DrugTest 5000: What’s Your Tolerance?...Recent Use DrugTest 5000: What’s Your Tolerance “Well...
Transcript of DrugTest 5000: What’s Your Tolerance?...Recent Use DrugTest 5000: What’s Your Tolerance “Well...
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DrugTest 5000: What’s Your Tolerance?
2019 Mining Health and Safety Conference
Dräger, April 11th 2019
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Dräger Mining Solutions
An extensive portfolio
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Thermal Imaging Cameras Workshops and Training
Systems
Portable Gas Detection Stationary Gas Detection
Breathing ProtectionSelf Rescuer & Life
Support Systems
Respiratory Protection Test Equipment &
Breathing Gas Supply
Fitness
for Duty
Opencast
Mining
Emergency
Escape
Underground
Mining
Cleaning, Dis-
infection and
Maintenance
Processing
and Refining
Emergency
Response and
Rescue
Mine Exploration,
Planning and
Construction
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Dräger Mining Solutions
An extensive portfolio
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Dräger DrugTest®
Drug testing devices
Dräger Alcotest®
Screening and evidential
alcohol measuring devices
Dräger Interlock®
Alcohol measuring
devices with vehicle
immobilizer
Extended portfolioAlcohol and drug detection
From providing top of the
line evidential breath alcohol
testing to roadside alcohol
and drug screening, Draeger
is dedicated to improving
safety.
With our alcohol and drug
detection devices you
benefit from the results of
our extensive experience.
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HairOral Fluid
Months
Urine
DaysHours
Recent drug use recent/mid-term consumption drug history
How to detect for drugs in the workplace
DrugTest 5000: What’s Your Tolerance?
“...because marijuana metabolites are detectable for many days to weeks after
cessation of use, a positive urinary drug screen does not imply impairment.”
Dr. Brendan Adams, Marijuana and the Safety-Sensitive Worker, COAA website, 2018
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Dräger DrugTest® 5000 – How it Works
DrugTest 5000: What’s Your Tolerance?
Our Drug Detection Instrument for Oral Fluid screening consists of 2 main parts:
DrugTest Cassette DrugTest 5000 Analyzer
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Current Affairs
DrugTest 5000: What’s Your Tolerance?
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Approved by Minister of Justice
for Law Enforcement Use
“A positive result [on the Draeger
DrugTest 5000 oral fluid screener] would
be a strong indication of recent use.”
How has workplace prepared for the
decriminalization of marijuana?
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Current Affairs
DrugTest 5000: What’s Your Tolerance?
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Cannabis use amongst youth aged
15-24 is 3X more than adults*
Rate of daily use among general
population is steadily increasing*
Canadians already spend $6B a year
on cannabis**
*Canadian Center on Substance Use and Addiction,
Canadian Drug Summary, June 2018
**Statistics Canada, Cannabis Economic Account, 1961 to
2017
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Detection Times after consumption
Blood, Saliva & Urine
AMP
MAMP
MDMA
THC
THC-
COOH
COC
BE
MOR
2d24h 3d 4d 5d
Blood
UrineSaliva
Consumption
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Blood
Urine
Saliva
Cessation ~5 days later
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Recent Use
DrugTest 5000: What’s Your Tolerance
“Well established that cannabis is an impairing drug. Blood concentrations
do not correlate well with impairment - blood concentration can decline
rapidly after smoking well before the impairing effects have dissipated
From a toxicologist point of view, recency of use can give useful information
about whether an individual is impaired by cannabis use”
Karen Woodall, Forensic Toxicologist, “Oral Fluid Screening Devices and Toxicology”, presented at Arrive
Alive Conference 2018
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HairOral Fluid
Months
Urine
DaysHours
reasonable cause pre-employment
post-incident,
post accident
pre-entry
random
random
Recent drug use recent/mid-term consumption drug history
pre-employment
Which test methods to choose
DrugTest 5000: What’s Your Tolerance?
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Cannabis - Pharmacology
Cannabinoids
> 500 chemicals &
109 Cannabinoids, like:
Cannabinol, CBN
Cannabidiol, CBD
Cannabigerol, CBG
THC-cannabivarin, THCV
TetraHydroCannabinol, 9-THC
OH
O
CH3
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1. Absorbtion
(Consumption),
i.e. via lung or
veins into blood
stream
2. Distribution
through the blood
system in the
body; effects
3. Metabolism,
(Degradation)
mainly in the liver
4. Elimination
(Excretion);
from the body i.e.
by the urine,
which is produced
in the kidney
Consumption Distribution, Effects Degradation Excretion
Drug
Metabolites
The Path of Drugs in the Human Body
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Cannabis - Pharmacology
Main Metabolism Route – Plasma Concentrations after smoking
www.leafly.com drawn from data in Huestis et al: J Anal Toxicol. 1992 Sep-Oct;16(5):276-82.
Delta-9-THC
Hydroxy-THC
Carboxy-THC
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Sample Pad Detector particles:
Color-labeled antibodiesCapture zone with
drug conjugatesAbsorbent
fleece
Sample
...without drugs
...or with drugs
Basic design of a lateral flow test strip
Inside the Test Cassette
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Oral Fluid when NO Drug is present
YYYY
Detection zone with
Embedded drug-conjugate
Sample pad Labeled antibodyAbsorbent pad
Y
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Oral Fluid when NO Drug is present
Detection zone with
Embedded drug-conjugate
Sample pad Labeled antibodyAbsorbent pad
Y
signal to
detector
Signal = Negative
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Oral Fluid when a DRUG is present
YYY
Detection zone with
Embedded drug-conjugate
Sample pad Labeled antibody
Absorbent pad
No signal to
detector
Low or No Signal = Positive
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Validation and Evaluation
As the analyser determines a positive or negative sample based on the intensity of the line,
line intensity is the key.
Its precise and reproducible occurrence is based on many factors, like the quality of the
antibody, but also on the quality of marking reagents.
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Validation and Evaluation
As the analyser determines a positive or negative sample based on the intensity of the line,
line intensity is the key.
Its precise and reproducible occurrence is based on many factors, like the quality of the
antibody, but also on the quality of marking reagents.
A faint signal may be negative or positive depending on intensity compared to calibration
values stored in the barcode.
This technique makes the DrugTest® 5000 system more reliable than visually read tests.
Plus: Temperature control
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Minutes Hours YearsDays Weeks Months
From: Caplan & Goldberg, 2001, J. Anal. Tox 25, 396-399
Blood
“Oral Fluid”
“recent
consumption
Urine
Hair, Nails
Timepoint of consumption
Window of Detection
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„Cut-off“ when drug testing
Time
= THC Curve (simplified)
Concentration
Recent Use
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„Cut-off“ when drug testing
Time
= THC Curve (simplified)
T1
Windows of detection
POCT high Cutoff
(unsensitive)
Concentration
Recent Use
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„Cut-off“ when drug testing
TimeT2
= THC Curve (simplified)
T1
Windows of detection
POCT high Cutoff
(unsensitive)
POCT low Cutoff
(sensitive)
Concentration
Recent Use
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Standardization:
each maximum got the value 100
Cannabis - Pharmacology
THC Conc – Performance Deficit – Subjective High
To cover as much potentially impaired persons as possible→ sensitive detection, low cutoff
5 ng /ml =
still performance deficit
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Cost Calculator
DrugTest 5000: What’s Your Tolerance
Value Calculator Oral-Fluid versus Urine Drug Testing
(hypothetical)
Item Description Oral-Fluid Urine
Number of Tests 1,000 1,000
Cost per screening test $40.00 $20.00
Cost per test regime $40,000.00 $20,000.00
Positive Rate in %** 2% 6%
Number of Lab Confirmations 20 60
Cost for Lab Confirmation Each $150.00 $100.00
Total Cost for Lab Confirmation $3,000.00 $6,000.00
Downtime in days 20 180
Cost per downtime day $200.00 $200.00
Total Downtime Cost**** $4,000.00 $36,000.00
Lab Re-test $3,000.00 $6,000.00
Labour Hire Per Person, Per Day $300.00 $300.00
Labour Hire Total $6,000.00 $54,000.00
Total Cost $56,000.00 $122,000.00
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** There are more positive tests in Urine testing due to the longer duration of test period – ie months not hours.
**** There is a longer downtime in Urine testing as it takes longer for the drug to dissipate and so the employee must stay away
from the workplace longer
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DrugTest 5000: What’s Your Tolerance
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Risk Mitigation
Employee gets positive test
days after consuming THC
Replace urine test with oral fluid test to ensure small
window of detection and best indication of recent use
Lost time due to employees
waiting for test results
Use OF POCT screener to get result on-spot within
minutes. Return workers to work upon negative test
Lack of national standard
for workplace drug testing
Develop policy that suits the workplace using proven
technology – OF mobile screener validated by
Canadian government for roadside law enforcement
Challenge by
employees/unions
Use technology with least invasive sample collection,
high degree of accuracy, results in minutes, indication
of recent use (short window of detection)
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Draeger DrugTest 5000
Test Cassette – Cut Off Levels
5 ng/ml THC (Δ9-tetrahydrocannabinol)
Immunoassay (Competitive Inhibition)
Electro-Optical Reader
Clear Results / No Interpretation
Integrated Data Management
Non-invasive & hygienic
Only oral fluid screening device approved in
Canada by the DOJ for roadside testing
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THANK YOU
Sandi Davis John
Director of Marketing
Tel: +416 709 5572
Workplace Safety North Mining Health & Safety Conference | Sandi Davis John | 04/11/201929 | 30
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DrugTest 5000: What’s Your Tolerance
Workplace Safety North Mining Health & Safety Conference | Sandi Davis John | 04/11/201930 | 30
Risk Mitigation
Employee gets positive test
days after consuming THC
Replace urine test with oral fluid test to ensure small
window of detection and best indication of recent use
Lost time due to employees
waiting for test results
Use OF POCT testing to get result on-spot within
minutes. Return workers to work upon negative test
Lack of national standard
for workplace drug testing
Develop policy that suits the workplace using proven
technology – OF mobile screener validated by
Canadian government for roadside law enforcement
Challenge by
employees/unions
Use technology with least invasive sample collection,
high degree of accuracy, results in minutes, indication
of recent use