Diseases Of Breast
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Transcript of Diseases Of Breast
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Diseases of Breast
Pathology-B LabRavi A Patel
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M++Paget disease
Fibrocystic change
Infiltrating/Invasive ductal carcinoma
Fibroadenoma
Lipoma
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There are 2 types of Breast diseases
1) Invasive(Infiltrating)a. Invasive ductal carcinomab. Medullary carcinomac. Colloid carcinomad. Tubular carcinomae. Other types
2) Non invasivea. Ductal carcinoma in situ(DCIS – intraductal carcinoma)-
includes Paget diseaseb. Lobular carcinoma in situ(LCIS)
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Paget disease
• Characterized by extension of of Ductal carcinoma in situ (DCIS) up to the lactiferous ducts and into the skin of Nipple.
• Clinical appearance- Unilateral crusting exudate over the nipple and areolar skin.
• Its a benign breast lesion
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Skin of Areola
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PAGET CELLS WITHCLEAR CYTOPLASM AND HYPERCHROMATICPLEOMORPHIC NUCLEI WHICH ARE INFILTRATING THE DERMIS
Atypical liningcells
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Paget cells and Atypical ductal lining cells
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Fibrocystic Change
• The term change is applied to miscellany changes in the female breast that range from harmless to patterns associated with Breast Carcinoma.
• Some of these alteration- Stromal fibrosis and micro/macro cyst produce palpable lumps.
• These changes are the consequence of an exaggeration and distortion of the cystic breast changes that occur normally in menstrual cycle.
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There are 2 types
• Proliferative- Includes atypical duct or ductal epithelial cell hyperplasias.
• Non proliferative- includes cyst and fibrosis without epithelia hyperplasia..Also known as Simple fibrocystic change.It is very common(found in 60-80% of women)
• All these changes tend to rise during the reproductive period of life but may persist after menopause.
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* Dilated duct with visible lining epithelial cells-LPO
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NumerousMicrocysts Produced by The dilated ducts
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Observation
--- Increased Fibrosis in stroma--- Dilated ducts within fibrosis--- There is no Epithelial hyperplasia of the ductal lining cells. If there is hyperplasia then the whole lumen gets filled with heterogenous cells.
---- So we can conclude that that the slide shown falls under the most commonly found Fibrocystic change that is Non proliferative type..
HPO
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Non-ProliferativeType of Fibrocystic Change
--Fibrosis seen but No Hyperplasia
HPO
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Fibrosis
Dilated ducts
HPO
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HPO
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Infiltrating/Invasive Ductal Carcinoma
• Due to abnormally proliferating ductal lining cells, there is invasion of stroma
• In normal breast tissue– Ducts= Stroma
– Whereas in Infiltrating ductal carcinoma there is very little stroma
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Normal Breast tissue is not found
Malignant Ductal lining cellsObserved to be arranged in sheetsPleomorphism
And Hyperchromatic nuclei Of the ductal lining cells
HPO
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Fibroadenoma
• Proliferating intralobular stroma pushing the epithelium
• There are 2 types of fibroadenoma1. Pericanalicular Fibroadenoma
In this kind of Fibroadenoma the ductal space are round/oval and fairly regualar
2. Intracanalicular Fibroadenoma Over here there is extensive proliferation of
surrounding stroma which compresses the ducts giving them irregular/star shape on cross section.
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Poliferating Stroma is pushing The ducts leading to their irregularShape..This signifies of the slide being Intracanalicular fibradenoma
Fibroadenoma
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Intracanalicular type Pericanalicular type
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Lipoma
• Lipomas are benign tumours of fat and are most common soft tissue tumour of adulthood.
• Most are solitary lesions.
• Most Lipomas are mobile,slowly enlarging painless masses(angiolipoma can present with local pain)
• Complete excision is usually curative..
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Subtypes of Lipoma• Conventional- Most common subtype- they are soft, yellow, well
encapsulated masses of mature adipocyytes with considerable varying size.
• Myolipoma
• Spindle cell
• Myelolipoma
• Pleomorphic
• Angiolipoma(locally painful)
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Lipoma
LPO
Mature Fat cells withScanty stroma
RemnantsOf mammaryGlandlobules
Fat cells areWithin a thin fibrous capsule
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LPO
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HPO
Fibrous capsule
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HPO
Scanty stroma and Fat cells
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Thanking to the entire Universe