Distributor Meeting MEDICA November, 2009 Dr. Ariel Weisz R&D Department Metrolab, Argentina.
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Transcript of Distributor Meeting MEDICA November, 2009 Dr. Ariel Weisz R&D Department Metrolab, Argentina.
Distributor Meeting MEDICANovember, 2009
Dr. Ariel WeiszR&D DepartmentMetrolab, Argentina
Metrolab is a company which designs and manufactures
Clinical Chemistry Analyzers with its own technology.
+ reliable instruments to the global market+ easy of use+ effective after-sale service+ competitive prices
Clinical Chemistry AnalyzersThe Principle: Spectrophotometry
Beer-Lambert LawBeer-Lambert Law
concentrationconcentration
Ab
sorb
ance
Ab
sorb
an
ce
T = P / P0
A = log10(P0 / P)
A = bc: molar absorbtivity
c: molar concentration
ColorimetryColorimetry
Samples
Reactions
Reagents
Mix Incubation(37°C)
Measure
Double beam photometerDouble beam photometer
reference detector
sample detector
beam splitter
filterlamp
reaction cuvettes
A = log(R/S)
R
S
Dual photometerDual photometer
Front sampleFront sample detector detector
reference reference detectordetector
beambeamsplitterssplitters
filterfilterlamplamp
AAFF = log(R/S = log(R/SFF))
AABB = log(R/S = log(R/SBB))SSFF
RR
Back sample Back sample detectordetector
SSBB
Clinical Chemistry AnalyzersApplications and Measuring Methods
One Reagent End PointOne Reagent End Point
A
Time
Ab
sorb
an
ce
B
R1+S
Measure = A - B
MetabolitesAlbuminGlucoseCholesterolUric acidTriglyceridesTotal proteins
AA22
TimeTime
Ab
sorb
an
ceA
bso
rban
ce
AA11
RR11+S+S RR22
BB11
BB22
Measure = (AMeasure = (A22-A-A11) – (B) – (B22-B-B11))
Two-Reagent End PointTwo-Reagent End Point
BilirubinIgA, IgG, IgMLDL, HDLPhosphorous
AA22
TimeTime
Ab
sorb
an
ceA
bso
rban
ce
AA11
RR11+S+S
BB22BB11
Measure = (AMeasure = (A22-A-A11) – (B) – (B22-B-B11))
Fixed Point KineticsFixed Point Kinetics
ALPCreatinineFructusamineUrea
KineticsKinetics
AAnn
TimeTime
Ab
sorb
an
ceA
bso
rban
ce
AA11
BBnnBB11
RR11+S+S
Measure = rateMeasure = rateAA – rate – rateBB
EnzymesAmylaseCK, CPKGGTGOTGPT
Clinical Chemistry AnalyzersMETROLAB Instruments
// Metrolab history
4000
1600 DRK
1990 1995 2000 2005
1600 PLUS 2100 2300
1600 DR
305
315
330
1985
// Current Line - Main Instruments
medium labs big labs / hospitalssmall labs
M4000
600test/hr
400
200 M2300v4
M2300GL
M1600DRv3
semiautomatic
10-40 patients/day240 test/hr
20-60+ patients/day280 test/hr
60-250+ patients/day600 test/hr
veterinary
Clinical Chemistry AnalyzersMETROLAB 4000
Troughput: 550 test/hr without ISE
• 600 test/hr single reagent
• 450 test/hr double reagent
• 720 test/hr with ISE
Split reagent trays for effective carryoverand interference control
Methods are distributed, at operator’s
will between two trays.
In this way, interfering methods never
come into contact in the same cuvette
Continuous sample load with coded sectors
Positions can be assigned to normal
samples or STATS,
Handling priorities accordingly
Positive BCR identification of samples,reagents and sectors
• Coded sectors for instantaneous load
• Any coding system for samples
• Coded reagents and optional closed system
• Open channel support
Optional ISE module: Na+, K+, Cl-
• Direct serum readings
• Indirect urine readings (dilution 1:10)
• Integrated pack for simple operation
• Automatic electrode conditioning
User friendly software with different access levels
Menu bar
Main operationcontrol tool bar
Messages list
Requests tooperator bar
Quick keys menu
Current activityand summary
Test in progress
Reagents statusreport
General status bar
Mixer in probe
• High efficiency mixing guarantees reliable data in double reagent systems and viscous media
• Shake time can be programmed for every method
72 on board cooled single reagents
R2 30 ml
R1 40ml
Outer 30 ml
Full size 70 ml
LIS Interface Connection - Customized Reports
Metrolab 4000
Monitor
PC
Monitor
PC
Data Management System
LIS
ASTM Standard serial connection
Low Water Consumption
4 mL / test
// Current Line - Main Instruments
medium labs big labs / hospitalssmall labs
M4000
600test/hr
400
200 M2300v4
M2300GL
M1600DRv3
semiautomatic
10-40 patients/day240 test/hr
20-60+ patients/day280 test/hr
60-250+ patients/day600 test/hr
veterinary
Clinical Chemistry AnalyzersMETROLAB 2300 PLUS version 4
FULLY AUTOMATIC RANDOM ACCESS CLINICAL ANALYZER
• End Point
• Kinetics
• Immunoturbidimetry
• Coagulation
• ISE
• Barcode: Samples & Reagents
• Automatic Sample Dilution
• Mixer on Probe
• Quality Control
Version 4
Samples
• 48 positions for primary tubes,
tubes 75 to 100 mm (Ø 13 mm),
accepts microtainers.
• Positive BCR identification of samples
• Test request through LIS
Version 4
Reagents
• 48 positions cooled reagent
• Bar code for reagents
• Dual reagent capability
• 50, 30 and 20 mL containers
• 24 hours non stop cooling
Version 4
Cuvette washing system
• 4-Step washing station
• Automatic cuvette check
• 6 mm light path PMMA cuvettes
Version 4
Multifunction probe
• Mixer on probe
• Collision detector
• Capacitive liquid level detection
• Effective probe washing
Version 4
Optical system
• Double beam
• 9 interference filters:
340, 405, 505, 550, 590, 650, 700 and 767 nm.
• Optional filters available (380 and 620 nm )
Version 4
Software
• User friendly
• Flexible
• Designed for the clinical analyst
• Continuous upgrade meeting your requirements
Version 4
Easy service
• Open cabinet with only 4 screws
• Calibration through PC
Version 4
// Current Line - Main Instruments
medium labs big labs / hospitalssmall labs
M4000
600test/hr
400
200 M2300v4
M2300GL
M1600DRv3
semiautomatic
10-40 patients/day240 test/hr
20-60+ patients/day280 test/hr
60-250+ patients/day600 test/hr
veterinary
Clinical Chemistry AnalyzersMETROLAB 2300 GL
Easy service
• Calibration through PC
• No cooling system
• No washing system
• No BCR
• No ISE
METROLAB 2300 GL
Quick cuvette load
• Simple and Fast
• Double tray
• One tray in use (80 cuvettes)
• Preloaded tray ready to use
METROLAB 2300 GL
Clinical Chemistry AnalyzersCommon Hints
Clinical Chemistry AnalyzersCommon Hints
• Pipetting principle
• Semi-disposable plastic cuvettes
• Low water consumption
• Probe technology
• Line style
Clinical Chemistry AnalyzersCommon Hints
• Proprietary Technology
• Proprietary software
• Open or closed customized systems
• Dedicated after-sales service
Clinical Chemistry AnalyzersNext Steps…
• Modular electronics
• Reduce manufacturing costs
• Standardization
Clinical Chemistry AnalyzersThank you for your attention !!!