Embryology Doc. MUDr. Ing. RNDr. Peter Celec, DrSc., MPH [email protected] .

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Embryology Doc. MUDr. Ing. RNDr. Peter Celec, DrSc., MPH [email protected] www.imbm.sk

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Transcript of Embryology Doc. MUDr. Ing. RNDr. Peter Celec, DrSc., MPH [email protected] .

Page 1: Embryology Doc. MUDr. Ing. RNDr. Peter Celec, DrSc., MPH petercelec@gmail.com .

Embryology

Doc. MUDr. Ing. RNDr. Peter Celec, DrSc., [email protected]

www.imbm.sk

Page 2: Embryology Doc. MUDr. Ing. RNDr. Peter Celec, DrSc., MPH petercelec@gmail.com .

Stem cells

• Totipotency• All tissue types

• Pluripotency• All tissues except placentaand amniotic sac

• Multipotency• Several related tissue types

Page 3: Embryology Doc. MUDr. Ing. RNDr. Peter Celec, DrSc., MPH petercelec@gmail.com .
Page 4: Embryology Doc. MUDr. Ing. RNDr. Peter Celec, DrSc., MPH petercelec@gmail.com .
Page 5: Embryology Doc. MUDr. Ing. RNDr. Peter Celec, DrSc., MPH petercelec@gmail.com .

Differentiation

Page 6: Embryology Doc. MUDr. Ing. RNDr. Peter Celec, DrSc., MPH petercelec@gmail.com .

Programming and reprogramming

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Nucleus transfer

• John Bertrand Gurdon (1933 - )• Nobel prize in Physiology or medicine 2012

Page 8: Embryology Doc. MUDr. Ing. RNDr. Peter Celec, DrSc., MPH petercelec@gmail.com .

Somatic cell nuclear transfer

• Dolly(5 July 1996 – 14 February 2003)

Page 9: Embryology Doc. MUDr. Ing. RNDr. Peter Celec, DrSc., MPH petercelec@gmail.com .

Cloning

• Reproductive • Therapeutic

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Cloning

Page 11: Embryology Doc. MUDr. Ing. RNDr. Peter Celec, DrSc., MPH petercelec@gmail.com .

Pluripotency

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iPSC

Shinya YamanakaKyoto University

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Page 14: Embryology Doc. MUDr. Ing. RNDr. Peter Celec, DrSc., MPH petercelec@gmail.com .

iPS

• Reprogramming of differentiated cells• Pluripotency• No immune response

• Without retroviral vectors• Without oncogenes• pH?

• Reproducibility

Page 15: Embryology Doc. MUDr. Ing. RNDr. Peter Celec, DrSc., MPH petercelec@gmail.com .

Shinya Yamanaka(1962 – )Nobel prize2012 – Physiology or medicine

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Malignant transformation

• Robert Weinberg (1942 - )

• Oncogenes• Ras

• Tumor suppressors• Rb1

Page 18: Embryology Doc. MUDr. Ing. RNDr. Peter Celec, DrSc., MPH petercelec@gmail.com .

Hallmarks of cancer

Hanahan & Weinberg, Cell, 2000

Page 19: Embryology Doc. MUDr. Ing. RNDr. Peter Celec, DrSc., MPH petercelec@gmail.com .

Hallmarks of cancer

Hanahan & Weinberg, Cell, 2011

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Malignant transformation

• Bert Vogelstein (1949- )

• Vogelgram

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Genometastasis

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Genometastasis

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www.imbm.sk

[email protected]


Navigating the University: Research and Resources Management Retreat August 19, 2014 Michael Jamieson DRSc Associate Director, International Center for.

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