Electrophysiological biomarkers of gene modulation in the Alzheimer’s disease pathway

7
Electrophysiological biomarkers of gene modulation in the Alzheimer’s disease pathway Ajay Karpur

description

Electrophysiological biomarkers of gene modulation in the Alzheimer’s disease pathway. Ajay K arpur. Introduction. Introduction. conventional protein measurements…. Introduction. electrophysiology. Methods. Results. Results. - PowerPoint PPT Presentation

Transcript of Electrophysiological biomarkers of gene modulation in the Alzheimer’s disease pathway

Page 1: Electrophysiological biomarkers of gene modulation in the Alzheimer’s disease pathway

Electrophysiological biomarkers of gene modulation in the Alzheimer’s disease pathwayAjay Karpur

Page 2: Electrophysiological biomarkers of gene modulation in the Alzheimer’s disease pathway

INTRODUCTION

Page 3: Electrophysiological biomarkers of gene modulation in the Alzheimer’s disease pathway

INTRODUCTION

conventional protein measurements…

Page 4: Electrophysiological biomarkers of gene modulation in the Alzheimer’s disease pathway

INTRODUCTION

electrophysiology

Page 5: Electrophysiological biomarkers of gene modulation in the Alzheimer’s disease pathway

METHODS

Page 6: Electrophysiological biomarkers of gene modulation in the Alzheimer’s disease pathway

RESULTS1

20

37

20

73

20

10

92

01

45

20

18

12

02

17

20

25

32

02

89

20

32

52

03

61

20

39

72

04

33

20

46

92

05

05

20

54

12

05

77

20

61

32

06

49

20

68

52

07

21

20

75

72

07

93

20

82

92

01

20

37

20

73

20

10

92

01

45

20

18

12

02

17

20

25

32

02

89

20

32

52

03

61

20

39

72

04

33

20

46

92

05

05

20

54

12

05

77

20

61

32

06

49

20

68

52

07

21

20

75

72

07

93

20

82

92

00

1000

2000

3000

4000

5000

6000

7000

Spike rate for BACE1 transfection (channel 1)

Time (s)

spik

es/m

inut

e

Page 7: Electrophysiological biomarkers of gene modulation in the Alzheimer’s disease pathway

RESULTS

120 9120 1812027120361204512054120631207212081120 3720 1272021720307203972048720577206672075720847200

500

1000

1500

2000

2500

3000

3500

Spike rate for GAPDH transfection (channel 1)

Time (s)

spik

es/m

inut

e