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1st Global Forum on Bacterial Infections, New Delhi 2011
Bacterial Infections & Antimicrobial Resistance, a Chellenge for Chile and Latin América
Juan Carlos Hormazábal, M.D, Head Infectious Diseases Dept. Public Health Institute of Chile
Misuse of Antibiotics in Clinical Practice
Improper use of Antibiotics by the public
Bioinequivalent Antibiotics Biopharmaceutical
Interactions
Emerging Infections: XDRTB MDRTB Neisseria gonorrhoeae Streptococcus pneumoniae Shigella, Salmonella Vibrio spp.
Nosocomial Infections and Potentially Epidemic Resistance Mechanisms
ESBLs Metallo Betalactamases VISA VRSA
ATB Resistance in Chile
Regulatory Framework
(+)
Travel and Globaliza;on
(-‐)
Popula;on Characteris;cs
(-‐)
Improvement in Diagnos;cs
(+)
New Resistance Mechanisms
(-‐)
Antimicrobial Resistance
Sub Systems
Ethiologic Agentes Surv. Antimicrobial Resistance Surv.
Community Adquired Nosocomial
.
Universal Surv. (cases) Centinel Surv. Foodborne Diseases Outbreak Surv.
Morbidity Surveillance
Laboratory Based Surveillance
Environmental Surveillance
Epidemiological Surveillance
System, Chile
*1999
Surveillance System for Communicable Diseases
The indiscriminate use of antibiotics increases the bacterial resistance and forces the use of more expensive alternatives The Chilean Ministry of Health is regulating the consumption of antibiotics since September 1999. Restricted sale of antibiotics by law: only prescribed by an MD or an DS
Gráfico de promedio anual de DDD/1.000 habitantes-día entre los años 1996 y 2000
Rev. méd. Chile v.130 n.11 Santiago nov. 2002
Antimicrobial Resistance: Strategies
Decrease Antimicrobial Resistance Expansion
Strong Regulatory Framework for Drugs Suppliers
National Drug Agency of Chile
Healthy Medicine Industry Market, High Standards
and Affordable Costs
Education General Population,
Heatlh Care Staff
Detection Standards and Quality System in Clinical Labs
Surveillance Laboratory Based
System
¡Gracias!