc* "Buijghmc mt
gc# ^JG\ 6>>8+
Lajtrgltkckty0Dum ta gltkj/oyaskj rkjh graujd tbm pmrkomtmr ai tbm
lmcc*"Igrbgdkigr mt gc# Lurrmjt Fkacahy 6>>8+
Ckjm tmjskaj0
Gltkvm hmc oadmc"@cklbmr mt gc ^bys* Vmp*6>>8+
Dawj/rmhucgtmd fy lmcc/lmcc gdbmskaj* Mjbgjlmd fy lartklgc gltkj lytasemcmtaj*
"smm m*h* Ogjjkjh mt gc# ^JG\ 6>7>+
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Oadmckjh tkssums uskjh \uriglm Mvacvmr
]skjh rmjmd pacyhaj tkckjh ta rmprmsmjt 6/d lajstumjt
oajacgymr Lajhurgtkajs aftgkjmd fy okjkokzkjh
Tbm pgrgomtmrs G># ^> #eG# e^ larrmspajd ta dkiimrmjt lmccucgr
prapmrtkms* Aftgkj irao mxpmrkomjts*
Mtat ?R
lmcc
Mlmcc
Juomrklgc Oadmckjh
>*6 > >*6 >*4 >*9 >*2 7 7*6>*6
>
>*6
>*4
>*9
>*2
7
7*6
7 > 7 6 < 4 = 9 8 27
>
7
6
*= > >*= 7>
>*6
>*4
>*9
>*2
\brkje mdhm fmiarm T/7 Gt T/7 Hraw mdhm gitmr T/7
Twa typklgc lgsms0
>*4 >*6 > >*6 >*4>*>6
>
>*>6
>*>4
>*>9
>*>2
>*7
>*76
Mt
atgc
trgjsktkaj pgtb# C trgjsktkaj pgtb# C
M
T/7 oavm ks igvargfcmT/7 oavm ks ujigvargfcm
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Tapacahy ks kopartgjt '
4 = 9 8 2
4
=
9
8
2
\7
\6
>*6
>*4
>*9
>*2
7
Tapacahy ks mgskmr ta gllmssmxpmrkomjtgccy'
Calgc tapacahy ai ajm lmcc^rafgfkckty ai aftgkjkjh g
igvargfcm T/7 trgjsktkaj
Mjmrhy Fgrrkmr stgtkstkls
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> 6 4 9 2 7>
>*6
>*4
>*9
>*2
7
> 6 4 9 2 7>
7>4
7>6
7>>
>*4 >*6 > >*6 >*4>*>6
>
>*>6
>*>4
>*>9
>*>2
>*7
>*76
Mtatgc
trgjsktkaj pgtb# C
M
4 = 9 8 2
4
=
9
8
2
\7
\6
7
>
7
6
7
6