Editing the genome and New technique boosts efficiency of

blood cell production from human stem cells

Jennifer Alejandra Correa GutierrezMedicine student

3rd semester

establish multi-viral resistance by rewriting code hijacked by viruses

could be used in stem cell therapies for a wide variety of conditions including cancers and immune ailments

Editing the genome

July 14, 2011 Esciencenews

Using a platform called multiplex automated

genome engineering, or MAGE, the team replaced

instances of the TAG codon with another stop codon, TAA, in living E. coli cells.

they found…A genome-scale editing tools as fast and easy as word processing have rewritten the genome of living cells using the genetic equivalent of search, replace and combined those rewrites in novel cell strains, strikingly different from their forebears.

The first: add functionality to a cell by encoding for useful new amino acids.

The second: introduce safeguards that prevent cross-contamination between modified organisms and the wild.

A third: establish multi-viral resistance.

Three Goals

Observation

The cell has the hability to adapt to different environments has

therefore been increasingly easier to manipulate and perform such studies which contribute to the

human sciences.

New technique boosts efficiency of blood cell production from human stem cells July 15, 2011 esciencenews

Researchers now want to find the precise mixes and sequences of chemical compounds needed to coax iPSCs to mature into the tissue-specific stem cells of their choice. The latter are self-renewing, and can be transplanted into the body to produce the 'progenitor' cells that multiply locally and produce mature tissue cells.

,

These may be more valuable medically than any other tissue-specific stem cell, because they can supply not only oxygen-carrying red blood cells but also all the white blood cells of the immune system.

the research team sought to do a better job of mimicking the changing conditions that naturally direct ESCs to become HSCs in the womb.

With their best such cocktail they were able to detect blood-specific markers on 84% of their cells after three weeks.

Observation

through different techniques for the study of cellular life has been to understand the different processes that take place in the cell and could provide great results for medicine.

Medical utility

Medical Utility

Beyond that provide a cure for cancer or other degenerative disease has broken through the barrier of the unknown, and thus contribute to a preventive medicine that is what the world needs.

Medical Utility

Now not only have a treatment, but also can have health in our hands and decide to do with it,

the intelligence of man has come so far that is capable of

controlling the same genome

Bibliography

Biology and nature, Editing the genome. URL:http://esciencenews.com/articles/2011/07/14/editing.genome (esciencenews) Biology and nature, New technique boosts efficiency of blood cell production from human stem cells. URL: http://esciencenews.com/articles/2011/07/15/new.technique.boosts.efficiency.blood.cell.production.human.stem.cells (esciencenews) 

Martínez S. Lina María. Biología Molecular. 6 Ed. Medellín: Upb. Facultad de Medicina, 2011. p 7-36.