Immune System Disorders - Anaphylaxis, Angioedema, Drug Allergies
Disorders of the Immune System
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Transcript of Disorders of the Immune System
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Disorders of the Immune System
• Autoimmune Disorders – body produces antibodies against its own tissue, e.g. Grave’s disease (hyperthyroidism) and rheumatoid arthritis
• Allergies occur when the body reacts to materials which should not be antigenic, e.g. peanuts
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Immunity
Active immunityProduction of a person’s own
antibodies; long lasting
Passive immunityAn individual is given antibodies by
another ; short-term (weeks- 6 months)
Natural ActiveWhen pathogen
enters body in the normal way, we make antibodies
Natural PassiveFrom mother in
uterus & breast milk
Artificial PassiveImmunoglobulin
injection;extremely fast, but
short lived (e.g. snake venom)
Edward Jenner
Artificial ActiveVaccination – person makes
antibodies without becoming ill
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Blood Groups & Immunology
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The ABO System
• Discovered in 1901 by Dr. Karl Landsteiner
• 4 main phenotypes (A, B, AB, O)
• Type of inheritence: multiple alleles (each person has only 2 alleles but more than 2 alleles exist)
• Three possible alleles: IA, IB, i
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Phenotype vs. Genotype
Phenotype Genotype
A IA IA or IA i
B IB IB or IB i
AB IA IB
O i i
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Inheritance of ABO Groups
If the mother has blood type O and her husband is blood type AB, what will be the blood type of their baby?
IA i IA i
IB i IB i
i i
IA
IB50 % chance A blood type
50 % chance B blood type
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Distribution of the A allele
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Distribution of the B Allele
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Distribution of the O Allele
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Universal Donor and Recipient
Universal Donor
• Group O
– Carries no A or B antigens
Universal Recipient
• Group AB
– No anti-A or anti-B present
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The Rh(D) System
• Discovered in 1940 on Rhesus monkeys
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Simple Genetics of Rh(D)
• 86% of caucasians are Rh(D) positive• The d gene is recessive:
– DD & Dd persons are Rh(D) pos– Only dd persons are Rh(D) neg
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Distribution of Rh(D) Types
Population Rh(D) pos Rh(D) neg
Caucasian 86% 14%
African-American 95% 5%
Oriental >99% <1%
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Significance of Rh(D)
• Rh(D) negative persons exposed to Rh(D) pos blood will develop anti-D
• Anti-D can also be stimulated by pregnancy with an Rh(D) positive baby– Can be prevented by the use of anti-D
immunoglobulin (RhoGam shot) administered before and after childbirth
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Inheritance of ABO and Rh(D)
Mother
Group A IA i
Rh(D) pos Dd
Father
Group B IBi
Rh(D) pos Dd
Draw a Punnet Square for this DIHYBRID CROSS; show phenotypic ratios.