Dr. Prabhakar Singh SEM-III_Gycogen Metabolism
-
Upload
department-of-biochemistry-veer-bahadur-singh-purvanchal-univarsity-jaunpur -
Category
Education
-
view
89 -
download
5
Transcript of Dr. Prabhakar Singh SEM-III_Gycogen Metabolism
![Page 1: Dr. Prabhakar Singh SEM-III_Gycogen Metabolism](https://reader033.fdocuments.us/reader033/viewer/2022052406/588b3c881a28ab5a5b8b5f25/html5/thumbnails/1.jpg)
Glycogen Metabolism1. Glycogenesis2. Glycogenolysis3. Regulation Of Glycogen Metabolism4. Glycogen Storage Disease
![Page 2: Dr. Prabhakar Singh SEM-III_Gycogen Metabolism](https://reader033.fdocuments.us/reader033/viewer/2022052406/588b3c881a28ab5a5b8b5f25/html5/thumbnails/2.jpg)
GLYCOGENESIS
1- Synthesis of UDP-glucose2-Glycogen synthesis by glycogen synthase3-Formation of branches in glycogen
![Page 3: Dr. Prabhakar Singh SEM-III_Gycogen Metabolism](https://reader033.fdocuments.us/reader033/viewer/2022052406/588b3c881a28ab5a5b8b5f25/html5/thumbnails/3.jpg)
1- Synthesis of UDP-glucose
![Page 4: Dr. Prabhakar Singh SEM-III_Gycogen Metabolism](https://reader033.fdocuments.us/reader033/viewer/2022052406/588b3c881a28ab5a5b8b5f25/html5/thumbnails/4.jpg)
2-Glycogen synthesis by Glycogensynthase
![Page 5: Dr. Prabhakar Singh SEM-III_Gycogen Metabolism](https://reader033.fdocuments.us/reader033/viewer/2022052406/588b3c881a28ab5a5b8b5f25/html5/thumbnails/5.jpg)
3- Formation of branches in glycogen
amylo-(1,4 S 1,6)-transglycosylase
![Page 6: Dr. Prabhakar Singh SEM-III_Gycogen Metabolism](https://reader033.fdocuments.us/reader033/viewer/2022052406/588b3c881a28ab5a5b8b5f25/html5/thumbnails/6.jpg)
Glycogen Breakdown
A. Glycogen Phosphorylase
B. Phosphoglucomutase
C. Glycogen Debranching Enzyme
Gycogenolysis
![Page 7: Dr. Prabhakar Singh SEM-III_Gycogen Metabolism](https://reader033.fdocuments.us/reader033/viewer/2022052406/588b3c881a28ab5a5b8b5f25/html5/thumbnails/7.jpg)
• Glycogen phosphorylase is a dimer of identical 842-residue (97-kD) subunits
that catalyzes the controlling step in glycogen breakdown.
• It is regulated both by allosteric interactions and by covalent modification.
• The enzyme-catalyzed modification/demodification process yields two forms of
phosphorylase: phosphorylase a, which has a phosphoryl group esterified
to Ser 14 in each of its subunits, and phosphorylase b, which lacks these
phosphoryl groups.
1- Glycogen Phosphorylase
![Page 8: Dr. Prabhakar Singh SEM-III_Gycogen Metabolism](https://reader033.fdocuments.us/reader033/viewer/2022052406/588b3c881a28ab5a5b8b5f25/html5/thumbnails/8.jpg)
2. Phosphoglucomutase
![Page 9: Dr. Prabhakar Singh SEM-III_Gycogen Metabolism](https://reader033.fdocuments.us/reader033/viewer/2022052406/588b3c881a28ab5a5b8b5f25/html5/thumbnails/9.jpg)
Glycogen Debranching Enzyme
![Page 10: Dr. Prabhakar Singh SEM-III_Gycogen Metabolism](https://reader033.fdocuments.us/reader033/viewer/2022052406/588b3c881a28ab5a5b8b5f25/html5/thumbnails/10.jpg)
REGULATION OF GLYCOGEN METABOLISM
1. Allosteric Regulation
![Page 11: Dr. Prabhakar Singh SEM-III_Gycogen Metabolism](https://reader033.fdocuments.us/reader033/viewer/2022052406/588b3c881a28ab5a5b8b5f25/html5/thumbnails/11.jpg)
2- Hormonal Regulation
![Page 12: Dr. Prabhakar Singh SEM-III_Gycogen Metabolism](https://reader033.fdocuments.us/reader033/viewer/2022052406/588b3c881a28ab5a5b8b5f25/html5/thumbnails/12.jpg)
3- Regulation by Ca++
![Page 13: Dr. Prabhakar Singh SEM-III_Gycogen Metabolism](https://reader033.fdocuments.us/reader033/viewer/2022052406/588b3c881a28ab5a5b8b5f25/html5/thumbnails/13.jpg)
GLYCOGEN STORAGE DISEASES