E-Cigarette ENSP Athen 2013 Press Conf PDF

ENSP e-cigarettes 2013 www.ofta-asso.fr/docatel/Rapport_e-cigarette_VF_1.pdf 1

Rapport et avis dexperts sur

le-cigarette Avec le soutien de la Direction gnrale de la sant

Mai 2013

E-cigarette : Lessons from 31

may French report

Bertrand Dautzenberg,

Professor of pneumology University Pierre

et Maris Curie Paris, Piti-salptire hospital

and OFT (Office franais de prvention du

tabagisme).

[email protected]

No conflicts of interest on the topic


Tobacco

e-cigarette

Tobacco control

E-cigarettes is in 2013 a very small part of the tobacco control

problem in 2013. In 2016 we may anticipate a signifiant part

We have the certitude than tobacco smoke kill 700 000 EU citizens each year

e_cigarette is much less toxic than regular cigarette but need precautions.

ENSP e-cigarettes 2013 www.ofta-asso.fr/docatel/Rapport_e-cigarette_VF_1.pdf

First patent

1965


HON LIK [CN] +

Applicant(s): HON LIK [CN] +

Classification:

- international: A24B15/16; A24D1/00; A24F47/00; A61K9/00; (IPC1-

7): A24B15/16

- cooperative: A24F47/002; A61K9/007

Application number: EP20040718242 20040308

Priority number(s): WO2004CN00182 20040308 ; CN20031011582

20030429

Also published as:

EP1618803 (A4) EP1618803 (B1) US201227358

9 (A1) US2012090630 (A1) US2006196518 (A1)

more

Brevet 2006 de Hon Lik

The invention relates to a non-smokable electronic spray cigarette which only comprises nicotine without harmful tar. The cigarette includes a smoke mouth integer comprised with a shell, a cell, a high frequency ionizer, nicotine solution storage and its container, control circuit, a display screen, a human contact sensor, a piezoelectric supersound atomizer, a high temperature vaporization nozzle and attachments, an electro-thermal vaporization nozzle installed in the air suction end of the shell goes through an electric control pump or a valve with a measuring chamber and a liquid storage container which contains nicotine solution and is connected to the electric control pump or a valve with a one-way flow valve, the control circuit plate has four export ends individually connected with the high frequency ionizer, electric heater, pump or valve and the display screen,; a human resistence sensor and an air flow sensor are connected to the input end of the control circuit. The advantages of the present invention are smoking without tar, reducing the cancerogenic risk, the user still feel smoking and experiercing the excitement, the cigarette is no need to be lit and is no fire danger.

Kon Lik 2006

patent


The market of e-cigarettes will be more important than

the market of smoking cessation in 2013

5

30 60 120

260

510

1000

0

200

400

600

800

1000

1200

2008 2009 2010 2011 2012 2013*

US market of e-cigarettes millions $


According to 2012

eurobarometer,

Greck population is

more heavy user than

other Eu citizen with

8% experimentation

1% occasionnal use

2% regular use

2013 data are expected

soon

6


e-cigarette & e-liquide ?

Mouth piece

atomizer batterie diode

cartridge

New e-refilling e-cigarette dont look like cigarettes but are more attractives

Single use e-cigarette look like cigarettes, but where usually less attractive


E.liquide

Tabacco smoke

vapor

Same chemical content

Different chemical content


1 e-liquide in cartridge.

e.ci

gare

tte

air

Use

r

2 Electric shock heath e-liquide

produce vapor

3 Condensation of gaze in small liquid particules

4 Smoker inhale gaz and liquid particules

5 inhalation.

Half life of liquid particule is short

(11 sec with PG)

6 Dissipation of gazes

Formation of artificial fume


E cig 78

Aerosol characteristic are not the same with vegetal

glycerin and propylene glycol

Propylne glycol

Glycrine vgtale

10 100 1000 10 100 1000

180 000

100 000

0

20 000

0

10 000

Immdiate 10 secondes 40 secondes

Immdiate 10 secondes 40 secondes

CMAD

CMAD


Vansickel AR, Cobb CO, Weaver MF, Eissenberg TE.A clinical laboratory model for evaluating the acute effects of electronic "cigarettes": nicotine delivery profile and cardiovascular and subjective effects. Cancer Epidemiol Biomarkers Prev. 2010 Aug;19(8):1945-53.

2010 5


No more NNK than

in NRT medication

12

Product NNN NNK NAT NAB Total Electronic

Cigarette 3.87 1.46 2.16 0.69 8.18

Nicotine Gum 2 ND ND ND 2

Nicotine Patch ND 8 ND ND 8

Swedish Snus 2400 Canadian Mild

Ultra 445 540 552 NQ 1537

Du Maurier

Regular 308 523 448 NQ 1277

Export A Ultra

Light King 794 848 752 122 2516

Gitanes Kings 6369 1477 2965 354 11165

Benson &

Hedges Ultra

Mild

522 733 629 NQ 1884

Winston 2200 580 560 25 3365 Newport 1100 830 1900 55 3885 Camel 3100 1400 2800 150 7450

Skoal 4500 470 4100 220 9290

Marlboro 4300 1800 4900 190 11190

http://smoke-vs-

vapor.webs.com/nitrosa

minelevels.htm


Some chemical substances in cigarette smoke and e-cigarette aerosol

13

Composs N CAS background e-cigarette

1 e-cigarette

2 e-cigarette

3 cigarette 1,2-Propandiol 57-55-6


Cancerogen in e-liquide and in cigarette smoke

14

Substance UK e-

cigarette UK cigarette Groupe IARC

cancrognes % (e.cig/20 cig)

Anthracne 7 130 3 0,27%

Phnanthrne 48 350 3 0,69%

1-Mthyl phnanthrne 5 30 3 0,83%

Pyrne 36 130 3 1,38%

Benz(a) anthracne Under limit 45 2A 0%

Chrysne Under limit 50 3 0%

Benzo(b) fluoranthne Under limit 30 2B 0%

Benzo(k) fluoranthne Under limit 9 2B 0%

Benzo(a) pyrne Under limit 35 2A 0%

Benzo(e) pyrne Under limit 16 3 0%

Perylne Under limit 4 3 0%

Indeno(1,2,3-cd)pyrne Under limit 12 2B 0%

Dibenz(ah) anthracne Under limit 4 2A 0%

Benzo(ghi) prylne Under limit 60 3 0%


tar

CO

PM

Cancer

cardio

vascular risk

COPD

Upper

airway

addiction

tar

CO

PM

irritants irritants

nicotine nicotine


Vansickel AR, Eissenberg T. Nicotine Tob Res. 2013

Jan;15(1):267-70

5 11ng/ml

In 2013 Electronic cigarettes: effective nicotine delivery

after acute administration.


0

5

10

15

20

2010 2010 2012 2013 piccigarette

nicotine ng/ml

New devices are good delivery system


60,6

2,4

61,3

2,6 0

10

20

30

40

50

60

70

Actif Passif

Cotinine in serum (ng/ml) in active and passive user of e-cigarette and cigarette

e.cigarette

cigarette

http://informahealthcare.com/doi/abs/10.3109/08958378.2012.758197 Flouris 2013


Effect on cigarette and e-cigarette

on lung mesured by FEV(1)

19

3%

2,30%

7,20%

3,40%

0%

1%

2%

3%

4%

5%

6%

7%

8%

Actif Passif

decrease FEV1/VC e-cigarette

cigarette

http://informahealthcare.com/doi/abs/10.3109/08958378.2012.758197


Time to decrease desir to smoke

5 Cigarette

25

inhaleur

14 E-cig 16 mg

E-cig 0 mg


Nicotine depedance ?

tobacco E.cigarette

Nicotine dependance ?

Tabacco e.cigarette

Persistance addiction

Decrease of addiction

E-cigarette : Product of initiation of Tobacco dependance

e-cigarette to go in and out nicotine dependence


What we want to see in

France 1- A product to help smokers to quit tobacco

risk reduction : cigarettee-cigarette

out of tobacco and nicotine

2- NOT a product for non smokers

Risk of initiation to nicotine dependence

Use to re-normalize-cigarette (non smoking place)

Use as promotion as cigarette

22


Sail of

cigarettes

13,5 millions user

Sail of

cigarettes

-8%

13,5M 12,5M ?

1M e-cig

extrapolation

2012 2013 14/ 2012 14/ 2013

Official datas

Yes Decrease of tobacco market (and use)


Yes

First page of a

French new paper

31 may 2013


No

First page of a

French new

paper early 2013

Promotion of

use e-cigarette

every where

including non

smoking place


Some advertising is clearly for teenagers

26

No


Placement of e-cigarette in fim : Johnny Depp

explain to Angelina Jollie how to use e-cigarette

27

http://www.wat.tv/embedframe/198477chuPP3r5586959

No


A product to dont stop to smoke

28

No


Use by non smoke increase

Rapport et avis dexperts sur

le-cigarette Avec le soutien de la Direction gnrale de la sant

Mai 2013

0,8% 1,1% 1,4%

3,2% 3,8% 4,0%

6,0%

8,40%

0,0%

1,0%

2,0%

3,0%

4,0%

5,0%

6,0%

7,0%

8,0%

9,0%

USA Pearson(2012)

Core jeunes(2012)

Pologne 15-19 ans filles

(2011)

Pologne 15-19 ans

garons(2011)

USA Regan(2013)

France PST12-14 ans

(2012)

France OFTMdecine W

(2013)

FrancePST12-19ans

Non-fumeurs exprimentant l'e-cigarette

No


To achieve the end tobacco, the first

preventable cause of death, e-cigarette

may play a positive and a negative role

+ How to facilitate access to e-cigarette to all

smoker who dont plane to quit by usual way for cessation or reduction ?

- How to prevent : Use by non smokers and adolescents

tobacco industry lobbying and indirect promotion

Renormalization of tobacco use

30

E-Cigarette ENSP Athen 2013 Press Conf PDF

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