Dr Mat Callister - Cancer Research UK · Increasing early detection of lung cancer in Leeds Mat...
Transcript of Dr Mat Callister - Cancer Research UK · Increasing early detection of lung cancer in Leeds Mat...
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17 December, 2010
Dr Mat CallisterConsultant Chest Physician
Leeds Teaching Hospitals NHS Trust
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Increasing early detection of lung cancer in Leeds
Mat CallisterConsultant Chest Physician
Leeds Teaching Hospitals NHS Trust
On behalf of Leeds Lung Cancer Early Diagnosis Project Steering Group
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Lung cancer survival by stage in Leeds
Stage I
1 year survival = 78%
Stage II
1 year survival = 73%
Stage III
1 year survival = 48%
Stage IV
1 year survival = 18%
27%
21%
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Delays in cancer treatment
First
symptom
First
contact
with GP
Ordering
of Ix
(CXR)
Referral
to
hospital
First
clinic
visit
Diagnosis
and
referral for
treatment
Treatment
starts
Olesen et al. BJC 2009;101:S5-S8
Delay in primary care Delay in secondary care
14/7 target
62/7 target
Patients present earlier 31/7 target
CXR ordered earlier
Patient delay
Leeds Early Lung Cancer Project
Primary care
education
campaign
Primary care
software
prompts
Self-referral
chest X-ray
Social
marketing
campaign
Primary care
software
prompts
Self-referral
chest X-ray
Social
marketing
campaign
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Primary care education campaign
• Planned to commence January 2011
• Presentations planned for
– GP target training days x 4 (N, E, S, W)
– Practice nurse training days
– Community respiratory nurse education events
– Community matron training days
• Ongoing GP surgery visits throughout year
– Focusing on low referral practices
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20052000
“The symptoms and signs of lung cancer can be difficult for GPs to distinguish from those of other diseases”
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• Haemoptysis
• Unexplained or persistent – for three weeks or more
– Cough
– Breathlessness
– Chest/shoulder pain
– Weight loss
– Chest signs
– Hoarseness
– Clubbing
Indications for urgent chest X-ray (DH/NICE)
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Symptoms strongly
suggestive of lung
cancer
No symptoms
suggestive of lung
cancer
Symptoms mildly
suggestive of lung
cancer
Spectrum of lung cancer symptoms
CXR done
CXR threshold
CXR not done
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Mr MC
38yr old man
Healthcare professional
Never smoker
6/52 non-productive cough
No other concerning symptoms
Mrs JB
55 yr old woman
Never smoker
A-level teacher
3/52 persistent dry cough
No other concerning symptoms
Consulted GP 09.10.08
Mr CW
79 year old man
Smoker (105 pack years)
Returned from cruise 05.01.09
Since then daily haemoptysis
1 stone weight loss over 1/12
3/52 increasing breathlessness
GP consultation 14.01.09
Mr DA
68 yr old man
Smoker (45 pack years)
No respiratory symptoms
Borderline hypertension
Attends surgery for BP check
CXR done
CXR threshold
CXR not done
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0.2 0.3 140.02
WHO Ionising Radiation Data – Cosmic radiation on selected flights - http://www.who.int/ionizing_radiation/env/cosmic/en/index1.html
National Dose Assessment Working Group – Radiation Protection Division – Health Protection Agency - http://www.ndawg.org/documents/Paper7-02.pdf
Radiation exposure from medical diagnostic imaging procedures – Health Physics Society - http://www.hps.org/documents/meddiagimaging.pdf
0.01 0.1 1 10 100mSv
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£12K£672
£28K
£20 £2K
£10 £100 £1,000 £10,000 £100,000
£8K
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LTHT has 25 X-ray
machines
One Leeds Chest Clinic
X-ray machine can
process 70 patients/day
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Leeds Early Lung Cancer Project
Patients present earlier CXR ordered earlier
Primary care
education
campaign
Primary care
software
prompts
Self-referral
chest X-ray
Social
marketing
campaign
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Leeds Early Lung Cancer Project
Patients present earlier CXR ordered earlier
Primary care
education
campaign
Primary care
software
prompts
Self-referral
chest X-ray
Social
marketing
campaign
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Primary care software prompts
• Liason with TPP (SystmOne), EMIS, PCT information support team
• Triggered by entry of relevant symptoms (read codes) or prescription of antibiotics
• Need to balance sensitivity, specificity, GP goodwill
• Cough/Chest infection
• Antibiotic prescription (Amox/Clar/Aug/Dox)
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Leeds Early Lung Cancer Project
Patients present earlier CXR ordered earlier
Primary care
education
campaign
Primary care
software
prompts
Self-referral
chest X-ray
Social
marketing
campaign
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Self-referral chest X-ray
• Patients complete tick-box questionnaire
• Criteria
– Age > 50yrs
– Cough or other respiratory symptoms > 3/52
– No previous CXR on system in previous 3/12
• Reports sent to GP – automatically recalled for CT then chest clinic if suspicious for cancer
• REC, IR(ME)R, R&D, NIHR CSP approved
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Social marketing campaign
If you have cough or other chest symptom for 3 weeks, you need a chest X-ray to rule out serious lung disease
• Community health educators
• Bus routes through target area
• Media events
• Beer mats/flyers/posters
• Pharmacy bags
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Community health educators
Practice nurses
District nurses
Community respiratory nurses
Pharmacists
Smoking cessation counsellors
Pass onto a friend or relative
GPs
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Leeds Early Lung Cancer Project
Patients present earlier CXR ordered earlier
Primary care
education
campaign
Primary care
software
prompts
Self-referral
chest X-ray
Social
marketing
campaign
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Outcome measures
• Primary outcome measure – number of CXRs per 1,000 population per year
2009(Run-in)
2010(Run-in)
2011(Campaign)
Inner East & Inner South Leeds 27.6
Rest of Leeds 29.3
Kirklees
Wakefield
Calderdale
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Outcome measures
• Secondary outcome measure
– Public awareness of symptoms of lung cancer (CAM) pre-vs post-campaign
– Number of lung cancers diagnosed
– Proportions of stage I and II cancers
– Proportions receiving radical treatment (curative surgery or radical/stereotactic radiotherapy)
– 1 year survival rates
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Outcome measures
• Proportion of stage I/II lung cancers (%)
2009(Run-in)
2010(Run-in)
2011(Campaign)
Inner East & Inner South Leeds 22.9
Rest of Leeds 29.4
Mid-Yorkshire NHS Trust
Calderdale & Huddersfield NHS Trust
Yorkshire Cancer Network
England and Wales (NLCA)
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Challenges and risks
• No one turns up!
• Study underpowered to detect stage shift in presentation
• Effect of IASLC 6th → 7th staging system
• Increase of lung cancer referrals and poor compliance with 62/7 referral to treatment target
• Increase of non-malignant respiratory referrals
• Failure of self-referral centres to cope with demand
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Legacy
• Need to demonstrate efficacy
• Current block-contract between NHS Leeds and LTHT for community CXR referrals – easy to add on
• Significant enthusiasm in primary care for scheme –may bode well for GP-commissioning funding
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Summary
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Thank you