Endocrinal and metabolic disorders
-
Upload
tarek-mansour -
Category
Documents
-
view
1.177 -
download
0
Transcript of Endocrinal and metabolic disorders
![Page 1: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/1.jpg)
ENDOCRINAL, METABOLIC AND
NUTRITIONAL BONE DISORDERS
By
Dr. Tarek Mansour
Faculty of medicine
Al-Azhar university
![Page 2: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/2.jpg)
The amount of bone at any part of skeleton at ant time depend up on the balance between bone resorption and formation.
![Page 3: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/3.jpg)
The three hormonal regulators include
1. Parathormone (PTH), produced by the four parathyroid glands on the back side of the thyroid gland.
2. The active form of vitamin D produced in the proximal renal tubule 1,25(OH)2.
3. And calcitonin produced by the parafollicular cells in the thyroid gland.
![Page 4: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/4.jpg)
PTH The major function of PTH is to prevent the
dangerous reduction in the serum calcium level by:
1. Increasing the production of 1,25,(OH)2 vitamin D in the kidney which then increases the absorption of calcium from the gut and renal tubule.
2. PTH also activates osteoclastic mobilization of calcium from bone mineral.
3. PTH is to promote urinary excretion of phosphorous.
![Page 5: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/5.jpg)
The major function of 1,25,(OH)2 vitamin D is to activate the absorption of calcium from the gut and bone.
The least important calcium regulator is calcitonin which is designed to prevent an increase of serum calcium by inhibiting the osteoclastic mobilization of calcium at the bone level.
![Page 6: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/6.jpg)
![Page 7: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/7.jpg)
Hormonal regulation of calcium and phosphate The crude inactive form of vitamin D comes
from the gut and the skin that is exposed to sun light which is then transported to the liver for its first phase of activation by a hydroxylation process at the 25 position of the sterol ring.
This still inactive form then goes to the kidney for its finial activation by a hydroxylation process on the 25 position of the sterol ring.
This now activated vitamin D acts as a hormone similar to PTH to help absorb calcium from the gut and bone.
![Page 8: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/8.jpg)
Calcium and phosphate metabolism
![Page 9: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/9.jpg)
Mobilization of Ca from Bone When the serum calcium level drops below normal
the parathyroid gland puts out PTH which then activates resting bone cells to differentiate into an active lytic osteoclast.
On the bone surface the active brush border of the cell secrets collagenase enzyme which dissolves bone mineral thus liberating calcium and phosphorous ions which are then transported across the cell to its outer membrane
Where a 1,25,(OH)2 pumping mechanism transports the calcium and phosphorous into the blood stream.
![Page 10: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/10.jpg)
Metabolic, endocrinal and nutritional bone diseases affect the skeleton through too much or too little calcified bone.
Too little calcified bone is either due to
- Decrease bone formation.
- increase bone resorption.
![Page 11: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/11.jpg)
![Page 12: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/12.jpg)
Radiographic criteria of endocrinal, metabolic and nutritional diseases They are commonly diffuse or at least
multifocal, although isolated bone lesion may be found as in brown tumor.
They tend to involve specific location, and tend to be symmetrical in the body.
![Page 13: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/13.jpg)
Endocrinal diseases
![Page 14: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/14.jpg)
Endocrinal disorders
Acromegaly. Gigantism. Cushing syndrome. Hyperparathyroidism. Hypoparathyroidism. Pseudohypoparathyroidism. Pseudo-pseudohypoparathyroidism. Hyperthyroidism. Hypothyroidism.
![Page 15: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/15.jpg)
Acromegaly (hyperpituitrism). Result from excess production of growth
hormone by anterior pituitary gland. In adult Acromegaly. In children Gigantism
![Page 16: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/16.jpg)
Radiological findings
Skull Thickened
calvarium. Frontal bossing. Prognathism. Enlarged mastoid air
cells and sinuses. Enlargement of
pituitary fossa.
![Page 17: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/17.jpg)
Spine. Enlarged vertebral
bodies with posterior scalloping.
Increase disc height.
![Page 18: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/18.jpg)
Hands. Enlarged bone and
soft tissue shadow. Spade like terminal
tufts or arrowhead distal phalanges.
![Page 19: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/19.jpg)
Measurments Sesamoid index of the thumb.
< 40 mm. in male.
< 32 mm. in female. Tuftal width of the third finger.
< 10 mm. in female.
< 12 mm. in male. Joint space of the second
MCP joint.
= 2.5 mm. in both men and female.
Thickness of phalangeal soft tissue
< 26 mm. In male.
< 23 mm. in female.
![Page 20: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/20.jpg)
Joint spaces
Wide joint spaces due to enlarged articular cartilage
Feet
Increase thickness of fat pad Long bone
Elongated with prominent muscle attachment. Calcifications
Ear pinna
Chondrocalcificinosis Cardiomegaly + visceromegaly
![Page 21: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/21.jpg)
![Page 22: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/22.jpg)
Gigantism
Imaging findings.
Proportional yet exaggerated bone growth.
Bone increase in length and diameter. Enlarged sella turcica.
![Page 23: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/23.jpg)
![Page 24: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/24.jpg)
Cushing disease
It is hyperadrenocorticism due to Anterior lobe tu. Adrenal cortex tu. Complication of therapy.
Imaging findings. Osteoporosis (more at trabecular bone). Increase insufficiency fractures in
vertebra, scapula, ribs and pubic bones.
![Page 25: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/25.jpg)
![Page 26: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/26.jpg)
HYPERPARATHYROIDISM
![Page 27: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/27.jpg)
Hyperparathyroidism
It is defined by increase level of parathormone and parathormone peptides in the serum.
It can be divided in to three types. Primary.
Secondary. Tertiary.
![Page 28: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/28.jpg)
Primary hyperparathyroidism
May be the result of. Adenomas (single or multiple) 90% Diffuse hyperplasia. Carcinomas.
In all cases : serum Ca level is increased.
This disorder is due to a primary defect in the parathyroid glands >>> increased secretion of PTH >>> increase serum calcium and decrease serum phosphorus.
The increase in serum calcium concentration is due in part to activation of the osteoclastic system.
![Page 29: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/29.jpg)
Secondary hyperparathyroidism
Is induced by any condition or circumstance that cause serum calcium to fall.
It may be the result of: Vit. D deficiency. Chronic renal failure. Intestinal malabsorption of Ca (rare).
In diseased kidney>>> decrease active Vit. D >>> decrease int. ca absorption>>> hypocalcaemia>>> stimulate parathyroid gland>>> increase PTH
![Page 30: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/30.jpg)
Tertiary hyperparathyroidism
It is result of long standing secondary hyperparathyroidism due to chronic renal failure.
In tertiary hyperparathyroidism, the parathyroid glands function autonomously.
![Page 31: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/31.jpg)
Clinical presentation
In primary hyperparathyroidism may be: Asymptomatic hypercalcemia. In younger patients, the most common
presentations are:
1. Renal stone and Nephrocalcinosis (25-35%).
2. High blood pressure (40-60%).
3. Acute arthropathy (pseudogout).
Other symptoms as osteoporosis, peptic ulcer, acute muscle weakness & mild non specific symptoms.
![Page 32: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/32.jpg)
To understand radiological changes in PTH you have to know: An elevated level of parathormone :
In early phase>>>> increase bone mass
In later stages>>>> trabecular bone resorption may occur.
Because HPT today is usually detected early through increased level of serum calcium, we observe more patients with more bone formation and fewer patients with less bone.
![Page 33: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/33.jpg)
Radiological findings in primary hyperparathyroidism.1. Subperiosteal bone resorption.
2. Subchondral bone resorption.
3. Subligamentous bone resorption.
4. Intracortical bone resorption.
5. Osteopenia.
6. Brown tumor.
7. Erosive arthropathy.
8. Chondrocalcinosis.
9. Renal calculi, rarely Nephrocalcinosis.
10. Rarely osteosclerosis.
![Page 34: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/34.jpg)
Radiologic findings of
HYPERPARATHYROIDISM The M/C radiologic abnormality is generalized
osteopenia.
Bone resorption, bone sclerosis, brown tumors, chondrocalcinosis, soft tissue calcification, and vascular calcification.
Brown tumors appear as well-defined lytic lesions. After resection of parathyroid adenomas, the lesions may
become sclerotic and may mimic blastic metastasis.
Bone resorption, the most characteristic finding, is usually classified as
subchondral, trabecular, endosteal, intracortical, subperiosteal, subligamentous, and subtendinous.
![Page 35: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/35.jpg)
Subperiosteal resorption - M/C Usually occurs in the hands and feet. M/C affected site: radial aspects of the middle phalanges. Acro-osteolysis or phalangeal tufts resoption may also be
present.
Trabecular resorption Often seen in the diploic space of the skull, where it has
a characteristic salt and pepper appearance.
Subchondral resorption May be seen in the sacroiliac joints, sternoclavicular
joints, acromioclavicular joints, symphysis pubis, and discovertebral junction .
![Page 36: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/36.jpg)
AP radiograph of the hand in a 66-year-old woman with primary hyperparathyroidism owing to parathyroid adenoma shows subperiosteal bone resorption ( arrows) along the radial aspect of 2nd, 3rd, and 4th middle phalanges.
![Page 37: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/37.jpg)
AP radiograph of the knee in a child with hyperparathyroidism shows subperiosteal bone resorption ( arrow) along the proximal medial tibia.
![Page 38: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/38.jpg)
Subchondral bone resorptionSites : Outer and sometimes inner end of the
clavicle. Symphysis pubis. Sacroiliac joints. Vertebral end plates.
![Page 39: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/39.jpg)
Subligamentous resorption:Sites: Greater & lesser trochanter. Ischial tuberosity Inferior calcaneum Inferior surface of clavicle.
![Page 40: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/40.jpg)
![Page 41: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/41.jpg)
Intracortical bone resorption Linear translucencies within the cortex
(cortical tunnelling), esp. tubular bones of the hands, 2-5 mm. oval or cigar shaped.
Loss of corticomedullary junction. In the skull, granular or mottled
appearance (pepper-pot) or salt and pepper.
Not specific for hyperparathyroidism.
![Page 42: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/42.jpg)
![Page 43: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/43.jpg)
![Page 44: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/44.jpg)
Osteopenia
More common in postmenopausal women and the elderly.
Loss of corticomedullary junction may occur.
![Page 45: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/45.jpg)
Chondrocalcinosis Due to deposition of calcium pyrophosphate
dihdrate (CPPD) in the cartilage. It can be seen in:
1. Hand (triangular ligament).
2. Knees (artigular cartilage & menisci).
3. Symphesis pubis.
4. Less common, the shoulder and hip. Chondrocalcinosis of the symphysis pubis and
nephrocalcinosis on the abdominal x ray is diagnostic of hyperparathyroidism.
![Page 46: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/46.jpg)
![Page 47: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/47.jpg)
![Page 48: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/48.jpg)
![Page 49: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/49.jpg)
Brown tumor (ostitis fibrosa cystica) .
These are cystic lesions within bone due to excessive osteoclastic resorption (osteopenia).
Radiographically, brown tumors appear as low density multiloculated cysts that can occur in any skeletal site and may cause expansion of bones.
![Page 50: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/50.jpg)
Brown tumor
![Page 51: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/51.jpg)
PHPT Erosion of the terminal
tufts. Resorption of the
radial side of the middle phalanx of the index and middle finger.
Coarsened trabeculae. Thinned cortices. Brown tumor.
![Page 52: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/52.jpg)
Osteosclerosis. Occurs uncommonly
in PHPT but is a common feature of SHPY secondary to chronic renal failure.
![Page 53: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/53.jpg)
A, AP radiograph of the spine in a patient with secondary hyperparathyroidism shows generalized bone sclerosis, small kidneys, and left renal calculi. B, Lateral radiograph of the lumbar spine in another patient with secondary hyperparathyroidism shows horizontal, bandlike ("rugger jersey") sclerosis of the vertebral bodies ( arrows).
![Page 54: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/54.jpg)
Erosive arthropathy. Involving hands, wrists, and shoulders.
Differentiate from RHD arthritis
1. Subperiosteal resorption.
2. Affection of distal interphalangeal joints.
![Page 55: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/55.jpg)
Radiological findings of secondary hyperparathyroidism.
Similar to 1ry hyperparathyroidism. Less frequent brown tumor. Calcification of arteries and soft tissue. Osteosclerosis more common.
![Page 56: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/56.jpg)
Secondary Bony sclerosis;
focal or generalized.
Rugger-jersey appearance of spine.
Soft tissue and vascular calcification.
Primary• Chondrocalcinosis• usually seen in
the menisci of the knee, the triangular fibrocartilage of the wrist, and the pubic symphysis
![Page 57: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/57.jpg)
![Page 58: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/58.jpg)
AP radiograph of the hand in a 50-year-old man with renal osteodystrophy shows acro-osteolysis ( short arrows), subperiosteal bone resorption ( long arrows), and vascular calcifications .
Secondary HPT. Radiograph of the hand showing resorption of the first to third tufts with soft tissue calcification (1). There is articular calcification (2), and subperiosteal and subligamentous resorption (3).
![Page 59: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/59.jpg)
The differential diagnosis of
HYPERPARATHYROIDISM Focal subperiosteal resorption involving a single
bone Neoplasms or osteomyelitis.
Bone sclerosis in patients with secondary hyperparathyroidism.
Metastatic disease, radiation-induced bone disease, hypoparathyroidism, myelofibrosis, mastocytosis, sickle-cell disease, and Paget's disease.
Chondrocalcinosis Pyrophosphate arthropathy (CPPD) or hemochromatosis.
Brown tumors includes other focal lytic lesions, such as giant cell tumor
and fibrous dysplasia.
![Page 60: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/60.jpg)
Hypoparathyroidism
It result from: The M/C cause is
excision of or trauma to the parathyroid glands.may not be
recognized for years after surgery.
I 131 therapy.
Clinical presentation: Neuromuscular
dysfunction. Short stature. Delay or failure of
tooth eruption. Gastrointestinal
complaints.
![Page 61: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/61.jpg)
Radiologic findings of
HYPOPARATHYROIDISM
Radiologic findings are varied. Bony sclerosis. = M/C finding
Focal or generalized Subcutaneous calcification. Calvarial thickening Basal ganglia calcification Hypoplastic dentition Premature physeal fusion Spinal ossification. Occasionally : Osteoporosis, Enthesopathy,
Dense metaphyseal bands.
![Page 62: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/62.jpg)
![Page 63: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/63.jpg)
differential diagnosis of
HYPOPARATHYROIDISM
Widespread bony sclerosis.Blastic metastasis, myelofibrosis, renal
osteodystrophy, sickle-cell disease, and fluorosis. Dense metaphyseal.
Leukemia therapy, heavy-metal poisoning, or hypothyroidism.
Calcifications of the basal gangliaToxoplasmosis or cytomegalovirus infections,
after radiation therapy, and after carbon monoxide exposure.
Subcutaneous calcifications.Collagen-vascular diseases, hypervitaminosis D,
and renal osteodystrophy.
![Page 64: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/64.jpg)
Pseudohypoparathyroidism
It is an x linked genetic disorder. Normal or enlarged parathyroid gland. End organ resistance (kidney & bone).
![Page 65: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/65.jpg)
Imaging findings in pseudo-hypoparathyroidism. Thickening of the skull. Basal ganglia calcification. Abnormal dentition with hypoplasia &
cranial defects. Connective tissue calcification in skin,
ligaments, tendons & facial planes. Coxa vara, coxa vulga and bowing of long
bones. Exostosis prependicular to long bone axis.
![Page 66: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/66.jpg)
Hands Short metacarpals
esp. 1st , fourth and fifth.
Metacarpals & phalanges esp. 1st digit may be wide with cone shaped epiphysis.
Metatarsals may be affected.
+ve metacarpal sign.
![Page 67: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/67.jpg)
![Page 68: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/68.jpg)
![Page 69: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/69.jpg)
Hyperthyroidism
Imaging findings: Generalized
osteoporosis. Increased cortical
striations in long bones.
Thyroid acropachy: Periosteal thickening in extremities esp. hands.
Exophthalmus & pretibial myxodema.
![Page 70: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/70.jpg)
AP radiographs of the hand in a 46-year-old man with thyroid acropachy who presented with hand swelling and hypothyroidism 2 years after a thyroidectomy. Note the dense, solid periosteal reaction with feathery contour ( arrows) along the shafts of 2nd, 3rd, and 4th proximal and middle phalanges.
![Page 71: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/71.jpg)
Thyroid acropachy. (A,B) Radiographs of the hands showing diaphyseal periostitis (arrows) and generalized swelling. (C) Radiograph in a different patient showing marked soft tissue prominence.
![Page 72: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/72.jpg)
Differential for HYPERTHYROIDISM Thyroid acropachy
Periosteal reaction involving multiple bones Hypertrophic osteoarthropathy:
○ long bones.○ Feathery contour is absent.
Pachydermoperiostosis: ○ Long bones. ○ Periosteal reaction extends to the
metaphyses and epiphysis.
![Page 73: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/73.jpg)
Hypothyroidism Deficiency of thyroid hormones (T4 and T3)
produce a spectrum of musculoskeletal abnormalities termed (cretinism) in infant, (juvenile myxoedema), in children, and (myxoedema or hypothyroidism) in adults.
It results from: Primary disorder of the thyroid gland Decrease stimulating hormones secondary to
disorders of the pituitary or hypothalamus (tertiary).
Rarely end organ resistance.
![Page 74: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/74.jpg)
Imaging findings in hypothyroidism.Delayed skeletal maturation in children.
Skull: Wormian bones. Small bowel shaped cherry sella (older
children). Paranasal sinuses underdeveloped.
Spine: Bullet shape vertebrae esp. thoracolumbar. Kyphosis may occur.
![Page 75: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/75.jpg)
Long bones; Short. Epiphyses appear
late and frahmented. Pelvis; Narrow Coxa vara deformity Slipped femoral
capital epiphysis.
![Page 76: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/76.jpg)
![Page 77: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/77.jpg)
Osteoporosis & delayed closure of growth plate
After treatment
![Page 78: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/78.jpg)
METABOLIC DISEASES
![Page 79: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/79.jpg)
METABOLIC DISORDERS
Osteoporosis. Hypophosphatasia. Hyperphosphatamia.
![Page 80: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/80.jpg)
Osteoporosis
Definition : reduced bone mass of normal composition.•Most common metabolic bone disease.•One of the most prevalent conditions associated with aging.
![Page 81: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/81.jpg)
Clinical definition: requires the presence of a nontraumatic fracture.
Histologic definition: requires normally mineralized bone to be present in reduced quantity.
![Page 82: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/82.jpg)
Ostoporosis Classification
Primary osteoporosis. (idiopathic) : more common Type 1 (postmenopausal) Type 2 (age-related or senile)
Secondary osteoporosis. Metabolic (acromegaly, hypercorticism, hyperthyroidism,
hyperparathyroidism, hypogonadism, pregnancy, diabetes mellitus)
Congenital (osteogenesis imperfecta, Ehlers-Danlos syndrome, homocystinuria, mastocytosis, ochronosis, Gaucher's disease)
Nutritional (alcoholism, malnutrition, calcium deficiency, scurvy)
Drug-related (steroids, heparin).
![Page 83: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/83.jpg)
osteoporosis Most common metabolic bone disease. Is defined as qualitatively normal bone
present in deficient quantities. It has three major categories.
1. Generalized: affecting majority of the skeleton.
2. Regional: affecting one limb or section of body.
3. Localized: focal osteopenia in one or more discrete portions of bone.
![Page 84: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/84.jpg)
![Page 85: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/85.jpg)
Imaging findings in osteoporosis
Requires 30-50% bone loss to be detected by plain x ray.
Bones: osteopenia with thin cortex. Resorption of horizontal trabeculae. Accentuated residual trabeculae more at weight bearing
areas. Fracture neck femur is common. The bone surfaces are well defined, with sharp margins.
Spine: Biconcave (cod-fish vertebrae) and anterior wedging. Decreased density with more dense end plates (penciling
in). Fracture (wedge shaped or vertebra plana).
![Page 86: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/86.jpg)
![Page 87: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/87.jpg)
![Page 88: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/88.jpg)
![Page 89: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/89.jpg)
DXA
![Page 90: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/90.jpg)
![Page 91: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/91.jpg)
Differential considerations for diffuse osteopenia
1. Osteomalacia. indistinct trabeculae and poorly defined
interfaces between cortical and trabecular bone.
Presence of Looser's zones.
2. Hyperparathyroidism. bone resorption at characteristic sites.
3. Multiple myeloma. MR imaging may show areas of marrow
replacement.
![Page 92: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/92.jpg)
Regional or localized osteoporosis 1. Immobilization and disuse
2. Reflex sympathetic dystrophy syndrome (RSDS)
3. Transient regional osteoporosis Transient osteoporosis of the hip. Regional migratory osteoporosis.
4. Inflammatory arthritis.
5. Tumors
6. Infection.
![Page 93: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/93.jpg)
This patient had a long-standing immobilization due to a fracture of the right humerus. The appearances in the right hand are classical for reflex sympathetic dystrophy, or Sudeck’s atrophy, and include: 1. Pronounced demineralization of the bones, particularly in the periarticular region.2. No joint involvement.3. Associated soft tissue atrophy.This condition has been recently renamed the “complex regional pain
syndrome.”
![Page 94: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/94.jpg)
Hypophosphatasia It is an autosomal
recessive disease. Imaging findings: In sever cases
exaggerated fraying of metaphysis is seen.
Craniostenosis. Nephrocalcinosis. Deformities of distal
phalanges and tibia.
![Page 95: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/95.jpg)
![Page 96: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/96.jpg)
Hyperphosphatamia
Autosomal recessive disorder, presents in early infancy
Imaging findings: Similar to Paget`s disease but occur in
infancy & more symmetrical. Skull vault is thickened. Long bones are tubular, enlarged and
bowed with cortical irregularity.
![Page 97: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/97.jpg)
Bowed extremities with osteopenic bones and heart shaped pelvis similar to rickets
Deformed bell shaped rib
cage with osteopenia like
rickets
![Page 98: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/98.jpg)
![Page 99: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/99.jpg)
NUTRITIONAL DISORDERS
![Page 100: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/100.jpg)
NUTRITIONAL DISORDERS Hypervitaminosis A. Hypervitaminosis D. Osteomalacia. Rickets. Scurvy (Hypovitaminosis C).
![Page 101: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/101.jpg)
Hypervitaminosis A:
X ray findings Subperiosteal cortical thickening. Osteoporosis.
Hypervitaminosis D:
X ray findings Generalized osteopenia. In young patients, alternating areas of
sclerosis and lucencies in the metaphysis.
![Page 102: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/102.jpg)
Hypervitaminosis A
![Page 103: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/103.jpg)
Hypervitaminosis D
Dense sclerotic bands seen in metaphyses similar to cretinism and phosphorous poisoning
Dense calvarium as osteopetrosis
![Page 104: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/104.jpg)
RICKETS AND OSTEOMALACIA
![Page 105: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/105.jpg)
Rickets and osteomalacia Rickets and osteomalacia are similar
histologically. Abnormality in vitamin D metabolism. Incomplete mineralization of normal
osteoid tissue.
Rickets
Occurs in children
Affects immature bone
Osteomalacia
Occurs in adult
Affects mature bone
![Page 106: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/106.jpg)
Clinical findings of Rickets and Osteomalacia
Rickets: stunted skeletal growth. Apathetic, Irritable, Hypokinetic. Frontal bossing, softening of the skull,
dental caries, rachitic rosary, kyphosis, joint enlargement, or bowing of long bones.
Fractures and slipped capital femoral epiphyses.
Depend in part on the etiology and severity of the disorder, as well as the age of the patient at presentation
![Page 107: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/107.jpg)
![Page 108: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/108.jpg)
Clinical findings of Rickets and Osteomalacia
Osteomalacia: more subtle. Fatigue, malaise, or bone pain. Proximal muscle weakness and
abnormal gait may be present.
Depend in part on the etiology and severity of the disorder, as well as the age of the patient at presentation
![Page 109: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/109.jpg)
Osteomalacia
Presence of poor quality bone (delayed or defective mineralization of osteoid matrix) due to vit. D deficiency.
![Page 110: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/110.jpg)
Imaging finding in osteomalacia
Generalized osteopenia with coarse, hazy appearing trabeculae.
Poorly defined interfaces between cortical and trabecular bone.
Pseudo fracture (Looser`s zone): narrow zone of lucency, usually perpendicular to bone cortex, usually bilateral & symmetrical.
Common sites are: Femoral neck, scapula, pubic bone, ribs,
occiput and long bones.
![Page 111: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/111.jpg)
Looser's zone. Linear areas of undermineralized
osteoid that occur in a bilateral and symmetric distribution.
Characteristic sites; inner margins of femoral neck, proximal ulna, axillary margin of the scapula, pubic rami, and ribs.
DDx; Paget's disease or fibrous dysplasia.
![Page 112: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/112.jpg)
Looser zone
![Page 113: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/113.jpg)
Coarse trabeculae
![Page 114: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/114.jpg)
Imaging finding continue
Vertebrae: Penciling in of the vertebral bodies, loss of vertebral height (cod fish).
Bone softening producing:
1. Bowing of long bones
2. Shepherd`s crook deformity
3. Protrusio acetabulae.
4. Basilar invagination.
5. Compression wedge fracture (less common than osteoporosis).
![Page 115: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/115.jpg)
Shepherd`s crook deformity
![Page 116: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/116.jpg)
Protrusio acetabulae.
![Page 117: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/117.jpg)
Basilar invagination
![Page 118: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/118.jpg)
Rickets The skeletal effects are due to a lack of
calcification, So, the most obvious changes are at metaphysis, where the most rapid growth is occurring.
![Page 119: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/119.jpg)
Imaging findings in rickets Generalized osteopenia. Skull bossing. Epiphysis are enlarged, flaring, cupping &
irregularity of metaphysis. Earliest; Slight axial widening of the physis Next; Increased lucency of the zone of provisional
calcification. More advance; The physis widens and its contour
becomes irregular.
Thoracic kyphosis with pigeon chest. Enlarged costochondral junction (rosary beads). Bowing of the legs.
![Page 120: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/120.jpg)
The regions of highest yield on radiologic evaluation of rickets are those that are undergoing rapid growth.
Costochondral junctions of middle ribs (rachitic rosary)
Distal femur Both ends of the tibia Distal radius and ulna Proximal humerus.
Differential diagnosis of rickets includes Hypophosphatasia and the Schmid-type of metaphyseal chondrodysplasia .
![Page 121: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/121.jpg)
The complication of rickets. Skeletal deformities. In neonates; posterior flattening and squaring
of the skull, or craniotabes, may be seen. In early childhood; bowing deformities of arms
and legs are common. Older children: scoliosis, vertebral end plate
deformities, basilar invagination of the skull may be seen.
Advance disease: Slipped capital femoral epiphysis.
![Page 122: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/122.jpg)
A, AP radiograph of the knee in a 2-year-old girl with rickets shows generalized osteopenia and widening of the metaphyses of the proximal tibia and fibula. B, AP radiograph of the wrist in another child with rickets shows generalized osteopenia, as well as widening and irregularity of the metaphyses of the distal radius and ulna.
![Page 123: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/123.jpg)
Rickets in a young child with growth plate widening and irregularity in the wrist (A) and knees (B). Note the small epiphyses in the knees .
![Page 124: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/124.jpg)
Vitamin D-resistant rickets in a 1-year-old child. (A) AP radiograph of the knees showing irregularity and widening of the growth plates. The epiphyses are
small and irregular as well. (B) Three years after high-dose vitamin D therapy, the knees appear normal. There is residual femoral bowing .
![Page 125: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/125.jpg)
Rachitic rosery nodularity at costochondral junctures
![Page 126: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/126.jpg)
![Page 127: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/127.jpg)
![Page 128: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/128.jpg)
4 year old rachitic child with knock-knee deformity
Healing rickets in 2 yr male with epiphyseal rings second to treated rickets
![Page 129: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/129.jpg)
Scurvy Dietary deficiency of vit. C (rare before 6 month).
Imaging findings: Small epiphysis, sharply demarcated by sclerotic
rim (Weinberger's sign). Dense zone of provisional calcification at
metaphysis. (Franket`s line). Lucent zone due to defective mineralization
(Trumerfeld zone). Cortical fractures (Pelkan`s spurs). Subperiosteal haemorrhage.
![Page 130: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/130.jpg)
Hemorrhagic Periostitis in Scurvy
![Page 131: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/131.jpg)
1 year old child with multiple slipped epiphyses second to scurvy
![Page 132: Endocrinal and metabolic disorders](https://reader035.fdocuments.us/reader035/viewer/2022062404/554afeeeb4c905c12d8b4bcb/html5/thumbnails/132.jpg)
Thank you