EFEYAN ALEJO RYC 2013 13546 - Ministerio Economía · exert tumor su the DNA dama rformed a sim...
Transcript of EFEYAN ALEJO RYC 2013 13546 - Ministerio Economía · exert tumor su the DNA dama rformed a sim...
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tulo: utrient sensing
sumen de lance my early sh.D., I studied hmed to dissect o exert tumor suf the DNA damaerformed a simoderate contribFor my postdocvolved in the pvery anabolic pand other hormoutrient signalingn nutrient sensammalian orgaTPases, my posmbryonic develf RagA activity ifeyan et al., Nacid and glucoseammalian phys
sumen del Cbrief, I obtainodels of breastobtained my Panuel Serrano e Extraordinaryapers in Natureor my postdoctond nutrient sendditional first‐addition, I wroteuthor. obtained five f
rontiers Scienceprovide a selectelected articles
RagA, bW, Sabatini DM
Rag GThang S, Gumperelected Articles
Limitedrtega‐Molina A
Inducti
MINISTERIO
E ECONOMÍACOMPETITIV
EFEYAN RYC‐2013
a: Biomedicnico: efey
by mTOR in ma
a Memoria: steps in scientifhow the tumorthe relative couppression funage response (milar genetic abution of the cectoral studies, Ipathogenesis ofathway in the cones, and cuesg pathway has sing by mTORCanism was obscstdoctoral workopment and fois key for coordature 2013). The sufficiency tosiology, in parti
Currículum Vned my grade ft cancer. From th.D. degree froat the CNIO, oy Thesis Awarde and Cell Metaoral experiencensing signaling uthor paper pee four reviews a
fellowships (3
e Program Orgated list of publics from my Postdbut not RagB, iM. Re‐submissioTPase‐mediatedr I, Snitkin H, Ws from my Ph.Dd evidence for , Soria R, Colladon of p53‐depe
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, ALEJO 3‐13546 cina [email protected].
ammals
fic research, I r suppressor prntribution of dctions. Our resEfeyan et al., Npproach to disell cycle regulatI switched to thf cancer and diacell, and is. MTs from local nujust begun, trigC1 was restrictecure. By meansk pushed forwaor adult life, beidinating fastingis work also deo mTORC1. I acular, in cancer
Vitae: from the Univethis work, I pubom the Autonon the regulatiod. From my Ph.bolism) plus one, I joined David pathway in mending to be reas first‐author,
Ph.D. fellowsh
anization and Chcations: doctoral work: s essential for on in preparatiod regulation of Wolfson R, KirakD. Thesis: the in vivo rodo M, Fernandeendent senesce
AYUDASCONVO
edu
have been interotein p53 exerifferent inputs ults unequivocaNature 2006; Efssect the relevtor p21 (Efeyanhe study of a mabetes. When pTOR integrates sutrient abundaggered by the ded to cell cultus of generating ard this field byng RagA more responses, foremonstrated tham currently ir and aging.
ersity of Buenoblished three paomous Universn of tumor sup.D. work, I pubne first‐author rd M. Sabatini lamice. During msubmitted afteincluding one i
hips: FPI, CNIO
harles King�s T
development aon after first revmTORC1 by nu O, Sabatini DD
le of ATM in tez‐Capetillo O, Sence by the MD
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erested in masrts its cancer prthat activate pally showed thefeyan et al., Cavance of certain et al., Oncogemaster regulatopart of mTOR csignaling cues fance. Unlike thdiscovery of theure studies, annovel genetica
y: 1) demonstraimportant thanr the regulationhat the Rag GTPnvestigating th
os Aires, and mapers, on of theity of Madrid, ppression by p5blished 9 paperreview. ab at the Whitemy postdoctoraer first revision.n Nature Revie
O Predoctoral a
Trust).
and adult life. Evision. utrients is neceD, Sabatini DM.
the response tSerrano M. PLoDM2 antagonis
Y CAJAL A 2013
ster regulators rotection. In pa53 (DNA damage dramatic impncer Research in targets of pne 2007). or of cell growtomplex 1 (mTOfrom the organe growth factoe family of Rag nd whether thisally‐engineeredating that this nn RagB (Efeyan n of autophagy,Pases work as mhe impact of t
my undergraduem as a first autand my Ph.D. 53. My Thesis ws (4 first‐autho
ehead Institute l work, I publi. I also publisheews in Molecula
and FPU; and
Efeyan A, Schw
essary for neonNature. 2013 J
o oncogenic stoS One. 2009;4(t nutlin‐3a in m
SDD
SDE
DDC
SDP
of fundamentaarticular, by mege response anortance of onco2007; Efeyan ap53 in p53‐spe
th: the mechanORC1), this kinaismal nutritionor signal transdGTPases. Befors pathway hadd mouse modelnutrient sensinget al., submitte, and for endurmulti‐node nutrhe nutrient se
uate Thesis wathor. Thesis was pe
work obtained Oor papers includ
at MIT, where ished one firsted two papers iar Cell Biology,
2 Postdoctora
weitzer LD, Bilat
natal autophagyan 31;493(7434
tress. Efeyan A(5):e5475.(*: eqmouse cells of f
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al biological preans of geneticnd oncogenic sigogenic signalinand Murga et aecific protectio
nistic target of ase drives cell gnal state, eliciteduction, our unre my postdoctd any function ls to study the g signaling pathed); 2) showingring the neonatrient sensors, sensing signaling
as focused in e
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I currently studt‐author paperin Science and for which I am
l Fellowships:
te AM, Chang S
y and survival.4):679‐83
A*, Murga M*, qually contribufibroblast origin
E ESTADO IÓN INNOVACIÓN
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rocesses. Durinc engineered mgnaling) to its ag, compared toal., PLoS 2009) n, which show
rapamycin (mTgrowth by reguled by growth fanderstanding otoral research, in the contextfunction of thehway is essentiag that the regultal starvation pignaling both ag pathway in
experimental m
r the supervisioum Laude gradeture, and addit
dy the mTOR k in Nature, anCell Metabolis also correspon
Long Term Hu
S, Kirak O, Lam
Efeyan A, Zon
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g my mice, I ability o that I also wed a
TOR), ating actors of the work t of a e Rag al for ation eriod mino adult
mouse
on of e and tional
inase nd an m. In nding
uman
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cu R,
tor B,
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olina A, VelascoTumou
006 Sep 14;443Genetic
errano M. Oncoelected articles
Establisfeyan A, Fabris V
MINISTERIO
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o‐Miguel S, Herr biology: Polic(7108):159. c dissection of ogene. 2007 Mas from my undeshment of two V, Merani S, La
A VIDAD
rranz D, Vassilecing of oncogen
the role of p2ar 8;26(11):164ergraduate Thehormone responari C, Molinol
AYUDASCONVO
ev LT, Serrano Mne activity by p
21Cip1/Waf1 in5‐9. sis: onsive mouse mo AA. Breast Ca
S RAMÓN YOCATORIA
M. Cancer Res. p53. Efeyan A,
n p53‐mediated
mammary carciancer Res Treat
Y CAJAL A 2013
2007 Aug 1;67(Garcia‐Cao I, H
d tumour supp
noma cell linest. 2004 Feb;83(3
SDD
SDE
DDC
SDP
(15):7350‐7. Herranz D, Vela
ression. Efeyan
s derived from a3):233‐44.
SECRETARÍA DEDE INVESTIGACDESARROLLO E
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SUBDIRECCIÓN DE RECURSOS HPARA LA INVEST
asco‐Miguel S,
n A, Collado M
a metastatic m
E ESTADO IÓN INNOVACIÓN
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Serrano M. Na
M, Velasco‐Migu
ammary tumor
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uel S,
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sumen de laood vessels areesponse to dives major endothgnificant imprond their differeechanism is thrterial‐venous dathological angngiogenesis indngiogenesis theegeneration. Thelated with endependent rolerder to improveangiogenic veith single‐cell reevelopment, th
the future, we To understanduring angiogene To identify nosease. y research prospects of the bnction during everal unique geo unveil new bio
sumen del Cy scientific careupervision of D
otch ligand Dll4ages of developnd Benedito etembrane, contalibre, a phenomfter finishing malf Adams, at tdvanced genetngiogenesis by
anonical Notch at express the
roject, while suntibodies and c
MINISTERIO
E ECONOMÍACOMPETITIV
DOS SANRYC‐2013
a: Biomedicnico: Rui.
e biology of b
a Memoria: e an importanterse stimuli. Theelial receptors ovement in the ent functions che Notch cell‐todifferentiation giogenesis. Condependently oferapies, speciallhe overall aim ondothelial prolie of Notch, in de current angiorsus quiescent esolution and iere are still ma
e will pursue thed how the Notcesis and in quieovel and key d
oject has the pbiology of blootumor developenetic tools andological mechan
Currículum Veer started in Or. António Dua
4. In collaborapment due to dt al. BMC Dev.tinue to prolifemenon also ob
my PhD work, athe renowned ic tools and eusing a wide ra
ligand Jagged1 Fringe family N
upervising a tecchemical inhibit
A VIDAD
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lood vessels b
t therapeutic tae knowledge acas targets in ntreatment of man also be cono‐cell and memprogramme a
ntrary to the pf VEGF signalinly in situations of my future caiferation or mdifferent endotogenesis‐relatedvasculatures bn a high‐througny open questi
e following key ch signaling patescent vessels. downstream ta
potential to incd vessels. Millpment or metad use complemnisms with ther
Vitae: October 2002, arte. My main p
tion with Janetdefects in the g Biol. 2008). Lerate, and migrserved in zebrat the end of 20London Researequipment, weange of techniq
is a potent proNotch glycosyltr
chnician and mtors in vivo we
AYUDASCONVO
DITO, RUI M
cnic.es
y Notch and it
arget in cancer ccumulated durumerous theramany vascular rntrolled by othmbrane‐to‐nuclnd also plays revious undersng (Benedito eof known resisreer is to define
maturation, andthelial contextsd therapies. Baby using advancghput manner.ions that in ord
objectives : thway regulate
argets of Notch
crease significaions of peopleastasis, cardiovmentary indepenrapeutic relevan
in Portugal, whproject involved
t Rossant�s ggenesis and diffLater on we alsate excessivelyafish embryos (006, I decided trch Institute ‐ Ce studied the ques and genet
o�angiogenic rransferases (Be
aster studentswere able to d
S RAMÓN YOCATORIA
MIGUEL
ts downstream
and cardiovasring the last yeapies designed trelated diseaseer mechanismsleus signaling a fundamentastanding of theet al., 2012, Nstance to anti‐Ve with high spad characterize s, as a way of gased on our preced genetic too Despite the adder to be answe
s different pro
h, and underst
antly our undere around the wvascular diseasndent approachnce.
here I did my Pd the phenotyp
group in Torontferentiation of so found that y towards othe(Benedito et alto move abroadCRUK. With throle of the ditically modified
regulator that aenedito et al. Ce
. By using indudissect the expr
Y CAJAL A 2013
m gene regulato
cular diseases ears in the fieldto stimulate ores and cancer. Bs which compepathway, whicl role during de Notch functiNature) which VEGF, which ocatial and temposome of the
gaining further eliminary data, ols that will endvances in the ered require a m
cesses related
and their func
rstanding of keworld already bes or in age rhes that will dif
PhD in the vascpic characteriza
to, we discovethe first embrythe mutant en
er areas of the . BMC Dev. Biod and I startede knowledge afferent Notch mice. Through
antagonizes Dll4ell, 2009, PHH‐
ucible loss�of�ression and fun
SDD
SDE
DDC
SDP
ory networks i
where their miof vascular bioinhibit the groBut VEGFs and ensate or overrh we found todevelopmental on, we recentwill be relevancur frequently oral detail how molecular meunderstandingwe will charactable us to modknowledge of tmore integrated
with endothelia
tion in vascula
ey molecular mbenefited with elated macularfferentiate our
ular biology anation of mutan
red that Dll4KOyonic arteries (Dndothelial cellsembryo, leadinol. 2008 and Bemy postdoctorcquired duringligands and m
h this methodo
4�Notch signaMP Prize 2009)
�function genenctional interac
SECRETARÍA DEDE INVESTIGACDESARROLLO E
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SUBDIRECCIÓN DE RECURSOS HPARA LA INVEST
in developmen
icrostructure cology allowed towth of blood vtheir receptorsrule the VEGF o be a key reg(Benedito et
tly found that nt for the desin cancer and aNotch controlsechanisms undg of the biologycterize the distidify and interrothe Notch funcd approach and
al proliferation
ar developmen
mechanisms invtherapies thatr degenerationresearch and h
nd Notch signalnt mice lacking
O embryos sucDuarte et al. Gs do not form ng to the reduenedito and Adral studies in thg my PhD and modulators dulogy we were a
aling in angioge). Later I started
etics in combinctions between
E ESTADO IÓN INNOVACIÓN
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nt, homeostasis
an change locathe use of VEGFvessels. This leds do not work afunction. One ulator of the ial., 2009, Cell)Notch can regsign of future age‐related ma different procederlying this Vy of blood vessenct Notch funcogate gene funtion during vasd new technolog
n and differenti
nt, homeostasis
volved in impot modulate vasn. We will genave a high pote
ing fields undethe function o
ccumb at very enes and Dev. a stable basection of the arams, Science 2he laboratory othe access to ring developmable to find tha
enic endotheliald a second pos
nation with blo Notch and the
s and
ally in F and d to a alone such initial ) and gulate anti‐
acular esses VEGF‐els in ctions ction scular gies.
ation
s and
ortant scular erate ential
er the of the
early 2004 ment terial 009). of Dr. more ental at the
l cells t‐doc
cking e two
mInanauotentousstefo
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ost important Vcontrast, VEGF
ntibodies can suuthor in this wother questions indothelial Notco supervise twosed advanced gem cells and thor the remodelin
MINISTERIO
E ECONOMÍACOMPETITIV
VEGF ligands aFR3, the main ruppress the sprork and I receivin the field andh signaling (Beo PhD students genetic tools tohat influences thng of veins and
A VIDAD
nd receptors. Wreceptor for VErouting of endoved the Werner suggest that sunedito and Helthat gave impo show that theheir clonal expa the perivenou
AYUDASCONVO
We found that EGF‐C, is strongothelial cells witr Risau Prize 20uccessful theralstrom, Exp. Ceortant contributre is an endothansion (Wang es capillary plex
S RAMÓN YOCATORIA
Notch can congly modulated th low Notch si013 for outstanpeutic targetinell Res. 2013). Dtions to the vashelial compartmet al. Embo J., 2us during vascu
Y CAJAL A 2013
trol angiogeneby Notch, and ignaling (Benedding studies ing of VEGF receDuring the last pscular biology ament in the bon2013). The studular maturation
SDD
SDE
DDC
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sis independenVEGFR3 kinasedito et al. Naturvascular biologptors or their liperiod of my poand Notch signane marrow closent Manuel Ehln (Ehling et al., D
SECRETARÍA DEDE INVESTIGACDESARROLLO E
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ntly of VEGFR2 e inhibition butre, 2012). I wasgy. These latesigands will depeostdoctoral stualling fields. Thsely associated ling showed thaDevelopment 2
E ESTADO IÓN INNOVACIÓN
ENERAL CNOLOGÍA
NERAL IÓN
ÉCNICA
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and VEGF signanot ligand blo
s also correspont results raise mend on the statdies, I also hadhe student Lin Wwith hematopoat Notch is esse2013).
aling. cking nding many tus of time Wang oietic ential
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sumen de laancer cells are enes, leading toegulation of micf 18‐25 nucleotpecifically methechanisms in thon‐coding RNAs, Oncogene. 20uppressor non‐c
uring my postdmor microenvie have uncoveairpin RNAs (shequired for dise
or my independancer) to dissec
sumen del Cstudied Biologyith the 2nd Prxperience in sevrovided me witMadrid, Spain), mor‐suppresso
egulation of othudied the impahort‐Term Felloycle and 1 in Na
October 2009,cott Lowe, I moery aggressive dmiting liver damancer Discoverynderstand liver terference andreparation). Forresentation as
RNAi) field acquas endowed meaining has allowas facilitated mye role of senes
MINISTERIO
E ECONOMÍACOMPETITIV
LUJAMBRYC‐2013
a: Biomedicnico: luja
ction of liver ca
a Memoria: characterized o their activatiocroRNAs and otides in length thylated in canhese pathologies, such as trans010). In theorycoding RNAs an
doctoral researronment, in pared a potentiaRNAs) targetinase maintenan
dent scientific t the involveme
Currículum Vy at the Universemio Extraordveral laboratorth excellent traunder the sup
or and metastaher non‐codingact of differentowship. My expature), and by t
, seeking to expoved to Cold Spdisease that lamage and hepay, Nature Cell Bcancer biology
d mosaic mouser my postdoctooral communic
uired while traine with a valuawed me to obtay developmentcence in tumor
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BIO GOIZUET3‐14331 cina mbia@mskc
ncer
by broad epigeon or inactivatiother non‐codinthat have a funncer and metaes (Lujambio etcribed ultra‐coy, this aberrannd reverting the
rch, I have shoart, through secl therapeutic tg known drug ce (manuscript
career, I plan ent of cellular s
Vitae: sity of Navarra,inario Fin de Cies, including thaining in molecpervision of Drasis‐suppressorg RNAs in canct microRNAs inpertise in the ephe "Premio Edu
pand my expertpring Harbor Lacks effective trtocellular carciBiology, and discy, but also to idee models of canoral research, I cations at seve
ning in Dr. Lowble experienceain extensive tht into an indeper suppression a
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enetic and genon, respectivelyg RNAs in cancction in gene reastasis, demont al. Cancer Resnserved RNAs (nt methylation e tumor phenot
wn that p53 acreted factors target for c‐Mytargets in a c‐Mt in preparation
to exploit the senescence in li
and was awarCarrera by the he laboratoriescular biology te. Manel Esteller microRNAs (er (Oncogene)n the epigenetipigenetic and nuardo Gallego"
tise in cancer anboratory (CSHLreatment. First,noma. This wocussed in a revientify potentiancer, and identwas awarded aeral prestigious
we�s lab, I havee that will be vheoretical and endent, highly mnd to exploit se
S RAMÓN YOCATORIA
A
netic alterationy, and to the dcer. MicroRNAsegulation. By unstrating, for ts. 2007;Lujamb(UCRs) can be dcould be reve
type (Lujambio
acts non‐cell‐auhat modulate myc overexpressiMyc‐driven mun).
use of shRNA iver cancer init
rded with the PMinisterio de
s of Gines Moraechniques. In 2er, and supportCancer Resear. Moreover, I vic landscape ofnon‐coding RNA from the "Fun
nd attracted byL) as a postdoct, I studied the ork was publishiew in Current Bl therapeutic tatified a promisian "EMBO Longs meetings. Ta
e been activelyvery useful whepractical knowmotivated and enescence with
Y CAJAL A 2013
s. These alteradevelopment ofs (miRNAs) are ndertaking diffthe first time, io et al. PNAS. deregulated by ersed by epigeet al. Nature. 2
utonomously tomacrophage funng liver tumorsrine liver cance
libraries (and iation.
Premio ExtraordEdudación y C
ata (CBMSO) an2005, I started ted by an FPUrch, PNAS), anvisited the lab f cancer cells. A field is reflecdación Francisc
y the cutting‐edtoral scientist. role of p53 aned in Cell (ApriBiology. Moreoargets for liver ing target for cg‐Term Fellowsking advantage
y involved in then setting up aledge in the fiehard‐working s
h therapeutic pu
SDD
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ation can affectf cancer. Duringsmall, evolutioferent approachthat miRNAs 2008). Moreovepigenetic mec
enetic drugs, re2012).
o suppress tumnction (Lujambs. Briefly, by scer model, we ha
to a lesser ext
dinario Fin de CCiencia. As an nd Manel Estellemy PhD at theFellowship. Dud described, fof Reuven AgaFor these studted by the pubco Cobos".
dge technology I decided to fond cellular senel 2013) and waover, I have devcancer. For tha‐Myc overexprship". In additioe of my new e
e inception of tand leading myelds of cancer, sscientist with a urposes.
SECRETARÍA DEDE INVESTIGACDESARROLLO E
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ct oncogenes og my PhD, I stuonary conservehes, I identifiedcan be regul
ver, I also demochanisms in caestoring the e
morigenesis by io et al, 2013, Ccreening a custave identified a
tent, the use o
Carrera by the sundergraduateer (CNIO). These Cancer Epigeuring my PhD, for the first tiami, at NKI (Ndies, I was awablication of thre
developed in tocus my researcescence of hepas highlighted bvoted my effortat, I have combressing liver tumon, my work haexpertise in th
the RNAi Core y laboratory. Fisenescence and strong desire t
E ESTADO IÓN INNOVACIÓN
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r tumor suppreudied the epiged, non‐coding d several microated by epigeonstrated that oancer (Lujambioxpression of tu
promoting an Cell). More recetom library of a candidate ge
of mouse mode
same universitye, I gained resese early experieenetics Lab at I identified seme, the epigeederlands), whrded with an Eee reviews (2 in
the laboratory och on liver cancpatic stellate ceby Nature Meds, not only to bined the use ofmors (manuscras been selectee RNA interfer
at MSKCC. Thisinally, my acadd RNAi screensto continue to s
essor enetic RNAs RNAs enetic other o A et umor
anti‐ently, small ne as
els of
y and earch ences CNIO everal enetic here I Embo n Cell
of Dr. cer, a ells in icine, better f RNA ipt in ed for rence
s task demic s, and study
Th
MDY
he average imp
MINISTERIO
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act factor of my
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y first‐author p
AYUDASCONVO
papers is 15, and
S RAMÓN YOCATORIA
d each has bee
Y CAJAL A 2013
n cited 155 tim
SDD
SDE
DDC
SDP
mes.
SECRETARÍA DEDE INVESTIGACDESARROLLO E
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E ESTADO IÓN INNOVACIÓN
ENERAL CNOLOGÍA
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GENERAL HUMANOS TIGACIÓN
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tulo: mplications of m
sumen de labecame interesGMP facility at D34+ and CD13as involved in logenic transplaterest in trans
athological factornell Medical rogenitor cells emogenic cells ardiol. 2007). Ineveloping protonowledge on thnly I succeededith only 2 of throcess of nucleaook (Springer Pe genomic inte011; Stem Cells ansdifferentiatinctional neurouman blood ceurrently, I am rategies for theased on tempor
sumen del Carting my careanscriptional reem cells (CBSCeveral human ineprogramming to demonstrate anscription faciorgetti et al., duced pluripotSCs amenable med to characudies demonstNature, 2011; Pemonstrated thnd c‐MYC (GiorWO US2012/042013 I moved toudy the role ofor the in vitro ge
MINISTERIO
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GIORGETRYC‐2013
a: Biomedicnico: agio
master transcrip
a Memoria: sted in haematthe Ospedale 33+ progenitor several clinicalantation of pedslational resea
ors on the mobCollege in Nein peripheral with a specifi
n 2008 I movedocols for the ghe biology of hd at demonstrathe 4 factors near reprogrammProtocol Handbegrity of huma2011; PNAS 20ion potential ons by the overeells directly intoworking at Joe in vitro generral regulation o
Currículum Veer as a stem egulation and tC). In 2008 I joinduced pluripotechnologies. Tthat CBSC canctors; OCT4 anNat Protocols tent stem cells to worldwide terize the genotrate that epigePNAS, 2012, Nhat these cells crgetti et al., PN2). In 2011, I joo Josep Carreraf lineage‐specifeneration of sp
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tem cells durinclinico Milano) rom cord bloodost relevant on. This experiencr, during this
culating endothe, I was involveents with lung ecular signaturof Regenerativebanking of ne
cells I reasonedell could be repprogram other resulted in two 11) and a patenl as in the diffee Communicatioward other lineSOX2 and c‐MYC progenitor ceLeukaemia Resc blood cells foscription factor
during my firstematopoietic sBank of CMRB(iPSC) lines dered my previous mmed to pluripoe data resultedchapter (Sprinod. 06‐18‐2010istribution. Myof human iPSCons are a generunications, 201ed directly into 12556‐12561; Pof Laboratory osearch Institutn factors duringls for cell repla
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ergence and dif
ng my bachelorin 2004. Durind (CB) by DNA ne was focusedce allowed me period I cultiv
helial progenitoed in the searg cancer. We ire (American Joe Medicine of Bew lines induced that CB cells programmed tor types of soma high‐impact punt (WO 12/819erentiation of ions 2013. Moreeages. I have reC (PNAS 2012).ells that can besearch Instituteor cell replacemrs to improve th
t postdoctoral stem cells and tB (Barcelona) wrived from hea experience in otency faster td in two high‐g Protocol Han0. WO 12/819.0y expertise in reCs derived fromral feature of t13). Following functional neuPatent title: Coof Hematopoiese in Barcelona g hematopoiescement therap
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or cells. I continrch of biomarkdentified the eournal of HemBarcelona (CMRed pluripotent could be an ideo iPSC, but I alsoatic cells, thereublications (Cel9.059). I also coPSCs toward geover, my intereecently demon. This work dese expanded ande as staff invement therapies he differentiatio
training I focutheir clinical apwhere I activelylthy volunteersCBSC biology wthan fibroblastimpact publicandbook Series, 059) and suppoeprogrammingm fibroblasts anhe hiPSCs statemy long‐stand
urons by the forord blood‐derivsis and Blood das a staff juniois developmentpies.
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nued this work kers through aexistence of a
matology 2005, RB), as researchstem cells (hiPeal source of ho found that theby providing nlStemCell 2009ollaborated in twerm cells, studest on CB stemstrated that thcribed for the fd further differstigator. My loin hematologicon of blood line
used my reseaplication, with y participated ins and patients, with my knowles and keratinotions (Giorgett2011) and a prt the use of Cwas also instr
nd other somate and are indepding interest orced expressionved neurons bydisorders at Inbor investigator.t from hiPSCs i
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PhD with Dr. Lapression analysstdoctoral trainf CB CD34+ celr and strengthef physiological
Laboratory, at culating endothation of circulsc Res. 2006; ere, I participatsed on my preeneic therapiesd be reprogramtic insights intocol 2010), a chamed to charactpublished in Na
me into explorinnverted directlypossibility to cofunctional neuis to develop
My initial approaSC.
expression anaterest on cord bon (and bankinuable knowledamming technoexpressing onlyStem Cell 2009title: Generatioative, safe souralizing two proThe results of tsomatic cell so
ells I have recription factors Sf SOX2; 15‐06‐2ation. In Septey main interest elop new strat
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articular, the ge
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ediated cancero develop cancemor suppressioene Par4 (prostevelop endomear4, with a partcontinued my reaconess Mediethodologies, aeveral genes imf its elevation. Ie complete PTETEN dose are vie organism leodulator that switch towards t
sumen del Cstarted my scieomplutense Uneatment. My re998 I received hemistry. After n tumor suppre
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53 and eliminate Faculty of Chs first‐author. A Dr. Serrano¿s ar4‐null mice. Trostate. My resolid backgroundstitute (New Yandolfi¿s lab I w
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Currículum Ventific career dniversity, whereesearch was sumy BSc in Biocmy graduationession. During
�Super p53� museful to test
owship. In 2003
tion of Par4 �hemistry (AutonAfter obtaining lab at the SpanThis mouse modsearch led to 3d in cell biologyYork), and subswas interested
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�Super p53� innce is lost in thresearch at Dr. response 4). Parcinomas and pn the endometrPier Paolo Pandrvard Medical Sable to develoorigenesis. Mygenerated trancus and thereforeduced body increased eneenergy metaboion, with broad
Vitae: during my BSc e I studied theupported by thchemistry (Comn, I joined Dr. Mmy PhD, I hav
mice proved thaseveral hypot
3 I defended my
�, obtaining thenoma Universitmy PhD, I contnish National Cadel was useful first‐author any and cancer mosequently at Bein studying the
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sed gene dosag
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n a p19ARF‐nulhe absence of pManuel Serranr4‐null mice shoprostate hyperprium and prostadolfi¿s laboratoSchool, Bostonop a number ofresearch at Pansgenic mice wore recapitulatinsize due to decrgy expenditurolism towards md implications t
education in Be biochemical pe Last Term Stmplutense UnivManuel Serranoe developed se
at it is possible theses on tumo
y PhD Thesis en
e maximum quay, Madrid). Myinued my reseaancer Researchto reveal the tnd several co‐aouse models, weth Israel Deace consequence
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sing genetically
sms underlyingthe Complutend). Since then,
ge of p53 (�Su
p53� mice exhmature aging. Thganism withoutO) to study therrying two or thg. I have also t
ll background).p19ARF, a p53 no¿s lab I have aow a decrease plasia. This moate. ory at the Sloann). The lab has f informative mandolfi¿s lab wawith increased Png the regulatiocreased cell numre and reducedmitochondrial ro the fields of c
Biochemistry. I properties of audent Fellowshversity, Madrido¿s lab at the Neveral genetica
to increase canor suppression
ntitled �New m
alification of Cy thesis project arch focused on Centre (CNIO)umor suppressauthor articles which led me toconess Medicaes and potentia
Y CAJAL A 2013
y engineered m
g tumor supprense University omy research fo
uper p53� mic
hibit an enhanche main contribt secondary effe effect of an hree functional tested the relev
We have prevactivator, indicalso generated in their survivaouse model wa
n Kettering Instwell‐known exmurine models as focused in thPTEN levels usinon and expressmber, with no ed body fat accrespiration. Thcancer develop
joined Dr. Rosallergens with thip from the Ed), obtaining theational Centre ally modified m
ncer resistancen, stress and a
mouse models f
um laude by uled to 4 publican cancer biolog. One of my prosor role of Par4in prestigious co join Dr. Pier Pl Center (Harval benefits of el
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ce) represents a
ced response tbution of this wfects, such as agextra copy of pcopies of the pvance of the tu
iously observedcating that p19a classical knocl compared wits useful to rev
titute (New Yorpertise in moleof cancer to i
he tumor supprng large genomion of the endoeffect on cell sizcumulation, revis study showsment and meta
alia Rodriguez¿the final aim oducation and Sce Degree¿s Extof Biotechnologmouse models t
without acceleging. I received
for the study of
nanimity and tations in prestiy and mouse geojects was the g4, with particulacancer journalsaolo Pandolfi¿sard Medical Scevating PTEN.
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eloping informthen joined Dr
cer biology and
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rk) and subsequecular biology ainvestigate in vressor PTEN anmic BAC clones (ogenous copy. ze. Interestinglyvealing PTEN s that PTEN proabolism.
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ative cancer mr. Manuel Serra mouse geneti
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p53� are resial for p53‐medor the pro‐apopice and are pror suppressor ro
uently at Beth and cancer genvivo the functiod the conseque(>100Kb) contaMice with increy, PTEN elevatias a key metaomotes a meta
tant Student alergy diagnosisy of Spain (MECze of the Faculart my thesis prer. In particular
�Super p53�port from the
ased gene dosa
xtraordinary Pric journals, 3 of tdoctoral Resead characterizatie endometriume years, I acquithe Sloan Kett. When I joineealed PTEN as a
mouse ano¿s cs. In
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Israel netics on of ences aining eased on at abolic abolic
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towards tumorve been publisd the HFSP Lor, and establishs well as intergave me the o
Y CAJAL A 2013
r suppression. shed as an articng Term Fellowh successful conational collabopportunity to
SDD
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PTEN elevationcle in Cell. Duriwship. During tollaborative relaborations abroabroaden my k
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n can offer a thng my researchthis time I hadationships withad. The interacknowledge on
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herapeutic apprh at Pandolfi¿sthe opportuni
h groups at Haction with sciecancer biology
roach lab I ity to rvard ntific y and
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y interest in coudy of the molerst one to demomplement actiherited risk facith Prof. Matthed. 2007). nce completed
ondon and joineat complemenxpertise in comollaboration wiCFHR5) associatork led to a Lannd gave me thelowed me to bence then, I havy major findingas published lashroughout six ynow different wave succeeded vitations receivsummary, my ternational con
sumen del Cam a complemmmunity, leads octoral thesis (órdoba. My PhDediated renal datl Acad Sci USAodel of the discluding 3 first aeing awarded in
2008, I movevestigated the nowledge of cod to 7 publicati2(1):137‐145; awas an invited s
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atthew Pickerilement in differegulation in vone invited comg. 2012, 8(10): e
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esearch interesate immunity wresponses.
octoral trainingolytic uremic syto loss‐of‐fun
HUS (Goicoecherequired for aHled to the deve
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s a postdoctoray to develop in he study of otniversity Collegopathy, describde Jorge, et al.,ogram of workpendent investinderstanding the dimerization et al. PNAS, 201road, I got to kdiverse experims an independl conferences ae is reflected inng an invited s
understanding ded by a FPI feiversity Autónomolecular basiral publicationsa‐Gordillo et al.p Med, 2007, 2ships, 3 reviewscommunication
ng�s group (erent animal mivo and to explmmentary and e1002981). Mo
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A
perial.ac.uk
st is the studywith crucial role
g in Prof. Santiayndrome (aHUSnction mutatioea de Jorge et aHUS to developelopment of the
ea of studying c
al researcher. our aHUS modther complemege London), I ibing for the fir, 2010). This fink and secure a igator. he biology of thstatus for som13) and led to tknow different mental techniquent investigatoand seminars. 26 publicationpeaker in 4 occ
g how dysreguellowship formoma of Madridis of atypical has having a majo Hum Mol Gen204(6)1249‐125s and one bookn.
(Imperial Collegmodels of renalore possible th 3 first authorsoreover, I partic
Y CAJAL A 2013
y of the comples in microbial
ago Rodríguez dS), a paradigm oons in complemal. PNAS, 2007)p. During my the first animal m
complement dy
During this timdel (Goicoecheaent‐mediated dentified a murst time a mutnding opened aJunior Researc
he CFHR gene fe of the CFHR pthe recent generesearch envirues. I have beeor and recogn
ns (7 peer‐reviecasions, and on
lation of comp Spanish Minisd (Spain) underaemolytic uremor contribution . 2005, 14(5):7056). Overall, du chapter. I also
ge London) asal disease, proherapeutic intehips (Lancet 20cipated in 5 inte
SDD
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de Córdoba�s of complementment regulato. I also demonshesis, I also perfmodel of aHUS
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e I completed a de Jorge et alrenal diseases utation in comant CFHR5 pronew avenue ofch Fellowship (
family and its aproteins and itseration of a patonments that hen involved in sised compleme
w first author ae patent.
plement systemstry of Science r the supervisiomic syndrome (aon the genetic03‐712), and onring this periodhad 9 internat
s a postdoctoroviding me therventions. The 010, 376(9743):ernational mee
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and its associtic cell clearanc
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association wits functional imptent. have giving meseveral fruitful ent biologist,
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iation with disce, immune com
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to Imperial Co
work demonstrI also expandelomerulopathieor H‐related 5 d with disease.he complementerial College, w
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profile journals
mponent of ingy, I completentiago Rodríguegm of complemicoechea et al.on of the first an to 16 publicatce communicat
During this tito deepen intopostdoctoral p Soc Nephrol. 2ker, in one of w
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ostdoctoral andr meetings andthe complemennars. My scientimmunications in
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that allowed mnd Inflammatioesearch interesic contributionSA, 2013, 110(1ovel biological
d subsequentlyd by participatint field, I servedific contributionn conferences (
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a Junior Researhis prestigious on elucidatingesearch Fellow). Importantly, ated with the
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rch Fellowship award launcheg the biology ow to date includmy work led tomodulation o
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In summary, eukaryotic ce
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sumen del Cstarted in scient001, at Carlos LMEC).
Once I om the MEC, wlowed me to putophagy resea In July 2007,ópez‐Otín lab as
In Januoved to the labred senior post
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my research caells, and in the
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finished my Biwhich funded mperform a two‐mrch and establi, I obtained mys a hired postdouary 2010, and b of Prof. Guidotdoc at Guido K
arch career, I hs, as well as wror co‐first autholism, JCB, JCI, s, with an averetings and part
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hagy, aging and
research was pain. Just after riod, I started aagy. Initially, mynto the actual e two genes. Tshment of an ese study of prepremature aginnon, this metabh axis was suffimy interest in
m fellowship. Thvel. Through thon reactions intophagy, thus in
areer has been e elucidation o
Vitae: while I was still soratory, funded
iochemistry deme during my month stage atshed ties with ty PhD. with theoc until decembgiven my intero Kroemer in PKroemer lab wh
have masteredriting scientific or) in top‐rankPNAS, EMBO Jrage rate of citticipated in a va
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d other human p
at Prof. Carlosgraduating, I jo new line of resy work was focphysiological rhis approach lessential and novmature aging, ang in mice activbolic reprogramcient to significthe links of mehere, I developehe use automatn autophagy regntegrating this
focused on theof autophagy
studying my Bad by a Collabo
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a large varietmanuscripts anked internationJ (x2) or EMBO tations per papariety of resear
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O
pathologies
s López‐Otín laoined López‐Otísearch focusedcused on the cloroles of autophed to the descrvel role for autoan ongoing linevates a pro‐survmming turned ocantly improve etabolic pathwaed and coordinted microscopygulation and vecatabolic pathw
e study of autoplinks with me
chelor in Biochration Grant (B
ed a FPU (Formstudies. During Mizushima labJapanese autop'Summa cum Lafinished some ohagy and in they an EMBO posto coordinate a
ty of techniquend handle revisal journals (inc Molecular Meper of 40 and arch projects of b
Y CAJAL A 2013
boratory in 20ín lab as a pre‐ on the study ooning and biochagins‐1 and ‐3ription of a newophagy in balane of research avival metabolicout to be essenthealth and enhays and longevnated a new liny and metaboloery recently, I sway in general
phagy, a catabotabolic alterat
emistry and MBeca de colabo
mación del Profthis period, Ioratory in Tokyphagy researchaude' at the Unof the projects te mechanisms ut‐doctoral Longautophagy‐relat
es and I have ion processes. cluding Cell, Sciedicine). Accordan h‐index of 1both national a
SDD
SDE
DDC
SDP
01, while studdoctoral studenof human autophemical charac through the gw protective funnce perception at López‐Otín lac response invotial for the devehance the lifespity, I moved toe of research foomics platformhowed for the metabolic regu
olic pathway wiions underlying
olecular Biologyoración), from t
esorado Univewas awarded wyo, Japan. Ther community. niversity of Ovithat I had starteunderlying physg‐Term Fellowsted projects.
acquired the cTo date, I haveence, Nature Rding to ISI web 18. I have also nd internationa
SECRETARÍA DEDE INVESTIGACDESARROLLO E
SECRETARÍA GEDE CIENCIA, TECE INNOVACIÓN
DIRECCIÓN GENDE INVESTIGACCIENTÍFICA Y TÉ
SUBDIRECCIÓN DE RECURSOS HPARA LA INVEST
ying my last yent under Spanisphagins (Atg4s)cterization of thgeneration andnction for autoand inner ear daboratory. My olving autophagelopment of prpan of progeroio Prof. Guido Kfocused on the ms, I was first afirst time that
ulation.
ith essential hog aging and a
gy at University the Spanish M
ersitario) pre‐dowith a mobilityre, I learned th
iedo. Then, I coed during my Psiological and pship. Since 2012
capacity to dese authored 45 sRev. Mol. Cell. B of knowledge, presented 14 al scope.
E ESTADO IÓN INNOVACIÓN
ENERAL CNOLOGÍA
NERAL IÓN
ÉCNICA
GENERAL HUMANOS TIGACIÓN
ear of Biochemsh Government, the only protehese enzymes. characterizatioophagin‐3 in tumdevelopment.participation ingy induction. Rarogeroid featured mice. roemer lab in Pstudy of autopable to describecytoplasmic Ac
meostatic funca variety of hu
of Oviedo (Spainistry of Educ
octoral grant (2y grant (MEC)e latest metho
ontinued workihD studies. pathological ag2, I am working
sign and coordscientific articleBiol., Molecula, my work has communicatio
mistry t FPU eases Later on of mour
n this ather es. In
Paris, phagy e the cetyl‐
ctions uman
in) in ation
2002) that ods in
ng at
ging, I g as a
inate es (19 r Cell been
ons in
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MDY
ombre: ferencia: ea Científicaorreo Electró
tulo: anslational Res
sumen de lahe focus of manslational focehavior. Autismepetitive/restricCDC, 2012), beissential to stuterventions. Fontnap2 mouse mesearch. This wo
hus, this mouseonsistently imphenotypes. Wetranasal admineatment in wilterestingly, wessociation of thxploring the nexytocin exerts it
y work includejections for geocus. The ultima
sumen del Creceived my Phpain. The focustellectual disabncient isolated fferent mutatioefore starting megative for Freurodevelopmendescribed mut006).
fter completinghere I continueuman Geneticsboratory, a leadneuropsychiatrehavior. It has ane of the primanimal models teuro‐anatomy,
MINISTERIO
E ECONOMÍACOMPETITIV
PENAGARYC‐2013
a: Biomedicnico: ope
search on Neuro
a Memoria: y research is us, studying thm is a neuropsycted interests. Iing one of thedy the disordor the last yearsmodel of ASD, aork has been re
e model providrove social beh have performnistration of thld‐type litterme found that ohe oxytocin sysurobiological bts behavioral ef
es mouse behavne delivery, anate goal of my r
Currículum VhD in 2003 froms of my Thesis bility, and one opopulation veronal pathwaysmy postdoctoraragile X syndental disorder tation in one o
g my PhD I beced my work ons,2007). In 200ding researcherric disorder chaa prevalence oary health issuhat faithfully rbrain develop
A VIDAD
ARIKANO AH3‐12558 cina [email protected]
opsychiatric Dis
on neuropsychhe molecular pychiatric disordIt has a prevalee primary healter at the mos I have been lea model that haecently publishe
es a new tool fhaviors. Currened an in vivo dhe neuropeptidates did not soxytocin levels stem and ASD, asis for the oxyffects.
vioral charactend microdialysisresearch is to a
Vitae: m the Departmwas Fragile X of the most cory well suited t leading towaral training I conrome for mucharacterized of our samples
came a postdocn Fragile X synd8, to deepen mr in this field, inaracterized by df 1 in 88 childres worldwide. replicate autismpment, neuron
AYUDASCONVO
HEDO, OLGA
edu
sorders
hiatric disordeathways and cer characterizeence of 1 in 88 th issues worldlecular level, eading a multi‐fas proven to haed in Cell (Peña
for mechanisticnt pharmacothedrug screeninge oxytocin drahow any behaare reduced inand clinical trytocin signaling
rization, in vivos to study the rpply findings in
ment of Geneticsyndrome, a mmon genetic o study the orrd Fragile X synducted some ctations in theby intellectual (Peñagarikano
ctoral researchdrome focusingmy knowledge n the Departmedeficits in two ren according toOne of the pr
m‐related behanal physiology
S RAMÓN YOCATORIA
A
rs and, specifcircuits that leaed by deficits inchildren accorddwide. Animal gain insight infaceted work, inave high constragarikano et al.,
c and therapeuerapy is used tg in Cntnap2 mamatically impravioral responsn the brains oials with oxytog deficits in the
o drug screeninrelationship ben mouse models
cs in the Schooneurodevelopm causes of Autiigin of unstableyndrome (Peñaclinical work sce MecP2 gendisability and
o et al., Human
her in the Depag on its molecuon the neuron
ent of Neurologbehavioral domo the latest estrimary reasons avior. During my and behavio
Y CAJAL A 2013
ically, Autism ad to abnormaln two behaviording to the latemodels that f
nto disease mnvolving anatomuct, face and p, 2011).
utic research ino mostly reduc
mutant mice tarroves social dese, suggesting af Cntnap2 mutocin in autistic e Cntnap2 mous
ngs, molecular etwee neurons,s of neuropsych
ol of Sciences omental disordeism. I studied te genes. Our regarikano et al.reening DNA sane. This geneautism‐like fea
n Genetics, 200
artment of Humlar basis (Peñanal basis of augy at the Univermains: social betimates from thfor the absenc
my late postdocoral characteriz
SDD
SDE
DDC
SDP
Spectrum Diso behavior withral domains: soest estimates frfaithfully replicechanisms andmy, developmeredictive validit
ASD. In autismce stereotypic brgeting affectedeficits in this ma hyper‐reactivtant mice. Sevpatients show se model of au
biology, neuro brain circuits hiatric disorder
of the Universir which is the he stability of tesults were in a, American Jouamples of intelis responsib
atures. I found5; Tejada, Peñ
man Genetics agarikano et al.tistic behavior,rsity of Californehavior/commuhe Center for Dce of effective ctoral work I lezation of the
SECRETARÍA DEDE INVESTIGACDESARROLLO E
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SUBDIRECCIÓN DE RECURSOS HPARA LA INVEST
orders (ASD). h the purpose ocial behavior/crom the Centercate autism‐reld test potentient, physiology ty, which is crit
m, no drug has behaviors and d social behavmouse model. Svity to oxytociveral lines of epromising res
utism and the m
oanatomy, in viand behavior, rs towards hum
ity of the Basqmost commonthe FMR1 geneagreement witurnal of Medicllectually disabble for Rett sd a predicted dagarikano et a
at Emory Unive., Annual Revie, I joined Dr. Dnia at Los Angelunication and rDisease Controtreatments fo
ed a multi‐faceCntnap2 mou
E ESTADO IÓN INNOVACIÓN
ENERAL CNOLOGÍA
NERAL IÓN
ÉCNICA
GENERAL HUMANOS TIGACIÓN
My research hof restoring nocommunicationfor Disease Colated behaviorial pharmacoloand behavior oical for translat
yet been provenoncore associors and foundStrikingly, the sn in Cntnap2 mvidence suggeults. Currently mechanism whe
vo stereotaxic with a translat
man intervention
que Country, Bin form of inhee in Basques, ath the hypothescal Genetics, 2led cases who syndrome, anodeleterious andl., Clinical Gen
ersity, Atlanta, w of GenomicsDaniel Geschwes (UCLA). Autirepetitive/restrl (CDC, 2012), br ASD is the laeted work, invouse model of
has a ormal n and ontrol s are ogical of the tional
en to ciated d that same mice. st an I am ereby
virus tional ns.
ilbao, erited very sis of 004). were other d yet etics,
USA, s and wind's ism is ricted being ck of olving ASD
(PthMint Cuthasprw
MDY
eñagarikano ete leading Founedicine (Penagternational neu
urrently, I contiis devastating as a Voucher Awresented as peeill be published
MINISTERIO
E ECONOMÍACOMPETITIV
t al., Cell, 2011ndations on Augarikano and Guroscience mee
inue to use thisaspect of the dward from theer selected orad shortly.
A VIDAD
1). This work wautism research.eschwind, 2012etings.
s mouse modedisease. For thise UCLA Clinicall presentations
AYUDASCONVO
as awarded the As a result of 2) a book chap
l to study theirs purpose I was and Translatis at Society for
S RAMÓN YOCATORIA
e "Top10 achief this work, I wpter on the sub
r deficits in socs awarded a Traonal Science Ir Neuroscience
Y CAJAL A 2013
evements in autwas invited to wbject (Peñagarik
ial behavior, siaining grant in nstitute (CTSI).2012 and Inter
SDD
SDE
DDC
SDP
tism research iwrite a review kano and Gesch
nce there is cuTranslational R. The initial rernational Meet
SECRETARÍA DEDE INVESTIGACDESARROLLO E
SECRETARÍA GEDE CIENCIA, TECE INNOVACIÓN
DIRECCIÓN GENDE INVESTIGACCIENTÍFICA Y TÉ
SUBDIRECCIÓN DE RECURSOS HPARA LA INVEST
in 2011" by Auon Autism in Thwind, 2013),
rrently no treaResearch by Auesults of these ting for Autism
E ESTADO IÓN INNOVACIÓN
ENERAL CNOLOGÍA
NERAL IÓN
ÉCNICA
GENERAL HUMANOS TIGACIÓN
tism Speaks, oTrends in Moleand as a speak
tment indicatetism Speaks, asstudies have Research 2013
ne of ecular ker at
ed for s well been 3 and
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20stth
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ombre: ferencia: ea Científicaorreo Electró
tulo: icroglial phagoc
sumen de laicroglia are theuroinflammatohich apoptosis urrent knowledostdoctoral traie adult brain ippocampal neuynamics in vivo chucarro Basquxperiments in vow cytometry, icroglia in conicroglial phagotations, a fully apacity to integonsolidated traj
sumen del CSc in Biology Comunidad de Mxtraordinary Awuthor; Young Inllow at Rockefe36 citations) anniversity, NY atations, impact esearch Profess
lial Cell Biology
013, as PI), Basqudents (Basquee board of dir
pringer book �
MINISTERIO
E ECONOMÍACOMPETITIV
SIERRA SRYC‐2013
a: Biomedicnico: ama
cytosis in healt
a Memoria: he brain profeory response. Dis known to o
dge on the recining, I discoveis fast and effiurogenic cascadand allow us foue Center for vivo and in vitrogenomic and
ntrolling adult cytosis in brainequipped lab
grate previous jectory as a you
Currículum V1995‐2000 (U.Madrid). ward 2003; Felvestigator Awaeller Universitynd Glia 2008 (94nd Baylor Colle factor 25); Keysor at Achucar
since 09/2011
que Governmee Government ectors of the S
�Microglia in He
A VIDAD
SAAVEDRA,3‐12817 cina anda.sierra@
h and disease
essional phagoDespite the cenoccur, from braeptors involvedred that contracient, and is tide, where newor the first timeNeuroscience ao (organotypicsproteomic ananeurogenesis
n diseases that with 3 PhD stuknowledge andung leader in Ne
Vitae: . Complutense lowship for Phard (Workshop y, NY 2004‐20064 citations) ege of Medicinystone Symposiro Basque Cen
; 3 papers publ
nt (50.000�, 2PhD and UniveSpanish Glial N
ealth and Disea
AYUDASCONVO
, AMANDA
@ehu.es
ocytes, a moretral role of phain developmend its mechanisary to the assumghtly coupled born cells undee to illuminate as Ikerbasque s, primary cultualysis, and muland hippocamleads to delayeudents, and fud technical appeuroscience in
e, Madrid): Be PhD
hD students 20on Steroid Hor6; Postdoc Fello ne, TX, 2006‐20ia Scholarship 2ter for Neuros
lished, 1 submi
2012‐2013, as corsity of the Basetwork; memb
se�; Marie‐Cu
S RAMÓN YOCATORIA
e beneficial anagocytosis in mant to brain disesms of executiomptions in the to apoptosis (ergo apoptosis,the intricate inResearch Profeures) in mice ativariate statismpal‐dependened clearance annding from a Nproaches into aSpain and Euro
st College Repin Neuroscien
000‐2004 (Carlomones, CO). owship (Minist 011; 3 papers 2011. cience and Un
itted, 1 in prepa
o‐PI), and Minesque Country feber of the Euro
urie Fellow 201
Y CAJAL A 2013
nd less exploreaintaining tissueases such as eon, and its funliterature, micrSierra et al., C, I established anteraction betwessor, we curreand human tisstics to expandnt learning andd inflammationNational Reseaa coherent, inteope.
port in Biologce 2000‐2003 (os III); 12 pape try of Education published, 2 a iversity of the
aration; fundin
eco (125.000�ellowships); teaoglia meeting 2
1‐2014 (Co‐Fun
SDD
SDE
DDC
SDP
ed role than e homeostasis epilepsy, strokenctional conseqroglial phagocyell Stem Cell 2a series of paraween apoptosis ently use a muue, as well as c these findingsd memory; 2, n. With 22 peerrch Plan from egrated, long‐te
y 2001; Fellow(Cajal Institute ers published s n); 4 papers pu Poss first autor, in Basque Countr
g from Ikerbasq
, 2012‐2015, asaching in two M2015 (Bilbao) o
nd Program).
SECRETARÍA DEDE INVESTIGACDESARROLLO E
SECRETARÍA GEDE CIENCIA, TECE INNOVACIÓN
DIRECCIÓN GENDE INVESTIGACCIENTÍFICA Y TÉ
SUBDIRECCIÓN DE RECURSOS HPARA LA INVEST
its traditional in all the widese, Alzheimer s quences remainytosis in physio2010). Using asameters that quand phagocytoultidisciplinary confocal and es in two directThe patholog
r‐reviewed manMineco, I haveerm research p
wship for Techand U. Compl
summing 1236
ublished, 2 as fistdoctoral assocncluding Cell S ry, and Head o
que Foundatio
s PI); fully equipMaster courses;organizing comm
E ESTADO IÓN INNOVACIÓN
ENERAL CNOLOGÍA
NERAL IÓN
ÉCNICA
GENERAL HUMANOS TIGACIÓN
implication inspread conditioor Parkinson sns poor. Durinlogical conditios a model the uantify phagocyosis. In my lab aapproach involectron microsctions: 1,The rogical impairmennuscripts, over e demonstrateplan, and build
hnicians 1999‐utense): PhD Tcitations, 3 as Postdocirst autor: Glia ciate at Stony Btem Cell 2010 Ikerba
of the Laborato
n (144.000�, 2
pped lab with 3 elected membmittee; co‐edit
n the ons in s, our g my ons in adult ytosis at the olving copy, ole of nt of 1900 d my up a
‐2001 Thesis s first ctoral 2007 Brook (174
asque ory of
2011‐
3 PhD ber of tor of
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ombre: ferencia: ea Científicaorreo Electró
tulo: ole of Telomere
sumen de laelomeres, specelomeres consis
�end replicatioowever, embrylomeric repeatelomerase comlomeres to shoave shown thatnd genome intelomeres. Both ecombination, prikingly I have te lead to a losequirement for nd the importaster telomere cspecially in Ephpithelial tumoretastasis; This haracteristics bytranscription faepress telomeralomere maintend for the deve
sumen del CS in Biology froxcellent cum lauthe laboratoryn the study of hmodel. This wot al. (Chomosomstitute of BiomTelomere main. (Journal of Ceycle, 2012). 3 stresentations, 4 ork State Depareptember 2011
MINISTERIO
E ECONOMÍACOMPETITIV
CANUDARYC‐2013
a: Biomedicnico: silvi
e maintenance d
a Memoria: cialized structust of TTAGGG D
n problem�, yonic, tumor ats to the endsplex. Recently orten dramaticat TIN2 is requiregrity. Cells lacphenotypes cpreventing theidentified thatss in sister teloHP1 at replicatnce of telomercohesin as wellithelial tumors.rs are the mosprocess happ
y tumor cells anactor is the keyase and regulatenance could inlopment of spe
Currículum Vom Universitat ude (2004). Supy of Dr. Fernanhomeotic gene ork resulted in 4ma Research, 2molecular Medicntenance and gell Biology, 200tays in internatposters) 5 natiortment of HealtI am working a
A VIDAD
AS PUIG, SIL3‐12598 cina a.canudas@
during tumor p
ures at the enDNA tandem re
in most somand stem cells of chromosomthe shelterin sually and stem cred to establishking TIN2 werecould be causee cells from re DC mutation cmere cohesionting telomeres,re maintenancel as the import. st common nepens in the latnd the acquisitiy inductor of EMtes telomere innterfere with caecific therapeut
Vitae: de Barcelona (ported by FPI fendo Azorín Marregulation and4 publications: 006). My interecine (New York genome integrit09), Canudas ettionally recognonal meetings, th (2006). In 20as postdoctoral
AYUDASCONVO
LVIA
gmail.com
progression
nd of chromosepeats and shel
tic cells, telomnormally mainmes. The humaubunit TIN2, waells to die earlyh or maintain coe unable to repaed by a failure epairing damagcluster in TIN2 n and interfere and further pre for stem cell tance of telome
eoplasic alteratte phases of ton of mesenchMT. My prelimntegrity importaancer treatmentic strategies.
(1998). PhD deellowship fromín at the Institu expression, wiEspinas et al. (Jest in Genome University) in Nty. This work ret al. (Gens & Dized centers (2. During My po
010 I was selectfellow at IMIM
S RAMÓN YOCATORIA
somes, are esslterin, a six‐sub
mere shortenintain telomeresan stem cell das found to be y. How these mohesion at teloair double stranto keep siste
ged DNA or leharbors a bindwith telomererovide insight infunction. Therere maintenan
tion in humanumorigenesis ahymal traits, a pinary, unpublisant for tumor pnt efficacy and
egree in Biologym Ministerio de ut de Biologia Mith particular emJCB, 1999), Espintegrity and mNew York as a esulted in 3 firstDev, 2011) and 2 in foreigners iostdoctoral studted to receive tM (Barcelona, Sp
Y CAJAL A 2013
sentials for gebunit complex (
g acts as a mos by expressingisease Dyskeramutated in ind
mutations resultomeres and thanded DNA brear chromatids cengthening teloding site for he length maintento the severe eby, my futurece in genomic
ns. Lethality isand is normalprocess known shed results shoprogression. Unshould prove u
y from the depEducación cultMolecular de Bmphasis on thepinas et al. (EMmaintenace led Postdoctoral Ret author publica1 second authinstitutions). 7 dies I obtained he Helen L. andpain).
SDD
SDE
DDC
SDP
enome integritTRF1, TRF2, TIN
olecular clock g Telomerase, atosis congenitdividuals with Dt in very short tat this cohesionks and were alsclose enough fomeres via theeterochromatinenance by telomtelomere dysfue research aim integrity in tum
mostly associly associated tas epithelial‐meowed that durinderstanding Snuseful for the u
partment of Bioura y Deportesarcelona (IBMBe GAGA proteinBO Rep.,2000),me join to Susesearch Fellow ations: Canudashor, Benjamin Rcomunicationsfundings from d Martin S. Kim
SECRETARÍA DEDE INVESTIGACDESARROLLO E
SECRETARÍA GEDE CIENCIA, TECE INNOVACIÓN
DIRECCIÓN GENDE INVESTIGACCIENTÍFICA Y TÉ
SUBDIRECCIÓN DE RECURSOS HPARA LA INVEST
ty and mainteN2, TPP1, POT1
leading to sena reverse tranta (DC) is causDC. The lack of telomeres is unn is essential foso prone to comfor them to une replication pn 1 (HP1γmerase. My daunction typical is to elucidate morigenesis an
iated to the pto the previouesenchymal trang EMT Snail1 nail1 mechanisnderstanding o
ochemistry ands, I conducted mB‐CSIC). My PhDn using Drosoph, Canudas et alsan Smith laborw in 2004. I was s et al. (EMBO JR. Houghtaling,s to internationHRSB Breast ca
mmel Stem Cell
E ESTADO IÓN INNOVACIÓN
ENERAL CNOLOGÍA
NERAL IÓN
ÉCNICA
GENERAL HUMANOS TIGACIÓN
nance. Mamm1, Rap1). Due to
nescence/apoptnscriptase that ed by mutatioTIN2 function cnknown. My stor telomere stampletely losing ndergo homolopathway called ;). Mutations inta suggest a unof TIN2 DC patthe mechanismd stem cell bio
presence of dius loss of epithansition (EMT). transcription fsm in stem cellsof particular can
d molecular Biomy graduate stD work was fochila melanogast. (NAR, 2005), Cratory at the Skspecially intereJ. 2007), Canud,Silvia Canudas nal meetings ( 3ancer research,Fellow award.
malian o the
tosis. adds ns in cause udies ability their
ogous ALT.
n this nique tients ms of ology,
stant helial Snail factor s and ncers
ology, udies cused ter as Costa kirball ested das et (Cell
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ombre: ferencia: ea Científicaorreo Electró
tulo: otein Biophysic
sumen de lahe candidate in003) and Biocupervision of Doctorate coursee was awarded niversity of Granta de Andaluc
uring his PhD hcanning Calorimroteins with incnd by using genesign of new caeer‐reviewed jo
he candidate obmolecular des
MBO Long Term
he candidate organization ande last round (soo‐translocationaagan Bayley is ocomplished his orresponding au
nally, I have heudents in the laequently prese
sumen del Che candidate hand correspondinas second autroperties [Rodr010], their actioat. Nanotech, 2014], aswell theom collaboratioxford Nanopor1/896,933 and Biophysical Sociniversity.
MINISTERIO
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RODRIGRYC‐2013
a: Biomedicnico: davi
cs
a Memoria: itiated his resehemistry (2004r. Valery Shnyres on the Molea fellowship franada to carry cia (competitive
he has been inmetry (DSC), Isocreased stabilitynetic algorithmatalytic activitieournals (out of a
btained his PhDsign". After thism fellowship.
obtained the Ed is considered ource EMBO). Tal unfolding. Thone of the worproposal, resuuthor). Further,
eld collaboratioab and have gant my research
Currículum Vas 19 publicationg author), 1 Nthor and 1 as criguez‐Larrea Don mechanism 2013] and the deir study by moon with leadingre Technologie UK patent 1iety, Protein So
A VIDAD
UEZ LARREA3‐12799 cina id.rodriguez‐
arch career in t4). He conductrov and Professecular Mechanisrom Junta de Con his PhD une).
volved in the sothermal Titratiy and catalysis s for charge dies and in Molea total of 19), 4
D with "suma cus he obtained
EMBO Long Teone of the moThe candidate he candidate dld leaders in thulting in publica, he has patent
ns with industrave lectures in th at both nation
Vitae: ons in well recat. Nanotech, 1corresponding D et al, JMB 20[Ousden N. et
development ofolecular dynamg companies ins [Rosen* CB, 316849.7). Theociety,..), and h
AYUDASCONVO
A, DAVID
‐larrea@che
the Departmented research osor Enrique Villsms of Biologicastilla y Leon (cnder supervisio
study of the bioon Calorimetryusing evolutionstribution optiecular Dynamic4 of them as firs
um laude" in 20a post‐doctora
erm fellowshipost prestigious fproposed a prodeveloped his pe use of single‐ations in Natured a methodolo
rial companies the University onal and internat
ognized intern1 Nat. Struct. Mauthor. These06], their desig al, Science, 20f biotechnologicics and designinn the biotechnoRodriguez‐Larre candidate phas been invite
S RAMÓN YOCATORIA
em.ox.ac.uk
nt of Biochemiston the study oar, obtaining tcal Processes oncompetitive feln of Professor
ophysical propy, Circular Dichrnary informatiomization. Furthcs simulations. st author and 5
008, with the thal contract in o
p in 2010. Thifellowships in toject for the usproposal in Pro‐molecule apprre Nanotechnology for the sing
such as Novozyof Granada. I ational meetings
ational peer‐reMol. Biol, 1 JACSe publications cgn for improve013], their studcal applicationsng new catalytiological sector rea*# D and Bpresents frequeed for talks at S
Y CAJAL A 2013
try, University oof erythrocite mhe Tesina (equn the same Unillowship) he moJose Manuel S
erties of proteroism, Fluorescon obtained wither, he has alsoFrom this peri as second auth
hesis "Energeticorder to finish
is fellowship ithe world. It is e of single‐molofessor Hagan roaches using nlogy (first authgle‐molecule de
ymes and Oxfoam member of s.
eviewed journaS, 3 JMB, 3 JBC,cover most of ed catalysis anddy at the singles [Rosen* CB, Ric activities by csuch as NovozBayley# H, Natently his workSEBBM, Jacobs
SDD
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s granted by highly competecule approachBayley lab at Onanopores. Remor), Science anetection of post
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after cursing theoteins by microters degree). Falent to Masterepartment of Ph2005‐2009) wit
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e degrees of Bioo‐calorimetry uFurther, coursedrs degree). Althhysical‐Chemisth a fellowship
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unta de Castillaogy Organizatioin grants from
ty of Zaragoza g proteins) andt year students niversity, Christer University).
riguez‐Larrea*# groups, leadinted to give talkBO Long Term bBayley H, Nat. 2014]. Further,).
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a‐Leon (rejectedon (EMBO) Lonthe US governm
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r his PhD). Has t‐doctoral resenced Grant from
tes in open prod SCUK. In addntly directs studsity, Sussane Bo
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n Italy, I obtaimolecular gen
I published 11 b
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as investigatoas also awarded
man genetics an
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diabetes.
red on understd combine diffegenetic and ep
of the insulin pcations and opcreatic islet‐cellof Type 2 DiabeT2D.
h to understanrovided a refe
d bioinformatication of the pannt forms of dieer in this field.
s at the Gaslindency at the Rected to this ce
sity of Pittsburucco, acquiringon the susceptijournals.
n human geneenic diabetes.
rs and reviews,
rent institute, acould integratetic islet cells. Tns and shed ligone coauthors
h of my first‐au
r in several intd a fellowship f
nd bioinformatic
Y CAJAL A 2013
tanding the moerent expertise igenetic suscep
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d the genomic erence cis‐regu
c knowledge toncreatic islets oabetes. I woul.
ni Institute in Regional Centernter.
gh (USA) wherg both expertisibility to the de
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holding the firs
as a CIBERDEM this knowledgThe outcome oht on the moleship in Cell Meuthor papers th
ternational collarom the Europe
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map. The integciated genetic v
regulation of tlatory map fo
o unmask the phof Langerhans ad like to use t
Genoa, Italy. I for Diabetes h
e I had the oppe in molecular evelopment of
g my basic res
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aborative projeean Fundation f
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SECRETARÍA GEDE CIENCIA, TECE INNOVACIÓN
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anisms that unhuman geneticdevelopment of
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nderlay diabetes, molecular biof diabetes.
lls. I could intefactor binding map with Genet enhancers, lin
ngerhans, shedorts to dissect
esis of diabetesinformation tothe Ramón y
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egulation of thforms of diabet
ave gained the rogram togethe
Y CAJAL A 2013
e pancreatic isltes.
maturity, techner with the fram
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ans and using s
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such notions to
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sumen de lais becoming wrocess termed rectly linked toven the rising if cases, brain mrimary tumors cnd consecutive mor will perishrgans. Howeve
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sumen del Cdid the bachelepartment of Gsease of dogs,myotrophic Latanipulations,
mmunohistochee University ofgnificantly my cven that I was df Neuroscienceseuronal migratiain projects. Invel for the firsMartini, F, Valieerebral cortex, ruided migrationap junctions in tdecided to travS), where I joiigrating neuronollaborations wompleting the Peuronal precursnique opportun
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a Memoria: widely acceptedmetastasis. Thio metastasis. Ancidence, extre
metastasis constcombined and csteps which mh and never takr what limits t
own. Understanalize future thcal samples andve in the brainced by the reace a protease acin. When theseerine proteasetlenecks in the bases to under
oal of identify a
Currículum Vlor in VeterinaGenetics (2002‐, named Ehrliceral Esclerosis biopsies pro
emistry. Since I f Zaragoza (200choices in the fdetermined to s (Alicante, Spaion during the n collaboration st time, identifente, M, et al.,radial and tangn of projection the migration ovel abroad (200ned the laborans in 3D matricwith other laborPhD I decided tsors to navigatnity to study m
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d that the mainis is the main rmong secondaemely poor protitutes the moscurrently affectmakes it extremke over. Much the colonizatio
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Vitae: ary Science at ‐2003). Under thiosis. During (ALS) in a moutocols from liked the proje04). However thfuture if I was gpursue a PhD inain) was the ondevelopment owith the laborfying the RhoG 2009, Developgential migrationeurons given
of neuronal pre07) to do a shoratory of Pedroces. I participatratories (Fazzarto change the me through the metastasis in th
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n caveat to maeason why canry organs commognosis and undst common neuting 200.000 pamely inefficient,of this attritionn of cancer ce
other limiting elopment to tahe host brain mnitial steps of he presence ofr cancer cells inatic cells were cific for this actbrain colonizatogy of dissemine the limiting st
the Universityhe supervision 2003 I startedse model for thdifferent tissct I decided to he year after I going to continun life sciences. Ane that I was loof the cerebral ratory of MigueGTPase ROCK apment). In paraons. This work d its interactioncursors (Valienrt stay of three Aza‐Blanc, Died in the publicri et al., 2010, main subject ofbrain, I found he brain was a
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TASIS
nage cancer isncer is still assomonly affectedderstudied biourological compatients only in t, yet lethal when is associated ells, and what
steps of metarget the diseasmicroenvironmecolonization (Vf metastatic cen the brain. A veanalyzed we dtivity. The apprtion. In a broadnated disease inteps of brain me
y of Zaragoza of Pilar Zaragod to take part his disease. Unsues, sensoryjoin the laborarealized the laue the scientificAmong differenooking for. As cortex as the mel Valdeolmilloas a critical regallel I studied tdissected the ro with connexinte et al., 2010, e months at therector of the Fcation of threeNature; Martinf my research, the phenomenvailable at the
Y CAJAL A 2013
the ability of ociated with ded during cancerlogy. Up to datplication of canthe U.S. Metasten developed. with the last sare the mecha
stasis will allowse more efficienent I have idenValiente et al., ells. Astrocytes ery limited numdiscovered thatoach followed der view the imn the brain. Myetastasis colon
(1998‐2003). Doza I developedin an ongoingder the supervy‐motor behaatory and starteboratory had vc career. I finalnt interviews I dI joined the lamain aim of myos, we charactegulator for thethe intracellulaole of Focal Adhn26 (Cx26). ThisJournal of Neue Sandford‐BurFunctional Gene reviews at then‐Ibanez et al., and even the sna of cancer cee laboratory of
SDD
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this disease toeath; in fact 90%progression, t
te epidemiologicer, being ten ttasis is a highly Most of the castep of metastaanisms required
w to expose thntly. By combinntified the mec2014, Cell). Mget immediate
mber of metasta they avoid thelead to identify
mplications and y future interestization and diss
During the lastd a PCR based dg research line ision of Rosariovior tests, qed a PhD in Anavery important ly took the decdid, the laboratb I decided to y PhD studies (erized the migrae steering navigar regulation ofhesion Kinase (s was the first roscience). Durnham Medical nomics Core Fae end of the Ph2010, Journal scientific field. lls colonizing aDr. Massagué
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o spread throug% of cancer‐ashe brain is of oical data indicatimes more cocomplex proceancer cells leavasis, the colonid to establish
he �Achilles�ning experimenchanism by whiMy research haely activated watic cells howeve lethal action y genetic detertechnical inno
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cision to exploretory of Oscar Mstudy the mole(2005‐2009). I wration of interngation of this f the two migr(FAK) as a criticreport linking fring the PhD anResearch Institacility, to use hD. I also particof ComparativGiven my intea secondary orgé. During my po
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ENERAL CNOLOGÍA
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ghout the bodysociated deathoutstanding intates that by nummon that all ess given its muving from a prization of secona metastatic le
� heel� of cantal models of ich brain metasas identified nawhen sensing caver will succeedof this proteasminants requirvations of this a research proular regulation.
studies I joinedhod for a tick‐blaboratory stude familiar with PCR, cloning ogy and Genetat will narrow de other laborat
Marín at the Instecular regulatiowas involved ineurons at a ceneuronal precratory modes incal regulator of focal adhesionsnd funded by EMtute (San Diegolentiviral vectocipated in succeve Neurology). rest in the abilgan fascinatingostdoctoral tra
y in a hs are terest mber brain ltiple mary ndary esion
ncer, brain static atural ancer d and se by ed to work gram
d the borne dying mice and
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(2
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SECRETARÍA GEDE CIENCIA, TECE INNOVACIÓN
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SUBDIRECCIÓN DE RECURSOS HPARA LA INVEST
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sumen de lafter having worology, the fieldnderstanding of
rimary cilia are re essential forevelopent and hliary diseases, aMKS) and Joube
uring my postdWhen I joined that most MKS ais complex loccking some of tosely resemblef this complex ao allow embrane prote
nce I made thee functional reomplex, which dditionally, I amomposition and
sumen del Cear Members o
am currently a pave been sincedependent rese
would not be aps a scientist in evelopmental b
fter graduating ay at the Univerticles (Garcia‐GChong‐Kopera eears I was also a
pon completion005‐2006) and
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a: Biomedicnico: fgar
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microtubule‐br us to sense homeostasis, inalso known as cert syndrome (JS
doctoral researchis laboratory, nd JS gene proalizes to the bathese genes. Thes human MKS, at the molecula
eins to localize i
ese important dlationship of thalso controls m now very in ciliary signalin
Currículum Vof the Search Co
postdoctoral ree 2008. I am eearcher and pa
pplying for thisfive different l
biology and mou
in biochemistrersity of GiessenGonzalo et al. et al. 2006, Casaactively involve
n of my PhD I The Salk Instit
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GONZALO, 3‐14887 cina rciagonzalo@
ary Cilia Functio
ds of membranean to stay in tms underlying
ased membranour environmencluding brain aciliopathies, whS), among othe
ch at UCSF (200most causativeoducts physicallase of primary hese studies shwhereas partiaar and cellular l
inside cilia.
discoveries, I hahe MKS/JS compciliary membrnterested in thg.
Vitae: ommittee:
esearcher in theextremely interticipate in the
s position if I dilabs, three diffuse genetics.
ry with highest n, Germany. I c2002, 2003, 20as‐Terradellas eed as a teacher
moved to the tute for Biologi
AYUDASCONVO
FRANCESC
@gmail.com
on
e trafficking (19the future. Thuprimary cilia fu
ne protrusions oent (we see, sand limb patterhich include poers.
08‐2014) I havee genes for MKSy interact with cilia, in a regioowed that comal loss of compevels: the com
ave focused on plex that I charrane compositihe role specific
e laboratory of erested in obta teaching of fut
d not feel prepferent countrie
honors in 1998completed my P004 & 2005). Aet al. 2006, Hadat the School o
United States cal Studies (20
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C
999‐2006) and sus, the main gnction.
of the cell surfsmell and hearrning or feedinolycystic kidney
e made major aS and JS had b each other anon known as thmplete loss of fuplex function leamplex plays a su
the question oracterized and aon. This studyc lipids (such a
Dr. Jeremy Reiaining a Ramoture generation
pared for it. Myes, and in mult
8, I performed PhD in 2005 aftAfter 2005, somdjebi et al. 2008of Medicine and
of America. I f006‐2008), in w
Y CAJAL A 2013
stem cell biologoal of my curr
ace that functir through ciliag behavior. Fai disease (PKD),
advances in oueen identified, d are part of a he transition zounction of this ads to a mouseupportive role in
of how ciliary coanother ciliopaty will be submas phosphoinos
iter at the Univon y Cajal fellons of scientists.
y preparedness iple areas of b
my PhD at the ter publishing mme of my PhD 8) and one pated Dentistry of th
first spent threwhich I publishe
SDD
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gy (2006‐2008),rent and future
on as cellular a) but they alsolure of primary Bardet‐Biedl s
r understandinyet their functmultiprotein coone. I also creaMKS/JS complee version of humn primary cilia f
omposition is rethy complex, thmitted for publsitides) play in
ersity of Califorowship, as this
derives from fiiomedicine, inc
University of Bmy work as the work was pub
ent (Casas‐Terrahe University of
e years at the d a study on th
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, I have becomee research is t
antennae. In huo regulate crity cilia to functiosyndrome (BBS
ng of two cilioptions were unkomplex. Furtheated and analyzex causes a moman JS. I also dformation, but
regulated. This he nephronophlication in the the control o
rnia, San Francs would allow
ifteen years of cluding bioche
Barcelona, inclu lead author in blished in threeadellas et al. 20f Barcelona.
University of Che role of lipid
E ESTADO IÓN INNOVACIÓN
ENERAL CNOLOGÍA
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e an expert in co achieve a de
umans, primarytical aspects ofon properly lea), Meckel synd
pathies, MKS anknown. I establermore, I foundzed mouse muouse phenotypedefined the fun its main funct
has led me to sthisis or NPHP next few moof ciliary memb
isco (UCSF), whme to becom
experience womistry, cell bio
uding a three‐mfour peer‐reviee additional ar006). During my
California San Ds in keeping hu
ciliary eeper
y cilia f our ds to rome
nd JS. ished d that tants e that ction ion is
study
onths. brane
here I me an
orking ology,
month ewed ticles y PhD
Diego uman
emMapbais cil(Gro Th Sin Fr
MDY
mbryonic stem ouse course atpplied this knowackground all caa great exampliopathy work aGarcia‐Gonzalo otations in our l
hank you very m
ncerely,
rancesc R. Garci
MINISTERIO
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cell pluripotent Cold Spring Hwledge when I ame together tple of this seamas a coauthor in& Reiter 2012ab, two of who
much for your c
ia‐Gonzalo
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ncy (Garcia‐GonHarbor Lab, Newjoined my curto study primarmless integration a Cell paper (2). Besides my om decided to j
consideration.
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08). In 2007, I iliar with mousbiochemical, ceused by their malo et al. 2011)ntly, I have revored three gra
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a: Biomedicnico: ana
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toral stay at theDr. Brian Blackegulation of carrole and regulatin developmeexpertise in gen
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vet� program lop news reseac and liver emional factors arention to GATA ular and cellularasis for hepatic
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de Biología Mol
ends by April 2urrent researchopment with emhe developmenactors, our linesn pancreas formtion and progre
the knowledg
1996). Ph.D. in shock proteinsst author (Prie002), (Rojas et ad my postdoctosco, USA, for 6 with a Spanish ip from Americpers, 3 of them mental Dynamental Biology, 2riptional contro
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2014. In CABIMh lines focus omphasis on trant of diseases as of research amation and in bession
ge, professiona
Biology at the s during embryeto‐Dapena et aal., Plant Physiooral training in years. During postdoctoral fecan Heart Asso as first author
mics, 2009) and 2011). I am alsol of cardiac bou
tarted to form
t lab we have dd liver developmdiabetes and hSubprograma nal Governmenhire personnelhas resulted so
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r Biology of IRNertise in molecuegulation in pla
niversity of CalI developed i
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ina Regenerativ
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University of Syogenesis in pal., Plant Molecology, 2002), (Athe laboratory this time my reellowship from ociation (AHA) r (Rojas et al., Dtwo of them ao the first authundaries, in Ad
my own grou
developed innoment and how hepatic fibrosisde Proyectos dnt, 2009). This . Our lab is curo far in the pu
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ifornia San Frain Dr. Black la
diac vertebrate manipulation
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pertise I believe
evilla (2001). Mlants. My worcular Biology, 1Almoguera et aof Dr. Brian Blaesearch focusedMinistry of EdWestern AffiliaDevelopment, 2as a second (Hhor of a reviewvances in Deve
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ion, 2012, and ave also estabin my lab have
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Hepatology, 2lished several cbeen objected
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el Centro Nacia problemas rel
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proteínas: técni
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Y CAJAL A 2013
cas espectroscó
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amiento y unió
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culum 22 publicndo un Nature Mdo su trabajo e la docencia, ha
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una estancia poen parte por unn medidas cinéones Biológicasboratorio de téuñoz ha publica
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caciones, entre Methods y varien numerosos a colaborado en
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S RAMÓN YOCATORIA
ostdoctoral de na beca postdoéticas y técnicas en Madrid junécnicas de moléado 6 artículos,
o pasado al Cee trabajo, incluyón. Además, es
las que se inclios PNAS) y un congresos cienn dos cursos of
as que el candtoral FPU, una brimero por la ebajo de carácternos, incluyend
Y CAJAL A 2013
3 años (2004‐octoral del gobias de moléculanto con el restoécula única para, 4 como prime
entro Nacionalyendo el trasladstá a cargo de
uyen 20 artícucapítulo del libntíficos, incluyeficiales de la Un
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l de Biotecnolodo de instrumela gestión de l
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tado, incluyenoral del gobiernños en EEUU y nternacional, donjero.
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E ESTADO IÓN INNOVACIÓN
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Victor Muñoz, tó el aprendizadiendo en EEUa beca postdocurante este pe
dato ha colabonización y puesécnicas de molé
medio‐alto impde la editorial
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sumen de lahe main challenformation of reancer patients brofile.) The firsthis database wi
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he main goal ofrugs, based on ontribute to maroject will be br
) Collect a databhe main outputf tumors, as wend xenografts.
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sumen del Cfter obtaining mocused on the tctors binding spplying these mata to produce
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a Memoria: nge I would likesponse to drugbased on their t step would beill also collect a
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e to address isgs from cell linemolecular profe to develop a kall information
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se of tumors tort of the projecon on the patte
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s the integratioes, xenografts afiles, whereas tknowledgebaseavailable on th
n, I plan to dell lines or xenognal architecturelow to make prtion of drugs wo
pursue consistsptomic and ephe putative resarts:
o targeted drugsct will be a knowern of response
tivity to targeteproject will be ugs. They will b
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did my PhD inwork of gammahese organismske them easily alution and dyna
s at the Biomedted platform foenomics mediceotide variants
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on of data on dand clinical triahe latter will hee of genomic anhe pattern of re
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s in identifying pigenomic altersponse of patie
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Bioinformaticsa‐proteobacteri. Then, I designaccessible to thamics of the ga
dical Genomicsor the analysiscine company. s and small in
Y CAJAL A 2013
driver and actiols. (The formerelp us determinnd epigenomic esponse to dru
�using machient's tumor, gir under analysishe clinical evoluget its specific p
biomarkers ofrations observeents' tumors to
genomic and eimary or secon
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s at the Nationia. I developed ned and implemhe microbiologicmma‐proteoba
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hods to retrieve
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nal Bioinformatcomputational
mented a web‐bcal research coacteria transcrip
University Pomeration sequenparticipated in eveloped two m
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E ESTADO IÓN INNOVACIÓN
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ary tumors withr even individuetter suited for housands of tumumors (from cl
o retrieve fromc alterations prnical informatioimilarly, it wouns.
tumors to targt ultimately aimr cancer types.
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ask meaningfulars, I have focusp of the biologenomics platfo
g languages tha‐oriented progrrently existing ented towardsseveral dozens together to for
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l questions, andused mainly onogy of tumors aorms, and the
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Babak Razagh
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working in the mtand the implicsh this year a
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cs of cancer cele a master reguhase is repressase Inhibitory Fmal colon, lung 2013). Accordisis also promotal., Mol Cell, 2s needed to supring the last 5 yutant version o
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eaching duties: 006‐2009: Assistant at Facraduate Courseeminars and ve
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AYUDASCONVO
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n Huntington's
oremost. I start
eputed in Huntnts with a life eI received a prexes in the devenanced projectt from the Spaédéric Saudou.
blished private restore the traraffic of non‐veole in several un
rs, �Moleculand European la
by François Boat leads technotdoc, I worked onisms that impa ultrastructuraon of TGF‐betaradiated mice.
rant that I obtas is known to bfield. My credeal and internati
with undergradepartment of
rcelona (5 yea
ançois Boussin
e‐doctoral gran
fessor� from U
but I also partic
r in the Medic
s period. I alsocular character
s )). I got my P
gency for Quali
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disease and irr
ted my career
tington�s diseexpectancy varye‐doctoral granelopment of difts I obtained manish "Ministry. Saudou's labo
center of internsport of BDNesicular PCM1 ncharacterised
ar Brain� and abs. Then I dec
oussin in the cological researcon neural stemair adult neuroal studies of nea neutralizing a
ained from "Fobe altered in HDentials include aional congresse
aduate researchf Cell Biology o
rs). As postdoc
n�s lab at �F
nt� and �Pos
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cine School, I le
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PhD with distin
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esearch� the "
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�The Journalcided to broad
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m cells and cancgenesis after ioeurogenic nichentibodies or an
ndation de FraD. I would like an overall H‐indes.
h experience (of University o
ctoral experienc
French Alternat
tdoctoral� gra
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nish research p
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and Accredita
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ural and cancer
ory of Dr. Jordi
tal neurodegen15 years after nish "Ministry oof genetic andgree with distinand Science" (ropean referen
rch. There I deprimary cultureg that PCM1 isknown) side‐e
of Clinical Inven my scientifi
D center of theand ensures ther stem cells, ponising irradiaties, I found than inhibitor of its
ance" to finish to return to Spdex 10, 13 pape
1997‐2000) as f Valencia. I jo
ce I had two st
tive Energies a
ant both from S
espectively. Cur
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tructure and fu
s "Animal modork " DiMI Netw
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digestive and
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tion 65, Cell Bio
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finalist of �I oin the corps ncian languages
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(2013), both eq
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tdocs). Globally
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Paris� (2008,
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s.
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quivalents to Sp
which 2 I am fir
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al congresses (F
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Paris, France).
ciety of Cell Bio
I moved to the
o Joven CV� od Inserm rese
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panish ANECA �
rst author and 2
ndex of 10 and
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ty� (2013, Du
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e French equiva
organized by Bearchers (2012
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2 second autho
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e �Journal of Neb of Knowledg
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blin, Ireland) a
ncluding a con
and �Europea
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ankia‐Levante 2 and 2013).
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ecturer PhD�.
or from my PhD
hed in internat
Neuroscience�gement January
oscience) 4 tim
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nference in �C
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des Neuroscien
EMT (2013). I I have skills
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D stage, and 3 I
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mes as a speak
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