Effective transportation and translocation of therapeutic molecules using suitably functionalized...
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Effective Transportation and Translocation of Therapeutic
Molecules Using Suitably Functionalized Carbon Nanotubes
AISWARYA.N School of Chemical Sciences,
Mahatma Gandhi University, Kottayam, Kerala, India.
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Introduction Deliverables Why carbon nanotubes? Functionalized CNTs as Innovative Tool. How the Drug Delivery…? Future Applications Concluding Remarks References
CONTENTS
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IntroductionIn 1991, Iijima discovered carbon nanotubes (CNTs) that are elongated fullerenes where the walls of the tubes are hexagonal carbon and often capped at each end.
Carbon Nanotubes
Micro-crystals with high aspect ratios of 1000 or more, although their diameter is close to molecular dimensions
Single-Walled Carbon Nanotubes (SWCNTs).
Multi-Walled Carbon Nanotubes (MWCNTs)
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Deliverables
Future aspects.
Importance of Carbon nanotubes as a ‘microshuttle’ for drug delivery.
The effect of functionalization for the therapeutic applications
Advantages and challenges in the field of drug delivery using the functionally modified carbon nanotubes.
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Why Carbon Nanotubes…?
CNTs – the pitt version
Bionano materials such as liposomes
Nanotubes over nanospheres….?
Polymer or lipid based conjugate system.
A new entity with novel therapeutic or diagnostic properties
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Functionalized CNTs as Innovative Tool
Solubility
Biocompatible natureNeed for Functionalization
........ . . .... . ... . . . .
X % X %
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Functionalization of CNTs
Step 1 :
Step 2 :
Step 3:
Step 4:
sidewall tip
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Molecular Structures of the Carbon Nanotube Conjugated
with Different Therapeutic Agents
Ultrathin transverse section of a HeLa cell treated with ammonium-functionalized CNT
Plasmid DNA delivery Cell internalisation
Antibiotic delivery Anticancer delivery
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Impact of f-CNTs in immune system
Dendritic CellMacrophages T Lymphocyte
Two aspects of cell functionality studied Potential activation of immune cells
The capacity of immune cells that have previously encountered f-CNTs to respond to a physiological stimulus
Immune Cells- ‘True Soldiers’ of human body
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Advantages of Using f-CNT as Vector Drug Delivery Offer multimodel options (Diagnosis, transport and targeted delivery to always) Specificity
Nano needle mechanism Solubility
Controlled drug release
Disadvantages Toxicity
Selectivity for functionalisation
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How the Drug Delivery?
..
.
.
.......
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Challenges Selection of the functionalizing agents. Translocation of the therapeutic molecule.
Biodistribution of f-CNTs.
Future Applications Microshuttle.
A new tool for the development of non-toxic drugs through cost effective routes.
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Concluding Remarks
●The functionalization of CNT is still a subject of intense research, which generates continuous advances as well as novel materials.
●Offers “rediscovering” of old drug molecules and also offer new discovery and design options for new molecules.
●Anticancer and antibiotic carbon nanotube conjugates as well as antigen- presenting conjugates for the potential fabrication of vaccines and plasmid DNA complexes for construction of gene therapeutics.
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References1.H.J.BWu,Dumortier,S.Lacotten,G.Pastorin,R.Marega,W.D.Bonifazi,J.Br
iad,M.Prato,S.Muller and A. Bianco,Nano letters,2006,6(7),1522.
2.A. Bianco,K.Kostarelos and M.Prato,Current Opinion in Chemical Biology,2005,9,674.3. CR Martin, P Kohli : The emerging field of nanotube biotechnology. Nat Rev Drug Discov 2003, 2:294. A.Bianco, K.Kostarelos, C.D Partidos, M.Prato. Biomedical applications of functionalised carbon nanotubes. Chem. Commun. 2005, 571.5. Y. Lin ,S.Taylor, H.Li , SKA.Fernando ,L. Qu ,W. Wang , et al. Advances towards bioapplications of carbon nanotubes. J Mater Chem 2004;14(4):527.
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Sincere Thanks ToDr.P.K.RadhakrishnanDr.Sabu ThomasDr.Suresh MathewSchool of Chemical SciencesIrshad.K
Muhammed Ashik U P
Special Thanks ToChemistry Alumni AssociationStaff and Students of M.E.S Ponnani College