Diphenidine The Drug Enforcement Administration's Special ... · The Drug Enforcement...
5
Diphenidine The Drug Enforcement Administration's Special Testing and Research Laboratory generated this monograph using structurally confirmed reference material. N 1. GENERAL INFORMATION IUPAC Name: 1-(1,2-diphenylethyl)piperidine CAS#: 36794-52-2 Synonyms: DEP, DPD, DND Source: DEA Reference Material Collection Appearance: White powder (HCl) UV max (nm): Not Determined 2. CHEMICAL AND PHYSICAL DATA 2.1 CHEMICAL DATA Form Chemical Formula Molecular Weight Melting Point ( o C) Base C 19 H 23 N 265 Not Determined HCl C 19 H 23 N . HCl 302 Not Determined Latest Revision: 4/11/2016 SWGDRUG.org/monographs.htm Page 1 of 5
Transcript of Diphenidine The Drug Enforcement Administration's Special ... · The Drug Enforcement...
DiphenidineThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
N
1. GENERAL INFORMATION
IUPAC Name: 1-(1,2-diphenylethyl)piperidine
CAS#: 36794-52-2
Synonyms: DEP, DPD, DND
Source: DEA Reference Material Collection
Appearance: White powder (HCl)
UVmax(nm): Not Determined
2. CHEMICAL AND PHYSICAL DATA
2.1 CHEMICAL DATA
Form Chemical Formula Molecular Weight Melting Point (oC)
Base C19H23N 265 Not Determined
HCl C19H23N. HCl 302 Not Determined
Latest Revision: 4/11/2016
SWGDRUG.org/monographs.htmSWGDRUG.org/monographs.htm
SWGDRUG.org/monographs.htm Page 1 of 5
DiphenidineThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
3. QUALITATIVE DATA
3.1 NUCLEAR MAGNETIC RESONANCE
Sample Preparation: Dilute analyte to ~5 mg/mL in deuterated methanol containing TMS for 0 ppm reference and maleic acid as quantitative internal standard.
Instrument: 400 MHz NMR spectrometerParameters: Spectral width: at least containing -3 ppm through 13 ppm
Pulse angle: 90o
Delay between pulses: 45 seconds1HNMR: Diphenidine HCl Lot 0459009-17; CD3OD; 400MHz
8 7 6 5 4 3 2 1 0
152211155
from CD3OD
TMS
Maleic Acid
from CD3OD
7.50 7.25 7.00
55
4.55 4.50
1
2.9 2.8
2
3.8 3.7 3.6 3.5 3.4
211
2.00 1.75 1.50
15
Latest Revision: 4/11/2016 SWGDRUG.org/monographs.htm Page 2 of 5
DiphenidineThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
3.2 GAS CHROMATOGRAPHY/MASS SPECTROMETRY
Sample Preparation: Dilute analyte ~3 mg/mL in methanol.
Instrument: Agilent gas chromatograph operated in split mode with MS detectorColumn: DB-5 MS (or equivalent); 30m x 0.25 mm x 0.25 µmCarrier Gas: Helium at 1 mL/minTemperatures: Injector: 280oC
MSD transfer line: 280oCMS Source: 250oCMS Quad: 150oCOven program:
1) 100oC initial temperature for 1.0 min2) Ramp to 280oC at 12 oC/min3) Hold final temperature for 9.0 min
Injection Parameters:MS Parameters:
Retention Time:
Split Ratio = 25:1, 1 µL injected Mass scan range: 30-550 amu Threshold: 150Tune file: stune.uAcquisition mode: scan9.738 min
EI Mass Spectrum: Diphenidine HCl Lot 0459009-17
m/z260240220200180160140120100806040
[x 1
06 ]In
tens
ity
0.5
1.0
1.5
2.0
2.5
3.0
3.5
265
265
265
265
265
265
265
265
265
265
265
265
265
265
265
265
265
265
265
265
265
26517
817
817
817
817
817
817
817
817
817
817
817
817
817
817
817
817
817
817
817
817
817
817
417
417
417
417
417
417
417
417
417
417
417
417
417
417
417
417
417
417
417
417
417
4
165
165
165
165
165
165
165
165
165
165
165
165
165
165
165
165
165
165
165
165
165
165
152
152
152
152
152
152
152
152
152
152
152
152
152
152
152
152
152
152
152
152
152
152
144
144
144
144
144
144
144
144
144
144
144
144
144
144
144
144
144
144
144
144
144
144
130
130
130
130
130
130
130
130
130
130
130
130
130
130
130
130
130
130
130
130
130
130
117
117
117
117
117
117
117
117
117
117
117
117
117
117
117
117
117
117
117
117
117
117
106
106
106
106
106
106
106
106
106
106
106
106
106
106
106
106
106
106
106
106
106
106103
103
103
103
103
103
103
103
103
103
103
103
103
103
103
103
103
103
103
103
103
103
919191 9191919191 9191919191 9191919191 91919191
777777 7777777777 7777777777 7777777777 77777777656565 6565656565 6565656565 6565656565 65656565515151 5151515151 5151515151 5151515151 51515151
414141 4141414141 4141414141 4141414141 41414141
Latest Revision: 4/11/2016 SWGDRUG.org/monographs.htm Page 3 of 5
DiphenidineThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
3.3 INFRARED SPECTROSCOPY (FTIR)
Instrument: FTIR with diamond ATR attachment (1 Bounce)Scan Parameters: Number of scans: 32
Number of background scans: 32Resolution: 4 cm-1
Sample gain: 1Aperture: 150
FTIR ATR (Diamond, 1 Bounce): Diphenidine HCl Lot 0459009-17
Wavenumber (cm-1)3500 3000 2500 2000 1500
%Tr
ansm
ittan
ce
56
64
72
80 3258325832583258325832583258325832583258325832583258325832583258325832583258325832583258
3161316131613161316131613161316131613161316131613161316131613161316131613161316131613161
2513251325132513251325132513251325132513251325132513251325132513251325132513251325132513
1494149414941494149414941494149414941494149414941494149414941494149414941494149414941494 1456
145614561456145614561456145614561456145614561456145614561456145614561456145614561456
1447144714471447144714471447144714471447144714471447144714471447144714471447144714471447
1436143614361436143614361436143614361436143614361436143614361436143614361436143614361436
918918918918918918918918918918918918918918918918918918918918918918
782782782782782782782782782782782782782782782782782782782782782782764764764764764764764764764764764764764764764764764764764764764764 742
742742742742742742742742742742742742742742742742742742742742742
718718718718718718718718718718718718718718718718718718718718718718
705705705705705705705705705705705705705705705705705705705705705705
671671671671671671671671671671671671671671671671671671671671671671667667667667667667667667667667667667667667667667667667667667667667
559559559559559559559559559559559559559559559559559559559559559559
536536536536536536536536536536536536536536536536536536536536536536
511511511511511511511511511511511511511511511511511511511511511511
Wavenumber (cm-1)1700 1600 1500 1400 1300 1200 1100 1000 900 800 700
%Tr
ansm
ittan
ce
56
64
72
80
1494149414941494149414941494149414941494149414941494149414941494149414941494149414941494 1456
145614561456145614561456145614561456145614561456145614561456145614561456145614561456
1447144714471447144714471447144714471447144714471447144714471447144714471447144714471447
1436143614361436143614361436143614361436143614361436143614361436143614361436143614361436
918918918918918918918918918918918918918918918918918918918918918918
782782782782782782782782782782782782782782782782782782782782782782764764764764764764764764764764764764764764764764764764764764764764 742
742742742742742742742742742742742742742742742742742742742742742
718718718718718718718718718718718718718718718718718718718718718718
705705705705705705705705705705705705705705705705705705705705705705
671671671671671671671671671671671671671671671671671671671671671671667667667667667667667667667667667667667667667667667667667667667667
621621621621621621621621621621621621621621621621621621621621621621
582582582582582582582582582582582582582582582582582582582582582582 559
559559559559559559559559559559559559559559559559559559559559559
536536536536536536536536536536536536536536536536536536536536536536
511511511511511511511511511511511511511511511511511511511511511511
Latest Revision: 4/11/2016 SWGDRUG.org/monographs.htm Page 4 of 5
DiphenidineThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
http://en.wikipedia.org/wiki/Diphenidine
4. ADDITIONAL RESOURCES
Wikipedia
Latest Revision: 4/11/2016 SWGDRUG.org/monographs.htm Page 5 of 5
