Dr Jeyran Shahbazi Supervisor: Dr Tao Liu Co-supervisor: Prof Richard Lock The BET Bromodomain...
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Transcript of Dr Jeyran Shahbazi Supervisor: Dr Tao Liu Co-supervisor: Prof Richard Lock The BET Bromodomain...
kelly 1 00.1250.2500.51103.664596.3355490.4509590.2760982.9438184.1623580.1326177.7780279.8331878.6990299.4844792.0349986.6255387.0907683.1521380.948478.5828674.4912679.1888777.0653291.528387.4512182.6759586.1118980.2607578.9999275.6174276.5603173.4751473.3972983.7798182.2536480.6275179.8384477.3148875.1795466.71166.2958462.2334860.2401758.8551964.3768158.162759.2488948.1145447.9329537.6274336.8368927.775828.8346312.7028215.8412316.1048815.9106615.2907716.7504515.9952517.1479316.8861715.537800.1250.250.51099.99988596.3875177.5108868.96955562.456561.25118.67693.03469579.7570667.69232564.5078452.5110.4560588.05611574.0047763.8901460.888115592.2881274.3077464.94613554.6541351.8583051063.79008555.839947.39670542.1517837.796672031.8971934.23866534.5964732.8149329.9292300.1250.250.51099.99999590.3635283.5530878.95531579.26611.2597.68686.85814582.05026576.5370678.1270952.594.222784.3939279.63033576.08886573.436215581.7942480.23297576.2472166.5034261.2368251054.4986155.83996142447.396757136442.15182636737.7967115764
00.1250.250.510100.0000290.3635283.5530878.95531579.26611.2595.7597386.85814582.05026576.5370678.1270952.589.48975584.3939279.63033576.08886573.436215583.01672580.23297576.2472166.5034261.2368251061.61658.70579548.02374537.2321628.305215102.081397.6864794.2227981.7942458.49861(+)-JQ1 (M)Panobinostat (nM)(+)-JQ1 (M) plus panobinostat (nM)CI Value
(+)-JQ1 0.1250.250.51LBH (nM) 1.252.2751.050.57NA2.51.4340.8780.7330.71851.2290.9910.5980.493100.8840.5960.7740.297
antagonistCI > 1.1synergy CI < 0.9 very synergy CI < 0.4
kelly 00.1250.250.510103.664596.3355490.4509590.2760982.9438184.1623580.1326177.7780279.8331878.699021.2599.4844792.0349986.6255387.0907683.1521380.948478.5828674.4912679.1888777.065322.591.528387.4512182.6759586.1118980.2607578.9999275.6174276.5603173.4751473.39729583.7798182.2536480.6275179.8384477.3148875.1795466.71166.2958462.2334860.240171058.8551964.3768158.162759.2488948.1145447.9329537.6274336.8368927.775828.83463
00.1250.250.510100.0000290.3635283.5530878.95531579.26611.2595.7597386.85814582.05026576.5370678.1270952.589.48975584.3939279.63033576.08886573.436215583.01672580.23297576.2472166.5034261.2368251061.61658.70579548.02374537.2321628.305215
sknbe 00.1250.250.51095.31207104.687792.9355599.8394782.5675772.4541966.457671.4815162.5648662.348261.25111.0481126.303993.7058792.3635275.5128584.0012766.8521468.5325164.2915864.724112.5106.2971114.61585.5125190.5997272.4539675.5555864.84162.9392858.4546263.32161588.3163696.2598872.8220575.7934362.7767267.1155555.0115954.2966750.4941453.222471061.0857266.4944555.7152155.9645947.3961447.3972742.2822442.0213239.2000636.393282028.2695535.5248333.7861334.691234.6961834.4967632.8331332.7967331.8437228.01474
00.1250.250.51099.99988596.3875177.5108868.96955562.456561.25118.67693.03469579.7570667.69232564.5078452.5110.4560588.05611574.0047763.8901460.888115592.2881274.3077464.94613554.6541351.8583051063.79008555.839947.39670542.1517837.796672031.8971934.23866534.5964732.8149329.92923
