Drugs used in epilepsy
-
Upload
buffy-floyd -
Category
Documents
-
view
74 -
download
3
description
Transcript of Drugs used in epilepsy
![Page 1: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/1.jpg)
![Page 2: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/2.jpg)
ObjectivesEpilepsy (1)Describe types of epilepsyClassify antiepileptic drugs according to the
type of epilepsy treated and generation introduced
Expand on pharmacokinetic and dynamic patterns of first generation antiepileptic drugs and specify their mechanism of action , therapeutic indications and adverse effects.
![Page 3: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/3.jpg)
ObjectivesEpilepsy 11Expand on pharmacokinetic & dynamic
patterns of 2nd generation of antiepileptic drugs and specify their mechanism of action , therapeutic indications & adverse effects
Specify management strategies adopted for status epilepticus concentrating on the drugs used.
![Page 4: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/4.jpg)
Prof. Mohammed
Saad Al-Humayyd
Prof. Azza Hafiz El-Medany
![Page 5: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/5.jpg)
Epilepsy
Is viewed as a symptom of disturbed electrical activity in the brain caused by a wide variety of disorders .
![Page 6: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/6.jpg)
• Epilepsy is a general name given to the
wide range of symptoms that reflect
functions of brain including changes in
movement, behavior, sensation or
awareness. These interruptions , known
as seizures. The attack may last from a
few seconds to a few minutes. People who
have two or more seizures (with in 6 -12
months) are considered to have epilepsy.
![Page 7: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/7.jpg)
![Page 8: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/8.jpg)
SeizureSeizure
![Page 9: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/9.jpg)
![Page 10: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/10.jpg)
EtiologyIdiopathic SymptomaticInherited abnormality in
the C.N.S.TumorsHead injuryHypoglycemiaMeningeal infectionsDrug withdrawalPhoto epilepsy ( by
watching TV)
![Page 11: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/11.jpg)
TriggersFatigue
Stress
Sleep deprivation
Poor nutrition
![Page 12: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/12.jpg)
Generalized: Both hemispheres + loss of consciousness. Tonic-clonic (Grand mal)
Stiffness (15-30 sec) followed by violent contractions & relaxation (1-2 minute)
Absence (Petit mal)
Brief loss of consciousness with minor muscle twitches eye blinking
Myoclonic Rhythmic, jerking spasmsClonic Spasms of contraction & relaxation
Tonic Muscle stiffness Atonic Sudden loss of all muscle tone
![Page 13: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/13.jpg)
PartialArise in one cerebral hemisphere
[1] Simple (consciousness is retained)
Features depend on part of brain affected
Motor cortex(Jacksonian epilepsy)
Jerking, muscle rigidity, spasms, head-turning
Sensory cortexVisual cortex
Unusual sensationsFlashing lights
Autonomic
Psychologic Memory or emotional disturbances
[2] Complex (Altered consciousness)
Automatisms (lip smacking, hand wringing) & behavioral changes, preceded by aura
[3] Secondarily generalized seizure
Begins as partial (simple or complex) and progress into grand mal seizure, tonic and clonic of all limbs.
![Page 14: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/14.jpg)
![Page 15: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/15.jpg)
Tonic-clonic (grand mal) seizures
![Page 16: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/16.jpg)
Absence seizuresbrief; loss of
consciousness
accompanied by minimal
motor manifestations
cessation of an ongoing
behavior
full recovery is evident
after 5-15 sec.
![Page 17: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/17.jpg)
Partial seizures
loss of awareness or contact with the
environment, often associated with
behavioral or complex motor
movements for which the patient is
amnesic after the attacks
Complex
consciousness is often preserved. (e.g.deviation of the head & eyes to one side)
Simple
![Page 18: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/18.jpg)
General rules for drug therapy of epilepsy
Antiepileptic drugs suppress but not cure seizures
Antiepileptic drugs are indicated when there is two or more seizures occurred in short interval ( 6 m-1y)
Monotherapy is an initial therapeutic aim .
![Page 19: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/19.jpg)
Drugs are usually administered orally
Monitoring plasma drug level is useful
Triggering factors can affect seizure control by drugs.
Sudden withdrawal of drugs should be avoided causing status epilepticus
![Page 20: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/20.jpg)
Withdrawal consideration
After seizure –free period of 2-3 up to 5 years from the last fit.
Normal neurological examination , Normal EEG, Brain Scan ( CT, MRI)
![Page 21: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/21.jpg)
Mechanism of Anti-Epileptic DrugsAnti –epileptic drugs inhibit depolarization of
neurons by following mechanisms:Inhibition of excitatory neurotransmission
(Glutamate )Enhancement of inhibitory neurotransmission
(GABA )Blockage of voltage-gated positive current
(Na+ )
(Ca2+ )
Increase outward positive current (K+ )
Many anti-seizure drugs act via multiple mechanisms
![Page 22: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/22.jpg)
Blockade of voltage –gated channels (Na+ or Ca+)
![Page 23: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/23.jpg)
Classification of antiepileptic drugs First-generation Phenytoin
Carbamazepine
Valproic acid
Ethosuximide
Second- generation Lamotrigine
Topiramate
![Page 24: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/24.jpg)
CarbamazepinePharmacokinetics :
Available only orally
Potent enzyme inducer & has the ability to induce its own metabolism
![Page 25: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/25.jpg)
CarbamazepineMechanism of action Blockade of Na+
channels reduces cell excitability.
Reduces propagation
of abnormal impulses in brain
Suppresses repetitive neuronal firing
Attenuates action & release of glutamate
Therapeutic uses: First drug of choice
for partial seizures especially complex type.
generalized tonic-clonic seizures.
Not used in :o Myoclonic , absence
seizures , status epilepticus
![Page 26: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/26.jpg)
Side effectsGIT upset. Skin rashes Neurosensory (confusion , ataxia,
diplopia, blurred vision, nystagmus)Leucopenia , aplastic anemia &
agranulocytosis Hyponatremia & water intoxication Teratogenicity . Induction of hepatic P450
![Page 27: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/27.jpg)
PhenytoinPharmacokinetics :
Given orally fosphenytoin IVI & IMI
Enzyme inducer
![Page 28: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/28.jpg)
FosphenytoinA Prodrug.
Given i.v. or i.m. and rapidly converted to phenytoin in the body
Avoids local complications associated with phenytoin injection
![Page 29: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/29.jpg)
Phenytoin Mechanism of actionBlockade of Na+
channels.
Interferes with the release of excitatory transmitters
Potentiates the action
of GABA
Therapeutic uses:Partial and
generalized seizures
In status epilepticus
Not used in absence seizure
![Page 30: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/30.jpg)
Side effects Acute C.N.S. toxicity (diplopia, vertigo,
nystagmus )Cardiac arrhythmiasNausea, vomiting
Chronic connective tissue effects ( gum
hyperplasia, coarsening of facial features, hirsutism , acne) . Better to be avoided in young women or adolescents .
![Page 31: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/31.jpg)
Phenytoin- induced gum hyperplasia
![Page 32: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/32.jpg)
Chronic adverse effects ( cont.)Folic acid deficiency ( megaloblastic
anemia)
Vitamin D deficiency (osteomalacia)
Teratogenic effects Induction of P450 enzymes
![Page 33: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/33.jpg)
Sodium ValproateBroad spectrum antiepilepticPharmacokinetics :
o Available in different forms mainly as capsules, Syrup , enteric-coated tablets
o Enzyme inhibitor
![Page 34: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/34.jpg)
Sodium valproate
Mechanism of action Blocks activated Na+
channels. Enhances GABA
synthesis & reduces degradation
Suppress glutamate action. Blocks T-type Ca2+
channels
Therapeutic Uses
[I] Epilepsy:It is effective for all forms of
epilepsy Generalized tonic-clonic
seizures (1ry or 2ry ). Absence seizures Complex partial seizuresMyoclonicAtonicphotosensitive epilepsy
Not in status epilepticus
[II] Other uses:•Bipolar disorder and mania •Prophylaxis of migraine •Lennox-Gastaut syndrome
![Page 35: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/35.jpg)
Lennox-Gastaut syndrome Is a severe form of epilepsy. Seizures usually
begin before 4 years of age.
Seizure types vary may include tonic , atonic and myoclonic
Most children with Lennox-Gastaut syndrome experience some degree of mental retardation along with behavioral disturbances.
![Page 36: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/36.jpg)
Side effects:
Weight gain Alopecia ( temporary)
Thrombocytopenia Hepatotoxicity Teratogenicity ( spina bifida) Enzyme inhibitor of P -450
![Page 37: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/37.jpg)
EthosuximideMechanism of action Inhibits NADPH-linked aldehyde
reductase necessary for the formation of ý- hydroxybutyrate which has been associated with the induction of absence seizures
Inhibits T- type Ca2+ channels in thalamo- cortical neurons.
![Page 38: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/38.jpg)
PharmacokineticsAbsorption is completeSyrup & capsule formsNot bound to plasma proteins or tissuesMetabolized in liver10-20% of a dose is excreted unchanged
the urine
![Page 39: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/39.jpg)
Therapeutic uses
Absence seizures
Adverse effects
Nausea & vomiting (up to 40%)
Drowsiness, fatigue , hiccups , headaches
![Page 40: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/40.jpg)
Lamotrigine
Mechanism of action Blockade of Na+
channels
Reduces the synthesis and release of glutamate & aspartate
Therapeutic UseAdjunctive therapy
for partial & generalized refractory seizures
Monotherapy in partial seizures
Lennox-Gastaut syndrome
![Page 41: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/41.jpg)
PharmacokineticsRapidly absorbedOral bioavailability is 98%Metabolized in liverLess than 1% is excreted renallyNo difference in elderly from those younger
subjects
![Page 42: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/42.jpg)
Side effectsDiplopia , Ataxia, drowsiness, headache ( most reported side effects )
Severe skin rashes (Steven –Johnson
reaction )
Somnolence
![Page 43: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/43.jpg)
TopiramateMechanism of
action Blockade of Na+
channels
Potentiates the action of GABA
Therapeutic UseAdjunctive therapy for
refractory partial seizures
Secondary generalized seizures
![Page 44: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/44.jpg)
Side effectsAtaxia , Dizziness , drowsiness
Somnolence Weight lossRenal stones Decreases the effect of oral
contraceptive
![Page 45: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/45.jpg)
Drugs used for treatment of Status Epilepticus
Most seizures stop within 5 minutes. When seizures
follow one another without recovery of consciousness,
it is called “status epilepticus”. It has a high mortality
rate . Death is from cardiorespiratory failure.
![Page 46: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/46.jpg)
Antiepileptic drugs used in treatment of status epilepticus Lorazepam /diazepam I.V Phenytoin / fosphenytoin (I.V)
Phenobarbital ( I.V.)
![Page 47: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/47.jpg)
Vagal nerve stimulationIt is an alternative for patients who have been refractory to multiple
drugs .
Who are sensitive to the adverse effects
It is an expensive procedure
![Page 48: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/48.jpg)
![Page 49: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/49.jpg)
NO antiepileptic drug is safe in pregnancy.
Patient has to continue therapy.
Use the lowest effective doses
![Page 50: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/50.jpg)
![Page 51: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/51.jpg)
Summary- Epilepsy is classified into partial or
generalized according to the site of lesion.The main mechanism of antiepileptic action is
through blocking the activated sodium channelsPhenytoin is mainly used for treatment of
generalized tonic-clonic seizures .The adverse effects of phenytoin include gum
hyperplasia , teratogenecity.Carbamazepine is mainly used for treatment of
partial seizures
![Page 52: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/52.jpg)
Summary ( con.)The main adverse effects of carbamazepine
includes :Blood dyscrasis & hepatic toxicitySodium valproate is a broad spectrum antiepileptic
drugThe adverse effects of sodium valproate includes
hepatic toxicity , increase body weightLamotrigine is used as monotherapy or adjunctive
therapy in refractory casesLorazepam , diazepam , phenytoin are used
intravenously for treatment of status epilepticus
![Page 53: Drugs used in epilepsy](https://reader030.fdocuments.us/reader030/viewer/2022033023/5681316d550346895d97e898/html5/thumbnails/53.jpg)
Summary therapeutic usesSeizures type and drug of choice: Partial-simple or complex: valproic acid ,
phenytoin , carbamazepineGeneral Tonic –clonic: valproic acid ,
phenytoin , carbamazepineAbsence: Ethosuximide, valproic acid,
clonazepamGeneral-myclonic: valproic acid, clonazepamStatus epilepticus: lorazepam/diazepam.
Fosphenytoin