DIvIsIon of Molecular BIology of HeMato ... - Immunologie · Winfried F. PICKL, MD Contact:...
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Institute of Immunology Institute of Immunology Center for Physiology, Pathophysiology & Immunology Medical University of Vienna Borschkegasse 8a A-1090 Vienna, AUSTRIA Phone +43 1 4277-64901 Fax +43 1 4277-9649 [email protected] www.immunology.at To add to a better understanding of the immune system by purposeful research and to provide this knowledge to students as well as for professional education is the main goal of the Institute of Immunology. Our efforts are especially dedicated to conduct applica- tion-oriented investigations relevant to human medicine. Elucidating the molecular basis of immunological reactions is aimed at increasing the insight into the principles of immune reactivity. This shall form the basis for the development of new strategies for therapeutic interventions as well as for decisive diagnostic procedures. Gerhard J. ZLABINGER, MD Contact: [email protected] It is a central concern in modern immunology to recognise how the immune system defeats potentially harmful invaders and spares host tissue. Knowledge about triggering appropriate reactions and insight into the highly complex regulatory mechanisms operating to sustain the integrity of an individual are essential to foster effective strategies for interference in case of disturbed or unwanted im- mune reactivity as allergy, autoimmunity, malignancy or transplantation. A longstanding interest of my research group is the naturally occurring immunomodulation, particularly in local immunity and on clinical conditions as obser- ved after transplantation or in autoimmune diseases. Identification of immunological deregulation as early as possibly and the understanding of the ongoing processes are pivotal for early diagnosis and the development as well as implementation of purposeful interference strategies. Herbert STROBL, MD Contact: [email protected] We focus on questions in cell biology applied to human immunology and molecular hematopoiesis. We aim to elucidate the transcriptional mechanisms underlying the lineage differentiation of granulocytes, monocyte and dendritic cells from common myeloid progenitor/stem cells. Furthermore, we study how certain dendritic cell subsets such as environmental exposed epithelial Langerhans cells get activated, and how they might be involved in tolerance induction. As a main model cytokine dependent unilineage differen- tiation cultures of human CD34 pos.cord blood proge- nitor/stem cells are combined with inducible retroviral vector systems. Furthermore, we performed function- al genetic screens to identify novel regulatory proteins involved in myeloid progenitor/stem cell differentiation and leukemia. > Chance favours only the prepared mind < Louis Pasteur DIVISION OF CLINICAL EXPERIMENTAL IMMUNOLOGY DIVISION OF MOLECULAR BIOLOGY OF HEMATO- POIETIC STEM CELLS AND DENDRITIC CELLS Center for Physiology, Pathophysiology & Immunology Impressum Text: Institut für Immunologie Grafik und Layout: Abteilung für Öffentlichkeitsarbeit der Meduni Wien www.meduniwien.ac.at/publicrelations
Transcript of DIvIsIon of Molecular BIology of HeMato ... - Immunologie · Winfried F. PICKL, MD Contact:...
Institute of Immunology
Institute of Immunology
Center for Physiology, Pathophysiology & ImmunologyMedical University of ViennaBorschkegasse 8aA-1090 Vienna, AUSTRIAPhone +43 1 4277-64901Fax +43 1 4277-9649
To add to a better understanding of the immune system by purposeful research and to provide this knowledge to students as well as for professional education is the main goal of the Institute of Immunology.
Our efforts are especially dedicated to conduct applica-tion-oriented investigations relevant to human medicine. Elucidating the molecular basis of immunological reactions is aimed at increasing the insight into the principles of immune reactivity. This shall form the basis for the development of new strategies for therapeutic interventions as well as for decisive diagnostic procedures.
Gerhard J. ZLABINGER, MDContact: [email protected]
It is a central concern in modern immunology to recognise how the immune system defeats potentially harmful invaders and spares host tissue.
Knowledge about triggering appropriate reactions and insight into the highly complex regulatory mechanisms operating to sustain the integrity of an individual are essential to foster effective strategies for interference in case of disturbed or unwanted im-mune reactivity as allergy, autoimmunity, malignancy or transplantation.
A longstanding interest of my research group is the naturally occurring immunomodulation, particularly in local immunity and on clinical conditions as obser-ved after transplantation or in autoimmune diseases. Identification of immunological deregulation as early as possibly and the understanding of the ongoing processes are pivotal for early diagnosis and the development as well as implementation of purposeful interference strategies.
Herbert STROBL, MDContact: [email protected]
We focus on questions in cell biology applied to human immunology and molecular hematopoiesis.
We aim to elucidate the transcriptional mechanisms underlying the lineage differentiation of granulocytes, monocyte and dendritic cells from common myeloid progenitor/stem cells. Furthermore, we study how certain dendritic cell subsets such as environmental exposed epithelial Langerhans cells get activated, and how they might be involved in tolerance induction. As a main model cytokine dependent unilineage differen-tiation cultures of human CD34 pos.cord blood proge-nitor/stem cells are combined with inducible retroviral vector systems. Furthermore, we performed function-al genetic screens to identify novel regulatory proteins involved in myeloid progenitor/stem cell differentiation and leukemia.
> Chance favours only the prepared mind <Louis Pasteur
DIvIsIOn OF CLInICAL ExpErImEnTAL ImmunOLOgy
DIvIsIon of Molecular BIology of HeMato-poIetIc steM cells anD DenDrItIc cells
center for physiology, pathophysiology & Immunology
Impressum Text: Institut für Immunologiegrafik und Layout: Abteilung für Öffentlichkeitsarbeit der meduni Wien www.meduniwien.ac.at/publicrelations
Folder Immunologie_hb.indd 1 14.09.2007 09:13:00
Winfried F. PICKL, MDContact: [email protected]
T cell activation is the result of a su-stained antigen-specific interaction of a T lymphocyte with a professio-nal antigen-presenting cell (pApC) in a secondary lymphatic tissue.
The detailed description of the molecular and functio-nal events within the immunological synapse formed by T cells and pApC is one of the keys to the better understanding of adaptive immune responses and their modulation. model systems in which the im-munological synapse can be rebuilt with receptors relevant for human diseases shall enable us to study the pathophysiology of allergies, autoimmune and infectious diseases as well as cancer in greater detail and may thus lead to novel strategies for their cure.
Peter STEINBERGER, PhDContact: [email protected]
We are interested in the contributi-on of surface molecules on human T cells and antigen-presenting cells (ApC) to immune responses.
For this we have developed experimental systems that make it possible to efficiently analyse the contribution of individual ligands to T cell activation processes. In addition we are trying to identify novel receptors that regulate the activation of T cells by ApC. To achieve this goal we rely on our experience in the generation, expression and screening of cDnA expression libraries. more recently we have extended the use of this technology to the identification of cell surface antigens that are recognized by sera derived from cancer patients and from stem cell transplanted individuals.
Johannes STÖCKL, PhDOtto MAJDIC, PhD
contact:johannes,[email protected]@meduniwien.ac.at
The central research interest of our group is a better understanding of regulatory mechanisms between the innate and adaptive immune system.
Our group has longstanding interests and experience in the molecular and functional analysis of cells of the
human phagocyte lineage, in particular dendritic cells (DC). It is our longterm goal to learn how phagocyte development and function is regulated by exogeneous (pathogen) and endogeneous (inflammatory) danger signals.
Our current research focuses are:
• How do human rhinoviruses modulate immune responses?• What is the impact of oxidized phospho- lipids on DC development and function?• Which receptors on DC regulate the activation of T cell?• What are the effector mechanisms of regulatory T-cells?
Wilfried ELLMEIER, PhDContact: [email protected]
Our long-term research interest is to understand molecular mecha-nisms that regulate the development and function of immune cells.
The research in our laboratory focuses on studies to understand epigenetic and transcriptional con-trol mechanisms that regulate CD8 coreceptor gene expression, on the identification of genes that control developmental processes such as CD4/CD8 cell fate decisions during T cell differentiation, and on studies to reveal the various roles of Tec family kinases in different cell lineages of the immune system. The experimental strategies to address our research interests include biochemical and molecular approaches, retroviral-mediated gene transduction into hematopoietic stem cells, and mouse molecular genetic tools.
DIvIsIOn OF CELLuLAr ImmunOLOgy AnD ImmunE HEmATOLOgy
DIvIsIOn OF ImmunE rECEpTOrs AnD T-CELL ACTIvATIOn
DIvIsIOn OF ImmunE-rEguLATIOn
DIvIsIOn OF ImmunObIOLOgy
w w w . i m m u n o l o g y . a t
Folder Immunologie_hb.indd 2 14.09.2007 09:13:04
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