EIPBN EUSPEN NOP LASER World of PHOTONICS ANM IEEE Nano · 2015-12-28 · We cordially invite you...
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www.nanoscribe.de We cordially invite you to our booth, e.g.: Maximum Precision in 3D µ-Printing 1+2 Exhibitions in Spring 2015 1 New IP-S Photoresist 2 Imprint 2 Bioinspired Osteoprints 3 Upcoming Exhibitions 3 Sponsorship 4 Contact 4 For the beginning of the new soccer season Nanoscribe sponsored the team of the Karlsruhe Institute of Technology (KIT-INT) with new jerseys. > read more on page 4 The Italian Nanoscribe customer IIT from Pontedera recently published an exciting paper about bioinspired osteoprints, manufactured by means of a Photonic Professional system. In the scientific magazine Acta Bio- materialia researchers of the Center of Micro-Robotics describe how the reproduction of the natural biologi- cal microenvironment in vitro should improve the understanding of cell behavior for exploiting cell functions in various healthcare applications. > read more on page 3 With a new extension set for its 3D printers consisting of hardware/soft- ware components and the new photo- resist IP-S, Nanoscribe provides the first available complete solution for micro- fabrication. By bridging the gap between 3D laser lithography and 3D printing, this highest resolution technology is now in line with other additive manufac- turing technologies. All advantages of 3D printing are also available for microfabrication. > read more on page 2 The new 3D printing set for the millimeter scale endows the tiny 3 mm figure skater with a grace that literally permits her to dance on the crystal. Watch the animated “Figure skater on a crystal” on www.youtube.com/nanoscribe Leuven, BE June 01-05, 2015 Booth: 50 Munich, DE June 22-25, 2015 Level A3, Booth: 417 May 26-29, 2015 Do not miss the demonstration of groundbreaking new applications, ranging from photonic wire bonding, micro-robotics, cell migration studies, fabrication of new materials up to hierarchical 3D nano-architectures for photonics and biomimetics. Find your matching exhibition on page 3 and visit us!
Transcript of EIPBN EUSPEN NOP LASER World of PHOTONICS ANM IEEE Nano · 2015-12-28 · We cordially invite you...
www.nanoscribe.de
We cordially invite you to our booth, e.g.:
Maximum Precision in 3D µ-Printing 1+2
Exhibitions in Spring 2015 1
New IP-S Photoresist 2
Imprint 2
Bioinspired Osteoprints 3
Upcoming Exhibitions 3
Sponsorship 4
Contact 4
For the beginning of the new soccer season Nanoscribe sponsored the team of the Karlsruhe Institute of Technology (KIT-INT) with new jerseys. > read more on page 4
The Italian Nanoscribe customer IIT from Pontedera recently published an exciting paper about bioinspired osteoprints, manufactured by means of a Photonic Professional system. In the scientific magazine Acta Bio-materialia researchers of the Center of Micro-Robotics describe how the reproduction of the natural biologi-cal microenvironment in vitro should improve the understanding of cell behavior for exploiting cell functions in various healthcare applications. > read more on page 3
With a new extension set for its 3D printers consisting of hardware/soft-ware components and the new photo-resist IP-S, Nanoscribe provides the first available complete solution for micro-fabrication. By bridging the gap between 3D laser lithography and 3D printing, this
highest resolution technology is now in line with other additive manufac-turing technologies.
All advantages of 3D printing are also available for microfabrication.> read more on page 2
The new 3D printing set for the millimeter scale endows the tiny 3 mm figure skater with a grace that literally permits her to dance on the crystal. Watch the animated “Figure skater on a crystal” on www.youtube.com/nanoscribe
Leuven, BEJune 01-05, 2015
Booth: 50
Munich, DEJune 22-25, 2015
Level A3, Booth: 417May 26-29, 2015
Do not miss the demonstration of groundbreaking new applications, ranging from photonic wire bonding, micro-robotics, cell migration studies, fabrication of new materials up to hierarchical 3D nano-architectures for photonics and biomimetics. Find your matching exhibition on page 3 and visit us!
NEWS AND REVIEWS
www.nanoscribe.de
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Although a variety of different materials can be used with Photonic Professional systems, Nanoscribe offers tailor-made photoresists to its customers. These negative-tone resists provide maximum 3D-printer performance with respect to resolution, writing speed, structural accuracy, and ease of use along the process chain. The new IP-S is a resist for large volume structures and for structures where a smooth surface is required.
Advantages:• Easy processing:
> drop-casting of the photoresist > no spin-coating > no pre-/post exposure bake
News and Reviews
Issue: May 2015
Editor: Martin Hermatschweiler
Assistant Editor: Anke Werner
Contribution: Attilio Marino (Italian Institute of Technology, Center for Micro-BioRobotics @SSSA)
Layout & Design: Anke Werner; Katja Thieme
Images: IIT, Nanoscribe
Nanoscribe GmbH
CEO: Martin Hermatschweiler
Registered office of the association:
76344 Eggenstein-Leopoldshafen (DE)
District court: Mannheim
HRB 703637, VAT-No. DE258161584
Tax-No. 34415/77104
> continued from page 1
Hardware, software and polymer printing material components care-fully adapted to each other comprise a complete solution thanks to which 3D printing of highly precise micro-structures has become very easy. Close adherence to tried-and-tested stan-dards from the macroscopic sphere permit fast realization of virtual struc-tural data as physical objects.
Consequently, the world market leader in 3D printing on the micrometer scale now facilitates the manufacturing of the most complex structural designs on a scale that was previously inacces-sible. This technology will become the new standard in additive microfabrica-tion.
Nanoscribe s Photonic Professional GT printer makes the free definition of layer distances and manufacture of structural details in the sub-micro-meter range effortlessly possible and in this respect differs fundamentally, e.g. from stereolithography. It is this that makes it possible to print surfaces even in optical quality.
The extension package consisting of hardware, software and a novel photoresist is bridging the gap between 3D laser lithography and 3D printing.
“The set supplements the Photonic Professional GT 3D printer with high precision optics and the newly devel-oped photoresist IP-S that has been optimized for it. This permits fast, ultra-precise exposure of the liquid printing material combined with
COMPLETE SOLUTION
• Smooth surfaces• Little shrinkage• Fast writing• Good adhesion to various substrates
maximum mechanical strength, accu-racy and surface smoothness on all kinds of substrates. These properties are reflected in the brilliance of the filigree figure skater on the crystal,” CEO Martin Hermatschweiler pointed out. Please ask our sales team for more information: [email protected]
NEWS AND REVIEWS
www.nanoscribe.de
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> continued from page 1
(Attilio Marino) Several biophysical investigations suggest that a peculiar cell behavior can be in vitro resembled by mimicking the corresponding in vivo conditions. [1] In order to in vitro mimic the 3D natural microenvironment of the bone tissue we prepared, thanks to the slice-by-slice two-photon polymer-ization (2PP) approach, trabecula-like structures (named ‘‘Osteoprints’’) that resemble the typical microenviron-ment of trabecular bone cells. [2]
Fig. 2: SEM imaging of an Osteoprint pre-pared by slice-by-slice 2PP of the hybrid ceramic Ormocomp® photoresist.
IDEAL TOOLS FOR BIO APPLICATIONS:
PHOTONIC PROFESSIONAL SYSTEMS
Particularly, the 3D model of the Osteoprint was obtained from X-ray micro-computed tomography (µ-CT) scans of a human trabecular bone biopsy, taken from the femoral neck (Fig. 1). Osteoprints were subsequently fabricated through 2PP of the biocom-patible ceramic photopolymer Ormo-comp®, the mechanical properties of which are similar to that of the natu-ral bone. SEM imaging (Fig. 2) of the obtained Osteoprints reveals a shape and size exactly resembling those of the corresponding 3D µ-CT model, thus demonstrating the high resolution and reliability of the 2PP technique. After an extensive Osteoprint charac-terization, the adhesion, proliferation and differentiation of SaOS-2 osteo-blast-like cells were studied on the obtained scaffolds.
Fig. 1: 3D reconstruction of bone trabe-culae obtained by µ-CT scans of a biopsy from the human femoral neck.
The presence of the Osteoprints was able to deeply affect cell behavior, promoting the cell cycle exit and the osteogenic differentiation. An up-reg-ulation of the genes involved on osteo-genesis and an enhancement of the hydroxyapatite nodule production were the major outcomes (Fig. 3).
These results encourage the exploita-tion of the 2PP for obtaining 3D bio-mimetic structures, useful for a wide range of in vitro application and even in tissue engineering and regenerative medicine. [3]
This article was provided by Nano-scribe’s customer, the Italian Institute of Technology, Center for Micro- BioRobotics @SSSA.
Fig. 3: 3D reconstruction of a bone cell cul-ture on the Osteoprint (in red), highligh-ting the deposition of several hydroxyapa-tite nodules (in green).
References:[1] A. Marino, C. Filippeschi, V. Mattoli, B. Mazzolai and G. Ciofani, Nanoscale, 2015, 07, 2815–3320.[2] A. Marino, C. Filippeschi, G. G. Genchi, V. Mattoli, B. Mazzolai and G. Ciofani, Acta Biomater., 2014, 10, 4303– 4313.[3] S. D. Gittard, A. Koroleva, A. K. Nguyen, E. Fadeeva, A. Gaidukeviciute, S. Schlie-Wolter, R. J. Narayan and B. Chichkov, Front. Biosci. Elite Ed., 2013, 5, 602–609.
EIPBNSan Diego, CA (US) May 26 - 29, 2015Booth: 213
EUSPEN Leuven (BE) June 01 - 05, 2015Booth: 50
NOPRauha (FI)June 01 - 04, 2015Booth: 17
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NEWS AND REVIEWS 4
We are proud to present the soccer team of the Institute of Nanotechnol-ogy (INT) at the Karlsruhe Institute of Technology (KIT) in its new steel-blue jerseys sponsored by Nanoscribe. In early May the team played its first competition in the new outfit.
We wish you a lot of goals and success-ful matches!
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