Editorial The Regulation of Innate Immunity by...
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Editorial The Regulation of Innate Immunity by Nutritional Factors Wenkai Ren, 1,2 Kai Wang, 3 Peng Liao, 1 Guan Yang, 1 Yong Zhao, 4 and Yang Zhou 5,6 1 Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Observation and Experiment Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan, China 2 University of the Chinese Academy of Sciences, Beijing, China 3 Institute of Apicultural Research, Chinese Academy of Agricultural Science, Beijing, China 4 Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark 5 College of Fisheries, Huazhong Agricultural University, Wuhan, Hubei, China 6 Department of Infectious Disease and Pathology, University of Florida, Gainesville, FL, USA Correspondence should be addressed to Wenkai Ren; [email protected] Received 9 November 2016; Accepted 9 November 2016 Copyright © 2016 Wenkai Ren et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Recent years have witnessed growing interest in the bio- chemistry and physiology of nutrients for mammals, such as amino acids, fatty acids, polyphenols, and oligosaccha- ride. Notably, dietary nutrients have critical importance on immune function, especially in the pathogenesis of many immune related diseases including autoimmune diseases, inflammatory bowel disease (IBD), and cancer. ese studies propose the way to manipulate immune associated diseases with a nutritional aspect. is special issue provides us with a better understanding of the role of nutrition on immunity at the molecular, cellular, and organ level, which suggests possible implications in nutritional manipulations. Mingxin Li et al. explored the effect of dietary methionine restriction on bone density and function of natural killer cells in mice. e results revealed that methionine-restricted diet decreases the bone mass and reduces the cytotoxicity of NK cells. Vitamin D has profound implications for animal and human health. However, the influence of the vitamin D signaling pathway on immunity and how it is regulated is only partially known which limits efforts to support immunity through the vitamin D pathway. R. Lin reviewed the recent knowledge on how immune signals regulate vitamin D metabolism and how innate immune responses are modulated by ligand-bound vitamin D receptor. Although osteopontin (OPN) is associated with the pathogenesis of osteoarthritis (OA), the underlying mechanism of OPN in the biology of OA remains to be known. Y. Li et al. demonstrated that OPN enhances the production of matrix metallopro- teinase 13 (MMP13) and activates the NF-B pathway, while inactivation of NF-B pathway reduces the production of MMP13. Y. Zhou et al. found that Fetuin-A may improve the excessive activation of hepatic stellate cells by inhibiting the expression of Smad2 and Smad3 genes but upregulating the Smad7 gene expression. e gastrointestinal tract is particularly responsive to stressors and inflammatory mediators. Oregano essential oil (OEO) has long been used to improve the health of animals and is widely known for its antimicrobial and anti- inflammatory effects. Y. Zou et al. investigated the eff- ects of OEO in the intestine of pigs and they found that OEO promotes intestinal barrier integrity. Mechanically, this modulation is probably through regulating intestinal bacteria and immune status in pigs. Weaning is known to compromise the digestive, absorptive, and secretory capacity of the small intestine, which can cause morphological and histological changes of the small intestine. M. C. B. Tossou et al. showed that tryptophan (Trp) affects the tight junction barrier and intestinal health in weaned pigs. ey found that 0.15% Trp supplementation did not affect pig performance, while 0.75% Trp supplementation negatively affects intestinal morphology and tight junction proteins in weaned pigs. Hindawi Publishing Corporation BioMed Research International Volume 2016, Article ID 5138706, 2 pages http://dx.doi.org/10.1155/2016/5138706
Transcript of Editorial The Regulation of Innate Immunity by...
EditorialThe Regulation of Innate Immunity by Nutritional Factors
Wenkai Ren,1,2 Kai Wang,3 Peng Liao,1 Guan Yang,1 Yong Zhao,4 and Yang Zhou5,6
1Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences,Observation and Experiment Station of Animal Nutrition and Feed Science in South-Central China, Ministry of Agriculture,Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, Hunan, China2University of the Chinese Academy of Sciences, Beijing, China3Institute of Apicultural Research, Chinese Academy of Agricultural Science, Beijing, China4Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark5College of Fisheries, Huazhong Agricultural University, Wuhan, Hubei, China6Department of Infectious Disease and Pathology, University of Florida, Gainesville, FL, USA
Correspondence should be addressed to Wenkai Ren; [email protected]
Received 9 November 2016; Accepted 9 November 2016
Copyright © 2016 Wenkai Ren et al. This is an open access article distributed under the Creative Commons Attribution License,which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Recent years have witnessed growing interest in the bio-chemistry and physiology of nutrients for mammals, suchas amino acids, fatty acids, polyphenols, and oligosaccha-ride. Notably, dietary nutrients have critical importance onimmune function, especially in the pathogenesis of manyimmune related diseases including autoimmune diseases,inflammatory bowel disease (IBD), and cancer. These studiespropose the way to manipulate immune associated diseaseswith a nutritional aspect.
This special issue provides us with a better understandingof the role of nutrition on immunity at themolecular, cellular,and organ level, which suggests possible implications innutritional manipulations.
Mingxin Li et al. explored the effect of dietarymethioninerestriction on bone density and function of natural killercells in mice. The results revealed that methionine-restricteddiet decreases the bone mass and reduces the cytotoxicity ofNK cells. Vitamin D has profound implications for animaland human health. However, the influence of the vitaminD signaling pathway on immunity and how it is regulatedis only partially known which limits efforts to supportimmunity through the vitamin D pathway. R. Lin reviewedthe recent knowledge on how immune signals regulatevitaminDmetabolism and how innate immune responses aremodulated by ligand-bound vitamin D receptor. Althoughosteopontin (OPN) is associated with the pathogenesis of
osteoarthritis (OA), the underlyingmechanismofOPN in thebiology of OA remains to be known. Y. Li et al. demonstratedthat OPN enhances the production of matrix metallopro-teinase 13 (MMP13) and activates the NF-𝜅B pathway, whileinactivation of NF-𝜅B pathway reduces the production ofMMP13. Y. Zhou et al. found that Fetuin-A may improve theexcessive activation of hepatic stellate cells by inhibiting theexpression of Smad2 and Smad3 genes but upregulating theSmad7 gene expression.
The gastrointestinal tract is particularly responsive tostressors and inflammatory mediators. Oregano essentialoil (OEO) has long been used to improve the health ofanimals and is widely known for its antimicrobial and anti-inflammatory effects. Y. Zou et al. investigated the eff-ects of OEO in the intestine of pigs and they found thatOEO promotes intestinal barrier integrity. Mechanically,this modulation is probably through regulating intestinalbacteria and immune status in pigs. Weaning is known tocompromise the digestive, absorptive, and secretory capacityof the small intestine, which can cause morphological andhistological changes of the small intestine. M. C. B. Tossouet al. showed that tryptophan (Trp) affects the tight junctionbarrier and intestinal health in weaned pigs. They found that0.15% Trp supplementation did not affect pig performance,while 0.75% Trp supplementation negatively affects intestinalmorphology and tight junction proteins in weaned pigs.
Hindawi Publishing CorporationBioMed Research InternationalVolume 2016, Article ID 5138706, 2 pageshttp://dx.doi.org/10.1155/2016/5138706
2 BioMed Research International
Chitosan is an attractive additive for animal feed because of itsinherent antimicrobial and anti-inflammatory properties. G.Guan et al. explored relationships between low dose dietarysupplementation of chitosan and body weight, feed intake,intestinal barrier function, and permeability in mice. Theyused the mouse model and demonstrated that 30mg/kgdose of chitosan supplementation did not influence growthperformance but compromised intestinal barrier integrity.M.Iser et al. also found that Agave fourcroydes powder can beused as a dietary supplement which had beneficial effects onincreasing the growth performance and serum concentrationof IgG, as well as improving the gut morphology withoutaffecting the hematology parameters in broiler rabbits. L.Cheng et al. purified and characterized thermostable 𝛽-Mannanase from Bacillus subtilis BE-91 which will havepotential applications as a dietary supplement in treatmentof inflammatory diseases.
The research article by M. Brianza-Padilla et al. showedthat chronic ingestion of sucrose in rats induces the upreg-ulation of inflammation related microRNAs (miR-21 andmiR-223) in plasma and extracellular vesicles. H. Ni et al.reported that isoquinoline alkaloids, derived from Macleayacordata extract, are beneficial to swine and poultry growthby increasing feed consumption, body mass, and weight, aswell as the concentration of serum amino acids. Isoquinolinealkaloid also boosts the innate immune system by regulatingthe concentration levels of haptoglobin and serum amyloidA. X. Chen et al. found that miR-166a is the most highlyenriched exogenous plant miRNAs in the blood of micefed with rapeseed bee pollen. The study also suggested thatfood-derived exogenous miRNAs from rapeseed bee pollencould be absorbed in mice and the abundance of exogenousmiRNAs inmouse blood is dependent on their original levelsin the rapeseed bee pollen.
Acknowledgments
We would like to thank the authors and reviewers for theirvaluable contributions.
Wenkai RenKai WangPeng Liao
Guan YangYong ZhaoYang Zhou
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