Directorate for Biological Sciences: Research and ...
Transcript of Directorate for Biological Sciences: Research and ...
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Directorate for Biological Sciences:Research and Infrastructure Investments
Dr. Jim OldsAssistant Director
National Science FoundationDirectorate for Biological Sciences
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(meters)
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Biology includes biological sciences and environmental biology; excludes National Institutes of Health.
NSF Support of Academic Basic Research in Selected Fields
(as a percentage of total federal support)
Source: NSF/NCSES FY2014
68%
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Applied
Basic
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Molecules
NanostructuresPolymersProteins
Populations Ecosystems
CellsOrganisms
Biosphere
Viruses
Biological Infrastructure (DBI)
Integrative Organismal Systems (IOS)Environmental Sciences (DEB)
Molecular & Cellular Biosciences (MCB)
Community
Emerging Frontiers (EF)
(m)
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BIO FY 2017 Budget Request $ = MillionsTotal = $791M
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NanostructuresPolymersProteins
Populations Ecosystems
CellsOrganisms
BiosphereCommunity
Rules of Life
Molecules
Viruses
RoL =$13M
(m)
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NanostructuresPolymersProteins
Populations Ecosystems
CellsOrganisms
BiosphereCommunity
Rules of Life
Molecules
Viruses
RoL =$13M
(m)NH2—X•••X•••X—COOH
Amino Acid
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Modeling and Theory Development
Experimentation
Observation
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NanostructuresPolymersProteins
Populations Ecosystems
CellsOrganisms
BiosphereCommunity
Molecules
Viruses
Rules of Life
(m)
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Modeling and Theory Development
Experimentation
Observation
Rules of LifeBiological Infrastructure (DBI)
Integrative Organismal Systems (IOS)Environmental Sciences (DEB)
Molecular & Cellular Biosciences (MCB)
Emerging Frontiers (EF)
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NanostructuresPolymersProteins
Populations Ecosystems
CellsOrganisms
BiosphereCommunity
Molecules
Viruses
(m)
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Origin of Life (Ideas Lab)
Rules of Life
Goal: Innovative approaches that explore the origin and early evolution of the two-polymer system that both drives and constrains life on Earth.
Impact: Understanding plausible pathways for the origin of life will contribute directly to understanding the indispensable properties of life on Earth and inform the search for life on other worlds.
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Brains and Behavior
“I love watching these cells be active while the animal is behaving. It’s just remarkable to me that we can see the brain work and try to understand how it’s functioning.” – PI Melina Hale
Rules of Life
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Rules of Life12
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NEON $ = MillionsNEON = $65M
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NanostructuresPolymersProteins
Populations Ecosystems
CellsOrganisms
BiosphereCommunity
National Ecological Observatory Network (NEON)
Molecules
Viruses
(m)
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Availability of Data Products
National Ecological Observatory Network (NEON)15
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Current Construction Status(81 locations in 20 domains)
National Ecological Observatory Network (NEON)16
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MacroSystems Biology and Early NEON Science AwardsExamples:• Collaborative Proposal: MSB-ENSA:
Forest Function from Genes to Canopies: Disentangling the fine scale spatio-temporal variation in gene expression and tree growth (Nathan Swenson, University of Maryland)
• MSB-ECA: Local and Migratory Spatial Foraging Affects Plant-Pollinator-Pathogen Networks (Erin Wilson-Rankin, University of California-Riverside)
• MSB-FRA Modeling Invasion Dynamics Across Scales (MIDAS) (Songlin Fei, Purdue University)
National Ecological Observatory Network (NEON)17
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FY 2017 Request: Major Investments $ = MillionsMajor Investments
= $244M= ~31% of Total
Request
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Molecules
NanostructuresPolymersProteins
Populations Ecosystems
CellsOrganisms
Biosphere
Viruses
Community
Understanding the Brain (UtB)
UtB = $46M(Includes
$19.54M for BRAIN Initiative
activities)
(m)
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BRAIN Initiative & Coordinating Global Brain Projects
(BIO=19.54)
Understanding the Brain (UtB)20
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integrative
transformative synergistic
1. Innovative research resources, instrumentation, & neurotechnologies
Understanding the Brain (UtB)
2. Theoretical frameworks for understanding brain
function...
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Molecules
NanostructuresPolymersProteins
Populations Ecosystems
CellsOrganisms
Biosphere
Viruses
Community
Clean Energy Technology
CET = $79.22M
(m)
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Molecules
NanostructuresPolymersProteins
Populations Ecosystems
CellsOrganisms
Biosphere
Viruses
Community
Microbiome
Microbiome = $16.37M
(m)
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Education, Training, & Career Development$ = Millions
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Tools and Data
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CyVerse
Platforms, tools, datasets Storage and compute Training and support
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NanostructuresPolymersProteins
Populations Ecosystems
CellsOrganisms
BiosphereCommunity
Molecules
Viruses
(m)
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Science and Technology Centers
• Center for Cellular Construction • Science and Technology Center for Engineering
MechanoBiology• Science and Technology Center on Real-Time Functional
Imaging• Center for Bright Beams
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BIOLOGY IS THE ENGINE OF INNOVATION
Basic Discoveries
Tool Development Data
Organisms&
Ecosystems
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Questions?
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Key Questions How can computational modeling and informatics methods enable
data integration for the purpose of analysis and prediction of complex living systems?
Variation in traits expressed by organisms is a feature of all life; what are the genetic, epigenetic and environmental factors that explain its magnitude and occurrence?
How to predict the behavior of living systems, from single molecules to whole cells, whole organisms, and whole ecosystems? To what degree do group interactions and behavior affect phenotypic expression?
To what degree is an organism’s phenome a result of the microorganisms that live in symbiosis with it? To what degree is the production of a phenotype a ‘joint effort’ among genomes of different organisms?
Can we synthesize cells and organisms based on knowledge of genome sequence and physical features of other basic molecules?
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