DR TAMSIN NEWLOVE-DELGADO MRCPSYCH MFPH NIHR DOCTORAL RESEARCH FELLOW UNIVERSITY OF EXETER MEDICAL...
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Transcript of DR TAMSIN NEWLOVE-DELGADO MRCPSYCH MFPH NIHR DOCTORAL RESEARCH FELLOW UNIVERSITY OF EXETER MEDICAL...
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DR TAMSIN NEWLOVE-DELGADO MRCPSYCH MFPH
NIHR DOCTORAL RESEARCH FELLOWUNIVERSITY OF EXETER MEDICAL SCHOOL
Research questions, governance, ethics and
funding
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PLAN OF THE DAY
o 10-11.30 ish o Framing a research question - remindero Research governanceo Research ethicso Research funding
o 11.30-11.45 - Break
o 11.45-12.30 – Journal club
o 13:00-15:00 – Study designs: case control, cohort and qualitative
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MRCPsych exam – Paper 3 Critical Review
Approx one third of the examResearch methodsStatisticsEvidence based practiceCritical appraisal
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Exam syllabus links to today
1. Translation of clinical uncertainty into an answerable question
3.1.10Knows the benefits and weaknesses of different
quantitative study designs to address different clinical
questions: Cohort studies Case control
3.4 Qualitative methods: methodologies, sampling, data collection, quality, analysis etc
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WHAT MAKES A GOOD RESEARCH QUESTION?
1. Framing the question
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FINER criteria
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PICOT
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2. Research Governance
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Tuskegee syphilis experiment 1932-1972
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Other examples
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What is research governance?
Principles, processes and standardsImprove research and safeguard public by:
Enhancing ethical awareness and scientific quality Promoting good practice Reducing adverse incidents and ensuring lessons are
learned Forestalling poor performance and misconduct
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DH research Governance Framework
EthicsScienceHealth and SafetyInformationFinanceQuality
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Influential legislation
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Who is responsible?
Research governance is the responsibility of everyone involved in research
Think about it: When asked to take part in a project When writing own proposal – consider time and
resources needed If a project is using NHS patients, staff, resources or
premises, NHS Research and Development (R and D) approval required – even for non-clinical research
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3. Research ethics
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Importance
To protect patientsTo protect researchersUsually a mandatory requirement of the
institution, and the funderA pre-requisite of publication
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Key ethical principles
Declaration of Helsinki:
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Key ethical principles
Could also be expressed as: Knowledge Necessity: Benefit Consent
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The three Cs of research ethics
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Informed consent
UK case law on consent: Consent should be given by someone with the mental
ability to do so Sufficient information should be given to the
participant Consent must be freely given
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Informed consent
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Competency
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Voluntariness
Consider the factors which might affect voluntariness
Ideally should be an independent researcherEmphasise that can withdraw at any timeCooling off period
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Information - disclosure
Example of a BAD participant information sheet (adapted from my GOOD PhD one!)
Take 5 minutes to read through and spot what’s missing or wrong
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Information: Disclosure
Aims and methodsFunding source and conflicts of interestBenefits – ‘reasonably expected’
Are there likely to be any benefits to the participants? If not, this should be made clear Randomisation
Risks and inconveniences – ‘foreseeable’Duration of involvementWhat happens to data/samplesWithdrawing from the trial
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Some examples
Ethical pitfall examples..........What might be the problem with these
research scenarios?If you were on the Ethics Committee, would
you: Accept outright Reject outright Request amendment – what/and what more might you
want to know?
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SCENARIO 1
An epidemiological cross sectional study is inviting men and women aged 65-84 for a cognitive assessment and MRI to measure their burden of cognitive impairments. All participants will be scanned, and all will receive feedback on any abnormalities found in their scan.
Issue here around feeding back...Is it unethical to inform patients about
abnormalities that are likely to be of no clinical significance and/or for which no further investigations or treatment exist?
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SCENARIO 2
A pilot non-controlled trial of art and music reminiscence programme for people with advanced dementia. The researchers plan to assess the capacity of each participant individually and then consult the relatives of those who don’t have capacity to consent.
Does this research have the potential to directly benefit the patients?
Can it be done in other groups instead?Are the risks disproportionate?
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SCENARIO 3
A basic science cohort study involving collecting blood samples once every three months for 5 years to monitor the concentrations of a biomarker in patients in a medium secure psychiatric unit. The current plan is for the consultant forensic psychiatrist to recruit patients to the trial.
Consent to samples and storage of samples (Human Tissue Act)
VoluntarinessWill it be made clear that there’s no direct
benefit to the patients?
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Psychiatric research ethics
‘Although certain individuals with psychiatric disorders may at times lack the capacity to consent, the vast majority of people with a mental illness have the right to decide for themselves whether or not they wish to take part in a study’
The Royal College of Psychiatrists statement on research ethics
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Psychiatric research ethics
There are specific groups of individuals in psychiatric or other research who require additional safeguards : Children People with learning disabilities People detained under the Mental Health Act People with reduced or lost capacity due to dementia And others……………….
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The mental capacity act and research
Aim is to balance the importance of properly conducted research with the need to protect the interests and respect the current or previously expressed wishes of those involved.
Covers ‘intrusive research’ – covers data collection as well as collection of samples
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Including participants who lack capacity: 2 questions
Is the research related to the impairing condition that causes the lack of capacity – or to treatment of the condition?
Could the research be carried out as effectively with people who do have the capacity to consent?
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Including participants who lack capacity: 2 questions
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Study must meet one of these requirements:
OR
It is likely to be of benefit to the person – either directly or indirectly;
and that the benefit is in proportion to any risks/burden
The research will serve to increase knowledge of cause, treatment or
care of people with the same/similar condition – AND that the risks will be
negligible with no significant interference with privacy or freedom
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Consultees for those lacking capacity
The researcher should take ‘reasonable steps’ to identify a ‘personal consultee’
This is a close contact who is not acting in a paid capacity
If no personal consultee is available, the researcher should nominate a ‘nominated consultee’
Can be a professional but must have no connection with the research study
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Exclusions from mca in research
Generally speaking………..Under 16sClinical Trials covered under Clinical Trials
RegulationsResearch involving only anonymised dataSome human tissue researchSpecial permissions……..
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Practicalities of ethical approval
Is it research or not?Can check with NHS R and D
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Practicalities of ethical approval
If not managed as research, don’t need NHS R and D or REC approval, but may need other local/institutional approval processes
If project is research and involves participants or data from the NHS, it will require NHS Ethics approval
Guidance is available from the National Research Ethics Service: http://www.nres.nhs.uk
Applications are through the Integrated Research Applications Systems (IRAS): https://www.myresearchproject.org.uk/
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Mhra: medicine and healthcare regulatory agency
Deals with clinical trialsCovers:
New drugs Old drugs being tested for a new use Old drugs reformulated/packaged differently Possibly more!
These will require authorisation from MHRA
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4. Research funding
What proportion of the medical research budget is spent on mental health research?
Guesses?
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Spending on health specific categories by year compared with health burden.3 DALY=disability adjusted life year.
Kingdon D , and Wykes T BMJ 2013;346:bmj.f402
©2013 by British Medical Journal Publishing Group
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Funders of mental health research
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Mechanisms of funding
National commissioned callsGrants and researcher-led proposals
NIHR Programme Grants for Applied Research
Fellowships for research and research training from big funders
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Mental health research networks locally
NIHR Mental Health Clinical Research Network – West Hub
NIHR Peninsula Comprehensive Local Research Network (CLRN)
NIHR Research Design ServiceUniversity of Exeter – Mental Health
Research Group, Child Health Research Group
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Thank you
Questions?