Supplementary Figure S1. Forest plot of subgroup analysis for OS; A, subgroup

analysis for EOC, GC, and BC; B, subgroup analysis for HCC, CRC, and NPC; C,

subgroup analysis for different ethnic background

Supplementary Figure S2: Forest plot of subgroup analysis for PFS/RFS/DFS. A,

subgroup analysis for breast cancer; B, subgroup analysis for different ethnic

background; C, subgroup analysis for NPC (distant metastasis-free survival)

Supplementary Figure S3: Forest plot of miR-22 high expression and

clinicopathological features (T stge/ tumor differentiation/ lymphatic invasion).

Supplementary Figure S4: Subgroup analysis of overall survival in different tissue

preservation method (FFPE, FTT, -, Fresh tumor tissue)

Supplementary Figure S5: Kaplan–Meier plots for Stomach adenocarcinoma patients’ overall survival for a discriminatory median miR-22 expression, from TCGA

sequencing data to assess prognostic accuracy

Supplementary Figure S6: Kaplan–Meier plots for rectum adenocarcinom patients’

overall survival for a discriminatory median miR-22 expression, from TCGA

sequencing data to assess prognostic accuracy

Supplementary Figure S7: Kaplan–Meier plots for breast cancer patients’ overall

survival for a discriminatory median miR-22 expression, from TCGA sequencing data

to assess prognostic accuracy

Supplementary Figure S8: Kaplan–Meier plots for Liver hepatocellular carcinoma

patients’ overall survival for a discriminatory median miR-22 expression, from TCGA

sequencing data to assess prognostic accuracy

Supplementary Figure S9: Kaplan–Meier plots for ovarian cancer patients’ overall

survival for a discriminatory median miR-22 expression, from TCGA sequencing data

to assess prognostic accuracy