Female Perineum and External Genitalia Dr. Zeenat Zaidi & Dr. Saeed Vohra.
Dr Saeed Yousefi - sinahospital.tums.ac.ir
Transcript of Dr Saeed Yousefi - sinahospital.tums.ac.ir
Dr Saeed Yousefi
Roux-en-Y gastric bypass (RYGB)
second most common bariatric procedure worldwide
leak at the GJ occurring in 1% to 4% of all cases
Mortality from leak is stated to range from 0.1% to 8.5%
Leak after Gastric bypass
Almost half (44%) of the leaks were identified within 3days of surgery (early leaks), with most leaks diagnosedon day 2
Leak after Gastric bypass
GI leaks after GB occur most often in one of 4 locations
gastrojejunal anastomosis
gastric pouch staple line
jejunojejunostomy
gastric remnant staple line
most commonly →gastrojejunal anastomosis
although some have reported a greater mortality from jejunojejunostomy leaks
Leak after Gastric bypass
risk factors for developing a leak after RYGB were
male sex
age 49 years
diabetes
hypertension
Conversion to open surgery
Operative time 90 minutes
Waist circumference, BMI, and smoking were not significant risk factors
Prevention of gastrointestinal leak after GB
intraoperative attempt to decrease the incidence of leak such as
oversewing the staple line and reinforcing the staple line with SLR or biologic or synthetic materials such as fibrin glue
There is no high-quality clinical evidence, including availableprospective randomized studies, to suggest that any suchinterventions significantly decrease leak incidence after GB
Prevention of gastrointestinal leak after GB
Intraoperative leak assessment using endoscopy and/or distention of the anastomosis with dye, air, or other gas may be useful to detect leaksthat can be repaired during the procedure
these techniques have not been reported to decrease the risk of leak after surgery
Management of GI leaks after GB
Clinically unstable patients suspected of having a leak → Re exploration through a laparoscopic or open approach
clinically stable patient with a suspected leak → CT of the abdomen and pelvis with oral and IV contrast
utility of identifying associated intraabdominal abscesses, hernias, or other pathologic conditions after GB.Addition of the chest component to the abdominal CT to rule out distinct or concomitant pulmonary pathologic conditions may be considered.
Management of GI leaks after GB
Surgical management should always be considered in the early postoperative
nonoperative management of a GI leak after GB may be considered in selectedand clinically stable patients
▪ bowel rest
▪ antimicrobial agents
▪ total parenteral nutrition
▪ percutaneous drainage of collections
▪ percutaneous access into the remnant stomach both fordecompression and feeding.
Management of GI leaks after GB
GI leaks can occur long after a primary GB as a secondary consequence of other types of complications such as
internal hernia
trocar site hernia
adhesive bowel obstruction
perforated marginal ulcer
Management of GI leaks after GB
Re exploration, open or laparoscopic, is an appropriate and acceptable treatment modality when a GI leak is suspected and remains the diagnostic test withthe highest sensitivity and specificity after GB
Management of GI leaks after GB
Response to treatment →clinically ,drain outputs, resolution of leukocytosis, fever,and reimaging to confirm closure.
Conversion of an acute leak into a controlled fistula that fails to close should raisesuspicion to search for other factors that may promotenonhealing, such as downstream obstruction, stenosis, orforeign body (e.g., from introduction of a drain into the siteof the leak)
low threshold for operative intervention in the face of clinical deterioration or failure of nonoperative management.
Nonoperative methods of GI leak treatment after both GB
endoscopic endoluminal self expandable stents
clips
endoscopic and percutaneously placed drain
biologic glue/tissue sealants
Multiple endoscopies and multimodality treatments may be required to achieve full healing of a chronic fistula
The available data do not favor one treatmentover another
leak from Gastrojejunostomy 60% other site 40%
In total 40,844 patients were included, and a leak at theGJ was confirmed in 262 patients (.6%)
Almost half (44%) of the leaks were identified within 3days of surgery (early leaks), with most leaks diagnosedon day 2
Mean duration of stay after a leak was 22 days comparedwith 2 days for those who did not have leak
suturing of the defect did not reduces duration of stay
new anastomosis was associated with increased duration of stay
Patients treated with stents also required a prolonged duration of stay: 30days versus 18 days for nonstented patients
Patients with leaks were similar to patients without leaks1 year after RYGB with regard to
BMI
excess weight loss
percent total weight loss
no difference was seen concerningbody mass index (BMI), obstructive sleep apnea syndrome,and history of smoking
Leak from Gastrojejunostomy
Surgical reintervention was done in 85% of patients
the defect was sutured in 45%
new anastomosis was done in 5%
feeding gastrostomy was placed in 24%
Stents were used in 31% of GJ leaks
drainage was placed in 89% of patients
6% treated conservatively
death (1%) 2 deaths →cardiac arrest shortly after the leak was diagnosed (0–2 d)
41,342 patients
leaks at the enteroenteral anastomosis (EA) →75 patients (.2%)
small bowel perforations →54 patients (.1%)
EA leaks average diagnose 6.5 days after surgery
small bowel leaks 3.5 days after surgery
Overall, surgical reintervention was done in .97% of patients
Risk factorsIn the multivariate analysis, the risk factors associated toEA leak is surgery at a low-volume center and prolongedoperative time, which agrees with other studies
No difference was seen between the stapled and sutured part of the EA anastomosis
Treatment and outcome
Closing the defect and adequate drainage is essential in managing aleaking EA or small bowel perforation
early diagnosis, preferably by laparoscopy, followed by anintervention that minimizes the spill of bowel contents
LOS was shorter for patients with small bowel perforationsdiagnosed within 3 days
STENT
The most common types of stents are selfexpandable plastic stents (SEPS) and
selfexpandable metal stents (SEMS). Covered SEMS (C-SEMS) are typically the
most utilized in the setting of post-bariatric surgery leak
Stents used for leak management are either fully or partially covered.
Partially covered SEMS offer the luxury of less migration compared to fully
covered SEMS and SEPS
generally prefer the use of fully covered stents
Self-expanding metal and plastic stents
overall proportion of successful leak/fistula closure was 89%
The proportion of successful leak closure in gastric bypass group was 96%
The overall proportion of stent migration was 23%
the period of maintaining stents in the gastrointestinal tract recommended by most authorswas 6–8 weeks
Double Pigtail Stent
Double Pigtail Stent Insertion for Healing of Leaks Following Roux-en-Y
Gastric Bypass.
Clipping techniques
leak/fistula with the OTSC system was achieved in 57 of85 patients (67.1%)
The studies reported use of clipping including the OTSC system for fistulas not larger than 20 mm
A 65-year-old woman with a history of Roux-en-Y
gastric bypass , developed a postoperative gastric
pouch leak and consequent intra-abdominal
abscess. Gastrocutaneous fistulization ensued
despite treatment with intravenous antimicrobial
agents and serial drainage procedures(2017)
OTSC
Tissue sealants
The most commonly used sealant for fistula closure is fibrin glue—a tissue-compatible adhesive working in a double manner
mechanically occludes the stomach wall defect
role in wound healing
inducing cellular response to tissue damage
forming matrix-building strands, which promote neovascularizationfibroblast proliferation
Tissue sealants
10 case series comprising 63 patients
time between bariatric operation and sealant application varied from 1 to 144 days
in 9 studies comprising of 49 patients Success was achieved in 48 patients .between 1 to 9 session of applying fibrin glue was done
In the majority of reports the sessions of sealing were repeated every 2 to 3 days
Endoscopic Injection of Fibrin Sealant
(EIFS)
Other types of tissue sealants
cyanoacrylate glue
high antibacterial properties
eliminated by hydrolysis after a significant time period (1–6 months)only a small quantity of the glue is needed
The costis approximately six times lower than one portion of fibrin glue
Other types of tissue sealants
SurgiSIS
acellular matrix biomaterial formulated from the porcine small intestine submucosa
stimulates proliferation and formation of fibroblasts
incorporates into the scar without initiating a foreign body inflammatory reaction
The rate of 5 to 20 mm wide fistulas closure after 3 sessions was achieved in 20 of 25 patients
Cases Selection for Endoscopic Therapy
hemodynamically stable and in many cases the leak wascontrolled by percutaneous drainage
Septic patients with uncontrolled gastrointestinal leaks or peritonitis should betreated surgically
The success of endoscopic therapies in the management of leak/fistula also depends on the defect’s size. In general, self-expanding stents allow closing the largest leaks and fistulas.
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