ECMO part 2 by Dr.Tinku Joseph
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Transcript of ECMO part 2 by Dr.Tinku Joseph
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Extracorporeal Membrane Oxygenation
Part - 2
Dr.Tinku JosephDM Resident
Department of Pulmonary medicineAIMS, Kochi
Email-: [email protected]
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Contents in ECMO part 1
What is ECMO ? Evolution of ECMO Various Trials Types Indications Veno-venous V/S veno-Arterial
ECMO. Cannulation and Circuit
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Contents in ECMO part 2
Monitoring ECMO patients Ventilatory strategies Sedation and pain control Weaning Complications Recent advances
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Monitoring ECMO patients
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Who comprises the ideal team?
Two intensivists (ECMO intensivist) and/or cardiothoracic surgeons: cannulation
One Medical Officer: monitor cannula position by ECHO
One Medical Officer: clinical management Perfusionist: ECMO priming and
maintenance Respiratory Therapist: lung protective
management, ventilator settings
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• Nurses:– assists in the procedure.– supports clinical
management.– ONGOING CARE FOR
ECMO PATIENT• Radiologic Technician
Who comprises the ideal team?
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Protocol for initiation and stabilization of ECMO
1) Check the cannula site2) Check all ports3) Connect the pressure tubing to the pressure line4) Connect the flow sensor to the flow meter5)Note patient vitals (prior to starting ECMO)6) Send pre –ECMO investigations: ABG, VBG, CBC
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Protocol for initiation and stabilization of ECMO
7) Confirm bolus dose of heparin is given8) Confirm the availability of blood and blood products9) Check for ACT machine10) Request Xray plate from radiology and place under
patient.11) Confirm circuit is primed properly
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Protocol for initiation and stabilization of ECMO
12) Connect Venous end of circuit to venous cannula13) Connect arterial end to artery (VA) or jugular vein
(VV)14) Recheck everything15) Open arterial clamp, clamp the bridge and then
open venous clamp for roller pump.16) Before starting ECMO start centrifugal pump to
provide forward flow
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Protocol for initiation and stabilization of ECMO
17) start the pump with flow of 20 ml/kg/min and gradually increase the flow after every 5-10 mins by 10ml/kg/min up to the desired flow.
18) Adjust gas flow to blood flow ratio 0-5:1 and start FiO2 of 21% and slowly increase to 100%.
19) Check for the color of venous and arterial blood.
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Protocol for initiation and stabilization of ECMO
20)Attach heater cooler unit to oxygenator and adjust temp to 37c
21) Check vitals again22) Check pre pump, pre and post oxygenator
pressures.23) Once desired flow is achieved come down on
ventilator settings to baseline.24) Monitor MAP-: 60-70mmhg25) Reduce inotropes26) If BP is high use NTG
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27) Check ACT & ABG after one hour of starting ECMO28) If ACT is around 200 seconds then start with
heparin infusion @ 20 units/kg/hr29) <160 -: bolus dose of heparin30) >200 -: decrease heparin dose31) Monitor ABG -: Adjust ECMO settings
Protocol for initiation and stabilization of ECMO
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Nursing Considerations:
•
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Nursing Actions Maintain strict infection control. Restrict access to essential personnel. Remove unnecessary invasive lines. Ensure that all required invasive access are
present, eg. NGT, core temp probe. Secure ET tube to maintain access during
procedure maintaining the sterile field.
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Ensure crash trolley in close proximity Ensure fecal softeners as prescribed. Prepare and position patient. Place appropriate
mattress on bed. Clip hair on the proposed site with electric razor. Move the bed so the ECHO machine, ECMO trolley
and sterile field can be positioned
Nursing Actions
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Nursing Assessments
• Routine Assessments:– HR, SaO2, SBP, MAP
• Hourly Assessments:– Neuro-vascular observation– Urine output– Core temperature– Ventilator observations
• Regular Assessments:– CVP– Neurological assessments– Sedation level
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Dressing the cannula Only if there is significant exudates
or if not intact or secured. Required two nurses for dressing.
Dressing changes preferable in day shift.
Pull the dressing off towards the insertion site.
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Blood Works and Diagnostics
Ensure current crossmatch PRBCs are available.
Daily electrolytes, Mg and LFT. CBC BD and as sos. PLATELET COUNT Daily blood cultures during spike of fever or
ideally beginning at 5th day of therapy. Pre and post oxygenator ABG c/o
perfusionist. ACT every 2 hours x 24 hours. APTT every 6 hours, target 55-75 s or as
specified by intensivist.
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Ventilatory strategies
ELSO GUIDELINES FOR RESPIRATORY SUPPORT: Indication: “In hypoxic respiratory failure due to any cause ECLS
should be considered when the risk of mortality is 50% or greater and is indicated when the risk of 80% or greater.
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Ventilatory strategies
A) 50% mortality risk can be identified by PaO2/FiO2 <150 on FiO2 >90% and/or Murray score 2 to 3. (Consider ECMO)
B) 80% mortality risk can be identified by a PaO2/FiO2 <80 on FiO2 >90% and Murray score 3 to 4. (ECMO Indicated)
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2) Co2 retention due to asthma or permissive hypercapnia with a PaCo2 >80 or inability to achieve safe inflation pressure (Pplat <30cmH2O).
3) Severe air leak syndromes.
Ventilatory strategies
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Goal -: to let the lung rest and yet not allow total lung collapse.
ECMO provides adequate gas exchange. Reduces chances of VILI. Patient may not require intubation at times. Low tidal volume required Less sedation Early rehabilitation.
Ventilatory strategies
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Sedation and Pain control
Goal: Keep the patient comfortable
with minimal sedation Daily interruption-give awake
cycle Avoid muscle relaxant as far as
possible.
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Sedation and Pain control
Indications for sedation: To relieve pain and anxiety Decrease O2 consumption and CO2 production Prevent patient from removing lines Patient ventilator asynchrony To give normal sleep pattern at night Before any procedure
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Sedation and Pain control
Indications for muscle relaxants: Patient ventilator asynchrony When patient movement interferes
with venous return To prevent accidental decannulation
– due to excessive patient movement
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In awake patient:
Better lymphatic drainage from the lungs with the spontaneous breathing as compared to positive pressure ventilation.
Lesser haemodynamic effect, lesser ventilator requirements and peak pressures.
Better infection control
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Sedation and Pain control
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Weaning
After giving adequate rest to the organ.
When they show signs of improvement.
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Criteria for weaning trial
RESPIRATORY: CXR is improving Lung compliance improve: compliance >0.5 mL/kg ABG- on rest ventilator setting with moderate ECMO
support PaO2 >60mmhg PaCo2 <50mmhg PH >7.35 Successful 100% oxygen challenge test.
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CARDIAC: HR <120/min Systolic BP >90mmhg or pulse pressure >40mmhg,
mean arterial pressure >70mmhg CVP <12 mmhg Urine output > 0.5 cc/kg/hr (ARF case excluded) Good tissue perfusion as revealed by blood lactate <3
mol/L and SVO2 >65% CXR improving 2 D Echo-: EF >40%
Criteria for weaning trial
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Method of weaning- VA
Slow gradual process Moderate ECMO & moderate ventilatory settings
(FIO2 <40%, PEEP 8-10)Method 1 Upgrade ventilatory settings and start inotropes if
required. Gradually reduce blood flow (10 ml/kg/hr). Continue
till minimum flow Heparin should be maintained to prevent circuit
clogging.
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Method 2: Withdraw a total ECMO support for few minutes and
observe parameters If patient tolerates gradually period of off ECMO is
increased. Patient can tolerate >2 hours off ECMO, consider
decannulation
Method of weaning-VA
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1) Decreasing pump flow (20 ml/kg/min) -: Not used now a days.
2)Oxygen supply is reduced. More simple way. FiO2 is reduced by 5% every 30 minutes. Ventilator
setting is upgraded. FiO2 is 21% then sweep gas flow is being reduced by
10% every 30 minutes Alternate method: Only sweep gas reduced. FiO2
unchanged.
Method of weaning-VV
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Rush weaning
Forced to remove ECMO even when higher degree of support is required
Indications: Massive bleeding Severe haemolysis Worsening intracranial bleed Infection related to cannula
Risk of continuing ECMO is more than risk of discontinuing ECMO
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Decannulation
Ensure two medical staff are involved in the removal of the cannulas, while a third medical staff clinically manage the patient.
Coordinate with perfusionist and respiratory technician about the plans.
Ensure that direct pressure is applied on the insertion site for at least 20 minutes and the ECMO intensivist will remain with the patient until hemostasis achieved.
Coordinate with intensivist about the need for sedation and pain medication before the procedure.
Carry out successive Doppler assessment of the decannulated limbs after catheter removal.
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Complications
• PATIENT RELATED:• Bleeding• Hemolysis• Recirculation• Infection
• CIRCUIT RELATED:• Clot
formation• Plasma Leak• Oxygenator
Failure• Heat
Exchanger Failure
• Tubing, Connector Cracks and Blood Leakage
• EMERGENCIES:• Pump Failure• Decannulation• Air Embolism • Cardiac Arrest
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Bleeding
Hourly cannula site assessment. Monitor clotting time, Hb, platelets. Ensure access sites are stabilized. Do
not dislodge clots directly from wounds or insertion sites.
Maintain enteral feeding if tolerated; ulcer prophylaxis.
Report blood loss. Ensure current crossmatched PRBC. Give blood products as ordered.
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Hemolysis Monitor the lab results( CBC, U/E and urine) Hourly assessment for movement(kinking) of the access
cannula Hourly assessment of the temperature of the heat exchanger
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Thromboembolism
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Recirculation
Monitor the SPO2 and ABG values Colour of RETURNED BLOOD Ensure catheter security during patient
movement.
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Infection
Prevent high risk of nosocomial infection. Closely watched for signs of infection
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Circuit Related Complications
Clot formation Maintain anti-coagulation as prescribed Plasma Leak. Oxygenator Failure Heat Exchanged Failure Tubing Cracks or blood leakage
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ECMO Emergencies
Pump failure- power check Decannulation- reinsertion Air embolism-
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Cardiac Arrest- VA ECMO- - No Chest compression -VV ECMO-chest compression
ECMO Emergencies
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Future of ECMO
Increased accessibility and use Reduction in costs Insurance / government support Smaller lines / volumes /
oxygenators Coated “stealth” tubings (nano
particles). Smaller or portable ECMO
machines
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Newer ECMO machines
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When God is going to do something wonderful he begins with a difficulty…….If he is going to do something very wonderful. He begins with a……..ECMO Machine(Quote by an ECMO survivor)