ENDOCRINOLOGY

CHEMICAL MESSANGER SYSTEM

NeurotransmitterEndocrine hormoneNeuroendocrine hormoneParacrine hormoneAutocrine hormone Intracrine hormoneNB –CYTOKINES, PARAHORMONE

ANATOMICAL LOCI OF PRINCIPAL ENDOCRINE GLAND

NEUROENDOCRINE AXIS

CLASSIFICATION OF HORMONE

HORMONE

PROTEIN & PEPTIDE

STEROIDAMINOACID DERIVATIVE

PROTEIN & PEPTIDE

SECRETION , TRANSPORT , CLEARANCE FROM BLOOD

Metabolic clearance rate = Rate of disappearance of hormone from plasma / Concentration of hormone

REGULATION OF HORMONE SECRETION

NERVOUS

DIRECT INNERVATION via ANS

NEUROSECRETORY NEURON CONTROLL OF NEUROHYPOPHYSIS

NEUROSECRETORY NEURON CONTROLL OF ADENOHYPOPHYSIS

DIRECT

Nervous Regulation

Feedback Control

-ve feedback control+ve feedback

control

MECHANISM OF HORMONE ACTION

RECEPTOR

RECEPTOR

INTERNAL

NUCLEAR

CYTOPLASMIC

EXTERNAL

CELL MEMBRANE

MEMBRANE RECEPTOR

Ion channel-linked receptorG –protein couple receptorEnzyme –linked receptor

G-protein couple receptor

Enzyme linked receptor

INTERNAL RECEPTOR

REGULATION OF RECEPTOR

UP REGULATION

DOWN REGULATION

SECOND MESSANGER MECHANISM OF HORMONACTION

cAMP- ACTH,Calcitonin,CatecholamineCRH, FSH,LH, Hcg ,PTH, Glucagon, somaatostatin,secretin , TSH, vasopresin, Ag II

IP3,DAG- AgII ,catecholamine, GnRH, GHRH, Oxytocin, TRH, vasopresin

cAMP as second messanger

IP3 ,DAG as second messanger

HORMONAL ASSAY

RIAELISASolvent extractionChromatographyMolecular shievingCytochemical assay