EmbaseFind quick, relevant answers to your biomedical questions

Section 1.Review / Confirm understanding of your research needs

• Conduct systematic reviews of the literature• Set up complex search strategies and alerts for stakeholders and departments• Search Medline and Embase together• Set up and distribute alerts relating to evidence-based medicine• Access the most up to date information related to a disease that you are tracking• Make sure that all relevant information is disseminated throughout the organization• Monitor and track all adverse events for early and complete detection

of any and all adverse effects (signaling)• Make sure you respond to your internal stakeholder’s request in a timely manner

Section 1. Your challenges & Research Needs

Section 2.Evidence Based Medicine / Systematic Searching

“How do you know if one treatment will work better than another, or if it will do more harm than good?”

Cochrane Reviews are systematic reviews of primary research in human health care and health policy, and are internationally recognized as the highest standard in evidence-based health care.

They investigate the effects of interventions for prevention, treatment and rehabilitation. They also assess the accuracy of a diagnostic test for a given condition in a specific patient group and setting.

They are published online in The Cochrane Library.

Section 2.

“How do you know if one treatment will work better than another, or if it will do more harm than good?”

Each systematic review addresses a clearly formulated question. For example:

Can antibiotics help in alleviating the symptoms of a sore throat? 

All the existing primary research on a topic that meets certain criteria is searched for and collated, and then assessed using stringent guidelines, to establish whether or not there is conclusive evidence about a specific treatment. The reviews are updated regularly, ensuring that treatment decisions can be based on the most up-to-date and reliable evidence.

Section 2.

A real example of the high risks of NOT using Embase

Section 2. Case Study: Embase & Evidence Based Medicine

Johns Hopkins’ Tragedy: Could Librarians Have Prevented a Death?

Source: http://newsbreaks.infotoday.com/nbreader.asp?ArticleID=17534

Section 2. Medicine Without Evidence

Section 2.

Section 2.

via Advanced Limits in Advanced Search

via Emtree

Section 2. EBM Terms in Embase / Emtree

Section 3.What is Embase and How it Supports Academic Institutions

Embase is the world’s most comprehensive, intelligent biomedical research tool, providing the drug and drug-related research community with reliable and authoritative content, to advance new biomedical and pharmaceutical discovery.

ConfidenceFind all relevant articles that may not otherwise be found by alternative databases

Deep Biomedical Indexing All relevant, up-to-date, biomedical information from the research literature

Precise RetrievalDeep and focused research through powerful retrieval tools

Section 3. What is Embase?

Conference proceedings

Very powerful Search Environment

...by including literature and information resources in a timely manner

...by reading full-text to identify drugs, diseases, adverse affects, clinical trials, drug trade names etc.

...by enabling advanced search filters to drill down a comprehensive search to a relevant and manageable record set

Scientific Journals

In Press (unpublished)

...by allowing users to automate searching and result management

Deep indexing using own taxonomy (EMTREE)

We make sure you don’t miss any

biomedical literature

They only close alternative is reading

all the articles

Good precision and recall balance

Automation and documentation

Section 3. How Embase Delivers Value…

Section 3.1Content

Emtree: Biomedical thesaurus, over 60k terms

AIP and In Process: Indexing added, from 2009

Conference Abstracts: Indexing added, from 2009

1947 1950 1974 2009

And counting…2,700 records added per day1,000,000 records added per year

Section 3.1 Content Overview

Embase: Fully indexed: Over 7,700 journals (including MEDLINE), 1950-

MEDLINE: 2,500 journals unique to Embase, mapped to Embase indexing, 1950- (including MEDLINE Classic)

Embase Classic: Digitally scanned and re-indexed, 1947-1973

Other topics 28%Including public health, basic biomedical science and topics included from MEDLINE

Pharmacology & Taxicology 12%General Clinical Medicine 11%Genetics, Biochemistry & Molecular Biology 10%Neurology & Behavioral Medicine 8%Microbiology & Infectious Disease 7%Cardiology & Hematology 6%Psychiatry & Mental Health 6%Oncology 5%Healthcare Policy & Management 4%Allergy & Immunology 4%Pediatrics 4%Endocrinology & Metabolism 3%Obstetrics & Gynecology 3%Biomedical Engineering & Medical Devices 3%Anesthesiology & Intensive Care 3%Gastroenterology 2%Respiratory Medicine 2%Nephrology & Urology 2%Dermatology 2%

Section 3.1 Embase Scope & Coverage (2012)

Similar overall pattern of coverage... but with two major differences

1. Pharmacology & toxicologyEmbase: 11.2% (889 titles)MEDLINE: 8.3% (465 titles)

2. General clinical medicineEmbase: 10.5% (835 titles)MEDLINE: 8.9% (495 titles)

Section 3.1 Embase vs MEDLINE – Scope

Section 3.1 Embase vs MEDLINE – Searching the Difference

Section 3.1 Embase Records

Section 3.1

Embase Records

Medline on PubMed

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Embase: now covers 7960 journals (20 March 2012)

Indexed by MEDLINE (e.g on PubMed) (5592 titles)

Indexed at Embase (5396 titles)

Section 3.1 Embase (Active) Journals in 2012

2368 journalsIndexed at EmbaseUnique to Embase

Search:[embase]/lim

3028 journalsIndexed at Embase

Also covered by MEDLINE

Search:[embase]/lim AND

[medline]/lim

2564 journalsIndexed by MEDLINE

Also in MEDLINE

Search:[medline]/lim NOT

[embase]/lim

Section 3.1

Journal Articles

Conference Abstracts

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Section 3.2Indexing (Emtree Thesaurus)

Section 3.2 Deep Indexing – EMTREE

Emtree is a Life Science Thesaurus. A controlled vocabulary for Biomedicine and related Life Sciences

Easy to SearchOver 60,000 preferred terms and more than 270,000 synonyms

Comprehensive Drug SearchingChemical names, trade names, laboratory/research codes, and more than 28,000 generic drugs and chemicals (FDA, EMEA and WHO)

Up-To-DateThe latest drugs, diseases, organisms and procedures are indexed and added annually

Inclusive TerminologyAll MeSH terms, with links to more than 20,000 CAS registry number

60K terms (>260,000 synonyms) and all MeSH terms

29K drug and chemical terms

Emtree updated 3 times a year (back-posting each time)

All drug generic names described by FDA and EMA, all International

Non-Proprietary Names (INNs) described by WHO from 2000.

What is mapping?Mapping means that searchers get the same results regardless of which

term they use, e.g. Vioxx (synonym) or rofecoxib (the preferred term).

Section 3.2 Deep Indexing – EMTREE

Database Thesaurus Search Result

Embase Emtree'monoclonal antibody'/exp/dd_dt AND 'breast cancer'/exp/dm_dt AND [2009-2010]/py [Note: dt = drug therapy]

2075

PubMed MeSH"Antibodies,Monoclonal/therapeutic use“[Mesh] AND "Breast Neoplasms/drug therapy"[Mesh] Limits: Publication Date from 2009 to 2010

357

Embase vs. PubMed : in-depth indexing + Emtree tree structure

Section 3.2 Deep Indexing – EMTREE

2 thesaurus assisted searches but different results!

Section 3.2 Embase vs PubMed

This article, although present in Medline, is not indexed with ‘digoxin’ and therefore our search for ‘digoxin’ and ‘antibacterial agents’ did not find this article – it’s found in Embase.

Section 3.2 Embase vs PubMed

Language Embase on Elsevier

Medline on Ovid

Embase Advantage Percent

Turkish 613 75 538 717%

Korean 134 46 88 191%

Portuguese 712 442 270 61%

Dutch 606 442 164 37%

Chinese 5366 3945 1421 36%

Polish 491 434 57 13%

Spanish 2316 2137 179 8%

French 3952 3904 48 1%

German 8393 8566 -173 -2%

Section 3.2 Embase vs MEDLINE – Randomized Controlled Trails

Product Name2

Search Term Citations

Emtree Preferred Term

MeSH Preferred Term or Substance Name3 Embase Medline

Liptor Atrovastatin Atrovastatin3 7,668 1,654

Advair Fluticasone propionate plus Salmeterol

Fluticasone propionate plus Salmeterol3 839 39

Plavix Clopidogrel Clopidogrel3 9,552 1,613

Nexium Esomeprazole Omeprazole4 1,493 1,558

Norvasc Amlodipine besylate Amlodipine4 439 621

Enbrel Etanercept TNFR-Fc fusion protein4 5,197 1,375

Zyprexa Olanzapine Olanzapine3 7,775 1,498

Remicade Infliximab Infliximab3 8,223 2,461

Diovan Valsartan Valsartan3 2,725 508

Risperdal Risperidone Risperidone 7,991 1,488

Section 3.2 Embase vs MEDLINE – Searching for Drugs