In learning we will teach,

and in teaching we will learn.

Doctor Training for POLY-MVA Lipoic Acid Mineral Complex

Targeted Integrative Biological Modifier

in “Metabolic Medicine”

Mitochondrial Role in Aging and Disease

– Power Plant - Controls Life/Death – ATP for Function & Active Transport – Mitochondrial DNA - NO defenses – Oxidative Balance is necessary – Recycling and support of Antioxidants

Protection of DNA

Cell membrane

METABOLISM Energy requirement between: – Anaerobic metabolism – without regard to

oxygen (produces 2 ATP) thru glycolysis – Aerobic metabolism – oxygen is required

(produces 34 ATP) via Oxidation of Pyruvate Krebs Cycle Oxidative Phosphorylation (e- transport chain)

Pyruvate Kinase

PKM1 PKM2

Cellular Apoptosis Pathway

Apoptosis

CAD

ICAD Endo

G

PI3K PKC

IkBa

SMAC

Arts

HTRA2

CIAP1

Caspase9

APAF1

Cytoc

MDM2

ATM

p53

EndoG

AIF

BAK

p90RSK Akt1

CAD

FLIP

p14(ARF)

Noxa

PARP

BID BAD

Caspase3

Caspase8

NF-kB

NF-kB

Apoptosis Apoptosis Depolari-

zation Oncogenic Signal

FLIP,CIAP2,BFL1, BCL2 BAK,BAK,BID,

Ras,Noxa,PUMA, APAF1,Survivin,

BCL2 DNA Fragmentation

Withdrawl of

Growth Factors

Apoptosis

IKKs

Procaspase8

TRAF2 RIP

MMP

BCL2 Caspase7

VDAC

Daxx

POD

Apo2/

Apo3

Procaspase8

tBID BCLX

L PMR

CypD

PML

p53

Chk2

2009 ProteinLounge.com C

Oxygen trigger in the Mitochondria

HIF= Hypoxia Inducing Factor In a normoxic state it is catalytically destroyed Therefore, in a hypoxic state it increases HIF-1α forms a dimer with HIF-1β (a non-

hypoxia related molecule) and is activated.

ROLE: Allows physiologic and metabolic adaptation to a abnormal environment

Taking Advantage of Metabolic Dysfunction

Oxygen is the final electron acceptor Hypothesis:

Providing alternative ENERGY source Hypoxic and/or cancer cells are limited

Normal cells are supplemented by it and thrive

Dr. Merrill Garnett

Lipoic Acid Mineral Complex (Trimer)

Bonding of electron accepting & donating mineral (palladium)

Alpha-Lipoic Acid water/fat soluble anti-oxidant

Thiamin (B1) resulted in the creation of a novel Redox complex!

Palladium

Lipoic Acid Thiamine

POLY-MVA/(LAMC)

What is POLY-MVA? POLY: Lipoic Acid Mineral Complex M-inerals: Molybdenum, Rhodium,

Ruthenium V-itamins: B1, B2, B12 A-mino Acids: N-Acetyl Cysteine &

Formyl Methionine Designed to support and promote

cellular energy production.

Poly-MVA Clean Room Manufacturing

Differs from free radical scavengers (e.g. a lipoic acid) no free lipoic acid or B1

Irreversibly bound together resulting in a complex that is both fat and water soluble.

Poly-MVA is a polymer (liquid crystal) rather than a single molecule. Therefore, provides a unified redox (accept charge and donate charge) reaction.

An extremely effective energy transferring molecule

ORAC Value Comparisons ORAC = Oxygen Radical Absorbance

Capacity (expressed as Trolox equivalent per gram)

Vitamin C = 1.12 (1,890) Melatonin = 2.04 (3,468) Lipoic Acid = 1.4 (2,400) Poly MVA = 5.65 (9,605) Brunswick Labs, Wareham, MA

HOW DOES LIPOIC COMPLEX WORK?

Redox molecule that facilitates energy charge transfer Therefore: protects and provides energy source

Mimics the electron transport chain.

LIPOIC ACID

+ Thiamine

Poly-MVA- Mechanism of Action and Role in Energy Metabolism

Poly-MVA

Energy

O2

Generates Oxygen Radicals

Cytochrome c +

initiator caspase

+ APAF

= CANCER

CELL DEATH

Cancer Cell

APOPTOSIS

Healthy

Cell

O2

Energy

Stabilize Electron Transport Chain

POLY-MVA Targeting Varying hypoxic conditions are

associated with different disease. Provides an alternative mitochondrial

ENERGY source

in a hypoxic state, cancer cells move toward Apoptosis

Normal cells are supplemented and thrive

Regardless of oxygen state

How to use POLY-MVA Nutrients

Other Antioxidants

Complementary and Integrative

An Integrative Approach

Other Metabolic Therapies

CoQ10, D-ribose, L-Carnitine, NAD Magnesium, Potassium, B-Complex Glutathione, Vitamins - C, A, K, E, D

Targeting oxygen and metabolic energy production and pathways

Poly-MVA brings Energy to the cell

Poly-MVA Osmolarity:

0.12m Osmol/ml

MG PER ML 5ml 10ml 20ml 40ml ACTIVE LAMC

INGREDIENT

ALA/Thiamin mg ≈ 8/9mg 40 / 45mg 80/90mg 160/180g 320/360mg

Lipoic Acid Thiamin Pd Complex ≈

21mg 105mg 210mg 420mg 840mg

Co-Factors

B2 Riboflavin .2mg 1 mg 2 mg 4 mg 8 mg

B12 as cobalamin .2mg 1 mg 2 mg 4 mg 8 mg

Molybdenum .1mg .2mg .4mg .8mg 1.6mg

Rhodium .1mg .1mg .2mg .4mg .8mg

Ruthenium .1mg .1mg .1mg .1mg .1mg

Formyl Methionine .1mg .2mg .4mg .8mg 1.6mg

N-AcetylCystein .1mg .1mg .2mg .4mg .8mg

Poly Plus Vit A 50 IU 500IU 1000IU 2000IU 4000IU

Total Co-Factors ≈ 0.5mg 1.25mg 2.5mg 5.0mg 10mg

Sodium (mg) ≈ 3mg 15mg 30mg 60mg 120mg

ALA Equivalent ≈ 40mg 200mg 400mg 800mg 1600mg

Applications and Research:

• Metabolically targeted therapy

• Alleviate mitochondrial damage and fatigue

• Potentiate chemo and radiotherapy • Attenuating their toxicity

Poly-MVA / LAMC In Fatigue, Mitochondrial

& Neuro-inflammatory Disorders

Initial clinical applications:

1. Oncology treatment 2. Quality of Life Advancing applications: 3. Chronic illness treatment 4. Metabolic Dysfunction

Combating Clinical Fatigue Multiple Sclerosis-associated fatigue:

Dr. Lauren Krupp, Stony Brook University, IND approved

• 80% of subject demonstrated statistically significant HIV-associated fatigue: Dr. Gary Blick, Circle Medical

• improvement in QOL/Energy/Fatigue:

Palliative Care - conducted by Pharmaceutical company CIPLA • Cognitive Functioning, Emotional Functioning,

Social Functioning, Fatigue, Sleep Disturbances, and Appetite Loss.

Floroquinillian/Anti-biotic associated fatigue:

CANINE–Osteosarcoma Open Labeled Study

Median Survival (in days)

367

288

268

165

0 100 200 300 400

Amputation w/ Chemotherapy +Poly MVA (n=17)

Amputation w/ Chemotherapy (n = 32)

Amputation w/ Poly MVA (n=11)

Amputation Alone (n=162)

Ogilvie, G. (2008)

Poly-MVA improved median survival 62% (103 days) compared to surgery Poly-MVA with the chemotherapy regimen (carboplatin + doxorubicin) resulted in a 27% (79 days) longer median survival, with improved objective parameters (i.e. weight, anemia, liver and kidney function).

Summary : Peer-reviewed studies have demonstrated the

ability of LAMC to: Anti-oxidant activity DNA protection and repair (human dose of 4 tsp/day)

Chromosomal protection Protected blood cells Increased spleen colony formation Attenuation of radiation-induced weight loss Enhanced radiotherapy Radiation-induced mitochondrial repair

4 months after chest radiation: Poly-MVA reduced markers of inflammatory infiltration

RADIATION STUDIES

An NCI/NIH study at the University of Arkansas studied Poly

MVA on a model of radiation-induced heart disease.

Late administration of Poly-MVA (human dose of 2 tsp/day) mitigated mitochondrial alterations and attenuated cardiac

inflammatory markers when administered eighteen weeks after irradiation.

The authors concluded that “An earlier onset of Poly MVA administration

may have more profound effects

on radiation-induced cardiac remodeling".

Sridharan, V., Seawright, J., Antonawich, F.J., Garnett, M., Cao, M., Singh, P., Boerma, M. (2017) Late

Administration of a Palladium Lipoic Acid Complex (Poly-MVA) Modifies Cardiac Mitochondria Induced Heart

Disease in a Rat Model. Journal of Radiation Research 187(3): 361-366.

Example: Integrated Protocol with POLY-MVA

Monday - INP + POLY-MVA IV

Tuesday - IPT + L - Glutathione IV-Oral Poly

Wednesday - Super “C”– 60 grams + H2O2 IV

Thursday - IPT + L - Glutathione IV-Oral Poly

Friday - INP + POLY-MVA IV

Immune Nutrient Protocol (INP)

Normal Saline L-Lysine and Zinc

B-Complex DMSO

Pyridoxine Folic Acid

Vitamin B-12 L-Glutathione

Vitamin C Magnesium Chloride

Novel Combination Therapy researched in Non-responders

Historical ALA/Thiamine combination benefits Poly-MVA has multiple collateral potential

Anti-cancer Cell protective Increased ATP/enrgy to target Fatigue

DCA is effective but has neurological effects

(c) PS Anderson - www.consultDrA.com - 2020 34

In Fatigue, Mitochondrial & Neuro-inflammatory Disorders

Paul S. Anderson, NMD © 2020

Typical series is (1) Vitamin-Mineral-Amino (2) Other (3) Other (4) Poly-MVA. Typically use for 6-12 weeks & then reassess.

First: Vit-Mineral-Amino formula Co-factors for mitochondrial and cellular function Second Optional: Glutathione/other Third Optional: Phosphatidylcholine /other Fourth: Poly-MVA

Multi-agent IV therapy

– well tolerated

– positive symptomatic and quality of life

Poly in place of the ALA

Oral doses can be 5 to 40mL (1-8 tsp) BID

Used as support between IV or stand-alone.

Generally this is dosed 2 IV/week, oral on the off days 6-12 weeks, then maintenance

Option for only oral daily 10-40ml or 6-12 weeks

All the benefits of Poly-MVA,

Plus the synergistic benefits of Vitamin A.

Vitamin A aerobic metabolism

Facilitates iron mobilization to form

hemoglobin in red blood cells. Reduces anemia

When cells are deprived of Vitamin A the synthesis of ATP decreases as did respiration, they were restored when vitamin A was restored.

Poly MVA: Increase metabolism and

ATP levels Demonstrate anti-oxidant

activity DNA and chromosome

protection Enhance DNA repair Attenuate radiation-

induced weight loss Protect blood cells and

increase spleen colony formation

Repair radiation-induced mitochondria

Enhance radio and chemotherapy

Poly-Plus Vit A: Enhance the visual

system Benefit skin: aging,

acne, dryness Strengthen the

immune system Improve health of

bones /teeth Facilitate erythrocyte

specialization & hemoglobin

Vitamin A is normally fat soluble Developed a unique version that stays in Poly-MVA solution Poly-PLUS with Vitamin A Enhanced version of the Poly-MVA Potentiate cellular energy Attenuate fatigue Support Mitochondrial concerns

50 year old Male no history of skin cancer. Been in the sun since he was a child ‘all summer long’ , swam competitively for 6 years. Continues to be outdoors and in desert areas with extreme sun and temperature exposure. Ignored scalpel growth for 10-12 months. Topical with cu-tip 1-3x/day for 60 days till gone June thru July 2015. Used Poly-MVA orally at ½ tsp.

CASE STUDY

Same Male March 2019 Right side below temple growth 2 months of watchful waiting, Family making note of change

Applied topical with roll on 1-3x/day old skin/scab rolled off in 90 days Was using Poly-MVA orally at 1tsp

Same Male Jan 2020 Cleaning ear and it bled immediately applied Poly-MVA via cue tip and saturated cotton ball 2-3x daily. Healed in 21 days and looks normal Used Poly-MVA orally at 1tsp

Case 2 86 Year old Female abnormal growth. Had a telemedicine with current doctor. Answer was wait till Pandemic is over to see dermatologist. Growth was advancing weekly and she was very nervous. Family friend called and recommended Poly to do at least something. Currently at 12 days applying Poly 2-3x per day for with significant improvement.

7 Additional Days

Case 3 18 Year old Male non healing deep shin Injury Feb 5th, 2020. Healing normally. Reinjured March 20th, 2020 Wound not healing and still oozing despite cleaning, covering, various topical applications of silver, light therapy, peroxide thru the month of April and into May Started Poly Injections on May 10th Scabbed in 2 days by May 12th Injecting every 7-10 days and monitoring

March 2020

May 10 May 12

May 23

Oxidative Stress in

Aging and Dry Eye Disease

Oxidative stress damages the ocular surface

Plays an important role in dry eye disease.

Investigate the therapeutic modalities employing topical/systemic use of antioxidants in dry eye disease.

The Association for Research in Vision and Ophthalmology Copyright © 2020. All rights reserved.

From: Potential Role of Oxidative Stress in Ocular Surface Inflammation and Dry Eye Disease Invest. Ophthalmol. Vis. Sci.. 2018;59(14):DES163-DES168. doi:10.1167/iovs.17-23402

Superoxide dismutase -SOD enzyme family is a major antioxidant system in all tissues An imbalance between radical-scavenging systems and free radical generation in the tears, Meibomian gland, and mitochondria may result in tissue inflammation, damage, and accumulation of ROS

Three reactions are particularly relevant to cell injury: – lipid peroxidation of membranes, – oxidative modification of proteins, – oxidative damage to DNA. The accumulation of ROS lead to Meibomian gland disease and dry eye disease.

accumulating evidence suggests that oxidative stress may have a direct and/or indirect effect on ocular surface health plays an important role in the pathogenesis of several forms of dry eye. Therapeutic modalities employing topical/systemic use of antioxidants may have a promising future in the treatment of dry eye disease.

Poly-MVA & Complementary Agents Melatonin Metformin DCA Salicinium Artesunate Ketogenic Diet

Curcumin

Photo/Light Therapy

Mistletoe

Naltrexone(LDN)

Oxaloacetate(NAD)

Vit C

Glutathione

Phosphatidylcholine

Integrative Medicine Protects

Patient improvements are not gained at the expense of toxic therapies leaving them with many adverse side effects:

Painful Neuropathies

Cardiomyopathies

Renal Failure / Platinum toxicities

Hepatic Failure

Severe Pancytopenias

Pulmonary Fibrosis

Devastating Fatigue, Anorexia and Wasting Syndromes

Osteoarthritis, myalgias, osteoporosis

Severe dermatoses

Chemo Brain Syndrome

Death

Outcome studies support that the Biological/Integrative approach to advanced therapies is far more successful.

“Information is the Force of Change”

Prevention is the most important and reliable

Dis-ease fighting tool that exists today.

Disease can be effectively treated, reversed and that prevention are the most important

messages we can share. www.polymva.com

www.electrogenetics.net www.consultDrA.com

https://www.ivnutritionaltherapy.com/

Email for Information: doctors@polymva.com