Editorial preface

Editorial Preface Daniel Flynn, Gunda Georg, Victor Snieckus Guest Editors ▼ This issue of the journal is the second of a three-part series dedicated to key presentations from the recently held Third Winter Conference on Medicinal and Bioorganic Chemistry, held January 23 – 29, 1999, in Steamboat Springs, Colorado. Two symposia are highlighted in this issue: Optimization in Chemical Synthesis and Methodologies for Parallel Array Medicinal Chemistry. Victor Snieckus (Queens University), Gunda Georg (University of Kansas), and Daniel Flynn (Amgen, Inc.) serve as guest editors for this issue. The articles from the Optimization in Chemical Synthesis symposium include contributions from Professors Matthais Beller, Carston Bolm, Gilbert Stork, and Paul Wender. Synthetic issues are presented with an emphasis on stereoselectivity, enantioselectivity, atom economy, the invention of new reactions to achieve desired biologically active templates, and recent advances in catalysis. Profes- sor Victor Snieckus provides an introductory perspective to this series of articles. The articles from the Methodologies for Parallel Array Medicinal Chemistry symposium include contributions from Professors David Bergbreiter, Dennis Curran, and Drs. Daniel Flynn, Aubrey Mendonca, and Daniel Pilipauskas. Strategies for controlling phase isolation of products and phase-switching of other reaction species are presented, with emphasis on resin capture techniques, fluorous-phase synthesis, soluble polymers which exhibit interesting phase-switching properties, and polymer-supported building blocks (reactants). An article is included on the practical use of ex- perimental design tools (once the domain of process chemistry optimization) to help practitioners of parallel synthesis identify optimized, validated reaction sequences more quickly. We thank all of the contributing editors for their willingness to provide this series of stimulat- ing articles and trust that you, the reader, will find their content useful and relevant to your own research endeavors. 341 Medicinal Research Reviews, 19, No. 5, 341, 1999 © 1999 John Wiley & Sons, Inc. CCC 0198-6325/99/050341-01

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Transcript of Editorial preface

Editorial Preface

Daniel Flynn, Gunda Georg, Victor Snieckus

Guest Editors

▼

This issue of the journal is the second of a three-part series dedicated to key presentations from therecently held Third Winter Conference on Medicinal and Bioorganic Chemistry,held January 23–29, 1999, in Steamboat Springs, Colorado. Two symposia are highlighted in this issue: Optimizationin Chemical Synthesisand Methodologies for Parallel Array Medicinal Chemistry. Victor Snieckus(Queens University), Gunda Georg (University of Kansas), and Daniel Flynn (Amgen, Inc.) serve asguest editors for this issue.

The articles from the Optimization in Chemical Synthesis symposium include contributions fromProfessors Matthais Beller, Carston Bolm, Gilbert Stork, and Paul Wender. Synthetic issues are pre-sented with an emphasis on stereoselectivity, enantioselectivity, atom economy, the invention of newreactions to achieve desired biologically active templates, and recent advances in catalysis. Profes-sor Victor Snieckus provides an introductory perspective to this series of articles.

The articles from the Methodologies for Parallel Array Medicinal Chemistrysymposium in-clude contributions from Professors David Bergbreiter, Dennis Curran, and Drs. Daniel Flynn,Aubrey Mendonca, and Daniel Pilipauskas. Strategies for controlling phase isolation of products andphase-switching of other reaction species are presented, with emphasis on resin capture techniques,fluorous-phase synthesis, soluble polymers which exhibit interesting phase-switching properties,and polymer-supported building blocks (reactants). An article is included on the practical use of ex-perimental design tools (once the domain of process chemistry optimization) to help practitioners ofparallel synthesis identify optimized, validated reaction sequences more quickly.

We thank all of the contributing editors for their willingness to provide this series of stimulat-ing articles and trust that you, the reader, will find their content useful and relevant to your own re-search endeavors.

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