Dr. William Herring - Genetic Influences on Robustness of Weaned Pigs
Transcript of Dr. William Herring - Genetic Influences on Robustness of Weaned Pigs
Genetic Influences on Robustness of Weaned Pigs
Birth Weight Sets The Stage
• Lower viability at birth
• Greater pre-weaning mortality
• Lower weaning weights
• More culls• Lower ADG• Fewer full value pigs
Continued Selection for Total Born
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Selecting for profitability
Maternal Lines Only All Lines*
Total Born Scrotal Hernia Lifetime Growth
Number of Stillborns Umbilical Hernia Backfat
Preweaning Mortality Cryptorchid Loin Depth
Birth Weight Wean-to-Finish Mortality Leg Score
Weaning Weight Semen Quality Feed Intake
Wean-to-Estrus interval Primal Values
Teat Number pH
Lactate*
IMF*
G/F Survival & Robustness Reproduction
Efficient Growth Carcass Traits
Terminal Lines
Selecting for Profit
PIC’s breeding program is focused to drive towards total value across multiple traits
Maternal Lines
PIC improves total born & pre-wean survivability
61. Relationship based genomic selectionSource: PIC L02, L03 pure lines (Camborough)
Introduction of RBGS1
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Pre-wean survivability(% of born alive)
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Total born (pigs/sow/yr)
(relative to '13-'15 avg)
Birth year / month
Trend: genetic improvement in pre-wean survivability and total born(PIC Genetic Nucleus)
Total Born
Prewean Survival
PIC improves total born & birth weight
71. Relationship based genomic selectionSource: PIC L02, L03 pure lines (Camborough)
Introduction of RBGS1
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Birth weight(kg/pig)
(relative to '13-'15 avg)
Total born (pigs/sow/yr)
(relative to '13-'15 avg)
Birth year / month
Trend: genetic improvement in birth weight and total born(PIC Genetic Nucleus)
Total Born
Birth Weight
PIC Genetic PlatformFull utilization of genomic
science
• Scope, scale, experience…
• Today, ~100,000 animals/year• Deep genomic pedigrees• Every nucleus male is genotyped• Every animal around the world is positively impacted• Every trait we select for on every animals is impacted
How genomic selection works
Sire
Child 1 Child 2 Child 3 Child 4
Child 5 Child 6
In theory you can have sibs that are genetically unrelated
This is why I am different from my brother
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HSFSm=4
And “hidden” relationships
5 Years of PIC Genetic Trend
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Maternal
Terminal
Genomic Implementation
The Next Wave of Innovation
Genome Sequencing
• Impact• Greater selection accuracy• Causal variants• Capture de-novo mutations• Molecular biology targets
• Timeline• Roslin project• 3 years
Accelerating Genetic GainWhat’s Next?
Without PRRS….
• Healthier, more robust litters and individual
piglets
• Improved pre-weaning mortality
• Better downstream growing pig performance
and feed efficiency
• Reduces disease interaction
Gene editing
GE is the process of precise editing genome
Nucleotides can be
• added
• deleted
• replaced
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PRRS ResistanceHigh Level Overview
• Pigs were created with minor nucleotide edits within their existing DNA
• No new or foreign DNA was inserted into the pigs
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Accelerating Progress
PIC Full Program
1 Year Avg
Index 19.5
Pigs weaned/sow/year 1.1
Pounds weaned/sow/year 17.7
Pigs marketed/sow/year 1.0
Total Pounds marketed/sow/year 410.7
PROFIT PER PIG 3.89
Summary
• We continue to improve the pig at a faster pace
than ever before
• Breakthrough technologies will further
accelerate the pace
• Execution will be the key to success