Digestive System

Sharif TanvirExecutive, PMDConcord Pharmaceuticals Ltd.

Digestive SystemThe human gastrointestinal tract, or GI tract,or GIT is an organ system responsible for consuming and digesting foodstuffs,absorbing nutrients, and expelling waste.

Digestive SystemGI tract includes all structures betweenthe mouth and the anus. On the other hand,the digestive system is a broader term thatincludes other structures, including thedigestive organs and their accessories

Part of Digestive System

Functions of the GI system• Motility: movement through the GI tract

• Digestion: breakdown of food or chyme

• Secretion and absorption: across and epithelial layer

either into the GI tract (secretion) or into blood

(absorption)

• Storage and elimination

Parts of the stomach• Fundus• body• pyloric region (pyloric sphincter)• material passed from the stomach to the small

intestine is called the chyme.• The gastric glands of the stomach contain

several types of cells:

Parts of the stomach

Antiulcerants• Esmax (Esomeprazole)

20 mg & 40 mg Capsule20 mg Tablet

• Pramax (Pantoprazole) 20 mg & 40 mg Tablet

• Opmax (Omeprazole)20 mg & 40 mg Capsule

H2 Receptor Blocker

• Recodin 150 Tablet (Ranitidine)

Physiology of Gastric Acid Secretion

Indications of PPIs 1. Gastro esophageal reflux disease: ( GERD) •  It is a chronic symptom of mucosal damage caused by stomach acid

coming up from the stomach into the esophagus tube.

2. Heart burn: • It is a painful burning feeling in the chest or throat. It happens when

stomach acid backs up into esophagus tube that carries food from mouth to stomach.

3. Zollinger-Ellison syndrome• Zollinger-Ellison syndrome is a complex condition in which one or more

tumors form in your pancreas or the upper part of your small intestine (duodenum).

4. NSIDs induced ulcer

Indications of PPIs 5. Gastric Ulcer Peptic ulcers are open sores that develop on theinside lining of your esophagus, stomach and theupper portion of your small intestine. The mostcommon symptom of a peptic ulcer is abdominalpain.

Gastro-Prokinetic Agent

• Doagut Tablet 10 mg (Domperidone)• Doagut Tablet Suspension

5mg/5ml (Domperidone)

Mechanism of ActionDomperidone is a peripheral dopamine (D2) and(D3) receptor antagonist.

It provides relief from nausea by blockingreceptors at the chemo-receptor trigger zone (alocation in the nervous system that registersnausea) at the floor of the fourth ventricle (alocation near the brain).

Indications

• Nausea & Vomiting• Non-ulcer dyspepsia• Reflux Esophagitis and Gastritis • Functional Dyspepsia• Migraine

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