Disruptive Innovation - Moving Beyond the Talk
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D I S R U P T I V E I N N O V A T I O N S Disruptive Innovation: Moving Beyond the Talk Thomas Krohn Eli Lilly & Company
description
Thomas Krohn's keynote presentation at Disruptive Innovations to Advance Clinical Trials in Boston in September 2012. A case for change is presented along with a challenge to status quo approaches. Tom shares a few examples from the Lilly COI portfolio and challenges the participants to get on board with transformative change.
Transcript of Disruptive Innovation - Moving Beyond the Talk
DIS
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Disruptive Innovation:Moving Beyond the Talk
Thomas KrohnEli Lilly & Company
Case for Disruptive Innovation
Source: FDA.gov
Productivity Down, Costs Up Future revenues under pressure
Unsustainable Business Model
The Far Sideby Gary Larson
Drug Development
$- $50 $100 $150 $200 $250 $300
Mill
ions
US$
Typical Cost/NME/Phase
Precompetitive Competitivepatent
Innovation Process
3 Challenges
• Incremental vs. Disruptive• Precompetitive vs. Competitive• Closed vs. Open
Incremental Improvement
Clinical Research Improvement
Outsourcing
BPMCritical ChaineDC
Investigator Portal
Good, but not sufficient
Disruptive Innovation
to S1'
to S2
S1
Time
Performance
DisruptiveChange
Simpler, Faster, Cheaper?
Who is being disrupted?
Precompetitive vs. Competitive
Precompetitive Competitive
Collaboration should and can exist across model
patent
Closed vs. Open
Trial Planning & Design Example
Reality• Distant from practice• Small number• Slow and expensive• Naïve
Today’s Closed Fortress Model:• Internal product teams• Advisors• Third party organizations• Competitive = Secret
Time to explore other models
Experiment Portfolio
• Open Clinical Intelligence Network– Trials, Labels, Sites, CTM Reqs, Stds of Care, OpenAPI
Open Clinical Intelligence Network
Commons Licensing
3. Curate
4. Connect1. Collect
ClinicalKnowledgeGeneration
2. Consume
Uncurated Data
Curated Data
Crowd
Public Data
Motivation
Technology
Worldbank
ROAR
Open Clinical Intelligence Network
Knowledge Generating System
Krohn & Crist Whitepaper
TrialSite
PublicationDrug
DiseaseRegulatory
TimelineGeographic
Network DiagramScatter Plot
ExportAPI
Search/FilterAnnotateCorrect
Cross LinkAPI
Social ShareCollaborate
External DataGamification
Commons Licensing
3. Curate
4. Connect1. Collect
ClinicalKnowledgeGeneration
2. Consume
Uncurated Data
Curated Data
Crowd
Public Data
From data to insights
Experiment Portfolio
• Open Clinical Intelligence Network– Trials, Labels, Sites, CTM Reqs, Stds of Care, OpenAPI
• Protocol Design– Crowd-based feedback
Protocol Design
Experiment Portfolio
• Open Clinical Intelligence Network– Trials, Labels, Sites, CTM Reqs, Stds of Care, OpenAPI
• Protocol Design– Crowd-based feedback
• Site Training & Experience– Credentials, Training, Historical Trials
• Predictive Analytics– Kaggle style enrollment projections
Predictive Analytics
We’re making data science a sport.™
Experiment Portfolio
• Open Clinical Intelligence Network– Trials, Labels, Sites, CTM Reqs, Stds of Care, OpenAPI
• Protocol Design– Crowd-based feedback
• Site Training & Experience– Credentials, Training, Historical Trials
• Predictive Analytics– Kaggle style enrollment projections
• Q&A Forum– Site to site sharing, clinical research topics
Q&A Forum
So What?
If...– Incremental improvement is a slow death,– Competitive mindset is stopping collaboration, and,– Closed model is part of the problem…
Then…check your assumptions:– Incremental vs. Disruptive– Precompetitive vs. Competitive– Closed vs. Open
Time to Engage!
Tide is rising for disruptive change.
Are you on board?
The case is clearThe opportunities are manyThe question is leadership
