Emery Pharma Services power point presentation December 2015
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Transcript of Emery Pharma Services power point presentation December 2015
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Emery Pharma ServicesAnalytical, Microbiology and Synthetic Services Worldwide
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About us
• Experienced CRO supporting small business and large government contracts:
• Over 60 years of combined experience in drug
discovery support and innovation
• Pharmaceutical method development and consulting
• “Hard to solve problems” are our specialty
• Analytical chemistry (NMR, LCMS, HPLC)
• Microbiology (MIC, MBC, MFC, Time Kill)
• Formulations (nanotechnology)
• Custom synthesis
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NMR Spectroscopy
• Bruker 400 MHz spectrometer
• Analyzes Small (<1kD) molecules, synthetic or natural
• 1-D: 1H, 13C, 19F, 31P, 15N, 11B, and more
• 2-D: 1H-1H, 1H-13C, and more
• Variable temperature
• T1 measurement
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LC-MS
• Separates molecules using column (C18 or other)
• Small (0.1-2 kD) molecules, synthetic or natural,
purified or mixture
• Unique set up: allows for detection of virtually any
molecule
• PDA: detects 200-800 nm
• ELSD: detects non-volatile material and non UV active
• MS: dual ESI/APCI ionization, detects charges
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Organic synthesis
• FTE or project based
• Small molecule and building block synthesis from milligram to kilogram scale
• Comprehensive analytical characterization
• Large scale LC purification capability (both Normal- and Reversed-Phase)
• Fast and efficient optimization of chemical reactions based on proprietary methods
• Hit-to-Lead / Lead optimization (SAR studies, compounds for PK studies, etc.)
• All compounds are guaranteed a minimum of 95% purity
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Formulations services
• All types of Pre-formulations and product developments of small molecules with liposomes (parenteral) and other type of drug delivery systems (dermal, ocular and others)
• Process development, scale-up technology transfer and process optimization and filtration studies.
• Writing protocols, performing stability and container-closure compatibility studies
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STEALTH Liposome
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Formulation Analytical Services
• HPLC method development
• HPLC measurement of drug potency and degradation
• Formulation stability (chemicals and physical testing)
• pH and osmolality
• Review stability reports and shelf-life assessments of drug
products
• In-vitro drug release testing, topical and ocular tissue
permeation by Franz cell
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Multi Station Franz Diffusion Cell System
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MIC / MBC / MFC / Time Kill
• Measures inhibition of growth or killing of bacteria and fungi as a function of concentration and/or time
• Test articles can be natural or synthetic, mixtures or purified
• Hundreds of bacterial strains available including drug-resistant clinical isolates
• Multiple fungal strains available
• Antiviral testing also available
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Resistance Testing
• Tests potential for development of resistance to antibiotics
• Multiple passage at sub-lethal concentrations of antibiotics
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• Biofilm models test "real-world"
conditions
• Calgary Biofilm Device (MBECTM)
• Drip-flow reactor
• CDC reactor
• MRD reactor
• In vitro urinary catheter
crystalline biofilm model
• Colony biofilm
• Custom reactor design
Biofilm Testing
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Cytotoxicity in Cell Cultures & Tissues
• Sensitivity of human cells and
human tissues to test articles
• IC50 measurement
• Multiple cell lines available
• EpiOcular multilayered tissue
mimics corneal epidermis
• EpiDermal multilayered tissue
mimics stratum corneum
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Microscopy
•Visualization of bacteria,
cells and tissues
•Confocal microscopy
•Fluorescent microscopy
•Stereozoom microscopy
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Acanthamoeba castellanii trophozoites Acanthamoeba castellanii cysts
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Emery Pharma Services: Analytical, Microbiology and
Synthetic Services Worldwide
For more information please visit our website:
http://www.emerypharmaservices.com/
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