Prof. Ahmed Fathalla Ibrahim DEVELOPMENTOF KIDNEYS & URETES.
Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from...
-
Upload
brianne-dawson -
Category
Documents
-
view
214 -
download
0
Transcript of Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from...
![Page 1: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/1.jpg)
Dr. Ahmed Fathalla Ibrahim
![Page 2: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/2.jpg)
VERTEBRAL COLUMNVERTEBRAL COLUMN
![Page 3: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/3.jpg)
VERTEBRAL COLUMNVERTEBRAL COLUMN
• Mesenchymal cells from Mesenchymal cells from sclerotome sclerotome are found in 3 areas:
1.1.Around notochordAround notochord
2.2.Around neural tubeAround neural tube
3.3.In body wall near to notochord & In body wall near to notochord & neural tubeneural tube
![Page 4: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/4.jpg)
VERTEBRAL COLUMNVERTEBRAL COLUMN
• Mesenchymal cells around notochord: Mesenchymal cells around notochord: form bodies of vertebraeform bodies of vertebrae
• Mesenchymal cells around neural tube: Mesenchymal cells around neural tube: form vertebral (neural) arches form vertebral (neural) arches
• Mesenchymal cells in body wall: Mesenchymal cells in body wall: form form costal processes (give ribs in thoracic costal processes (give ribs in thoracic region)region)
![Page 5: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/5.jpg)
FORMATION OF BODYFORMATION OF BODY At 4At 4thth week week, , each sclerotome is formed
of:
1.1.A cranial part of loosely arranged cellsA cranial part of loosely arranged cells
2.2.A caudal part of densely packed cellsA caudal part of densely packed cells The densely packed cells of one The densely packed cells of one
sclerotome fuse with the loosely sclerotome fuse with the loosely arranged cells of succeeding arranged cells of succeeding sclerotome to form sclerotome to form centrumcentrum (primordium of body)(primordium of body)
![Page 6: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/6.jpg)
FORMATION OF BODYFORMATION OF BODY
As a result:As a result:Each centrum develops from 2 adjacent Each centrum develops from 2 adjacent
sclerotomes (intersegmental)sclerotomes (intersegmental)Nerves lie in close relation to discsNerves lie in close relation to discsArteries (first intersegmental) now lie Arteries (first intersegmental) now lie
on each side of vertebral bodieson each side of vertebral bodiesNotochord degenerates where it is Notochord degenerates where it is
surrounded by vertebral bodiessurrounded by vertebral bodies
![Page 7: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/7.jpg)
INTERVERTEBRAL DISCINTERVERTEBRAL DISC
• Nucleus pulposus: Nucleus pulposus: notochord notochord (between vertebral bodies)(between vertebral bodies)
• Annulus fibrosus: Annulus fibrosus: surrounding surrounding mesenchymemesenchyme
![Page 8: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/8.jpg)
VERTEBRAL DEVELOPMENTVERTEBRAL DEVELOPMENT
![Page 9: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/9.jpg)
VERTEBRAL DEVELOPMENTVERTEBRAL DEVELOPMENTCartilaginous stage Cartilaginous stage
At 6At 6thth week, week, chondrification centers appear
At the end of embryonic period, At the end of embryonic period, the 2 centers in centrum fuse then fuse with those of vertebral arches
![Page 10: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/10.jpg)
VERTEBRAL DEVELOPMENTVERTEBRAL DEVELOPMENTBony stage Bony stage
Primary ossific centersPrimary ossific centers:: Present by the end of embryonic periodthe end of embryonic period Three in number Three in number (one in centrum , one
in each half of vertebral arch) The 2 halves of vertebral arches fuse at
3-5 years 3-5 years (first in lumbar, fusion proceeds cranially)
Vertebral arches articulate with centrum through neurocentral joints neurocentral joints until 3-6 years 3-6 years when fusion occurs
![Page 11: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/11.jpg)
VERTEBRAL DEVELOPMENTVERTEBRAL DEVELOPMENTBony stageBony stage
Secondary ossific centersSecondary ossific centers:: Appear after pubertyafter puberty Five in number Five in number (two in body , one at tip
of spinous process, one at tip of each transverse process)
All centers unite around 25 yearsaround 25 years
![Page 12: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/12.jpg)
DEVELOPMENT OF RIBSDEVELOPMENT OF RIBS
Ribs develop from costal processes in costal processes in thoracic regionthoracic region:
1.They become cartilagecartilage during embryonic periodembryonic period
2.They ossifyossify during fetal periodfetal period
3.Site of union with vertebra is replaced by costovertebral jointcostovertebral joint
Costal processes in other region fuse with transverse processes of vertebrae
![Page 13: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/13.jpg)
DEVELOPMENT OF STERNUMDEVELOPMENT OF STERNUM
Appears in the form of 2 vertical 2 vertical mesenchymal bars (sternal bars)mesenchymal bars (sternal bars)
FusionFusion of 2 bars occurs craniocaudallycraniocaudallyChondrificationChondrification occurs during fusionduring fusionOssification centers Ossification centers appear
craniocaudally craniocaudally before birth before birth EXCEPT for xiphoid process (during childhoodduring childhood)
![Page 14: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/14.jpg)
DEVELOPMENT OF CRANIUMDEVELOPMENT OF CRANIUMTHE CRANIUM CONSISTS OF:THE CRANIUM CONSISTS OF:
• NEUROCRANIUM:NEUROCRANIUM: PROTECTIVE CASE PROTECTIVE CASE FOR BRAINFOR BRAIN
• VISCEROCRANIUM:VISCEROCRANIUM: SKELETON OF SKELETON OF FACEFACE
• EACH PART IS SUBDIVIDED INTO:EACH PART IS SUBDIVIDED INTO:
• CARTILAGINOUS PART: CARTILAGINOUS PART: OSSIFY BY ENDOCHONDRAL OSSIFICATIONENDOCHONDRAL OSSIFICATION
• MEMBRANOUS PART:MEMBRANOUS PART: OSSIFY BY INTRAMEMBRANOUS OSSIFICATIONINTRAMEMBRANOUS OSSIFICATION
![Page 15: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/15.jpg)
DEVELOPMENT OF CRANIUMDEVELOPMENT OF CRANIUM
![Page 16: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/16.jpg)
CARTILAGINOUS CARTILAGINOUS NEUROCRANIUMNEUROCRANIUM
PARACHORDAL CARTILAGE:PARACHORDAL CARTILAGE: Forms around cranial end of notochord around cranial end of notochord Forms occipital bone (together with occipital bone (together with
sclerotome of occipital somites)sclerotome of occipital somites)
HYPOPHYSEAL CARTILAGES:HYPOPHYSEAL CARTILAGES: Form around pituitary glandaround pituitary gland Fuse to form body of sphenoid bonebody of sphenoid bone
![Page 17: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/17.jpg)
CARTILAGINOUS CARTILAGINOUS NEUROCRANIUMNEUROCRANIUM
ALA ORBITALIS:ALA ORBITALIS: Forms lesser wing of sphenoid bone lesser wing of sphenoid boneOTIC CAPSULES:OTIC CAPSULES: Form petrous & mastoid parts of petrous & mastoid parts of
temporal bonestemporal bonesTRABECULAE CRANII & NASAL TRABECULAE CRANII & NASAL
CAPSULES:CAPSULES: Fuse to form ethmoid bone ethmoid bone
![Page 18: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/18.jpg)
![Page 19: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/19.jpg)
MEMBRANOUS MEMBRANOUS NEUROCRANIUMNEUROCRANIUM
• Forms the calvaria (cranial vault): the calvaria (cranial vault): frontal & parietal bonesfrontal & parietal bones
• Bones are separated by fibrous joints fibrous joints (sutures)(sutures)
• Six fontanelles Six fontanelles (site of meeting of several sutures) are present
![Page 20: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/20.jpg)
CARTILAGINOUS CARTILAGINOUS VISCEROCRANIUMVISCEROCRANIUM
Derived from pharyngeal arches:Derived from pharyngeal arches: Dorsal end of 1Dorsal end of 1stst arch: arch: malleus & incusmalleus & incus Dorsal end of 2Dorsal end of 2ndnd arch: arch: stapes & styloid stapes & styloid
process of temporal boneprocess of temporal bone Ventral end of 2nd arch: Ventral end of 2nd arch: lesser horn & lesser horn &
superior part of body of hyoid bonesuperior part of body of hyoid bone Ventral end of 3Ventral end of 3rdrd arch: arch: greater horn & greater horn &
inferior part of body of hyoid boneinferior part of body of hyoid bone
![Page 21: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/21.jpg)
MEMBRANOUS MEMBRANOUS VISCEROCRANIUMVISCEROCRANIUM
• Squamous part of temporal boneSquamous part of temporal bone
• Maxillary boneMaxillary bone
• Zygomatic boneZygomatic bone
• MandibleMandible
![Page 22: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/22.jpg)
POSTNATAL GROWTH OF POSTNATAL GROWTH OF CRANIUMCRANIUM
At birth, At birth, calvaria is larger than facecalvaria is larger than face Increase in size of calvaria is greatest
during first 2 years during first 2 years (period of most rapid postnatal growth of brain)
Rapid growth of face & jaws coincide with:
1.Eruption of teeth
2.Development & enlargement of paranasal sinuses (which are absent or rudimentary at birth)
![Page 23: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/23.jpg)
SPINA BIFIDASPINA BIFIDA
Cause:Cause: Failure of fusion of the halves of the vertebral arch
Incidence:Incidence: 0.04 – 0.15% Sex:Sex: more frequent in femalesin females Types:Types:
1.1.Spina bifida occulta (20%)Spina bifida occulta (20%)
2.2.Spina bifida cystica (80%)Spina bifida cystica (80%)
![Page 24: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/24.jpg)
SPINA BIFIDASPINA BIFIDA
![Page 25: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/25.jpg)
SPINA BIFIDA OCCULTASPINA BIFIDA OCCULTAThe closed typeThe closed typeOnly one vertebra is Only one vertebra is affectedaffectedNo clinical symptomsNo clinical symptomsSkin over it is intactSkin over it is intactSometimes covered by Sometimes covered by a tuft of haira tuft of hair
![Page 26: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/26.jpg)
SPINA BIFIDA CYSTICASPINA BIFIDA CYSTICA
with meningomyelocelewith meningomyelocele with with myeloschisismyeloschisis
![Page 27: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/27.jpg)
SPINA BIFIDA CYSTICASPINA BIFIDA CYSTICA• The open typeThe open type• Neurological symptoms are presentNeurological symptoms are present• Subdivided into:Subdivided into:
1.1. Spina bifida with meningocele: Spina bifida with meningocele: protrusion of sac containing meninges & cerebrospinal meninges & cerebrospinal fluidfluid
2.2. Spina bifida with meningomyelocele: Spina bifida with meningomyelocele: protrusion of sac containing meninges with meninges with spinal cord and/or nerve rootsspinal cord and/or nerve roots
3.3. Spina bifida with myeloschisis: Spina bifida with myeloschisis: spinal cord is spinal cord is open (due to failure of fusion of neural folds)open (due to failure of fusion of neural folds)
![Page 28: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/28.jpg)
CRANIOSYNOSTOSISCRANIOSYNOSTOSIS
![Page 29: Dr. Ahmed Fathalla Ibrahim. VERTEBRAL COLUMN Mesenchymal cells from sclerotomeMesenchymal cells from sclerotome are found in 3 areas: 1.Around notochord.](https://reader035.fdocuments.us/reader035/viewer/2022062803/56649f005503460f94c15e57/html5/thumbnails/29.jpg)
CRANIOSYNOSTOSISCRANIOSYNOSTOSIS• Premature closure of cranial sutures Premature closure of cranial sutures
(more severe if occurs prenatally)(more severe if occurs prenatally)
• Sex: Sex: more frequent in malesmore frequent in males
• Types:Types: depend upon which suture depend upon which suture closes prematurelycloses prematurely
1.1.ScaphocephalyScaphocephaly (50%): (50%): sagittal suturesagittal suture
2.2.OxycephalyOxycephaly (30%): (30%): coronal suturecoronal suture
3.3.PlagiocephalyPlagiocephaly: : both coronal and both coronal and lambdoid sutures on one sidelambdoid sutures on one side
4.4.TrigonocephalyTrigonocephaly: : frontal suturefrontal suture