Effect of growth hormone on aging connective tissue in muscle and tendon: gene expression, morphology, and function following immobilization and rehabilitation A. P. Boesen, K. Dideriksen, C. Coupp, S. P. Magnusson, P. Schjerling, M. Boesen, P. Aagaard, M. Kjaer, and H. Langberg

Effect of growth hormone on aging connective tissue in muscle and tendon:gene expression, morphology, and function following immobilization and rehabilitationA. P. Boesen, K. Dideriksen, C. Coupp, S. P. Magnusson, P. Schjerling, M. Boesen, P. Aagaard, M. Kjaer, and H. Langberg

Presented by Juni Royntan TampubolonGuided by dr. Vera Sp.PD., K.Ger.

KSM ILMU PENYAKIT DALAMRUMAH SAKIT IMMANUELBANDUNG - 2015

BackgroundPhysical activity is with aging inactivity loss in skeletal strengthElderly >> prone comorbidity and hospitalization accelerate loss of skeletal muscle mass and strength detrimental for the functional capacity and the risk for fall injuriesRecent studies inactivity has no major morphological effect on tendon size it self but rather seems to decrease tendon biomechanical properties and reduce collagen synthesis

The growth hormon(GH)/IGF-1 collagen turnover + inhibit muscle protein degradation potential importance during immobilizationAging gradual loss of the GH/IGF-I axis change body composition with body fat & loss muscle massit is unknown whether loss in musculotendinous tissue during inactivity can counteracted by GH and whether GH accelerate rehabilitation in aging individuals. BackgroundMethods

Study designStatistics analysisUsing two-way repeated-measures ANOVA Post hoc test65-80- yrBMI 18-30

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ConclusionIn elderly humans, GH seems to have a matrix stabilizing effect during inactivity and rehabilitation by stimulating collagen expression in the musculotendinous tissue and increasing tendon CSA.