Differential pulse polarographic Determination

of Submicrogram Quantities of Carmustin and Related Compounds

in Biological Samples

Bartosek I., Daniel S., Sykora S.

J.Pharmac.Sci. 67, 1160-1163 (1978)

This copy, scanned from an Author’s reprint, is intended for personal perusal only.

Other uses require permission of the American Pharmaceutical Association.

Other works by Stan Sykora can be found at www.ebyte.it

Abstract:

A polarographic method was developed to determine the antineoplastic agent carmustin and other nitrosoureas,

such as N-methyl-N-nitrosourea and N-cyclohexyl-N-nitrosourea, in biological liquids at levels well below

1µg/ml or g. The stability of carmustin in different media was investigated to prevent losses during

administration or essay. Examples of nitrosourea determination in biological samples are given.

Keywords: Polarography, Carmustin, Nitrosourea, Biological samples, Antineoplastics