Dr. Charles Onunkwo, Infectious Disease Medicine Erika ... · De-escalation “Myths” Common...
Transcript of Dr. Charles Onunkwo, Infectious Disease Medicine Erika ... · De-escalation “Myths” Common...
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Dr. Charles Onunkwo, Infectious Disease Medicine
Erika Ingram, Infectious Disease/Critical Care Clinical
Pharmacy Specialist
Southeastern Regional Medical Center
Cancer Treatment Centers of America
May 25, 2017
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Disclosures
We have no conflicts of interest to disclose
and no financial relationships relevant to
this activity.
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Learning Objectives
Review national initiatives that directly influence the
role of Antimicrobial Stewardship Programs
Highlight common challenges observed in
antimicrobial stewardship
Identify quantifiable metrics and performance
measures for ASP
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Antimicrobial Stewardship
“Icebreakers”
“Superbugs…these are our babies…now they have
body piercings and anger!”
“Antibiotics kill bacteria, not your anxiety. Stop the
‘just-in-case’ indications.”
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Importance of Antimicrobial Stewardship
Increasing incidence of antimicrobial resistance Injudicious antibiotic use / Inappropriate antibiotic selection
Treatment failures and poor patient outcomes
Prolonged hospitalization
Increasing medical expenditures (use of additional medication, extra
laboratory testing)
Stabilization of antibiotic resistance Multifactorial approach
Antibiotic formulary restrictions
Prospective audit and feedback
Surveillance of antibiotic utilization and resistance patterns
Daily interventions tailored to optimize appropriate antibiotic use
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“Mirror, Mirror on the Wall…..Who is
the Best Supporter of Them All?”
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Infectious Diseases Society
of America
Centers for Disease Control
The Joint Commission
(6/2016)
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September 2014
President’s Executive Order
and National Strategy
PCAST Report to the President
March 2015
National Action Plan for
Combating Antibiotic-Resistant
Bacteria (CARB)
PCAST-President’s Council of Advisors on Science and Technology
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Proposed Policy Changes
Strengthen antibiotic stewardship in inpatient, outpatient, and
long-term care settings
Alignment with Centers for Disease Control (CDC) Core Elements and IDSA/SHEA
Compliance with Conditions of Participation and The Joint Commission (TJC) Accreditation requirements
Implement annual reporting of antibiotic use in inpatient and
outpatient settings and identify variations at geographic,
provider, and patient levels
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Proposed Policy Changes
Establish and improve antibiotic stewardship
programs across ALL healthcare settings
Reduce inappropriate antibiotic use by 50% in
outpatient settings and 20% in inpatient settings
Establish State Antibiotic Resistance (AR)
Prevention (Protect) Programs in all 50 states
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Goals of Antimicrobial Stewardship
Improve patient outcomes
Optimize selection, dose and duration of Rx
Reduce adverse drug events including secondary
infection (e.g., Clostridium difficile infection)
Reduce morbidity and mortality
Limit emergence of antimicrobial resistance
Reduce length of stay
Reduce health care expenditures
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Challenges in ASP
The work to achieve success in Antimicrobial Stewardship
closely parallels the storybook of…..
“The Little Engine That Could...”
“When it comes to Infectious Diseases and Antibiotics, there is only do or do not,
there is no try.”
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Challenges
ASP Misconceptions
Stakeholder Cooperation
Problem Prescribers
& Behaviors
Minimal Support / “Buy-in”
Where is the ‘Stamp & Seal’
from Leadership?
Lack of Collaboration
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“Are there any familiar hurdles?”
Stakeholder Cooperation
Internists/Hospitalists
Intensivists
General, advanced
practitioners
Collaboration
Microbiology
Pharmacy
Physicians
Infection Prevention
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Common Misconceptions
If an Infectious Diseases consultant approves or uses
an antibiotic, it must be appropriate
Retrospective data collection and analysis can result in
change in behavior
The adoption of information technology (IT) will
automatically make data collection, analysis and
change in behavior easy
Restricting use of certain antibiotics will reduce
antibiotic misuse and overuse
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Challenges: Fact or Fiction
Not all literature in Infectious Diseases is “black & white”
Everyone is an “Expert” on the use of antibiotics
Providers perceive their autonomy is compromised
Concerns for litigation
Obtaining “buy-in” for support of ASP
Financial pressures that influence decision-making processes
Pharmaceutical Industry
Hospitals (Budget)
Payer sources
Insurance industries
Centers for Medicare & Medicaid Services [CMS])
Patients/Support network
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Physician Barriers
“Antibiotics are among the most potent of all anxiolytics – for prescribers.”
Physician accountability & acknowledgement of need
for improvement
Misperceptions
Knowledge gaps in the appropriate use of
antimicrobial agents
Lack of standardized, risk-adjusted measures
Adaptive/behavioral changes needed to modify
prescribing practices
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• Timing of discussion & recommendations is prudent
• Be strategic and pick your battles
Map-Out Your
Approach
• Research & gather as much “valid” data as possible
• Understand the provider’s practice & patient population
Do Your Homework
• Do not initiate or engage in “heat-of-the-moment” battles
• Accept a “stewardship-appropriate” compromise
Do Not
“Go Postal!!”
“Pearls of Wisdom” for the Problem Prescriber
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Involvement of senior physician leadership is critical
Administrative & Clinical
Continue to share your stewardship message and
education points with non-ID providers/clinicians
ID should not be excluded from stewardship
process
Understand local culture and patient population
Modifying Prescribing Behaviors
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“Fever is not a sign of ‘Vosyn’ deficiency.”
Are there any solutions?
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IDSA/SHEA, CDC, TJC Guidelines A multidisciplinary ASP team infrastructure
ID physician and Pharmacist and other key stakeholders as determined by the institution
Incorporate Core Strategies
Prospective audit with intervention and feedback
Formulary restriction and preauthorization
Additional approaches to stewardship
Education
Guidelines and clinical pathways
Order forms
De-escalation
Dose optimization
IV to PO conversion
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Antibiotic De-escalation
Advantages
Allows initial use of broad-
spectrum therapy
Narrows spectrum while
maintaining efficacy
May influence future prescribing
behavior
Decreases inappropriate
antibiotic use
Reduces adverse events
Cost savings
Disadvantages
Prescribers may be reluctant to change therapy if the patient is doing well
If not done correctly,
may narrow therapy
“inappropriately”
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De-escalation “Myths”
Common myths that negatively impact appropriate de-escalation:
Lack of conclusive microbiology results
Continued use of broad-spectrum antimicrobial therapy
Diagnostic uncertainty
Treatment of fever, colonization and/or contamination
Insecurity
Treatment of noninfectious syndrome associated with fever
Duration of therapy exceeds evidence-based
recommendations
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® 2017 Rising Tide
SERMC-CTCA Antimicrobial Stewardship Program
24
Source:
“Antimicrobial stewardship is a team game with the patient at the center, and it’s our teamwork that makes the dream
work.”
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® 2017 Rising Tide
Source:
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® 2017 Rising Tide
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® 2017 Rising Tide 27
Source:
CTCA Enterprise Antimicrobial Stewardship Dashboard
+ The Joint Commission Standards
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® 2017 Rising Tide
Methods to Control Antimicrobial Use
Methods to control
antimicrobial use
Restrictive use (formulary
control)
Prospective audit and feedback
Dellit TH et al. Clin Infect Dis. 2007; 44:159-77.
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® 2017 Rising Tide
Ceftaroline
Ceftazidime-avibactam
Ceftolozane-tazobactam
Dalbavancin
Daptomycin
Ertapenem
Linezolid
Tigecycline
SERMC - Formulary Restriction and Preauthorization
31
Source:
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® 2017 Rising Tide 32
Source:
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® 2017 Rising Tide 33
Source:
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® 2017 Rising Tide 34
Source:
SERMC - Formulary Restriction and Preauthorization
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® 2017 Rising Tide
ERTAPENEM 2015
1 1 1 0
0.2
0.4
0.6
0.8
1
1.2
Q1 Q2 Q3 Q4
Fre
qu
en
cy o
f U
se
Quarter
Rationale for Inappropriate Utilization by Quarter
Empiric therapy(complicated): IAI,aBSSI, UTI, PNA
Treatment ofpathogen outside ofspectrum
Surgical prophylaxis(excludingcolorectal)
Other
-Q3: abSSI
-Q4:
Inappropriate
post-op duration
3 6 1 2 0
1
2
3
4
5
6
7
Q1 Q2 Q3 Q4
Fre
qu
en
cy o
f U
se
Quarter
Appropriate vs. Inappropriate Utilization by
Quarter
Appropriate
Inappropriate
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® 2017 Rising Tide
ERTAPENEM 2016
3 3 2 4 1 0
0.5
1
1.5
2
2.5
3
3.5
4
4.5
Q1 Q2 Q3 Q4
Fre
qu
en
cy o
f U
se
Quarter
Appropriate vs. Inappropriate Utilization by
Quarter
Appropriate
Inappropriate
2 1 1 0
0.5
1
1.5
2
2.5
Q1 Q2 Q3 Q4
Fre
qu
en
cy o
f U
se
Quarter
Rationale for Inappropriate Utilization by Quarter
Empiric therapy(complicated): IAI,aBSSI, UTI, PNA
Surgical prophylaxis(excludingcolorectal)
Other-Q1: Asymptomatic
bacteruria
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® 2017 Rising Tide
SURGICAL ANTIBIOTIC PROPHYLAXIS: COST ANALYSIS
$3.82
$97.02
$5.59 $7.36
$-
$20.00
$40.00
$60.00
$80.00
$100.00
$120.00
cefazolin/metronidazole ertapenem
Co
st
Surgical prophylaxis agent
Cefazolin/Metronidazole vs. Ertapenem
1st Dose
2nd Doses
3rd Doses
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® 2017 Rising Tide
SERMC Antibiotic Stewardship Initiative CORE ELEMENTS STATUS ACTION PLAN
BROAD
INTERVENTIONS
Chart review of
appropriate use 48-hrs
post initiation
Pre-authorization (by
MD/PharmD) for specific
abx agents
MD/PharmD review of
courses of abx therapy
(prospective audit with
feedback)
Yes
Yes
Yes
-Established chart review
process for appropriate abx
use at ~48-72 hrs post-
initiation. All abx reports
print daily (Pyxis Reports)
for all inpatient areas.
Vigilanz (clinical
surveillance sytem) for
tracking different entities of
ASP
- Eight abx utilization
protocols developed for
pre-authorization process
for specific abx.
<Continuous>
- Dr. Charles Onunkwo
(SERMC Infectious Disease
Physician) will implement
process of prospective
audit with feedback will be
implemented October 2016
(tentative).
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® 2017 Rising Tide
ASP Initiatives: Daily Antimicrobial Report (Inpatient)
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Antimicrobial Stewardship:
Performance & Quantitative
Measures
“The most expensive antibiotic is the one that does not work.”
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ASP Framework: Metrics National Quality Forum
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ASP Framework: Metrics National Quality Forum
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® 2017 Rising Tide
0
0.5
1
1.5
2
2.5
3
3.5
4
4.5
SERMC-CTCA Number of HO-CDAD Cases July 2014 - Feb 2017
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® 2017 Rising Tide 45
Source:
2016 – October – Prospective Audit with Feedback
ASP Reviews Total
Surgical Prophylaxis
Discontinue antibiotics
Establish Duration ofTherapy
Modify Abx & DischargeCounseling
Add abx therapy & Labanalysis
Dose optimize / Doseadj. / New ID consult
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® 2017 Rising Tide 46
Source:
2016 – November – Prospective Audit with Feedback
ASP Reviews
Surgical Prophylaxis
Discontinue antibiotics
Establish Duration ofTherapy
Discharge Counseling
IV to PO Modification
Modify abx / New IDconsult / Lab analysis
De-escalate abx / Add abxcoverage
Dose optimization / BBIregimen
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® 2017 Rising Tide 47
Source:
0.00
1,000.00
2,000.00
3,000.00
4,000.00
5,000.00
6,000.00
2016 October 2016November
2016December
Modify Abx Regimenper Cx
Establish TherapyDuration
Discontinue Abx
**Cost analysis derived from
Vigilanz Clinical Surveillance Tool**
Antimicrobial Stewardship Potential Cost Savings
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Conclusion
Antimicrobial resistance is a significant public health and
patient safety concern
Highest levels of government officials are highlighting
antimicrobial stewardship and efforts to decrease resistance
TJC and CMS are developing guidance for accreditation
based on an effective ASP, including publicly reportable
measures
All stakeholders should be engaged in antimicrobial
stewardship and across the continuum of care.
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“To learn how to use antibiotics, one must first learn how not to use antibiotics.”
“Mir
ror,
mir
ror
on t
he w
all. D
o I n
eed
anti
bio
tics a
t all?”
Asym
pto
matic
Bacte
riuria
: “Sym
pto
m fre
e
pee: L
et it b
e”
“If we use antibiotics when not needed, we may not have them when they are most needed.”
Thank You!
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References