Differential leukocyte
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Transcript of Differential leukocyte
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Differential LeukocyteCount
Dr.Raghuveer.CR
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Objectives
▪ Definition of DLC▪ Identification of WBCs▪ Functions▪ Conditions effecting WBCs count
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DLC-Relative proportion of different leukocytes expressed as percentage.
USES:▪ To support the diagnosis of infectious ,
inflammatory or allergic disorders.▪ Diagnosis of malignant blood disorders
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Identification-Neutrophils
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Neutrophilia-ANC7500/microL
▪ Acute bacterial infections▪ Tissue necrosis▪ Acute blood loss▪ Acute haemorrhage▪ Metabolic disorders▪ Poisoning▪ Malignant tumors
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Neutropenia-ANC<2000/microL
▪ Decreased or ineffective production in BM▪ Infections- Typhoid , Miliary Tuberculosis,
measles , rubella , influenza▪ Hematologic disorders▪ Drugs-Analgesics , antithyroid drugs , anti
cancer drugs▪ Ionizing radiation
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Increased destruction
▪ Neonatal isoimmune neutropenia▪ Systemic lupus erythematous▪ Felty’s syndrome
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Eosinophil
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Eosinophilia-AEC>600/microL
▪ Allergic diseases▪ Skin diseases- Eczema , dermatitis herpetiformis▪ Parasitic infection ▪ Carcinoma with necrosis▪ Lung diseases- Loffler's syndrome , tropical
eosinophilia
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Basophil
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Basophilia- ABC >100/ microL
▪ CML▪ Polycythemia vera▪ Myxedema▪ Drug/food allergies
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Monocyte
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Monocytosis AMC>1000/micro l
▪ Infections-TB , Sub Acute Bacterial Endocarditis▪ Hodgkins disease▪ Ulcerative colitis , Chrons disease
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Small and Large lymphocyte
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Lymphocytosis
▪ ALC >4000(adults) >9000(children)Infections- Hepatitis , Cyto megalo virus ,
mumps , rubella , varicella , TB , BrucellosisAML , CML , Multiple myeloma
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Summary
▪ DLC-Relative proportion of leucocytes▪ Neutrophils-40 -60%- Acute infection▪ Lymphocytes-20 – 40%-Viral infection▪ Monocytes: 2 – 8%-Chronic inflammation▪ Eosinophils: 1 – 4%-Allergy and parasitic infection▪ Basophils: 0.5 – 1%--CML
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Thank You