Digital Light Innovations...Life Sciences Economic Impact on Austin • Dean of Dell Medical School...
Transcript of Digital Light Innovations...Life Sciences Economic Impact on Austin • Dean of Dell Medical School...
Digital Light Hyperspectral Imaging for the Medical Arena
Brian Crowell
May 6, 2014
A Texas Technology Story 9 Years in the Making
Digital Light Hyperspectral Imaging for the Medical Arena
Chronicling the journey of commercializing innovative imaging technology for
A Texas Technology Story 9 Years in the Making
surgical & medical applications
A Joint Texas Entrepreneurial Venture
TX Industry Military
Federal & TX Government
Austin
San Antonio
Plano
Dallas Arlington
Houston
Fort Worth
& Academic Institutions TX Medical Centers
The DLHsi Commercialization Stages
I. The Science & Technology
II. Early Research & Support
III. Clinical Exercises
IV. Entrepreneurship / Eng / Dev
V. Commercialization
Stage I. The Science & Technology
I. The Science & Technology
II. Early Research & Support
III. Clinical Exercises
IV. Entrepreneurship / Eng / Dev
V. Commercialization
Stage I. The Science & Technology
Video: Intro to Hyperspectral Imaging
Dr. Karel Zuzak, P.h.D. – DLHsi Inventor
• Developed Hyperspectral Imaging, Hsi, at the University of Texas Arlington
• Translated Hsi to the surgical and clinical bedside at UT Southwestern Medical Center
• Founded The Laboratory of Biomedical Imaging (LBI) at UTA
Arlington
• By measuring the spectrum of reflected light, the biochemical composition of the tissue can be evaluated
• DLP ® technology has the unique ability to conform light to any desired spectral illumination scheme - Active Illumination
• Real-time mapping & visualization of tissue oxygen levels of a patient 10
20
30
40
50
60 Relative HbO2
DLHsi for Medical & Surgical Utilities
Arlington
DLHsi for Medical & Surgical Utilities
• As expected the tissue oxygenation falls below normal with a tourniquet restricting blood flow to a finger and above normal after removing the tourniquet
Tourniquet In-Place:
58 % HbO2
Tourniquet Removed:
83 % HbO2
Arlington
10
20
30
40
50
60
70
80
90
Percentage HbO
2
82%HbO2
DLHsi Prototype Setup
Texas Instruments DLP® Chip
Arlington
Stage II: Early Research & Support
I. The Science & Technology
II. Early Research & Support
III. Clinical Exercises
IV. Entrepreneurship / Eng / Dev
V. Commercialization
University of Texas at Arlington
Engineering Laboratory Building
Arlington
UTA Chemistry & Science Building
The Laboratory of Biomedical Imaging (LBI)
The Laboratory of Biomedical Imaging
Mission
Bringing Better Health To Everyone by Developing Hyperspectral Imaging for Surgical and Clinical Utilities
Arlington
Texas Congressman Joe Barton
Representative Joe Barton
R-Texas, 6th District
Fort Worth
Texas Congressman Joe Barton
Demonstrating DLHsi to Congressman Joe Barton
• Provided funding to support the translation of medical imaging technology from the research laboratories at UT Arlington to the clinics and surgeries at UT Southwestern Medical Center
• Resulted in building the Advanced Medical Imaging Laboratory on the UT Southwestern campus
• Created a complete team of specialists from the research & developers, to the clinicians that will use the technology
Congressman Joe Barton giving Funding Check
Fort Worth
Texas Instruments
Plano
Texas Instruments, Plano, TX
Platform Technology Patent
• Research resulted in a Platform Technology Patent application being issued in 2012
• UT system as the IP Assignee
Arlington
Stage III. Clinical Exercises
I. The Science & Technology
II. Early Research & Support
III. Clinical Exercises
IV. Entrepreneurship / Eng / Dev
V. Commercialization
UT Southwestern Medical Center
• The premier location for the Biomedical Industry to interact with clinical, surgical, academic, sciences, engineering, and technology.
UT Southwestern Medical Center, Dallas, TX
UT Southwestern Medical Center, Dallas, TX
Dallas
Clinical Collaborators – Endocrinology
Dr. Edward Livingston, M.D.
• Chairman of GI Endocrine Surgery • Southwestern Medical Center • Clinical & Surgical collaborator • Early Clinical Advocate • Helped acquire TI funding • Used own endowment to fund preliminary data collection
Dallas
Clinical Collaborators – Plastic Surgery
Dr. Michel Saint-Cyr, M.D.
Skin Flaps
Dr. Lawrence Lavery, D.P.M.
Lower Limb Amputation
Dr. Javier La Fontaine, D.P.M.
Lower Limb Wounds/Wound Debridement
Dallas
Clinical Collaborators - Endoscopy
Dr. Jeffrey Cadeddu, M.D.
• Director of the UT Southwestern Clinical Center for Minimally Invasive Treatment of Urologic Cancer
• Endoscopy
Dallas
Dallas Veterans Affairs Medical Center
Dallas
Dallas VA Medical Center, Dallas, TX
United States Army – Fort Sam Houston
Brooke Army Medical Center (BAMC) - San Antonio, TX Fort Sam Houston - San Antonio, TX
San Antonio
Clinical Collaborators – Combat Medicine / Burns
Leopoldo C. Cancio, M.D., FACS
• Colonel, MC, US Army
• Brooke Army Medical Center
• Critical Care Fellow
• Combat Medicine & Burns
San Antonio
Stage IV: Entrepreneurship / Engineering / Standards
I. The Science & Technology
II. Early Research & Support
III. Clinical Exercises
IV. Entrepreneurship / Eng / Dev
V. Commercialization
Digital Light Innovations (DLi)
DLP ® Design House
Austin
Digital Light Innovations (DLi)
DLP ® Design House
Austin
Video: Intro to DLP ® Technology
Digital Light Innovations (DLi)
• Authorized Design House for DLP® embedded products
• DLi TI DLP® Symposium
• Recognized Zuzak & HSi at research state
• Hired Dr. Zuzak from UTA
• Began licensing negotiations for UTA IP
• Zuzak & DLi engineers quickly added synergistic IP applications
• Implemented ISO 13485 & FDA 21 CFR 820 Design Controls
Austin
Digital Light Innovations (DLi)
• Licensing Contracted with large medical device channel owner for development, sales & support of DLHsi device
• Other, clinically proven, fields of use
• Opportunity to broaden technology within medical market, additional biomarkers
• Ability to add complementary technology (non-contact, 3D measurement, vein location) to DLHsi device
• Researching extending technology into adjacent markets, i.e. food safety (preliminary)
Austin
TIETRONIX Software
• Software development partner
• ISO 13485 and 21 CFR 820 Compliant
• Strategic initiative to penetrate Austin medical development market
• Deliver complex, mission-critical systems to NASA’s space flight operations
• Augmented Reality
Houston
ISO Certification
• ISO 13485 Compliant Processes
• Represents the requirements for a comprehensive quality management system for the design and manufacture of medical devices
• EMERGO GROUP consulted on our implementation
• Building Design History File
•Third-Party Audit in Q4 2014
Austin
FDA Certification
• Food & Drug Administration
• Compliance for Medical Devices
• 21 CFR 820 Certification
• Code of Federal Regulations Title 21
Austin
Stage V. Commercialization
I. The Science & Technology
II. Early Research & Support
III. Clinical Exercises
IV. Entrepreneurship / Eng / Dev
V. Commercialization
The Client – Texas Medical Device Company
• Headquartered in Texas
• Worldwide footprint
• Clinic & hospital environments
• Multi-billion dollar revenue
• Focusing on improving standard of care while reducing direct & indirect costs of healthcare within field of use
Economic Spend
I. The Science & Technology $1M UTA < 2005
II. Early Research & Support $1M Gov/TI 2006/2010
III. Clinical Exercises $0.5M UTSWMC 2009/2010
IV. Entrepreneurship/Eng/Dev > $0.5M DLi 2011
V. Pre-sales Commercialization > $6M Client 2014
Life Sciences Economic Impact on Austin
• Dean of Dell Medical School at University of Texas Austin
• Dr. Clay Johnston
• Digital Healthcare Initiative
• Austin-Round Rock-San Marcos Metropolitan Area (MSA)
* The Life Sciences sector in Austin MSA represents:
• > $1 billion in value added to the regional economy
• 206 companies
• Approximately 6,052 jobs
• Five industries contributed > $100 million
Dr. Clay Johnston, M.D., Ph.D. Dean of Dell Medical School, UT Austin
Digital Light Hyperspectral Imaging for the Medical Arena
Thank You
A Texas Technology Story 9 Years in the Making